Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review
Keywords: FABP4; A-FABP; aP2; Antidiabetes; Antiobesity; Antiatherosclerosis;
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MicroRNA-192* impairs adipocyte triglyceride storage
Keywords: ALDH3A2; aldehyde dehydrogenase 3 family member A2; aP2; adipocyte protein 2; BMI; body mass index; GLUT4; glucose transporter type 4; miRNA; microRNA; NT; non-targeting; PLIN; perilipin 1; qPCR; quantitative reverse transcriptase PCR; SCARB1; scavenger r
RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells
Keywords: Dopamine D2 receptors; RGS2; Gαi/o signaling; Internalization; β-arrestin; D2Rs; dopamine D2 receptors; RGS2; regulators of G protein signaling protein 2; GPCRs; G protein coupled receptors; ERK; extracellular signal-regulated kinases; AP2; adaptor prot
Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea
Keywords: Adipogenesis; Glucose uptake; Maslinic acid; PPARγ and aP2 transcription factors; Triglycerides; aP2; adipocyte fatty acid-binding protein; CT; threshold cycle; DMEM; dulbecco's modified eagle medium; DMSO; dimetilsulfoxide; FBS; fetal bovine serum; GADP
Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia
Keywords: AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor; AP2; Clathrin adaptor protein 2; CaMKIIα; Ca2 +-calmodulin kinase IIα; LDH; Lactate dehydrogenase; MK-801; (5S,10R)-(+)-5-methyl-10,11-dihydroÂ-5H-dibenzo[a,d]cyclohepten-5,10-imi
AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis
Keywords: BMSC; bone marrow stromal cell; AMPK; AMP-activated protein kinase; OPN; osteopontin; Gfi1; growth factor independence-1; Runx2; runt-related transcription factor 2; Osx; Osterix; ALP; alkaline phosphatase; BSP; bone sialoprotein; OC; osteocalcin; PPARγ;
Crabapple fruit extracts lower hypercholesterolaemia in high-fat diet-induced obese mice
Keywords: Crabapple; Hyperlipidaemia; Hypercholesterolaemia; Metabolic syndrome; Anti-oxidation; CYP7A1; Procyanidin (PubChem CID: 107876); Epicatechin (PubChem CID: 72276); Isoastilbin (PubChem CID: 10114809); Quercetin 3-O-glucoside (PubChem CID: 44258003); Avicu
Anti-obesity effects of Asian dayflower, Commelina communis, in mice with high-fat diet-induced obesity and in 3T3-L1 cells
Keywords: C/EBP; CCAAT/enhancer-binding protein; PPAR; peroxisome proliferator-activated receptor; GLUT; glucose transporter; CCT; C.âcommunis tea; WAT; white adipose tissue; HFD; high-fat diet; LFD; low-fat diet; qPCR; quantitative PCR; TBP; TATA-binding protein
SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner
Keywords: Seven transmembrane receptors; G-protein coupled receptors; Cannabinoid receptor 1; Protein-protein interactions; Bias signaling; Receptor endocytosis; SGIP1; src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1; CC
Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1
Keywords: Pparγ; peroxisome proliferator activated receptor γ; aP2; adipocyte protein 2; siRNA; small interfering RNA; MSC; mesenchymal stem cells; DMI; Dexamethasone, IBMX, and Insulin; Dnajb1; DnaJ (Hsp40) Homolog, Subfamily B, Member 1; LCA; licochalcone A; TN
(2S)-7,4â²-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells
Keywords: (2S)-7,4â²-dihydroxy-8-prenylflavan; Adipogenesis; Glucose uptake; p38MAPK; Type 2 diabetes; aP2; aFABP, adipocyte fatty acid-binding protein; FFA; free fatty acid; GLUT4; glucose transporter type 4; IL; interleukin; TG; triglyceride; TZDs; thiazolidined
ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells
Keywords: aP2; adipocyte fatty acid binding protein; ATF3; activation transcription factor 3; ATF/CRE; ATF/CREB responsive element; ChIP; chromatin immunoprecipitation; ER; endoplasmic reticulum; LBD; ligand-binding domain; PPARγ; peroxisome proliferator activated
Trans-Golgi protein p230/golgin-245 is involved in phagophore formation
Keywords: AP2; adaptor-protein 2; EBSS; Earle's balanced salt solution; ER; endoplasmic reticulum; KD; knock-down; MACF1; microtubule actin crosslinking protein 1; LC3; microtubule-associated protein 1 light chain 3; PM; plasma membrane; TGN; trans-Golgi network;
n-3 polyunsaturated fatty acids stimulate osteoclastogenesis through PPARγ-mediated enhancement of c-Fos expression, and suppress osteoclastogenesis through PPARγ-dependent inhibition of NFkB activation
