The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine
Keywords: HSP90; AML; Ganetespib;
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SALL4: An emerging cancer biomarker and target
Keywords: ESCs; embryonic stem cells; AML; acute myeloid leukemia; CSCs; cancer stem cells; iPS; induced pluripotent stem cell; HSCs/HPCs; hematopoietic stem/progenitor cells; MDS; myelodysplastic syndrome; LSCs; leukemic stem cells; CML; chronic myeloid leukemia;
The Ras/Rap GTPase activating protein RASA3: From gene structure to in vivo functions
Keywords: Ras; Rap; GTPase activating protein; RASA3; Megakaryocyte; Platelet; Cancer; Leukemia; AML; acute myeloid leukemia; Btk; Bruton tyrosine kinase; [Ca2+]i; intracellular calcium concentration; EBV; Epstein-Barr virus; GAP; GTPase activating protein; GEF; gu
Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines
Keywords: PLK1; Polo-like kinase 1; AML; acute myeloid leukemia; BMB; bone marrow biopsies; AML-MRC; AML with myelodysplasia related changes; CAE; chloroacetate esterase; HPF; high power field; HSCT; hematopoietic stem cell transplantation; AML; PLK1 inhibition; BI
Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors
Keywords: FLT3; Kinase inhibitor; AML; Ligand efficiency; Computer aided drug discovery; FLT3; Fms-like tyrosine kinase 3; acute myeloid leukemia; AML; ITD; internal tandem duplication; juxtamembrane; JM; RAS; rat sarcoma; RAF; rapidly accelerated fibrosarcoma; JAK
Comparison of outcomes of idarubicin intensified TBI-CY and traditional TBI-CY conditioning regimen for high-risk acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation: A single center experience
Keywords: ALL; acute lymphoblastic leukemia; allo-HSCT; allogeneic hematopoietic stem cell transplantation; TRM; transplant-related mortality; IDA; idarubicin; HR; hazard ratio; CI; confidence interval; NR; no remission; TBI; total body irradiation; CY; cyclophosph
Clinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignancies
Keywords: BiTE; Immunotherapy; NHL; ALL; AML; Blinatumomab; AMG 330;
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues
Keywords: PTL; parthenolide; LSC; leukemic stem cell; AML; acute myeloid leukemia; SL; sesquiterpene lactone; HSC; hematopoietic stem cell; DMAPT; dimethylamino-parthenolide; MelB; melampomagnolide B; ROS; reactive oxygen species; PtO2; platinum(IV) oxide; DME; dim
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics
Keywords: DMT; N-desmethyltamoxifen; AC; acid ceramidase; AML; acute myelogenous leukemia; SphK1; sphingosine kinase 1; S1-P; sphingosine 1-phosphate; GC; glucosylceramide; 4-HPR; fenretinide; GCS; glucosylceramide synthase; P-gp; P-glycoprotein; ATCC; American Typ
Working with the HL7 metamodel in a Model Driven Engineering context
Keywords: HL7; Health Level 7; MDE; Model Driven Engineering; UML; Unified Modeling Language; MIF; Model Interchange Format; NDT; Navigational Development Techniques; CDA; Clinical Document Architecture; OMG; Object Management Group; EA; Enterprise Architect; M2M;
Acute myeloid leukemia cells MOLM-13 and SKM-1 established for resistance by azacytidine are crossresistant to P-glycoprotein substrates
Keywords: AML; acute myeloid leukemia; AzaC; Azacytidine; CDNB; 1-chloro-2,4-dinitrobenzene; CisPt; cisplatin; Dox; doxorubicin; GST; glutathione S-transferase; MDR; multidrug resistance; MDS; myelodysplastic syndrome; MOLM-13; AML cell line derived from the periph
A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells
