A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions
Keywords: STIM1; EB1; APC; SOCE; Orai;
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Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients
Keywords: Circulating tumor cells; Metastatic breast cancer; PIK3CA mutations; SNaPshot assay; PIK3CA; Phosphatidylinositol-4,5-bisphosphate 3-kinase; Catalytic subunit alpha; APC; allophycocyanin; CK-PE; cytokeratin-phycoerythrin; CS; CellSearch®; CTC(s); circula
Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells
Keywords: PAK4; p21-activated kinase 4; Apc; adenomatous polyposis coli; LEF/TCF; the lymphoid enhancer factor/T-cell factor; TNKS; tankyrase; ORF; open reading frame; UTR; untranslated region; miR-145; Wnt/β-catenin signaling; Catenin δ-1; Colon cancer;
CR3 is the dominant phagocytotic complement receptor on human dendritic cells
Keywords: ADCC; antibody dependent cellular cytotoxicity; APC; antigen presenting cell; C3d(g); C3 d(g) fragment of C3; iC3b; inactivated complement C3b fragment; CR1; complement receptor type1; CR2; complement receptor type 2; CR3; complement receptor type 3; CR4;
Activation of complement by monoclonal antibodies that target cell-associated β2-microglobulin: Implications for cancer immunotherapy
Keywords: Al; Alexa; APC; allophycocyanin; β2M; β2-microglobulin; CDC; complement dependent cytotoxicity; HBMT; Hepes buffered modified Tyrode's; HI; heat-inactivated; mAb; monoclonal antibody; MESF; molecules of equivalent soluble fluorochrome; RT; room temperat
ReviewManipulating T cell-mediated pathology: Targets and functions of monoclonal antibody immunotherapy
Keywords: Ab; antibody; ADCC; Antibody dependent cellular cytotoxicity; AICD; activation induced cell death; ATG; Anti-thymocyte globulin; ATGAM; Lymphocyte immune globulin; APC; Antigen presenting cells; CDC; Complement dependent cytotoxicity; CIA; Collagen induce
Promotion and prevention of autoimmune disease by CD8+ T cells
Keywords: Autoimmune disease; CD8+ T cell; Tolerance; AIHA; autoimmune hemolytic anemia; ALPS; autoimmune lymphoproliferative syndrome; APC; antigen presenting cells; CTL; cytotoxic T lymphocytes; EAE; experimental autoimmune encephalomyelitis; HLA; human leukocyte
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors
Keywords: TDGF-1; teratocarcinoma-derived growth factor-1; CFC; Cripto-1/FRL1/Cryptic; GPI; glycosylphosphatidylinositol; TGF-β; transforming growth factor-β; GDF; growth differentiation factor; Tcf; T-cell factor; Fz; frizzled; LRP; low-density lipoprotein recep
Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling
Keywords: Apc; Ctnnb; Nkx2.1; TGF-beta; PNEC; Lung development;
P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway
Keywords: ABC; ATP-binding cassette; APC; Allophycocyanin; BSA; bovine serum albumin; CHX; cycloheximide; CsA; cyclosporine A; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; D-PBS; Dulbecco's phosphate buffered saline; FasL; Fas ligand; FBS; fo
Distribution of transmembrane AMPA receptor regulatory protein (TARP) isoforms in the rat spinal cord
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; AMPAR; AMPA receptor; APC; adenomatous polyposis coli; DSA; dense sinusoid axon terminal; EDTA; ethylenediaminetetraacetic acid; GFAP; glial fibrillary acidic protein; HEPES; hydroxyethyl piper
Rhinitis, sinusitis, and upper airway diseaseA novel allergen-adjuvant conjugate suitable for specific immunotherapy of respiratory allergy
Keywords: Adjuvants; immunotherapy; allergy; vaccines; Toll-like receptors; adenine derivatives; TH cells; APC; Antigen-presenting cell; BALF; Bronchoalveolar lavage fluid; DC; Dendritic cell; DMSO; Dimethyl sulfoxide; ESI; Electrospray ionization; Foxp3; Forkhead