Keywords: AA; arachidonic acid; aP2; adipocyte fatty acid binding protein; BMCs; bone marrow cells; BMMs; bone marrow-derived macrophage/monocyte precursor cells; COX2; cyclooxygenase 2; EPA; eicosapentaenoic acid; DHA; docosahexaenoic acid; LA; linoleic acid; M-CS
Molecular and cellular pharmacologyIdentification and characterisation of a prototype for a new class of competitive PPARγ antagonists
Keywords: ANGPTL4; angiopoietin-like 4; AP-1; activator protein 1; aP2; adipocyte protein 2; CD36; cluster of differentiation 36; DMEM; Dulbecco׳s Modified Eagle׳s Medium; FABP4; fatty acid binding protein 4; FCS; foetal calf serum; FMOC-l-leucine; N-(9-fluorenyl
A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion
Keywords: aP2; adipocyte protein 2; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; CHOP-10; C/EBP homologous protein; DVL; disheveled; ERK; extracellular signal-regulated kinase; F
Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes
Keywords: Akt; protein kinase B; Dex; dexamethasone; Dok1; downstream of tyrosine kinases-1; ERK1/2; extracellular signal-regulated kinase 1 and 2; ap2; fatty acid binding protein 4; IBMX; isobutylmethylxanthine; IRS; insulin receptor substrate; InsR; insulin recep
Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR
Keywords: mgp96; uPAR; Liver cancer; MAPK; DFS; ADAMTS9; a disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; AIMP1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; AKT; v-akt murine thymoma viral oncogene homo
Constitutive expression of DaCBF7, an Antarctic vascular plant Deschampsia antarctica CBF homolog, resulted in improved cold tolerance in transgenic rice plants
Keywords: AP2; APETALA2; CaMV; cauliflower mosaic virus; CBF; C-repeat binding factor; CDPK; calcium/calmodulin-dependent protein kinase; CRT; C repeat; DEG; differentially expressed gene; DRE; dehydration responsive element; FDR; false discovery rate; GO; gene ont
Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
Keywords: 6PGD; 6-phosphogluconate dehydrogenase; 20-HETE; 20-hydroxyeicosatetraenoic acid; AA; arachidonic acid; ADP; adenosine diphosphate; ADSCs; adipose-derived stem cells; aP2; fatty-acid binding protein; AREs; antioxidant response elements; ATP; adenosine tri
PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway
Keywords: AMPK; AMP-activated protein kinase; aP2; adipocyte protein-2; BAT; brown adipose tissue; BMP; bone morphogenic protein; BMPR; bone morphogenic protein receptor; BRE-Luc; bone morphogenic protein-responsive luciferase reporter plasmid; DMEM; Dulbecco's m
ATF3 represses PPARγ expression and inhibits adipocyte differentiation
Keywords: ATF3; activation transcription factor 3; ATF/CRE; ATF/CREB responsive element; C/EBP; CCAAT/enhancer-binding proteins; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; ER; endoplasmic reticulum; aP2; adipocyte fatty acid bi
The Arabidopsis thaliana At4g13040 gene, a unique member of the AP2/EREBP family, is a positive regulator for salicylic acid accumulation and basal defense against bacterial pathogens
Keywords: AP2; Apetala 2; APD1; Apetala 2 family protein involved in SA mediated disease defense; Avr-Pst; avirulent strain of Pseudomonas syringae pv. tomato DC3000; DAPI; 4â²,6-diamidino-2-phenylindole; dpi; days post inoculation; DREB; dehydration response elem
Activation of early phase of adipogenesis through Krüppel-like factor KLF9-mediated, enhanced expression of CCAAT/enhancer-binding protein β in 3T3-L1 cells
Keywords: KLF; Krüppel-like factor; C/EBP; CCAAT/enhancer-binding protein; PPAR; peroxisome proliferator-activated receptor; N.C.; negative control; aP2; fatty acid binding protein 4; LPL; lipoprotein lipase; FAS; fatty acid synthase; SREBP; sterol regulatory elem
Chlormadinone acetate promotes osteoblast differentiation of human mesenchymal stem cells through the ERK signaling pathway
Keywords: CMA; Chlormadinone acetate; hBMSCs; Human bone marrow-derived mesenchymal stem cells; ERK; Extracellular signal-regulated kinase; ALP; Alkaline phosphatase; OSX; Osterix; OCN; Osteocalcin; BSP; Bone sialoprotein; col1a1; Collagen type 1, alpha 1; PPAR-γ;
Isolation, promoter analysis and expression profile of Dreb2 in response to drought stress in wheat ancestors