Keywords: CaM; calmodulin; CaMK; Ca2Â +-calmodulin dependent kinase; RAR; retinoic acid receptor; CDKi; cyclin dependent kinase inhibitor; AML; acute myeloid leukemia; Rb; retinoblastoma; CaMK; Proliferation; Calcium; Cell cycle;
Multicomponent assembly of 4-aza-podophyllotoxins: A fast entry to highly selective and potent anti-leukemic agents
Keywords: Multicomponent reactions; Aza-podophyllotoxins; Anti-leukemic agents; AML; SAR study; Etoposide; APT; 4-aza-2,3-didehydropodophyllotoxins; MCR; multicomponent reaction;
The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage
Keywords: MAPK; ERK5; ERK1/2; M-CSFR; Vitamin D; AML;
Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells
Keywords: AML; acute myeloid leukemia; BSA; bovine serum albumin; DCFH-DA; 2â²,7â²-dichlorofluorescensin diacetate; DCM; dilated cardiomyopathy; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FZD; furazolidone; HepG2; hepatoblastoma cell line; IGF-1; insulin-
MicroRNA and pediatric tumors: Future perspectives
Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AT/RT; atypical teratoid/rhabdod tumors; BL; Burkitt lymphoma; MB; medulloblastoma; NB; neuroblastoma; OS; osteosarcoma; RMS; rhabdomyosarcoma; Circulating biomarker; MicroRNA; Pediatric canc
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
Keywords: ADC; antibody drug conjugate; ALL; acute lymphoid leukemia; AML; acute myeloid leukemia; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMA; European Medicines Agency; EPR; enhanced permeability and retention effect; FDA; US Food an
Targeting Survivin with YM155 (Sepantronium Bromide): A novel therapeutic strategy for paediatric acute myeloid leukaemia
Keywords: Survivin; YM155; AML; Paediatric;
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer
Keywords: ABTS; 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid); AML; acute myeloid leukemia; ApnA; diadenosine polyphosphates; ATP; adenosine-5â²-triphosphate; ATX; autotaxin; BALF; bronchoalveolar lavage fluid; bis-pNPP; bis(p-nitrophenyl) phosphate; BLM
Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
Keywords: Apoptosis; Smac; Leukemia; Necroptosis; AML; acute myeloid leukemia; CI; combination index; cIAP; cellular inhibitor of apoptosis protein; FACS; fluorescence-activated cell-sorting analysis; FCS; fetal calf serum; FLT3; Fms-like tyrosine kinase 3; FSC/SSC
Loss of TRIM62 Expression Is an Independent Adverse Prognostic Factor in Acute Myeloid Leukemia
Keywords: AML; Proteomics; Reverse phase protein array; RPPA; TRIM62;
PIM kinase (and Akt) biology and signaling in tumors
Keywords: PIM kinases; Akt; Oncogenes; Cancer; Therapeutic resistance; AML; acute myeloid leukemia; AMPK; AMP activated protein kinase; CXCR-4; C-X-C chemokine receptor type 4; EGFR; epidermal growth factor receptor; EBV; Epstein-Barr virus; FLT3; FMS-like ty
Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells
Keywords: ROS; reactive oxygen species; SOD; superoxide dismutase; PMA; phorbol 12-myristate 13-acetate; PKD2; protein kinase D2; CML; chronic myeloid leukemia; AML; acute myeloid leukemia; Myeloid leukemia; Reactive oxygen species (ROS); Superoxide dismutase 1 (SO
Prevalence and impact of colony stimulating factor 3 receptor (CSF3R) mutations among Egyptian acute myeloid leukemia patients
Keywords: AML; CSF3R; Mutation;
High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia
Keywords: Prognosis; GRAF; AML; Focal adhesion;
Orphan drug designation for pracinostat, volasertib and alvocidib in AML