The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets
Keywords: APC; adenomatosis polyposis coli; Cby; Chibby; CK-1; casein kinase-1; CK-2; casein kinase-2; CRD; cysteine-rich domain; CREBBP or CBP; cAMP responsive element binding protein (CREB) binding protein; DEP; DV, Egl-10, pleckstrin; DIX; dishevelled/axin; DKK;
The mitochondrial transporter family SLC25: Identification, properties and physiopathology
Keywords: AAC; ADP/ATP carrier; AGC; aspartate/glutamate carrier; ALA; δ-aminolevulinic acid; APC; ATP-Mg/Pi carrier; CAC; carnitine/acylcarnitine carrier; CoA; coenzyme A; FA; fatty acid; HHH; hyperornithinemia-hyperammonemia-homocitrullinuria; MC; mitochondrial
ReviewT-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation
Keywords: Td; T-cell dependent, thymus dependent; T; thymus; ADA; anti-drug antibodies; Ti; T-cell independent; APC; antigen-presenting cells; HLA; human leukocyte antigen; MHC; major histocompatibility complex; TCR; T cell receptor; Treg; regulatory T cells; FVIII
Mechanisms of allergy and clinical immunologyProinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation
Keywords: Asthma; allergy; exosomes; epithelial cells; IL-13; monocytes; AAI; Allergic airway inflammation; AHR; Airway hyperresponsiveness; APC; Allophycocyanin; BALF; Bronchoalveolar lavage fluid; FITC; Fluorescein isothiocyanate; Hsp-70; Heat shock protein 70; O
Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway
Keywords: FZD; Frizzled; LRP; LDL receptor-related protein; Dvl; Disheveled; APC; Adenomatous polyposis coli; CK1α; Casein kinase 1α; GSK3β; Glycogen synthase kinase 3β; HCC; Hepatocellular carcinoma; EZH2; Zeste homologue 2; sFRPs; Secreted frizzled-related
Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling
Keywords: RA; rheumatoid arthritis; FLS; fibroblast-like synoviocytes; ACPA; anti-citrullinated peptide antibody; DKK1; dickkopf-1; 11β-HSD1; 11beta-hydroxysteroid dehydrogenase type 1; PADI4; peptidylarginine deiminase-4; hTERT; human telomerase reverse transcrip
IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice
Keywords: Mouse Model; Metabolism; Ulcerative Colitis; IBD; AOM; azoxymethane; APC; antigen-presenting cell; CAC; colitis-associated cancer; CRC; colorectal cancer; DSS; dextran sodium sulfate; DbKO; double gene knockout mouse for indoleamine 2,3 dioxygenase 1 and
Lower GI hemorrhage controlled with endoscopically applied TC-325 (with videos)
Keywords: INR; international normalized ratio; APC; argon plasma coagulation;
Oral administration of chitin and chitosan prevents peanut-induced anaphylaxis in a murine food allergy model
Keywords: Ag; antigen; APC; antigen-presenting cells; CPE; crude peanut extract; CT; cholera toxin; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorbent assay; GWP; ground whole peanut; HRP; horseradish peroxidase; IFN; interferon; Ig; immunoglobulin; IL; i
Role of endoscopy in the staging and management of colorectal cancer
Keywords: APC; argon plasma coagulation; CRC; colorectal cancer; ESD; endoscopic submucosal dissection; EUS-FNA; EUS-guided FNA; MRI; magnetic resonance imaging; SEMS; self-expandable metal stents;
Efficacy, Safety, and Long-term Results of Endoscopic Treatment for Early Stage Adenocarcinoma of the Esophagus With Low-risk sm1 Invasion
Keywords: Esophageal Cancer; Neoplasia; Barrett's Esophagus; Endoscopic Resection; Treatment; APC; argon plasma coagulation; CER; complete endoluminal remission; EAC; esophageal adenocarcinoma; ER; endoscopic resection; ET; endoscopic therapy; EUS; endoscopic ultra
OT-II TCR transgenic mice fail to produce anti-ovalbumin antibodies upon vaccination