Keywords: aa; amino acid(s); bp; base pair(s); cDNA; DNA complementary to RNA; mRNA; messenger RNA; nt; nucleotide(s); UTR; untranslated region(s); TFs; transcription factors; DREB; dehydration-responsive element-binding; AP2; APETALA2; CBF; c-repeat binding factor
RARγ-C-Fos-PPARγ2 signaling rather than ROS generation is critical for all-trans retinoic acid-inhibited adipocyte differentiation
Keywords: Adipocyte differentiation; All-trans retinoic acid; Retinoic acid receptor; Peroxisome proliferator-activated receptors γ; C-Fos; aP2; adipocyte protein 2; ATRA; all-trans-retinoic acid; C/EBP; CCAAT/ enhancer binding proteins; GCLc; catalytic subunit of
The miR172 target TOE3 represses AGAMOUS expression during Arabidopsis floral patterning
Keywords: AG; AGAMOUS; AP2; APETALA2; CaMV; cauliflower mosaic virus; ChIP; chromatin immunoprecipitation; FT; FLOWERING LOCUS T; GUSβ; -glucuronidase; miR172; microRNA172; MS; Murashige & Skoog; qRT-PCR; quantitative real-time RT-PCR; SOC1; SUPPRESSOR OF OVEREXPR
Gene expression profile analysis of Ligon lintless-1 (Li1) mutant reveals important genes and pathways in cotton leaf and fiber development
Keywords: ACO; 1-aminocyclopropane-1-carboxylic acid oxidase; ADNI1; adenine nucleotide transporter 1; ALDH; aldehyde dehydrogenase; AP2; AP2-EREBP transcription factors; AS1; ASYMMETRIC LEAVES1; AS2; ASYMMETRIC LEAVES2; ATSS3; Arabidopsis starch synthase 3; ATBFRU
Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6
Keywords: C/EBPα, β, δ; CCAAT/enhancer binding protein α, β, δ; PPARγ; peroxisome proliferator-activated receptor γ; FAS; fatty acid synthase; ap2; adipocyte fatty acid binding protein; LRP5/6; low-density lipoprotein receptor-related protein 5/6; GSK3β; g
Genetic analysis of the ATG7 gene promoter in sporadic Parkinson's disease
Keywords: AP2; Activator protein-2; α-Syn; α-syncuclein; ATGs; autophagy-related genes; ATG3; autophagy-related gene 3; ATG7; autophagy-related gene 7; ATG12; autophagy-related gene 12; CREB; cAMP-responsive element binding protein; HNF-1; hepatocyte nuclear fact
Biochemical changes induced by strontium ranelate in differentiating adipocytes
Keywords: Adipogenesis; Mesenchymal stem cells; Strontium ranelate; Osteoblastogenesis; Adipokines; PPARγ2; peroxisome proliferator activated receptor gamma 2; HGF; hepatocyte growth factor; IGFBP; insulin-like growth factor binding protein; BMD; bone mineral dens
Lucidone from Lindera erythrocarpa Makino fruits suppresses adipogenesis in 3T3-L1 cells and attenuates obesity and consequent metabolic disorders in high-fat diet C57BL/6 mice
Keywords: PPARγ; peroxisome proliferator-activated receptor γ; C/EBP; CCAAT-enhancer-binding protein; LXR-α; liver X receptor α; LPL; lipoprotein lipase; aP2; adipocyte protein 2; GLUT4; glucose transporter type 4; ND; normal diet; HFD; high fat diet; LSH/L; lu
Ginsenoside Re reduces insulin resistance through activation of PPAR-γ pathway and inhibition of TNF-α production
Keywords: PPAR-γ; peroxisome proliferator-activated receptor γ; TNF-α; tumor necrosis factor α; TG; triglyceride; ap2; adipocyte fatty acid binding protein; IRS-1; insulin receptor substrate 1; GLUT4; glucose transporter 4; IFN-γ; interferon γ; LPS; lipopolys
Antiobesity effects of quercetin-rich onion peel extract on the differentiation of 3T3-L1 preadipocytes and the adipogenesis in high fat-fed rats
Keywords: OPE; onion peel extract; AP2; activating protein; CPT-1α; carnitine palmitoyltransferase-1 α; FABP4; fatty acid binding protein 4; FAS; fatty acid synthase; ACC; acetyl-CoA carboxylase; Onion peel extract; Quercetin; 3T3-L1; High-fat diet; Adipogenesis;
Active form Notch4 promotes the proliferation and differentiation of 3T3-L1 preadipocytes
Keywords: N4IC; active form Notch4; Pref-1; preadipoctye factor 1; C/EBP; CCAAT/enhancer binding protein; PPAR; peroxisome-proliferator activated receptor; aP2; adipocyte protein 2; LPL; lipoprotein lipase; HSL; hormone-sensitive lipase; Notch; 3T3-L1; Adipogenesis
Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice
Keywords: HFD; high-fat diet; FFA; free fatty acid; ALT; alanine aminotransferase; AST; aspartate aminostransferase; AdipoR1; adiponectin receptor-1; AdipoR2; adiponectin receptor-2; AMPK; AMP-activated protein kinase; CPT1; carnitine palmitoyltransferase 1; CD36;