Keywords: AML; Pracinostat; Alvocidib; Flavopiridol; Volasertib; Rational combinations;
Myelomastocytic Leukemia With Aberrant CD25 Expression: Case Report and Review of the Literature
Keywords: AML; Mast cell differentiation; Mast cell leukemia; Myelomastocytic overlap syndrome; Systemic mastocytosis;
ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells
Keywords: 1,25D; 1α,25(OH)2 vitamin D3; AML; acute myeloid leukemia; CC; cell cycle; VDD; vitamin D derivative; BIX; BIX02189; PD; PD98059; U0; U0126; XMD; XMD8-92; Vitamin D derivatives; ERK5; ERK1/2; MAPK inhibitors; Acute myeloid leukemia (AML); Cell differenti
BMI1 gene expression in myeloid leukemias and its impact on prognosis
Keywords: BMI1; AML; CML; Myeloid; Leukemia; Polycomb;
Distinct poor prognostic subgroups of acute myeloid leukaemia, FLT3-ITD and P-glycoprotein-positive, have contrasting levels of FOXO1
Keywords: AML; FLT3-ITD; p-glycoprotein; ABCB1; FOXO1;
Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components
Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4
Regional Annular Geometry in Patients With Mitral Regurgitation: Implications for Annuloplasty Ring Selection
Keywords: 3D; 3-dimensional; AA; anterior mitral annulus; AC; anterior commissure; AH; annular height; AHCWR; annular height: commissural width ratio; AML; anterior mitral leaflet; AoV; aortic valve; CW; commissural width; IMR; ischemic mitral regurgitation; L; lat
Promising roles of mammalian E2Fs in hepatocellular carcinoma
Keywords: E2Fs; E2F family of transcription factors; HCC; hepatocellular carcinoma; pRb; retinoblastoma protein; CDK; cyclin dependent kinase; DBD; DNA binding domain; DP; dimerization partner; LZ; leuzine zipper; MB; marked box; NLS; nuclear localization signal; C
Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer
Keywords: CRC; colorectal cancer; APC; adenomatous polyposis coli; KRAS; Kirsten rat sarcoma viral oncogene homolog; TP53; tumor protein p53; IDH1; isocitrate dehydrogenase 1 (NADPÂ +), soluble; IDH2; isocitrate dehydrogenase 2 (NADPÂ +), mitochondrial; DNMT3A; DNA
Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1
Keywords: HIV; latency; eradication; reservoir; cure; stem cell transplantation; antiretroviral therapy; AML; Acute myelogenous leukemia; ART; Combination antiretroviral therapy; HCV; Hepatitis C virus; HSCT; Hematopoietic stem cell transplantation; LRA; Latency-re
Znaczenie mutacji genów modulujÄ
cych zmiany epigenetyczne w ostrej biaÅaczce szpikowej
Keywords: ostra biaÅaczka szpikowa; epigenetyka; mutacje TET2; mutacje IDH1/2; mutacje EZH2; mutacje DNMT3A; mutacje ASXL1; Epigenetic; AML; TET2 mutations; IDH1/2 mutations; EZH2 mutations; DNMT3A mutations; ASXL1 mutations;
Degradation of AF1Q by chaperone-mediated autophagy
Keywords: 3-MA; 3-methyladenine; 6-AN; 6-aminonicotinamide; AML; acute myeloid leukemia; CMA; chaperone-mediated autophagy; CQ; chloroquine; HBSS; Hanks balanced salt solution; HSPA8; heat shock 70 kDa protein 8; LAMP-2 A; lysosome-associated membrane protein 2A; A
Musashi2 modulates K562 leukemic cell proliferation and apoptosis involving the MAPK pathway
Keywords: Msi; Musashi; Msi2; Musashi2; HSCs; hematopoietic stem cells; AML; acute myeloid leukemia; CML; chronic myelogenous leukemia; MAPK; mitogen-activated protein kinase; MTT; methyl thiazolyl tetrazolium solution; FITC; fluorescein isothiocyanate; Musashi2; L
Armillaria mellea component armillarikin induces apoptosis in human leukemia cells
Keywords: A. mellea; Armillaria mellea; AML; acute myeloid leukemia; G. elata; Gastrodia elata; MFI; mean fluorescence intensity; MnTBAP; Mn(III)tetrakis (4-benzoic acid) porphyrin chloride; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophe
Genetics of rare mesenchymal tumors: Implications for targeted treatment in DFSP, ASPS, CCS, GCTB and PEComa
Keywords: DFSP; dermatofibrosarcoma protuberans; ASPS; alveolar soft part sarcoma; CCS; clear cell sarcoma; GCTB; giant cell tumor of bone; PEComas; perivascular epithelioid cell neoplasm; PDGFRB; platelet-derived growth factor receptor, beta; MET; met proto-oncoge
miR-223: An inflammatory oncomiR enters the cardiovascular field
Keywords: AAA; Abdominal Aortic Aneurysm; AML; Acute Myeloid Leukemia; Apo-E KO; Apolipoprotein-E Knock-Out; C/EBP; CCAAT-Enhancer-Binding Proteins; CKD; Chronic Kidney Disease; D-HF; Diabetic Heart-Failure; DMD; Duchenne Muscular Dystrophy; E2F1; E2F transcription
Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
Keywords: AML; acute myeloid leukemia; BRPF1; bromodomain-PHD finger protein 1; CBP; CREB binding protein; CD; circular dichroism; HAT; histone acetyltransferase; HDAC; histone deacetylase; hEAF6; homolog of Esa1-associated factor 6; HOX; homeobox; HSCs; hematopoie
The epigenetic landscape of T-cell acute lymphoblastic leukemia
Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; arrayCGH; array comparative genomic hybridization; BFLS; Börjeson-Forssman-Lehmann syndrome; bHLH; basic helix-loop-helix; CBP; CREB binding protein; CIMP; CpG island methylator phenotyp
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
Keywords: ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;
Sialosignaling: Sialyltransferases as engines of self-fueling loops in cancer progression
Keywords: ALL; acute lymphocytic leukemia; AML; acute myeloblastic leukemia; 5-AZA; 5â²-azacytidine; BCG; Bacillus Calmette-Guerin; CIN; chromosome instability; DP; degree of polymerization; ECM; extracellular matrix; EGF; epidermal growth factor; EGFR; epiderma
(6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression
Keywords: 6G; (6)-gingerol; iNOS; inducible nitric oxide synthase; NF-κB; nuclear factor κB; miRNA; microRNA; MRC; mitochondrial respiratory complex; ETC; electron transport chain; PBMC; peripheral blood mononuclear cell; AML; acute myeloid leukemia; CML; chronic
TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine
Keywords: α-KG; α-ketoglutarate; AML; acute myeloid leukemia; APOBEC; apolipoprotein B mRNA-editing enzyme complex; ARP; aldehyde reactive probe; β-GT; β-glucosyl transferase; 5-caC; 5-carboxylcytosine; 5-cadCyd; 5-carboxyl-2â²-deoxycytidine; C; cytosine; C5-M
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
MDR-1 and GST polymorphisms are involved in myelodysplasia progression
Keywords: AML; acute myeloid leukemia; CYP2B6; Cytochrome P450 2B6; del5q; 5qchrosome deletion; Gln; glutamine; GST; glutathione S-transferase; GSTM1; glutathione S-transferase Mu 1; GSTT1; glutathione S-transferase Theta 1; His; histidine; Ile; isoleucine; IPSS; i
Evaluation of human cytomegalovirus-specific CD8+ T-cells in allogeneic haematopoietic stem cell transplant recipients using pentamer and interferon-γ-enzyme-linked immunospot assays
Keywords: HCMV; human cytomegalovirus; HSCT; haematopoietic stem cell transplantation; ELISPOT; enzyme-linked immunospot; PBMCs; peripheral blood mononuclear cells; HLA; human leucocyte antigen; CTLs; cytotoxic T lymphocytes; AML; acute myeloid leukaemia; CML; chro