Keywords: T-B-cell interaction; Helper T-lymphocyte; B-cell; APC; Th1; Th2; Th17; Intranasal vaccine
The role of endoscopy in the assessment and treatment of esophageal cancer
Keywords: APC; argon plasma coagulation; BE; Barrett's esophagus; EAC; esophageal adenocarcinoma; ESD; endoscopic submucosal dissection; ND:YAG; neodymium-doped yttrium aluminium garnet; PDT; photodynamic therapy; SCC; squamous cell carcinoma; SEMS; self-expandab
Adenomatous polyposis coli gene involvement in ileal enterochromaffin cell neuroendocrine neoplasms
Keywords: APC; Polymorphism; Mutation; Allelic losses; Ileal neuroendocrine neoplasms
Myeloid derived suppressor cells (MDSCs) can induce the generation of Th17 response from naïve CD4+ T cells
Keywords: APC; antigen presenting cell; h; hour; MDSC; myeloid derived suppressor cell; TAM; tumor associated macrophage; Treg; T regulatory cell; Myeloid derived suppressor cells; Th17; Tumor associated macrophages; Cytokines;
miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A
Keywords: HCC; hepatocellular carcinoma; HBx; hepatitis B virus x; miR-101; microRNA-101; DNMT3A; DNA methyltransferase 3A; UTR; untranslated region; MSP; methylation-specific PCR; TSG; tumor-suppressor gene; GSTP1; glutathione S-transferase pi 1; RASSF1; Ras assoc
Chronic brain ischemia induces the expression of glial glutamate transporter EAAT2 in subcortical white matter
Keywords: APC; adenomatous polyposis coli; CBF; cerebral blood flow; EAAT; excitatory amino acid transporter; GFAP; glial-fibrillary acidic protein; GSTÏ; glutathione-S-transferase pi; LBCCA; ligation of bilateral common carotid arteries; MCAO; middle cerebral art
Diagnostic and therapeutic yield is not influenced by the timing of small-bowel enteroscopy: morning versus afternoon
Keywords: APC; argon plasma coagulation; AE; adverse event; BE; small-bowel enteroscopy; DBE; double-balloon enteroscopy; SBE; single-balloon enteroscopy; SE; spiral enteroscopy;
Innate autoreactive B cells as antigen-presenting cells in the induction of tolerance to conserved keratin polypeptide
Keywords: BCRs; B cell receptors; APC; antigen presenting cells; AK auto-Ab; anti-keratin autoantibody; LN; lymph nodes; TCR; T-cell antigen receptor; Ig; immunoglobulin; CDR; complementary determining region; FR; framework region; NHSB; N-hydroxysuccinimido-biotin
SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients
Keywords: AChR; acetylcholine receptor; APC; antigen-presenting cell; DC; dendritic cell; GC; germinal center; HEV; high endothelial venules; mDC; myeloid dendritic cell; MG; myasthenia gravis; pDC; plasmacytoid dendritic cell; PNAd; peripheral-node addressin; TEC;
Statins and Colorectal Cancer
Keywords: Statin; Colon; Rectum; Adenoma; Chemoprevention; APC; Adenoma Prevention With Celecoxib; HMG-CoA; 3-hydroxy-3-methylglutaryl-coenzyme A; LDL; low-density lipoprotein; Min; multiple intestinal neoplasia; NSAID; nonsteroidal anti-inflammatory drug; RCT; ran
Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects
Keywords: CARD11; human; combined immunodeficiency; hypogammaglobulinemia; profound combined immunodeficiency disorder; transitional B cell; nuclear factor κB; B cell-activating factor receptor; inducible T-cell costimulator; germinal center; APC; Allophycocyanin;
Endoscopic Management of Complications After Gastrointestinal Weight Loss Surgery
Keywords: Weight Loss; Gastric Bypass; NSAIDs; Endoscopic Ultrasound; APC; argon plasma coagulation; BPD; biliopancreatic diversion; DS; duodenal switch; ERCP; endoscopic retrograde cholangiopancreatography; GJA; gastrojejunal anastomosis; LAGB; laparoscopic adjust
Plasmacytoid dendritic cells: Biomarkers or potential therapeutic targets in atherosclerosis?
