APOE and aging-related cognitive change in a longitudinal cohort of men
Keywords: آپو; Normal cognitive aging; APOE; longitudinal studies;
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Age, APOE and sex: Triad of risk of Alzheimer's disease
Keywords: آپو; Age; ApoE; Sex difference; Alzheimer's disease; Mitochondria; Bioenergetics; Brain;
Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review
Keywords: آپو; APOE; Apolipoprotein E; Dementia; Ischemic heart disease; Triglycerides;
Associate editor: P. MolenaarAngiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease
Keywords: آپو; ACE; angiotensin converting enzyme; AGE; advanced glycosylation end product; ApoE; apolipoprotein E1; ARB; angiotensin receptor blocker; ANG; angiotensin II; AT1R; angiotensin II type 1 receptor; AT2R; angiotensin II type 2 receptor; BP; blood pressure; C
Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries
Keywords: آپو; ApoE; TLEN; Knockout; Atherosclerosis
Methylation analysis of multiple genes in blood DNA of Alzheimer’s disease and healthy individuals
Keywords: آپو; DNA methylation; Alzheimer’s disease; Folate; Homocysteine; Vitamin B12; PSEN1; BACE1; MTHFR; DNMTs; APOE
Metformin reduces the endotoxin-induced down-regulation of apolipoprotein E gene expression in macrophages
Keywords: آپو; Metformin; Apolipoprotein E; NF-κB; Macrophages; Multienhancer; LPS; AMPK; adenosine-monophosphate-activated protein kinase; apoE; apolipoprotein E; cAMP; cyclic adenosine monophosphate; CD36; cluster of differentiation 36; Cox2; cyclooxygenase 2; DMEM;
Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice
Keywords: آپو; ApoE; apolipoprotein E; AP-PG; A.âpullulans-produced β-glucan; CAD; coronary artery disease; HDL; high-density lipoprotein; HFD; high-fat diet; LDL; low-density lipoprotein; ox-LDL; oxidized low-density lipoprotein; β-glucan; Aureobasidium pullulans;
Global changes in DNA methylation in Alzheimer's disease peripheral blood mononuclear cells
Keywords: آپو; Alzheimer's disease; APOE; DNA methylation; DNMT; Epigenetics; PBMC; Peripheral markers; Pyrosequencing;
Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription
Keywords: آپو; ANOVA; analysis of variance; AD; Alzheimer's disease; AP-1; activator protein 1; APP; amyloid precursor protein; apoE; apolipoprotein E; BIS-1; bisindolylmaleimide 1; ChaT; choline acetyltransferase; L-NAME; NÏ-nitro-L-arginine methylester; LRP1; low d
Quantification of total apolipoprotein E and its specific isoforms in cerebrospinal fluid and blood in Alzheimer’s disease and other neurodegenerative diseases
Keywords: آپو; CSF biomarkers; Alzheimer’s disease; SRM; Protein isoforms; apoE
Chylomicron remnant model emulsions induce intracellular cholesterol accumulation and cell death due to lysosomal destabilization
Keywords: آپو; ACAT; acyl CoA:cholesterol acyltransferase; ac-LDL; acetylated LDL; apoE; apolipoprotein E; BSA; bovine serum albumin; CE; esterified cholesterol; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; FBS; fetal bovine serum; HSPGs; heparan
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype
Keywords: آپو; Mild cognitive impairment; Alzheimer; Dementia; Magnetic resonance spectroscopy; MRS; GABA; Glx; Glutamate; Beta-amyloid; PiB; Posterior cingulate cortex; APOE;
Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women
Keywords: آپو; Air pollution; cognition; APOE;
Differential effects of white matter hyperintensity on geriatric depressive symptoms according to APOE-ε4 status
