دانلود مقالات ISI درباره آلک + ترجمه فارسی

Fatal acute disseminated intravascular coagulation as presentation of advanced ALK-positive non-small cell lung cancer: Does oncogene addiction matter?

Keywords: آلک; NSCLC; ALK; Thrombosis; DIC;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naïve versus alcoholic liver in rats

Keywords: آلک; AFL; alcoholic fatty liver; ALD; alcoholic liver disease; ALK; alkaline phosphatase; ALT; alaninetransaminase; ASA; acetylsalicylic acid; AST; aspartate transaminase; Bcl2; B cell lymphoma type 2; BSP; bromsulphthalein; COX-I; cyclooxygenase I; GSH; gluta

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol

Keywords: آلک; ALK; TrkA; Alcohol use disorder; Binge-drinking; Pleiotrophin; Midkine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer

Keywords: آلک; ADC; adenocarcinoma; ALK; anaplastic lymphoma kinase; CT; computed tomography; HGF; hepatocyte growth factor; IHC; immunohistochemical; KIF5B; kinesin family member 5b; MET; MET proto-oncogene, receptor tyrosine kinase; NSCLC; non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysis

Keywords: آلک; LUSC; lung squamous cell cancer; TCGA; the Cancer Genome Atlas; GTEx; genotype-tissue expression; UGT1A1; UDP glucuronosyltransferase family 1 member A1; UGT1A3; UDP glucuronosyltransferase family 1 member A3 UGT1A6 UDP glucuronosyltransferase family 1 me

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

The tyrosine kinase inhibitor crizotinib does not have clinically meaningful activity in heavily pre-treated patients with advanced alveolar rhabdomyosarcoma with FOXO rearrangement: European Organisation for Research and Treatment of Cancer phase 2 trial

Keywords: آلک; Alveolar rhabdomyosarcoma; ARMS; Metastasis; FOXO1; ALK; Crizotinib;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives

Keywords: آلک; NNSCLC; non-small cell lung cancer; OS; overall survival; EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; ALK; Anaplastic lymphoma kinase; MET; mesenchymal epithelial transition factor; PFS; progression free survival; HER2; human e

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Dually modified transmembrane proteoglycans in development and disease

Keywords: آلک; ActR; activin type receptor; ALK; activin receptor like kinase; AV; atrioventricular cushion; BMP; bone morphogenetic protein; BMPR; bone morphogenetic protein receptor; C1; conserved domain 1; C2; conserved domain 2; Cdc42; control protein 42 homolog; CS

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Coupling of partial nitritation and anammox in two- and one-stage systems: Process operation, N2O emission and microbial community

Keywords: آلک; Partial nitritation; Anaerobic ammonium oxidation; Sequencing batch reactor; Sewage sludge anaerobic digester supernatant; Nitrous oxide emission; Phosphate; ALK; alkalinity; anammox; anaerobic ammonium oxidation; ANR; autotrophic N removal; AOB; ammonium

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

ALK-TPM3 rearrangement in adult renal cell carcinoma: Report of a new case showing loss of chromosome 3 and literature review

Keywords: آلک; Renal cell carcinoma; translocation; ALK; TPM3;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma

Keywords: آلک; ALK; Anaplastic Lymphoma kinase; ATRA; all-trans-retinoic acid; BMP4; Bone morphogenetic protein 4; CCND1; Cyclin D1; EGF; Epidermal growth factor; EPAS1; Endothelial PAS Domain Protein 1; ERK; extracellular signal-regulated kinases; EMT; Epithelial-mesen

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Baseline and On-Treatment Characteristics of Serum Tumor Markers in Stage IV Oncogene-Addicted Adenocarcinoma of the Lung

Keywords: آلک; Serum tumor marker; CEA; CA125; CA199; CA2729; Non-small cell lung cancer; EGFR; KRAS; ROS1; ALK;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Next generation sequencing reveals a novel ALK G1128A mutation resistant to crizotinib in an ALK-Rearranged NSCLC patient