The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
Keywords: aP2; fatty acid binding protein 4; ATGL; adipose triacylglycerol lipase; BMI; body mass index; CGI-58; α/β-hydrolase domain containing 5; CNI; calcineurin inhibitor; CsA; cyclosporin A; DGAT1; diglyceride acyltransferase 1; FAS; fatty acid synthase; FFA
Hypoxia downregulates PPARγ via an ERK1/2-NF-κB-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells
Keywords: PPARγ; peroxisome proliferator-activated receptor-γ; PH; pulmonary hypertension; HPASMC; human pulmonary artery smooth muscle cell; NF-κB; nuclear factor-κB; Nox4; NADPH oxidase 4; ERK1/2; extracellular signal-regulated kinase 1/2; aP2; adipocyte prot
Regulation of the two kiss promoters in goldfish (Carassius auratus) by estrogen via different ERα pathways
Keywords: GPR54 or Kiss1R; G protein-coupled receptor 54; GnRH; gonadotropin-releasing hormone; ER; estrogen receptor; ERα; estrogen receptor α; ERβ; estrogen receptor β; Sp1; specificity protein-1; Sp3; specificity protein-3; ERE; estrogen response element; RN
Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality
Keywords: mdMSC; marrow-derived mesenchymal stem cells; FBS; fetal bovine serum; SMαA; smooth muscle alpha-actin; Adipogenesis; Bone marrow; Rosiglitazone; aP2; β-catenin;
Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells
Keywords: MOR; mu opioid receptor; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein/extracellular signal-regulated kinase; NF-κB; nuclear factor-kappaB; DP; distal promoter; PP; proximal promoter; Oct-1; octame
ATF3 inhibits adipocyte differentiation of 3T3-L1 cells
Keywords: ATF3; activation transcription factor 3; ATF/CRE; ATF/CREB responsive element; C/EBP; CCAAT/enhancer-binding proteins; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; aP2; adipocyte fatty acid binding protein; HIF-1α; hyp
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis
Keywords: GPCR; G protein-coupled receptor; GRK; GPCR kinase; GIT; GRK-interacting protein; ARF-GAPs; ADP-ribosylation factor GTPase-activating proteins; GEF; guanine nucleotide exchange factor; MSC; mesenchymal stem cell; qCT; quantitative micro-computed tomograph
Transcriptome analysis of tree peony during chilling requirement fulfillment: Assembling, annotation and markers discovering
Keywords: AP2; APETELA2; ARF; Auxin Response Factor; AUX/IAA; Auxin/Indole-3-Acetic acid; bHLH; basic helix-loop-helix; cDNA; DNA complementary to RNA; CTAB; cetyltrimethylammonium bromide; DAM; Dormancy Associated MADS-BOX; ds; double stranded; ERF; Ethylene Respo
Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats
Keywords: Rosiglitazone; Epicardial adipose tissue; Fatty rat; TZD; thiazolidinedione; RSG; rosiglitazone; TG; triglycerides; PPARγ; peroxisome proliferator-activated receptor gamma; RXR; retinoid X receptor; CEBP; CCAAT enhancer binding protein; RAT; retroperiton
The endocrine disruptor diethylstilbestrol induces adipocyte differentiation and promotes obesity in mice
Keywords: aP2; adipocyte-specific fatty acid binding protein; C/EBPα; CCAAT/enhancer-binding protein alpha; DES; diethylstilbestrol; EDCs; endocrine disrupting chemicals; ER; estrogen receptor; ERR; estrogen-related receptor; FAS; fatty acid sythetase; ip; intrape
Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes
Keywords: Ap2; Thiazole- and indole-based; TNF-α; Diet-induced obesity
Sustained expression of lipocalin-type prostaglandin D synthase in the antisense direction positively regulates adipogenesis in cloned cultured preadipocytes
Keywords: PG; prostaglandin; L-PGDS; lipocalin-type PGD synthase; COX; cyclooxygenase; 15d-PGJ2; 15-deoxy- Π12,14-prostaglandin J2; PPARγ; peroxisome proliferator-activated receptor γ; G418; geneticin; FBS; fetal bovine serum; RT-PCR; reverse transcriptase-poly
Exploiting powder X-ray diffraction for direct structure determination in structural biology: The P2X4 receptor trafficking motif YEQGL
Keywords: γ-Abu; γ-aminobutyric acid; AP2; clathrin adaptor protein complex 2; CD; circular dichroism spectrometry; Piv; pivaloyl; Φ; any hydrophobic amino acid; P2X; Powder X-ray diffraction; Trafficking; Direct-space structure solution; Genetic algorithm; Stru