Keywords: مهندسی آنتی بادی; Antibody engineering; Glycosphingolipid; Glycoprotein; Oligosaccharide; Ceramide; Very long chain fatty acid;
مقالات ISI مهندسی آنتی بادی (ترجمه نشده)
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Keywords: مهندسی آنتی بادی; Antibody engineering; Antibody fragments; Bacterial production; Cetuximab Fab; Humanization; Antibody-drug conjugates;
Keywords: مهندسی آنتی بادی; Amino acid composition; Antibody engineering; Feline antibody repertoire; Immunoglobulin heavy chain complementary-determining region 3;
Keywords: مهندسی آنتی بادی; Monoclonal antibodies (mAbs); Therapeutic antibodies; Biologicals; Biosimilars; Biobetters; Antibody engineering; Antibody drug conjugates (ADC); Bispecific antibodies; Manufacture; Degradation; Stability; Formulation;
Keywords: مهندسی آنتی بادی; Humanization; Phosphospecific antibody; Phosphothreonine-binding motif; Chicken antibody; Antibody engineering; CDR; complementarity determining region; VH; heavy chain variable domain; VL; light chain variable domain;
Keywords: مهندسی آنتی بادی; Complement; Immunology; Antibody; Therapy; Antibody engineering; Cancer;
Keywords: مهندسی آنتی بادی; Antibody folding; Antibody assembly; Antibody engineering;
Keywords: مهندسی آنتی بادی; Immunogen design; Antiviral immunotherapy; Antibody engineering
Keywords: مهندسی آنتی بادی; Antiviral immunity; Serum therapy; Monoclonal antibody; Antibody engineering;
Keywords: مهندسی آنتی بادی; Antiviral immunity; Serum therapy; Monoclonal antibody; Antibody engineering;
Keywords: مهندسی آنتی بادی; Antibody engineering; AML; Leukemic cancer stem cells; Bivalent scFv (biscFv); CD123LSC, leukemic cancer stem cell; AML, acute myeloid leukemia; IL-3, interleukin-3; mAb, monoclonal antibody; scFv, single-chain Fv; ADCC, antibody-dependent cell-mediated c
Site-specific photocoupling of pBpa mutated scFv antibodies for use in affinity proteomics
Keywords: مهندسی آنتی بادی; β-CD; β-cyclodextrin; CDR; complementarity determining region; FW; framework; pBpa; p-benzoyl-l-phenylalanine; scFv; single-chain Fragment variable antibody; UUA; unnatural amino acid; Antibody microarray; scFv antibodies; Antibody engineering; Dock'n'F
Application of a catenary PBPK model to predict the disposition of “catch and release” anti-PCSK9 antibodies
Keywords: مهندسی آنتی بادی; Monoclonal antibodies; Physiologically-based pharmacokinetics (PBPK); Antibody engineering
Structural consequences of aglycosylated IgG Fc variants evolved for FcγRI binding
Keywords: مهندسی آنتی بادی; Fc; fragment crystallizable; IgG; immunoglobulin G; Fab; fragment antigen binding; FcγR; Fc gamma receptor; ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cell-mediated phagocytosis; CDC; complement-dependent cytotoxicity;
Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM
Keywords: مهندسی آنتی بادی; Antibody engineering; Germline; HIV; IgM; Protein stability;
Targeting FcRn for therapy: From live cell imaging to in vivo studies in mice
Keywords: مهندسی آنتی بادی; FcRn; Antibody engineering; Immunoglobulin G; Live-imaging microscopy; Autoimmunity; Antibody pharmacokinetics
Antibody conjugation via one and two C-terminal selenocysteines
Keywords: مهندسی آنتی بادی; Antibody engineering; Antibody conjugation; Selenocysteine;
Fundamental characteristics of the expressed immunoglobulin VH and VL repertoire in different canine breeds in comparison with those of humans and mice
Keywords: مهندسی آنتی بادی; Immunoglobulin heavy chain complementary-determining region 3; Amino acid composition; Canine antibody repertoire; Antibody engineering; Canine breedsVH, variable heavy (for domain); VL, variable light (for domain); V-KAPPA, variable kappa domain; V-LAMBD
Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions
Keywords: مهندسی آنتی بادی; ADCC; CDC; Antibody engineering; Fc modification; Antibody glycosylation; Antibody therapy;
pH-dependent antigen-binding antibodies as a novel therapeutic modality
Keywords: مهندسی آنتی بادی; Monoclonal antibody; Antibody engineering; pH dependent;
Molecular design of recombinant scFv antibodies for site-specific photocoupling to β-cyclodextrin in solution and onto solid support
Keywords: مهندسی آنتی بادی; β-CD; β-cyclodextrin; pBpa; p-benzoyl-L-phenylalanine; Fab; fragment antigen-binding; FW-1; framework-1; MW; molecular weight; scFv; single-chain Fv variable; Tm; melting temperature; tRNA; transfer RNA; UAA; unnatural amino acids; RT; room temperature;
Protein engineering and the use of molecular modeling and simulation: The case of heterodimeric Fc engineering
Keywords: مهندسی آنتی بادی; RMSD; root mean squared deviation; RMSF; root mean squared fluctuation; RDF; radial distribution function; SASA; solvent exposed surface area; CCSD; close contact surface density (ÎÏtot); KBP; knowledge based potential; LJ; Lennard-Jones contributions;
Structural and functional characterization of the single-chain Fv fragment from a unique HCV E1E2-specific monoclonal antibody
Keywords: مهندسی آنتی بادی; CDR; complementarity-determining region; DAAs; direct-acting antivirals; ELISA; enzyme-linked immunoabsorbent assay; FR; framework region; GT; genotype; HCV; hepatitis C virus; HCVsp; serum-derived HCV particles; HRP; horseradish peroxidase; IgG; immunogl
Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies
Keywords: مهندسی آنتی بادی; Epiregulin; Humanization; Antibody engineering; Resurfacing; Antibody-dependent cellular cytotoxicity;
Toward aggregation-resistant antibodies by design
Keywords: مهندسی آنتی بادی; monoclonal antibody; IgG; VH; VL; scFv; Fv; Fab; variable domain; complementarity-determining region (CDR); bispecific; solubility; antibody engineering
Use of micro-emulsion technology for the directed evolution of antibodies
Keywords: مهندسی آنتی بادی; Phage display; Phage ESCape; Emulsions; Antibody engineering; Affinity maturation; Antibody evolution;
Secretion from bacterial versus mammalian cells yields a recombinant scFv with variable folding properties
Keywords: مهندسی آنتی بادی; scFv; Mammalian expression; Bacterial secretion; Protein misfolding; Antibody engineering; Bispecific;
Directed evolution of proteins for increased stability and expression using yeast display
Keywords: مهندسی آنتی بادی; Yeast surface display; Directed evolution; Stability engineering; Antibody engineering; Library screening;
Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast
Keywords: مهندسی آنتی بادی; IgG1; immunoglobulin G class 1; Fcab; antigen binding Fc protein; Fc-wt; recombinant wild-type Fc protein; scTCR; single-chain T-cell receptor; MHC; major histocompatibility complex; CDC; complement dependent cytotoxicity; ADCC; antibody dependent cell-me
Engineering antibodies by yeast display
Keywords: مهندسی آنتی بادی; Antibody engineering; Yeast display; Directed evolution;
Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition
Keywords: مهندسی آنتی بادی; Antibody engineering; Bispecific antibodies; Single chain Fv; IGF-1R; EGFR; GA201; R1507;
Effects of signal sequence on phage-displayed disulfide-stabilized single chain antibody variable fragment (sc-dsFv) libraries
Keywords: مهندسی آنتی بادی; Phage display; Antibody engineering; Signal sequence; Antibody library; sc-dsFv library;
Free energy perturbation approach for the rational engineering of the antibody for human hepatitis B virus
Keywords: مهندسی آنتی بادی; Free energy perturbation; Molecular dynamics; Antibody engineering; Mutation; Protein–protein interaction
A bioinformatics pipeline to build a knowledge database for in silico antibody engineering
