Monoclonal antibodies for prophylactic and therapeutic use against viral infections

► Neutralizing antibodies are instrumental in preventing or modulating viral diseases. ► Specific antibody titers have been identified as correlates of protection. ► Polyclonal antibodies are being replaced by their monoclonal counterparts. ► Antigenic variability and potential for escape mutants need to be considered. ► Cocktails of mAbs and bispecific antibodies are being developed.