Keywords: دامنه داخل سلولی APP; AP-1; activator protein-1; APP; amyloid precursor protein; AICD; APP intracellular domain; DAMPs; damage associated molecular patterns; FOXO3; forkhead box O3; HES; hairy-enhancer of split; HPCs; hematopoietic progenitor cells; HDAC; histone deacetylase;
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Keywords: دامنه داخل سلولی APP; ABAD; Aβ binding alcohol dehydrogenase; AD; Alzheimer's disease; ADAM; A Disintegrin and metalloproteinase; AICD; APP intracellular domain; APH1; anterior pharynx-defective 1; APP; amyloid precursor protein; ATP; adenosine triphosphate; Aβ; amyloid be
Keywords: دامنه داخل سلولی APP; Alzheimer disease; Synaptic plasticity; APP intracellular domain; APLP2 intracellular domain;
Keywords: دامنه داخل سلولی APP; Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain
Keywords: دامنه داخل سلولی APP; Aβ; amyloid β protein; NFT; neurofibrillary tangles; APP; amyloid precursor protein; PSs; presenilins; NICD; Notch intracellular domain; mTOR; mammalian Target of Rapamycin; PP2A; protein phosphatase 2; GSK-3; glycogen synthase kinase-3; CTFS; cytosol-s
Keywords: دامنه داخل سلولی APP; Aβ; amyloid beta; AD; Alzheimer's disease; AICD; APP intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APP; amyloid β precursor protein; Apo E; apolipoprotein E; BACE1; β-site APP converting enzyme 1; BDNF; brain derive
Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice
Keywords: دامنه داخل سلولی APP; Aβ; amyloid-β;; AD; Alzheimer's disease; ADL; activity of daily living; ANOVA; analysis of variant; APP; amyloid precursor protein; AICD; APP intracellular domain; APP/PS1; APPswe/PS1ÎE9; AUC; area under the curve; BBB; blood-brain barrier; BSB; 1-brom
Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer's disease
Keywords: دامنه داخل سلولی APP; Aβ; amyloid β; AD; Alzheimer's disease; AFT complexes; APP/AICD-FE65-TIP60 complexes; AICD; APP intracellular domain; APLP1,2; amyloid precursor like protein 1,2; APP; amyloid precursor protein; ChIP; chromatin immuneprecipitation; CTF; C-terminal fra
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: دامنه داخل سلولی APP; ABCA1; ATP-binding cassette transporter A1; AD; Alzheimerâ¿¿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid
Keywords: دامنه داخل سلولی APP; Aβ; β-amyloid; AD; Alzheimer's Disease; AICD; APP Intracellular Domain; APP; Amyloid Precursor Protein; ARG1; Arginase 1; CHF5074; 1-(3â²,4â²-dichloro-2-fluoro[1,1â²-biphenyl]-4-yl)-cyclopropanecarboxylic acid; FIZZ1; Found in Inflammatory Zone; GS
Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms
Keywords: دامنه داخل سلولی APP; APP; Amyloid-β Precursor Protein; AD; Alzheimer׳s disease; Aβ; Amyloid-β; ER; endoplasmic reticulum; ERGIC; ER-Golgi Intermediate Compartment; TGN; trans-Golgi network; AICD; APP Intracellular Domain; PTB; phosphotyrosine binding; JIP-1; JNK-interacti
Emerging roles of the γ-secretase-notch axis in inflammation
Keywords: دامنه داخل سلولی APP; Inflammation; Notch; γ-Secretase; Inflammatory diseases; Stroke; Aβ; amyloid-β; AD; Alzheimer's disease; AICD; APP intracellular domain; ALPS; autoimmune lymphoproliferative syndrome; Aph-1; anterior pharynx-defective 1; ApoE; apolipoprotein E; APP; am
Neuroscience Forefront ReviewSeizures in Alzheimer's disease
Keywords: دامنه داخل سلولی APP; Aβ; amyloid-β peptide; AD; Alzheimer's disease; AICD; APP intracellular domain; APP; Amyloid precursor protein; CAA; Cerebral amyloid angiopathy; CTFα; α C-terminal fragment; CTFβ; β C-terminal fragment; DS; Down syndrome; EEG; Electroencephalogra
Expression and function of APP and its metabolites outside the central nervous system
Keywords: دامنه داخل سلولی APP; AChRs; acetylcholine receptors; ADAM; a disintegrin and metalloprotease domain; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid beta; APH1; Anterior pharynx-defective 1; AICD; APP intracellular domain; BACE1; β-secretase; CNS; centr
A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1
Keywords: دامنه داخل سلولی APP; Alzheimer's disease; APP processing; APP intracellular domain; AICD-FE65 complex; Microtubule disorganization;
Presenilins are novel substrates for TRAF6-mediated ubiquitination
Keywords: دامنه داخل سلولی APP; AD; Alzheimer's disease; AICD; APP intracellular domain; APH-1; anterior pharynx-defective-1; APP; Amyloid precursor protein; Aβ; Amyloid β; C99; 99-amino acid APP C-terminal fragment; ER; Endoplasmic reticulum; FAD; Familial Alzheimer's disease; HEK293
Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis
Keywords: دامنه داخل سلولی APP; AD; Alzheimer's disease; PSEN; presenilin; APP; amyloid precursor protein; Aβ; β-amyloid; FAD; familial forms of AD; SVZ; subventricular zone; SGZ; subgranular zone; DG; dentate gyrus; NSCs; neural stem cells; DCX; doublecortin; NPC; neural progenitor c
Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Aβ-induced neurotoxicity in Drosophila
Keywords: دامنه داخل سلولی APP; IDE; insulin-degrading enzyme; DM2; type 2 diabetes mellitus; AD; Alzheimer's disease; LOAD; late-onset AD; GK rat; Goto-Kakizaki rat; dilp2; Drosophila insulin-like peptide 2; InR; insulin receptor; Aβ; β-amyloid; APP; Aβ precursor protein; BACE; β
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
Keywords: دامنه داخل سلولی APP; ADAM; a disintegrin and metalloprotease; ACDL; acidic dileucine; ADDL; amyloid-β derived diffusible ligands; APP; amyloid precursor protein; Aph; anterior pharynx defective phenotype; APLP; APP-like protein; AICD; APP intracellular domain; AD; Alzheimer'
Fe65 does not stabilize AICD during activation of transcription in a luciferase assay
Keywords: دامنه داخل سلولی APP; Aβ; β-amyloid peptide; APP; amyloid precursor protein; AICD; APP intracellular domain; sαAPP; soluble α-amyloid precursor protein; BACE; β-site APP-cleaving enzyme; CHO; Chinese hamster ovary; CTF; C-terminal fragment of APP; DAPT; N-[N-(3,5-difluoro
Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction
Keywords: دامنه داخل سلولی APP; Notch1-IC; Notch1 intracellular domain; ÎE1; Notch1 lacking the extracellular domain; APP; Amyloid beta-Precursor Protein; AICD; APP intracellular domain; ROS; Reactive oxygen species;
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
Keywords: دامنه داخل سلولی APP; APP, amyloid precursor protein; AICD, amyloid precursor protein intracellular domain; Abeta, Amyloid-beta peptide; CTF, carboxy-terminal fragment.Amyloid precursor protein; APP intracellular domain; Alzheimer’s disease; Lysosome; Gamma-secretase; Alkalizi