Keywords: مهندسی آنتی بادی; Germline; Hypermutation; Somatic mutation; Position specific scoring matrix; Knowledge database; Antibody engineering; Algorithm; Java; Bioinformatics; Web; CDR-IMGT
Module based antibody engineering: A novel synthetic REDantibody
Keywords: مهندسی آنتی بادی; Antibody engineering; Fluorescent proteins; scFv; Synthetic antibody
A human scFv antibody generation pipeline for proteome research
Keywords: مهندسی آنتی بادی; Phage display; Antibody engineering; Panning; scFv; scFv-Fc; Immunoglobulin; mAb, Monoclonal antibody; CD71; Human proteome research
Molecular engineering to improve antibodies' anti-lymphoma activity
Keywords: مهندسی آنتی بادی; immunotherapy; antibody engineering; ADCC; CDC; pharmacokinetics;
Antibody Fab display and selection through fusion to the pIX coat protein of filamentous phage
Keywords: مهندسی آنتی بادی; Phage display; pIX; Fab; Antibody engineering; Respiratory syncytia virus; RSV
Chicken scFvs and bivalent scFv-CH fusions directed against HSP65 of Mycobacterium bovis
Keywords: مهندسی آنتی بادی; Antibody engineering; Phage display; Chicken IgY; Immunoassays; Gold nanoparticle
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide
Keywords: مهندسی آنتی بادی; Alzheimer's disease; Passive immunotherapy; Anti-Aβ antibodies; Restricted antibody repertoire; Antibody engineering; Surface plasmon resonance
“Cleavable” hapten–biotin conjugates: Preparation and use for the generation of anti-steroid single-domain antibody fragments
Keywords: مهندسی آنتی بادی; Antibody engineering; Phage display; Hapten; Estradiol-17β; Steroid–biotin conjugate; Single-domain antibody fragment
Applications of single-chain variable fragment antibodies in therapeutics and diagnostics
Keywords: مهندسی آنتی بادی; Single-chain variable fragment (scFv); Antibody engineering; Therapeutics; Molecular display; Antibody expression; Pharmacokinetics
Anti-estradiol-17β single-chain Fv fragments: Generation, characterization, gene randomization, and optimized phage display
Keywords: مهندسی آنتی بادی; Antibody engineering; Single-chain Fv fragment; Hapten; Estradiol-17β; Random mutagenesis; Phage display;
A study of the structural correlates of affinity maturation: Antibody affinity as a function of chemical interactions, structural plasticity and stability
Keywords: مهندسی آنتی بادی; Affinity maturation; Mutational analysis; Substitution matrices; Antibody engineering
Technological Advances in Radioimmunotherapy
Keywords: مهندسی آنتی بادی; Antibody engineering; combination therapies; radioimmunotherapy; radionuclides; targeted radiotherapy;
Recombinant antibodies with T-cell receptor-like specificity: Novel tools to study MHC class I presentation
Keywords: مهندسی آنتی بادی; Antibodies; MHC-peptide complex; T-cell receptor; Recombinant antibodies; Cancer immunotherapy; Phage display; Antibody engineering; Immunotoxins
Co-expression of antibody fab heavy and light chain genes from separate evolved compatible replicons in E. coli
Keywords: مهندسی آنتی بادی; Antibody engineering; Fab expression; Compatible plasmids; Origin of replication; ColE1
Selection, design, and engineering of therapeutic antibodies
Keywords: مهندسی آنتی بادی; Antibody engineering; target selection; biologic therapeutics; ADCC; Antibody-dependent cellular cytotoxicity; CDR; Complementarity-determining region; FcγR; IgG Fc γ receptor; HER-2; Human epidermal growth factor receptor 2;
Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49
Keywords: مهندسی آنتی بادی; Antibody engineering; scFv; Fusion protein; Angiotensin II; Cancer therapy; Radioimmunotherapy;
Dissociation-independent selection of high-affinity anti-hapten phage antibodies using cleavable biotin-conjugated haptens
Keywords: مهندسی آنتی بادی; Antibody engineering; Phage display; Anti-hapten antibody; High-affinity antibody; Selection; Biopanning; Cleavable biotin;