A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1

► We studied the proteome of AICD-FE65-TIP60 (AFT) expressing cells vs. controls. ► We identified a new candidate protein significantly down-regulated in AFT cells. ► We confirmed our findings in an independent knock-down model. ► We confirm that AFT establishes a nuclear dot-like phenotype. ► We demonstrate that wtAPP and swAPP are able to generate the AFT complex as well.