کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737604 | 1614721 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice
ترجمه فارسی عنوان
سیمواستاتین موجب کاهش حافظه و عصبی عضلانی در موشهای دیابتی ناشی از استرپتوزوتوسین می شود
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
IODFBGHDL-CAβCMC-NaNF-κBBACEPPARγLDL-CAPPMWMamyloid-β - آمیلوئید βintegrated optical density - تراکم نوری یکپارچهEnzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاCNS - دستگاه عصبی مرکزیBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیnuclear factor-κB - فاکتور هسته ای κBfasting blood glucose - قند خون ناشتاhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالMorris water maze - ماز آب آب موریسamyloid precursor protein - پروتئین پیش ماده آمیلوئیsodium carboxymethyl cellulose - کربوکسی متیل سلولز سدیمLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Diabetes comes with an additional burden of moderate to severe hyperlipidemia, but little is known about the effects of lipid-lowering therapy on diabetic complications such as diabetes-associated cognitive decline. Herein we investigated the effects of statins on memory impairment and neurotoxicity in streptozotocin-induced diabetic mice. Our data indicated that oral administration of simvastatin at 10 or 20 mg/kg for 4 weeks significantly ameliorated diabetes-associated memory impairment reflected by performance better in the Morris water maze and Y-maze tests. The further study showed that these treatments caused significant increase of peroxisome proliferator-activated receptors gamma and decrease of NF-κB p65 in nucleus of hippocampus and cortex, and ameliorated neuroinflammatory response as evidenced by less Iba-1-positive cells and lower inflammatory mediators including IL-1β, IL-6 and TNF-α as well as suppressed neuronal apoptosis as indicated by decreased TUNEL-positive cells, increased ratio of Bcl-2/Bax and decreased caspase-3 activity in the hippocampus and cortex. Moreover, simvastatin pronouncedly attenuated amyloidogenesis by decreasing amyloid-β, amyloid precursor protein (APP) and beta-site APP cleaving enzyme-1. As expected, treated with simvastatin, the diabetic mice exhibited significant improvement of hyperlipidemia rather than hyperglycemia. Our findings disclosed novel therapeutic potential of simvastatin for the diabetes-associated cognitive impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 355, 4 July 2017, Pages 200-211
Journal: Neuroscience - Volume 355, 4 July 2017, Pages 200-211
نویسندگان
Shun-Chang Fang, Hang Xie, Fang Chen, Mei Hu, Yan Long, Hong-Bin Sun, Ling-Yi Kong, Hao Hong, Su-Su Tang,