کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5557678 | 1560930 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The versatility and paradox of GDF 11
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کلمات کلیدی
Days post coitusNgn3TSAEPOGASPHDACGDNFTGF βBmp and activin membrane-bound inhibitorDPCALK - آلکerythropoietin - اریتروپویتینolfactory epithelium - اپیتلیوم بویاییBambi - بمبیBiomarker - بیومارکرTransforming Growth Factor Beta - تبدیل بتا فاکتور رشدTrichostatin A - تریکوستاتین ADevelopment - رشدAging - سالخوردگیBMP signaling - سیگنالینگ BMPgrowth differentiation factor 11 - عامل تمایز رشد 11Glial cell line-derived neurotrophic factor - فاکتور نوروتروفی مشتق از سلول گلیاییNeurogenin 3 - نوروژنین 3histone deacetylase - هیستون داستیلازactivin receptor-like kinase - کیناز گیرنده مانند فعال است
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In addition to its roles in embryonic development, Growth and Differentiation Factor 11 (GDF 11) has recently drawn much interest about its roles in other processes, such as aging. GDF 11 has been shown to play pivotal roles in the rescue of the proliferative and regenerative capabilities of skeletal muscle, neural stem cells and cardiomyocytes. We would be remiss not to point that some controversy exists regarding the role of GDF 11 in biological processes and whether it will serve as a therapeutic agent. The latest studies have shown that the level of circulating GDF 11 correlates with the outcomes of patients with cardiovascular diseases, cancer and uremia. Based on these studies, GDF 11 is a promising candidate to serve as a novel biomarker of diseases. This brief review gives a detailed and concise view of the regulation and functions of GDF 11 and its roles in development, neurogenesis and erythropoiesis as well as the prospect of using this protein as an indicator of cardiac health and aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 175, July 2017, Pages 28-34
Journal: Pharmacology & Therapeutics - Volume 175, July 2017, Pages 28-34
نویسندگان
A. Jamaiyar, W. Wan, D.M. Janota, M.K. Enrick, W.M. Chilian, L. Yin,