Keywords: BACE; bronchial arterial chemoembolization; CBM; China biological medicine database; CNKI; China national knowledge infrastructure database; CENTRAL; Cochrane Central Register of Controlled Trials; Chi-CTR; Chinese clinical trial registry; DCR; disease co
مقالات ISI (ترجمه نشده)
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Keywords: AC; adenylyl cyclase; AKAP; A kinase anchoring protein; BACE; β-secretase; C1; AC catalytic domain 1; C2; AC catalytic domain 2; CaM; calmodulin; GPCR; G protein-coupled receptor; PDE; phosphodiesterase; PKA; protein kinase A; PKC; protein kinase C; PP2A
Keywords: APP; amyloid precursor protein; Aβ; amyloid-β; BACE; beta-site APP cleaving enzyme; BBB; blood-brain barrier; CMC-Na; sodium carboxymethyl cellulose; CNS; central nervous system; ELISA; enzyme-linked immunosorbent assay; FBG; fasting blood glucose; HD
Keywords: Alzheimer's disease; Amyloid-β; β-secretases; γ-secretases; Computer-Aided Drug Design; AD; Alzheimer's disease; Aβ1-40; beta-Amyloid isoform 40 amino acids in length; Aβ1-42; beta-Amyloid isoform 42 amino acids in length; NMDA; N-Methyl-d-aspart
Keywords: PM; plasmepsin; SPP; signal peptide peptidase; HIV; human immunodeficiency virus; SAR; structure-activity relationships; BACE; beta-site APP cleaving enzyme 1 or beta-secretase; TCAMS; Tres Cantos Antimalarial Set; RBC; red blood cells; CatD; cathepsin
Keywords: AChE; acetylcholinesterase; aCSF; artificial cerebral spinal fluid; AD; Alzheimer's disease; APP; amyloid precursor protein; ANOVA; analysis of variance; BACE; β-secretase; CAT; catalase; CSF; cerebral spinal fluid; DTNB; 5,5â²-Dithiobis(2-nitrobenzoi
Keywords: Hippocampus; Prefrontal cortex; Amyloid precursor protein; BACE; TACE; Aging
Keywords: DS; danshen-shanzha; CVD; cardiovascular disease; IMT; intima-media thickness; TC; total cholesterol; TG; triglyceride; LDL-C; low-density lipoprotein-cholesterol; HDL-C; high-density lipoprotein-cholesterol; ILâ1β; interleukin-1β; NO; nitric oxide; 6
sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling
Keywords: Aβ; amyloid β; AD; Alzheimer's disease; ADAM; A Disintegrin And Metalloproteinase (α-secretase); APP; amyloid precursor protein; AMPA-R; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; BACE; β-site of APP cleavage enzyme (β-secretase)
The amyloid precursor protein binds to β-catenin and modulates its cellular distribution
Keywords: APP; amyloid precursor protein; BACE; beta-APP cleaving enzyme; GSK3; Glycogen Synthase Kinase 3; PCP; planar cell polarity; TCF/LEF; T-cell factor/lymphoid enhancer factor; TopFlash; TCL/LEF-Firefly luciferase; Alzheimer's disease; β-catenin; Amyloid
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
Keywords: Aβ42; β-amyloid42; ABCA1; ATP-Binding Cassette Transporter A1; AD; Alzheimers disease; ADAM; AD-related disintegrin and metalloprotease; AICD; APP- intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoE; ApolipoproteinE;
Research reportMicroRNA-328a regulates water maze performance in PTZ-kindled rats
Keywords: miR-328a; microRNA-328a; PTZ; pentylenetetrazole; TLE; temporal lobe epilepsy; MWM; Morris water maze; BACE; beta-site APP-cleaving enzyme; APP; amyloid precursor protein; Abeta; amyloid beta; AD; Alzheimer's disease; Epilepsy; Cognitive function; microRN
Meta-analysis of BACE1 gene rs638405 polymorphism and the risk of Alzheimer's disease in Caucasion and Asian population
Keywords: APP; amyloid precursor protein; BACE; β-site APP cleaving enzyme; AD; Alzheimer's disease; SNP; single-nucleotide polymorphism; Aβ; amyloid beta-peptide; HWE; Hardy-Weinberg equilibrium; ApoE; Apolipoprotein E; The BACE1 gene; SNP rs638405; Alzheimerâ
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
Keywords: Alzheimer disease; APP; BACE; molecular dynamics; subcellular compartmentalization; membrane trafficking; secretase; amyloid; Neuregulin
Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice
Keywords: Alzheimer's disease (AD); APP23; BACE; Inhibitor; Cerebral amyloid angiopathy (CAA); Magnetic resonance imaging (MRI); Microbleeding; Microhemorrhage;