Keywords: آلک; ALK; anaplastic lymphoma kinase; CT; computed tomography; E-BUS; endobronchial ultrasound; IHC; immunohistochemistry; MRI; magnetic resonance imaging; NGS; next-generation sequencing; NSCLC; non-small cell lung cancer; PD; progression of disease; PR; part

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Excellent Outcomes with Radiosurgery for Multiple Brain Metastases in ALK and EGFR Driven Non-Small Cell Lung Cancer

Keywords: آلک; NSCLC; EGFR; ALK; Stereotactic radiosurgery; Brain metastases;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2018 سفارش ترجمه

Analysis of sporadic neuroblastic tumors reveals a novel PHOX2B mutation in neuroblastoma

Keywords: آلک; NB; neuroblastoma; GNB; ganglioneuroblastoma; GNR; ganglioneuroma; PHOX2B; Paired like homeobox 2b; ALK; anaplastic lymphoma kinase; CCHS; congenital central hypoventilation syndrome; HSCR; Hirschsprung syndrome; PARMs; poly-alanine repeat expansion mutat

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

Evaluation of a Dual ALK/ROS1 Fluorescent In Situ Hybridization Test in Non-Small-cell Lung Cancer

Keywords: آلک; ALK; Immunohistochemistry; Multiplex FISH; NSCLC; ROS1;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC

Keywords: آلک; ALK; cMET; EGFR; KRAS; Non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors

Keywords: آلک; ALK; anaplastic lymphoma kinase; cMet; hepatocyte growth factor receptor; DIPEA; N,N-Diisopropylethylamine; DMF; N,N-Dimethylformamide; EML4; echinoderm microtubule-associated protein-like 4; FDA; food and drug administration; gk; gatekeeper; μW; micro w

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Prognostic role of the VeriStrat test in first line patients with non-small cell lung cancer treated with platinum-based chemotherapy

Keywords: آلک; ALK; anaplastic lymphoma kinase; CPH; Cox proportional hazard; EGFR; epidermal growth factor receptor; ERCC1; excision repair cross-complementation group 1 protein; HR; hazard ratio; MALDI ToF; matrix-assisted laser desorption/ionization time-of-flight; N

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical Application of Genomic Profiling With Circulating Tumor DNA for Management of Advanced Non-Small-cell Lung Cancer in Asia

Keywords: آلک; ALK; EGFR; Liquid biopsy; NSCLC; Targetable alterations;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates

Keywords: آلک; ALK; anaplastic lymphoma kinase; Bab; combined Bcrp and Mdr1a/b knockout; Cyp3aXAV; Cyp3a knockout mice with specific expression of human CYP3A4 in liver and intestine; IS; internal standard; LC-MS/MS; liquid chromatography-tandem mass spectrometry; LLO

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the EGFR inhibitors afatinib, erlotinib and osimertinib, the ALK inhibitor crizotinib and the VEGFR inhibitor nintedanib in human plasma from non-small cell lung canc

Keywords: آلک; AFAT; afatinib; ALK; anaplastic lymphoma kinase; CRIZ; crizotinib; CS; calibration standard; CV; coefficient of variation; DMSO; dimethylsulfoxide; EGFR; epidermal growth factor receptor; ERLO; erlotinib; IQC; internal quality control; IS; internal standa

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

COL5A1 may contribute the metastasis of lung adenocarcinoma

Keywords: آلک; SCLC; Small-cell Lung Carcinoma; NSCLC; Non-small-cell Lung Carcinoma; TKIs; Tyrosine Kinase Inhibitors; EGFR; Epidermal Growth Factor Receptor; ALK; Anaplastic Lymphoma Kinase; DEGs; Differentially Expressed Genes; GEO; Gene Expression Omnibus; GO; Gene

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Concomitance of EGFR mutations and ALK rearrangement in patients with Lung Cancer

Keywords: آلک; ALK; Anaplastic lymphoma kinase; EGFR; Epithelial growth factor receptor; EML4; Echinoderm Microtubule Associated Protein Like 4; K-Ras; Kirsten rat sarcoma viral; MAPK; Mitogen-activated protein kinases; NSCLCs; Non-small cell lung cancers; PI3K; Phospha

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Evaluation of NGS and RT-PCR Methods for ALK Rearrangement in European NSCLC Patients: Results from the European Thoracic Oncology Platform Lungscape Project

