کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5945492 | 1172351 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Disruption of the TSLP-TSLPR-LAP signaling between epithelial and dendritic cells through hyperlipidemia contributes to regulatory T-Cell defects in atherosclerotic mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
TSLPTregsRetinoid X receptor alphaTECsLAPDCsThymic stromal lymphopoietin (TSLP)ACSPD-L1FOXP3rxraOx-LDLTREC - GOregulatory T-cells - T-cell های نظارتیAtherosclerosis - آترواسکلروز(تصلب شریان)Apoe - آپوapolipoprotein E - آپولیپوپروتئین Ecoronary artery disease - بیماری عروق کرونرforkhead box P3 - جعبه جعبه P3T-cell receptor excision circle - دایره برداشت گیرنده سلول TDendritic cell - سلول دندریتیکthymus epithelial cells - سلول های اپی تلیوم تیماسDendritic cells - سلول های دندریتیکAcute coronary syndrome - سندرم کرونری حادCAD - طراحی به کمک رایانه یا کَدThymic stromal lymphopoietin - لنفوپیتین استروما تیمیکoxidized low density lipoprotein - لیپوپروتئین با چگالی کم اکسید شدهLow-density lipoprotein (LDL) - لیپوپروتئین کم چگالی (LDL)Programmed death ligand-1 - لیگاند مرگ برنامه ریزی شده-1latency-associated peptide - پپتید وابسته به زمان تاخیر
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Regulatory T-Cells (Tregs) play a protective role against the development of atherosclerosis. Moreover, thymic stromal lymphopoietin (TSLP)/thymic stromal lymphopoietin receptor (TSLPR) signaling in myeloid dendritic cells (DCs) promote Treg differentiation. Here, we examined the potential role of TSLP/TSLPR on Treg homeostasis in atherosclerosis. The frequencies of both latency-associated peptide (LAP)+ and Foxp3+ Tregs were reduced in the thymus and spleen of ApoEâ/â mice compared with C57BL/6 mice, and this effect was associated with decreased thymic output. The tolerogenic function of DCs obtained from ApoEâ/â mice was compromised compared with those from C57BL/6 mice. The expression of TSLP and TSLPR was also inhibited in ApoEâ/â mice. In addition, we found that ox-LDL attenuated TSLP expression in cultured thymic epithelial cells (TECs) through the activation of retinoid X receptor alpha (RXRA) and IL-1β and decreased LAP and PD-L1 expression in oxLDL-activated DCs while both were up-regulated in TSLP-activated DCs. We also observed that the TSLP-DCs mediated differentiation of Tregs was abrogated through LAP neutralization. Furthermore, TSLP injection rescued Treg defects in ApoEâ/â mice. These findings suggest that Treg defects in ApoEâ/â mice might partially be attributed to the disruption of TSLP-TSLPR-LAP signaling in epithelial cells (ECs) and DCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 238, Issue 2, February 2015, Pages 278-288
Journal: Atherosclerosis - Volume 238, Issue 2, February 2015, Pages 278-288
نویسندگان
Kunwu Yu, Qian Dong, Xiaobo Mao, Kai Meng, Xiaoqi Zhao, Qingwei Ji, Bangwei Wu, Yucheng Zhong, Zhengfeng Zhu, Yuzhou Liu, Wei Zhang, Hasahya Tony, Huairui Shi, Qiutang Zeng,