Keywords: آپو; WMH; white matter hyperintensity; APOE; apolipoprotein E; CREDOS; clinical research center for dementia of South Korea; MMSE; mini-mental state examination; GDS; geriatric depression scale;
Association between apolipoprotein E gene polymorphism and depression
Keywords: آپو; Apolipoprotein E; ApoE; Depression; Polymorphism; Meta-analysis
Adulthood dietary exposure to a common pesticide leads to an obese-like phenotype and a diabetic profile in apoE3 mice
Keywords: آپو; OP; organophosphate; apoE; apolipoprotein E; CPF; chlorpyrifos; DTNB, 5; 5'-dithiobis-(2-nitrobenzoic acid); HOMA-IR; homeostatic model assessment for insulin resistance; ChE; cholinesterase; WHO; World Health Organization; apoE TR mouse model; apoE tar
Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis
Keywords: آپو; IL-6 family cytokines; Atherosclerosis; ApoE; Gp130; STAT3;
Universal Screening for Familial Hypercholesterolemia in Children
Keywords: آپو; cholesterol; familial hypercholesterolemia; next-generation sequencing; universal screening; APOB; apolipoprotein B; APOE; apolipoprotein E; FH; familial hypercholesterolemia; HDL; high-density lipoprotein; LDL; low-density lipoprotein; LDLR; low-density
Aminobisphosphonates inhibit dendritic cell-mediated antigen-specific activation of CD1d-restricted iNKT cells
Keywords: آپو; iNKT cells; invariant natural killer T cells; α-GalCer; alpha-galactosylceramide; Ag; antigen; APC; antigen presenting cell; NBP; aminobisphosphonates; moDC; monocyte derived dendritic cell; apoE; apolipoprotein E; IPP; isopentenyl pyrophosphate; SRA; sc
ReviewAkt isoforms in vascular disease
Keywords: آپو; Akt; oncogene identified in the Akt8 retrovirus; ApoE; apolipoprotein E; FOXO; forkhead class O transcription factor; HDL; high-density lipoprotein; OHT; 4-hydroxytamoxifen; IGF; insulin-like growth factor; LDL; low-density lipoprotein; SM22α; smooth mus
APOE and cerebral amyloid angiopathy in community-dwelling older persons
Keywords: آپو; APOE; Cerebral amyloid angiopathy; Capillaries; Alzheimer's disease;
RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages
Keywords: آپو; LDL; low density lipoprotein; HDL; high density lipoprotein; RIP140; receptor interacting protein 140; ABCA1; ATP-binding membrane cassette transporter A-1; ABCG1; ATP-binding membrane cassette transporter G-1; RCT; reverse cholesterol transport; oxLDL; o
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
Keywords: آپو; Alzheimer; Abeta; Amyloid; Tau; Genetics; Next generation sequencing; PICALM; SORL1; EPHA1; APOE; APP; Vaccine; Secretase; Nicastrin; Presenilin; PSEN1; Neurodegeneration; Dementia;
Effects of ApoE on intracellular calcium levels and apoptosis of neurons after mechanical injury
Keywords: آپو; ApoE; apolipoprotein e; BBB; blood-brain barrier; EGTA; ethylene glycol tetraacetic acid; FCM; flow cytometry; FITC; fluorescein isothiocyanate; MK801; dizocilpine; NMDAR; N-methyl-d-aspartate receptor; PBS; phosphate-buffered saline; PI; propidium iodi
Chronic administration of methamphetamine promotes atherosclerosis formation in ApoEâ/â knockout mice fed normal diet
Keywords: آپو; Atherosclerosis; Methamphetamine; NPY; NPYR; NPY; neuropeptide Y; ApoE; Apolipoprotein E; α-SMA; α-smooth muscle actin; NE; norepinephrine; NPYR1; neuropeptide Y receptor 1; NPYR2; neuropeptide Y receptor 2; NPYR5; neuropeptide Y receptor 5; ICAM-1; int
Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation
Keywords: آپو; ABCA; ATP-binding cassette transporter; ABCG1; ATP-binding cassette sub-family G; ApoE; Apolipoprotein E; CYP46; cholesterol 24S-hydroxylase; CYP51; Sterol 14 alpha-demethylase; ER; endoplasmic reticulum; FSS; forced swim stress; H2O2; Hydrogen peroxide;
Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice
Keywords: آپو; FAD; familial Alzheimer's disease; LDLr; low-density lipoprotein receptor; ApoE; Apolipoprotein E; APP; amyloid precursor protein; ROS; reactive oxygen species; OXPHOS; oxidative phosphorylation; NRF; nuclear respiratory factors; PGC-1α; peroxisome proli
Triterpenoid-enriched extract of Ilex kudingcha inhibits aggregated LDL-induced lipid deposition in macrophages by downregulating low density lipoprotein receptor-related protein 1 (LRP1)
Keywords: آپو; Ilex kudingcha; Triterpenoid-enriched extract; Foam cell; Low density lipoprotein receptor-related protein 1; Latifoloside G (PubChem CID: 44566333); Latifoloside H (PubChem CID: 44566328); ABCA1; ATP-binding cassette subfamily A member-1; AgLDL; aggregat
STAT4 deficiency reduces the development of atherosclerosis in mice
Keywords: آپو; Atherosclerosis; Inflammation; Leucocytes; Transcription factors; Apoe; Apolipoprotein E; WD; Western Diet; MΦ; Macrophages; PLN; Peripheral Lymph Node;
Development and analytical comparison of microflow and nanoflow liquid chromatography/mass spectrometry procedures for quantification of cardiac troponin T in mouse hearts
Keywords: آپو; AL KO; double knock-out for ApoE and receptor for LDL; ApoE; apolipoprotein E; AST; aspartate transaminase; CK; creatine kinase; cTnT; cardiac troponin T; TnC; troponin C; TnI; troponin I; HESI; heated electrospray; ICAT; isotope-coded affinity tags; iTRA
Disruption of the TSLP-TSLPR-LAP signaling between epithelial and dendritic cells through hyperlipidemia contributes to regulatory T-Cell defects in atherosclerotic mice
Keywords: آپو; Thymic stromal lymphopoietin (TSLP); Regulatory T-cell (Treg); Dendritic cell; Atherosclerosis; Low-density lipoprotein (LDL); TSLP; thymic stromal lymphopoietin; DCs; dendritic cells; ApoE; Apolipoprotein E; Tregs; Regulatory T-cells; TECs; thymus epithe
Emerging roles of the γ-secretase-notch axis in inflammation
Keywords: آپو; Inflammation; Notch; γ-Secretase; Inflammatory diseases; Stroke; Aβ; amyloid-β; AD; Alzheimer's disease; AICD; APP intracellular domain; ALPS; autoimmune lymphoproliferative syndrome; Aph-1; anterior pharynx-defective 1; ApoE; apolipoprotein E; APP; am
The mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function
Keywords: آپو; AD; Alzheimer's disease; ADAS-Cog; Alzheimer Disease's Assessment Scale-cognitive subscale; ADNI; Alzheimer's Disease Neuroimaging; ApoE; Apolipoprotein E; Aβ; β-amyloid; Aβ1-42; β-amyloid peptides 1 to 42; Bc; Bias-corrected; CFI; Comparative f
Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice
Keywords: آپو; ApoE; apolipoprotein E; ApoEâ/â; ApoE deficiency; BBB; blood-brain barrier; BCSFB; blood-cerebrospinal fluid barrier; CSF; cerebrospinal fluid; ECM; extracellular matrix; Gd; gadolinium; IL-1β; interleukin-1 beta; MMP; matrix metalloproteinases;
Sirtuins in vascular diseases: Emerging roles and therapeutic potential
Keywords: آپو; ACE; angiotensin converting enzyme; AICAR; 5-amino-4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATM; ataxia telangiectasia mutated; ATP; adenosin
Association of ApoE gene with type 2 diabetic nephropathy in a Chinese population: A meta-analysis of case-control studies
Keywords: آپو; ApoE; Gene polymorphism; Type 2 diabetic nephropathy; Meta-analysis; ChineseApoE; Polymorphisme génétique; Diabète de type 2; Néphropathie; Méta-analyse; Chinois
Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory
Keywords: آپو; Alzheimer disease; Familial Danish dementia; BRI2; ApoE;
Featured ArticleAPOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern
Keywords: آپو; Significant memory concern; SMC; Subjective cognitive decline; SCD; Apolipoprotein E; APOE; Neuroimaging; [18F]Florbetapir PET; [18F]Fluorodeoxyglucose; FDG; PET; Structural magnetic resonance imaging (MRI); Cerebrospinal fluid; CSF; Alzheimer's Disease N
Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels
Keywords: آپو; ADT-OH; anethole dithiolethione, 5-[p-methoxyphenyl]3H-1,2-dithiole-3-thione; AP219; 9-(Carboxynonyl)triphenylphosphonium bromide; AP39; (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide; ApoE; apolioprotein E; ARRIVE;
Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer dise
Keywords: آپو; Alzheimer; Children; Fructose; Leptin; APOE; PM2.5 Air pollution; Mexico City; Obesity; Vitamin D;
Molecular pathways associated with the intersex condition in rainbow darter (Etheostoma caeruleum) following exposures to municipal wastewater in the Grand River basin, ON, Canada. Part B
Keywords: آپو; APOE; apolipoprotein E; CAV1; caveolin 1; SAA1; serum amyloid A1; EPX; eosinophil peroxidase; PGD; phosphogluconate dehydrogenase; TNNI3; troponin I type 3 (cardiac); HSPB1; heat shock 27Â kDa protein 1; SERPINE1; serpin peptidase inhibitor, clade E; INS;
Epigenomics of Alzheimer's disease
Keywords: آپو; AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE-1; beta-site APP-cleaving enzyme 1 gene; CG; cytosine-guanine dinucleotide; ChIP-Seq; chromatin immunoprecipitation-sequencing; CVD; cerebrovascular disease; GWAS; gen
14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations
Keywords: آپو; Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime
Role of Nrf2 in the pathogenesis of atherosclerosis
Keywords: آپو; ABCA1; ATP-binding cassette, sub-family A, member 1; ABCG1; ATP-binding cassette, sub-family G, member 1; ApoE; apolipoprotein E; ARE; antioxidant response element; ArgII; arginase II; CDDO-Im; 2-cyano-3,12 dioxooleana-1,9 dien-28-imidazolide; CXCL4; chem
Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - Insights from the SATgenε study
Keywords: آپو; APOE; apolipoprotein E; BMI; body mass index; CHO; carbohydrate; CRP; C-reactive protein; CVD; cardiovascular disease; DHA; docosahexaenoic acid; GM-CSF; granulocyte-macrophage colony-stimulating factor; HSF; high saturated fat; ICAM-1; inter-cellular adh
APOE É4 polymorphism and cognitive deficit among the very old Chinese veteran men without dementia
Keywords: آپو; APOE; apolipoprotein E; CASI; Cognitive Abilities Screening Instrument; CDR; Clinical Dementia Rating Scale; DSB; Digit Span Backward; DSF; Digit Span Forward; MINI; Mini-International Neuropsychiatric Interview; MMSE; Mini-Mental Status Examination; Apol
Association between the SORL1 rs2070045 polymorphism and late-onset Alzheimer's disease: Interaction with the ApoE genotype in the Chinese Han population
Keywords: آپو; Alzheimer's disease; Sortilin-related receptor L1; Single nucleotide polymorphism; Chinese; ApoE;
Association of APOE polymorphisms and stressful life events with dementia in a Pakistani population
Keywords: آپو; Dementia; Pakistan; Stressful life events; APOE;
APOE gene polymorphisms and susceptibility to Creutzfeldt–Jakob disease
Keywords: آپو; APOE; Apolipoprotein E; Creutzfeldt–Jakob disease; Meta-analysis; Polymorphism