Keywords: آلک; NSCLC; ALK; NGS; RT-PCR;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

Keywords: آلک; ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; ANOVA; analysis of variance; AUC; area under plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BTB; blood-testis barrier; Cbrain; brain concentrat

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of 2,4-diarylaminopyrimidines bearing a resorcinol motif as novel ALK inhibitors to overcome the G1202R resistant mutation

Keywords: آلک; ALK; G1202R mutant; Drug resistance; 2,4-Diarylaminopyrimidine; Resorcinol;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Role of upregulated miR-136-5p in lung adenocarcinoma: A study of 1242 samples utilizing bioinformatics analysis

Keywords: آلک; NSCLC; non small cell lung cancer; SCLC; small cell lung cancer; LUAD; lung adenocarcinoma; miRNAs; microRNAs; GO; Gene Ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; PANTHER; Protein Analysis Through Evolutionary Relationships; GEO; Gene Expres

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

GDF11 expression in the adult rat central nervous system

Keywords: آلک; ALK; activin receptor like kinase; BMP; bone morphogenetic protein; CNS; central nervous system; GDF; growth differentiation factor; GFAP; glial fibrillary acidic protein; IR; like immunoreactivity; PB; phosphate buffer; RT; room temperature; TGF-β; tran

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R

Keywords: آلک; 2,4-Diarylaminopyrimidine; Dual inhibitor; ALK; ROS1; Crizotinib-resistant;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy

Keywords: آلک; Cirrhosis; DDAH-1; FXR; Kidney; Rosuvastatin; Silymarin; ADMA; asymmetric dimethylarginine; ALK; Alkaline phosphatase; ALT; alaninetransaminase; AST; aspartate transaminase; CRD; Chronic Renal Disease; DDAH; dimethylarginine dimethylaminohydrolase-; ED; E

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2018 سفارش ترجمه

TGFβ pathway inhibition in the treatment of non-small cell lung cancer

Keywords: آلک; ALK; Anaplastic leukemia kinase; CAF; Cancer-associated fibroblast; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; MSC; Mesenchymal stem cell; NK Cell; Natural killer cell; NSCLC; Non-small cell lung cancer; OS; Overall

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2018 سفارش ترجمه

Pulmonary adenocarcinoma with enteric differentiation: Dissecting oncogenic genes alterations with DNA sequencing and FISH analysis

Keywords: آلک; Lung adenocarcinoma; Enteric; EGFR; K-RAS; ALK; PIK3CA;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Validation of ALK/ROS1 Dual Break Apart FISH Probe probe in non-small-cell lung cancer

Keywords: آلک; ALK; ROS1; Fluorescent in situ hybridization; Non-small-cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Environmental tobacco smoke exposure and EGFR and ALK alterations in never smokers' lung cancer. Results from the LCRINS study

Keywords: آلک; Lung neoplasms; Never-smokers; Case-control study; Epidermal growth factor receptor; ALK; Environmental tobacco smoke;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers

Keywords: آلک; Human AlkB homolog 3; Non-small cell lung cancer; TP53; p53; Apoptosis; 1-meA; 1-methyladenine; 3-meC; 3-methylcytosine; ALK; anaplastic lymphoma kinase; ALKBH3; AlkB homolog 3; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and RAD3-relat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleRegulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells

Keywords: آلک; AC; adenylyl cyclase; ActRІІ; activin type ІІ receptor; ALK; activin receptor-like kinase; BMP; bone morphogenetic protein; BMPRІІ; BMP type ІІ receptor; BtcAMP; N6,O2-dibutyryl adenosine-3',5'-cyclic monophosphate monosodium salt; ER; estroge

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Phase I clinical trials in patients with advanced non-small cell lung cancer treated within a Drug Development Unit: What have we learnt?