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
Keywords: BACE; Alzheimer's disease;
Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila
Keywords: Circadian rhythms; period gene; Amyloid precursor protein; Amyloid intracellular domain; BACE; Alzheimer's disease; Drosophila
The Streptomyces metabolite anhydroexfoliamycin ameliorates hallmarks of Alzheimer's disease in vitro and in vivo
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; ARE; antioxidant response element; Aβ; amyloid-beta; BACE; β-secretase; EDTA; ethylenediaminetetraacetic acid; ERK; Extracellular signal-regulated kinase; GSK3β; glycogen synthase kinase-3beta;
Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides
Keywords: N-terminally truncated; Aβ; Alzheimer's disease; Neurons; Astrocytes; Microglia; Intracellular; Extracellular; BACE; Secretase;
14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations
Keywords: Aβ; Aβ-amyloid protein; AANEM; American Academy of Neuromuscular and Electrodiagnostic Medicine; AAN; American Academy of Neurology; AD; Alzheimer's Disease; API; Alzheimer's Prevention Initiative-APOE4; ADF; Abuse Deterrent Formulations; ADNI; Alzheime
Discovery of potent iminoheterocycle BACE1 inhibitors
Keywords: Alzheimer's disease; β-Secretase; BACE; Aspartyl protease inhibitors; Structure-based drug design;
Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen
Keywords: BACE; chlorin e6 13(1)-N-{2-[N-(1-carba-closo-dodecaboran-1-yl)methyl]aminoethyl}amide-15(2), 17(3)-dimethyl ester sodium; BLM; bilayer lipid membrane; gA; gramicidin A; t-BOOH; tert-butyl hydroperoxide; PDT; photodynamic therapy; DPhPC; 2-diphytanoyl-sn-
Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers
Keywords: Alzheimer's disease; Amyloid beta; BACE1; Pb; Sp1; Tolfenamic acid; Aβ; amyloid β; AD; Alzheimer's disease; ANOVA; analysis of variance; APP; amyloid β precursor protein; BACE; beta-site APP cleaving enzyme; FBS; fetal bovine serum; Pb; lead; SEM; stan
Photodynamic activity of the boronated chlorin e6 amide in artificial and cellular membranes
Keywords: PDT; photodynamic therapy; BACE; chlorin e6 13(1)-N-{2-[N-(1-carba-closo-dodecaboran-1-yl)methyl]aminoethyl}amide-15(2), 17(3)-dimethyl ester sodium; DPhPC; diphytanoylphosphatidylcholine; EggPC; egg yolk phosphatidylcholine; Chol; cholesterol; pyPC; 1-la
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation
Keywords: AD; Alzheimer disease; Aβ; β-amyloid; APP; amyloid precursor protein; ASMase; acid sphingomyelinase; BACE; β-secretase β-site amyloid cleaving enzyme; BBB; blood-brain barrier; BCA; bicinchoninic acid; BHT; butylated hydroxytoluene; BSO; buthionine
The evolution of amidine-based brain penetrant BACE1 inhibitors
Keywords: BACE; BACE1; Amyloid; Alzheimer's; Inhibitor;
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)
Keywords: Alzheimer's disease; BACE; Aminooxazolines; β-Secretase; Oxazolines;
24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases
Keywords: LXR; Oxysterols; Dementia; Biomarker; Mass spectrometry; 24OHC; 24S-hydroxycholesterol; 27OHC; 27-hydroxycholesterol; Aβ; amyloid beta; ABC; ATP-binding cassette transporter; ACAT; acyl-Coa:cholesterol acyltransferase; AD; Alzheimer disease; Apoe; apolip
Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2
Keywords: Radical reactions; Tyramine; BACE; Biaryl; Arylation;
Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor
Keywords: BACE; β-Secretase; Alzheimer′s disease; Iminohydantoin; In vivo
Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice
Keywords: Oxidative stress; APP; Alzheimer's disease; TASTPM mice; BACE; presenilin;
Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors
Keywords: BACE; Alzheimer’s disease; Amyloid; β-Secretase inhibitor; Neurodegeneration; Amyloid beta 42 (Aβ42); Memapsin
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2â² region
Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; β-amyloid precursor protein; BACE; β-site APP cleaving enzyme; FRET; fluorescence resonance energy transfer; ELISA; enzyme-linked immune sandwich assay; CHO; Chinese hamster ovary; Alzheimer's d
Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; BACE; beta-APP Cleaving Enzyme; GGA; Golgi-localized γ-ear containing ADP ribosylation factor-binding protein; HC; healthy control; NC; neurological control; SD; standard deviation; TGN; trans-Golg
Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APP; amyloid-precursor protein; CTF; C-terminal fragment of APP; sAPP; soluble APP; BACE; beta-site of APP cleaving enzyme; DHA; docosahezaenoic acid; PUFA; polyunsaturated fatty acid; ELISA; enzyme linked imm
Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells
Keywords: α-CTF; α-cleaved carboxyterminal fragment of APP (also known as C83); Aβ; amyloid-β peptide; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BACE; β-secretase; BBG; brilliant blue G; BzATP; 2â²(3â
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)
Keywords: Alzheimer’s; Beta-secretase; BACE; Transition-state isostere
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Keywords: Aging; Oligodendrocyte; Peroxisome; BACE; Neuregulin; Apolipoprotein; Prevention; Ubiquitin; α-Synuclein; TDP-43; FTLD
Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; BACE; β-site APP cleaving enzyme; sAPPα; soluble amyloid precursor protein α; HIF-1α; hypoxia-inducible factor 1α; HRE; hypoxia res
Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Aβ-induced neurotoxicity in Drosophila
Keywords: IDE; insulin-degrading enzyme; DM2; type 2 diabetes mellitus; AD; Alzheimer's disease; LOAD; late-onset AD; GK rat; Goto-Kakizaki rat; dilp2; Drosophila insulin-like peptide 2; InR; insulin receptor; Aβ; β-amyloid; APP; Aβ precursor protein; BACE; β
Piperazine sulfonamide BACE1 inhibitors: Design, synthesis, and in vivo characterization
Keywords: Alzheimer’s disease; β-Secretase; BACE; Aspartyl protease inhibitors; Peptidomimetics
Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease
Keywords: estradiol; Aβ; APP; TTR; BACE; Alzheimer's diseaseAβ, amyloid-beta; AD, Alzheimer's disease; APP, amyloid precursor protein; APPCTFs, APP C-terminal fragments; APPim, immature APP; APPm, mature APP; BACE, β-site APP cleaving enzyme; E2, 17 β-estradiol; ID
Signaling effect of amyloid-β42 on the processing of AβPP
Keywords: Alzheimer disease; Amyloid; Amyloid-β protein precursor processing; BACE; Oxidative stress
Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats
Keywords: AD, Alzheimer' disease; Aβ, amyloid β; APP, amyloid precursor protein; BACE, β-site APP cleaving enzyme; sAPPα, soluble APPα; ELISA, enzyme-linked immunosorbent assayTAK-070; Aβ; BACE; Alzheimer's disease; Aged rat; Water maze
Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing
Keywords: Alzheimer; beta-amyloid; presenilin; BACE; ADAM; neprilysinAβ, beta-amyloid; AD, Alzheimer's disease; APP, amyloid precursor protein; CM, cardiac muscle; IDE, insulin degrading enzyme; LI, liver; LU, lung; ME, mesencephalon; PS1, presenilin 1; PS2, presen
P2′-truncated BACE-1 inhibitors with a novel hydroxethylene-like core
Keywords: BACE-1; BACE; β-Secretase; Asp2; Memapsin; PI
Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: Matching high information content with high throughput
Keywords: BACE; β-secretase; DBA; direct binding assay; DSC; differential scanning calorimetry; ED; equilibrium dialysis; EDC; N-ethyl-Nâ²-(3-dimethylaminopropyl)carbodiimide; ESI; electrospray ionization; FAC; frontal affinity chromatography; HTS; high-throughpu
Identification of a small molecule β-secretase inhibitor that binds without catalytic aspartate engagement
Keywords: Alzheimer’s disease; BACE; Aspartyl protease inhibitors
Shock membrane electropotential drops and limited diffusive distance of β-amyloids in cerebral neurons are detrimental enhancement to Alzheimer's diseases
Keywords: Aβ; beta-amyloids; AD; Alzheimer's disease; ALS; amylotrophic lateral sclerosis; APP; amyloid precursor protein; BACE; β site APP cleaving enzyme; HD; Huntington's disease; NFT; intraneuronal tau-rich neurofibrillar tangles; PD; Parkinson's disease; ROS
Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits
Keywords: Ovariectomy; Alzheimer's disease; BACE; Amyloid β peptide; Phosphorylated-tau;