Keywords: Atherosclerosis; Plasmacytoid dendritic cells; Interferons; Autoimmunity; AMI; Acute myocardial infarction; ACPA; anti-citrullinated protein antibodies; APC; antigen presenting cells; apoE; apolipoprotein-E; BDCA; blood dendritic cell antigen; BST-2; bone
Electrosurgical generators
Keywords: APC; argon plasma coagulation; ES; endoscopic sphincterotomy; ESU; electrosurgical generator unit;
Update on Immune Mechanisms Associated with Sublingual Immunotherapy: Practical Implications for the Clinician
Keywords: Allergen; Biomarker; Mucosal immunity; Regulatory T cell; Sublingual immunotherapy; Tolerance; APC; Antigen presenting cell; DC; Dendritic cell; Eos; Eosinophil; ILT; Immunoglobulin-like transcript; LC; Langerhans DC cell; MC; Mast cell; MDC; Myeloid dend
Biomarkers and Targeted Therapeutics in Colorectal Cancer
Keywords: Colorectal cancer; Molecular biology; APC; p53; Loss of heterozygosity; Microsatellite instability; CPG-island methylation;
IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling
Keywords: Asthma; TH2 stability; IL-4; signal transducer and activator of transcription 1 signaling; suppressor of cytokine signaling 3; IL-27; APC; Allophycocyanin; IL-27R; IL-27 receptor; MFI; Mean fluorescence intensity; Non-TH2m; Memory non-TH2 cells, including
Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients
Keywords: Stevens-Johnson syndrome; toxic epidermal necrolysis; animal models; APC; Antigen-presenting cell; CTL; Cytolytic T lymphocyte; DC; Dendritic cell; FITC; Fluorescein isothiocyanate; GVHD; Graft-versus-host disease; GVHR; Graft-versus-host reaction; NK; Na
Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype
Keywords: Mast cells; TH cells; IL-22; immunologic synapse; inflammation; psoriasis; APC; Antigen-presenting cell; CLA; Cutaneous lymphocyte-associated antigen; DC; Dendritic cell; hMC; Human mast cell; hMCIFN-γ; hMC treated for 72 hours with IFN-γ; IHC; Immunohi
Targeting autophagy as a potential therapeutic approach for melanoma therapy
Keywords: 5-ALA; 5-aminolevulinic acid; AMBRA1; autophagy/Beclin 1 regulator 1; APC; antigen-presenting cell; ASS; argininosuccinate synthetase; ATG; autophagy-related; ATM; Ataxia telangiectasia mutated; BafA1; bafilomycin A1; Bif-1; endophilin B1; BN; benign nevi
TFPI-dependent activities of Protein S
Keywords: APC, activated protein C; K1/2/3, Kunitz domain 1/2/3; TFPI, full length tissue factor pathway inhibitor; TF, tissue factor; FVa/VIIa/VIIIa/Xa, factor Va/VIIa/VIIIa/XaTFPI; protein S; APC; anticoagulants
Copy number variation of the APC gene is associated with regulation of bone mineral density
Keywords: Bone mineral density; Osteoporosis; Copy number variation; APC; Association
Autophagy in the intestinal epithelium is not involved in the pathogenesis of intestinal tumors
Keywords: TOR, rapamycin; IFN-γ, interferon-γ; GFP, green fluorescence protein; LC3, microtubule-associated protein 1A/1B-light chain 3; H&E, hematoxylin and eosin; FAP, familial adenomatous polyposis; PI3K, phosphoinositide 3-kinaseAutophagy; Intestinal tumor; APC
Changes Over Time in Indications, Diagnostic Yield, and Clinical Effects of Double-Balloon Enteroscopy
Keywords: Small Bowel; Experience; Test; Imaging Analysis; APC; argon plasma coagulation; CE; capsule endoscopy; CT; computed tomography; DBE; double-balloon enteroscopy; OGIB; obscure gastrointestinal bleeding;
Subsquamous Intestinal Metaplasia: Implications for Endoscopic Management of Barrett's Esophagus
Keywords: Neoplasm; Cancer; Esophageal Mucosa; Treatment; Risk; PPI; AIM-Dysplasia; Ablation of Intestinal Metaplasia Containing Dysplasia; APC; argon plasma coagulation; BE; Barrett's esophagus; EMR; endoscopic mucosal resection; OCT; optical coherence tomograph
Loss of heterozygosity of the Mutated in Colorectal Cancer gene is not associated with promoter methylation in non-small cell lung cancer
Keywords: Non-small cell lung cancer; APC; MCC; DNA methylation; Loss of heterozygosity
Core curriculum for EMR and ablative techniques
Keywords: APC; argon plasma coagulation; PDT; photodynamic therapy; RFA; radiofrequency ablation;