Keywords: آلک; ALK; Anaplastic Lymphoma Kinase; DDU; Drug Development Unit; ECOG PS; Eastern Cooperative Oncology Group performance status; EGFR; epidermal growth factor receptor; EPR; electronic patient record; HDAC; histone deacetylase; IGF-1R; insulin growth factor-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC

Keywords: آلک; ADC; adenocarcinoma; ALK; anaplastic lymphoma kinase; ASR; age-standardized rate; BICR; blind independent central review; CI; confidence interval; CNS; central nervous system; CONSORT; Consolidated Standards of Reporting Trials; CT; computed tomography; D

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

The versatility and paradox of GDF 11

Keywords: آلک; ALK; Activin receptor-like kinase; BAMBI; BMP and activin membrane-bound inhibitor; dpc; Days post coitus; EPO; Erythropoietin; GASP; GDF-associated serum protein; GDF 11; Growth/differentiation factor 11; GDF 8; Growth/differentiation factor 8; Gdnf; Gli

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology

Keywords: آلک; ActRIIB; activin receptor type-2B; MSTN; myostatin; GDF11; growth differentiation factor 11; BMP9; bone morphogenetic protein 9; PPI; protein-protein interaction; ALK; activin receptor type-1B; ActRIIB; Antagonist; Ligand-selectivity; Peptide; Phage displ

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Therapeutic strategies and mechanisms of drug resistance in anaplastic lymphoma kinase (ALK)-rearranged lung cancer

Keywords: آلک; ALK; Fusion gene; Resistance; Mutation; Tyrosine kinase inhibitor; ALK; Anaplastic lymphoma kinase; TKI; Tyrosine kinase inhibitors; ALCL; Anaplastic large-cell non-Hodgkin's lymphoma; NB; Neuroblastoma; NSCLC; Non-small cell lung cancer; NPM; Nucleophosm

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewDrug resistance in ALK-positiveNon-small cell lungcancer patients

Keywords: آلک; ALK; Point mutation; Crizotinib; Ceritinib; Alectinib; Lorlatinib;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Original contributionExpression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma★

Keywords: آلک; ADC; adenocarcinoma; AKT; protein kinase B; ALK; anaplastic lymphoma kinase; BM; brain metastasis; EGFR; epidermal growth factor receptor; IGFR-1; insulin-like growth factor receptor-1; IHC; immunohistochemistry; mTOR; mammalian target of rapamycin; mTORC

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewManagement of ceritinib therapy and adverse events in patients with ALK-rearranged non-small cell lung cancer

Keywords: آلک; AE; adverse events; ALK; anaplastic lymphoma kinase; ALKi; anaplastic lymphoma kinase inhibitor; ALK+; anaplastic lymphoma kinase rearrangement; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BIRC; blinded independent review committee; CT

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleThe second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model

Keywords: آلک; Neuroblastoma; ALK inhibitor; Alectinib; PI3K/Akt/mTOR; Apoptosis; NB; neuroblastoma; ALK; anaplastic lymphoma kinase; WT; wild type; dox; doxorubicin; DMSO; dimethyl sulfoxide; FDA; Food and Drug Administration; ALCL; anaplastic large cell lymphoma; NSCL

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy

Keywords: آلک; ActRIIA; activin type II receptor A; ActRIIB; activin type II receptor B; ALK; activin receptor-like kinase; CFC; Cripto-1/FLR1/cryptic; ECD; extracellular domain; EGF; epidermal growth factor; GEM; Group epitope mapping; mAb; monoclonal antibody; SMAD; S

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Glycyrrhizic acid: A promising carrier material for anticancer therapy

Keywords: آلک; ACF; aberrant crypt foci; ADR; adriamycin; AKT; serine-threonine protein kinase; ALK; anaplastic lymphoma kinase; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; serum levels of aspartate aminotransferase; A549; lung adenocarcinoma cell lin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Research reportGenetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in Neurofibromatosis 1 mutant mice

Keywords: آلک; Alk; NF1; Hippocampus; Cognition; Neurofibromatosis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Treatment, outcome and quality of life of 1239 patients with advanced non-small cell lung cancer - final results from the prospective German TLK cohort study

Keywords: آلک; ALK; Anaplastic Lymphoma Kinase; BMI; body mass index; CCI; Charlson Comorbidity Index; CI; confidence interval; CR; complete response; CRISP; clinical research platform into molecular testing, treatment and outcome of non-small cell lung carcinoma patien

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه