Novel lead for potent inhibitors of breast cancer resistance protein (BCRP)
Keywords: ABCG2; Inhibitors; Multidrug resistance; BCRP; Hoechst 33342; Pheophorbide A
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Fludarabine-based induction therapy does not overcome the negative effect of ABCG2 (BCRP) over-expression in adult acute myeloid leukemia patients
Keywords: Acute myeloid leukemia; Fludarabine; Induction therapy; BCRP; Prognosis
The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9)
Keywords: Sf9; Affinity chromatography; Drug discovery; Receptor screening; ABC transporters; P-glycoprotein; MRP1; MRP2; BCRP; Membrane receptors
P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; Blood-brain barrier; mSOD1 mice; P-glycoprotein; BCRP; Riluzole;
Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy
Keywords: MRP1; BCRP; LRP; ERCC1; Non-small cell lung cancer; Neoadjuvant chemotherapy
Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11)
Keywords: BCRP; Breast cancer resistance protein; BSEP/Bsep; human/rat isoforms of the bile salt export pump; BRIC; benign recurrent intrahepatic cholestasis; CF/CFTR; cystic fibrosis/cystic fibrosis transmembrane conductance regulator; EGFR; epidermal growth facto
Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor
Keywords: BBB; blood-brain barrier; BCRP; breast cancer resistance protein; Bcrp1(â/â) mouse; BCRP knockout mouse; Mdr1a/b(â/â) mouse; P-gp knockout mouse; Mdr1a/b(â/â)Bcrp1(â/â) mouse; P-gp/BCRP knockout mouse; PET; positron emission tomography;
Enhanced bioaccumulation of dietary contaminants in catfish with exposure to the waterborne surfactant linear alkylbenzene sulfonate
Keywords: ABC transporters; ATP-binding cassette transporters; BaP; benzo(a)pyrene; BCRP; breast cancer resistance protein; DPH; 1,6-diphenyl - 1, 3, 5 - hexatriene; IVM; ivermectin; LAS; linear alkylbenzene sulfonate, C-12, sodium dodecylbenzene sulfonate; Meq
Research ReportABC efflux transporters in brain vasculature of Alzheimer's subjects
Keywords: Blood-brain barrier; Alzheimer's disease; P-glycoprotein; MRP4; BCRP;
Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients
Keywords: BCRP; Excipients; Inhibition; Reversible; Competitive or noncompetitive
Synthesis of new camptothecin analogs with improved antitumor activities
Keywords: Anticancer agent; Camptothecin analog; Topoisomerase I inhibitor; BCRP
Interactions between riluzole and ABCG2/BCRP transporter
Keywords: BCRP; Riluzole; Amyotrophic lateral sclerosis; Blood-brain barrier; CF1 mdr1a (â/â) mice; BeWo cells;
Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog
Keywords: Camptothecin analog; Topoisomerase I inhibitor; TP300, Antitumor agent; Water-soluble; Prodrug; Drug resistance; BCRP
Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513
Keywords: P-glycoprotein; BCRP; MRP2; LS513; ABC transporters
Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide
Keywords: TOP1-targeting agents; 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones; Cytotoxic activity; Multidrug resistance; Antitumor; Quaternary ammonium salts; ARC-111; CPT; camptothecin; BCRP; breast cancer resistance protein; MDR1; P-glycoprotein; TOP1; topoisomerase I
Development and characterisation of a new model of rat trophoblasts
Keywords: Placenta; Primoculture and cryopreserved trophoblasts; P-Glycoprotein; Bcrp; Rat;
Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
Keywords: BCRP; MRP2; ERCC1; BRCA1; Stage IV; Non-small-cell lung cancer
Breast cancer resistance protein (BCRP/ABCG2): New inhibitors and QSAR studies by a 3D linear solvation energy approach
Keywords: BCRP; Flavonoids; 3D-QSAR; VolSurf descriptors
In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [11C]gefitinib
Keywords: P-gp; BCRP; [11C]Gefitinib; GF120918; Cyclosporin A; Brain penetration
A fluorescence-based in vitro assay for drug interactions with breast cancer resistance protein (BCRP, ABCG2)
Keywords: BCRP; ABCG2; Fluorescence assay; ABC-protein; Mitoxantrone
Alzheimer's disease and blood–brain barrier function—Why have anti-β-amyloid therapies failed to prevent dementia progression?
Keywords: ABC transporter; Alzheimer's disease; Oligomers; Neurodegeneration; MDR1; ABCB1; MRP1; ABCC1; BCRP; ABCG2; Dementia; Abeta; Blood–brain barrier; P-glycoprotein; Immunization
ABCG2: A perspective
Keywords: ABCG2; BCRP; Drug-resistance; ABC transporter; Chemotherapy; Pharmacology
Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123
Keywords: ABC transporter; ATP-binding cassette transporters; BCRP; breast cancer resistance protein; BEC; brain endothelial cell; BBB; Blood-brain barrier; BSA; bovine serum albumin; FITC; fluoresceine-isothiocyanate; FTC; fumitremorgin c; MTT; methylthiazolyldi
Ibogaine labeling with 99mTc-tricarbonyl: Synthesis and transport at the mouse blood-brain barrier
Keywords: ABC transporters; BCRP; blood-brain barrier; CNS; P-glycoprotein; ibogaine; multidrug resistance transporters; radiopharmaceutical; 99mTc; 99mTc-tricarbonyl;
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators
Keywords: MDR; multidrug resistance; ABC; ATP-binding-cassette; P-gp; P-glycoprotein; BCRP; breast cancer-resistance protein; MRP; multidrug-resistance associated protein; Multidrug resistance modulators; P-Glycoprotein;
Treatment Options for Breast Cancer Resistant to Anthracycline and Taxane
Keywords: ABC; ATP-binding cassette; BCRP; breast cancer resistance protein; CI; confidence interval; EGFR; epidermal growth factor receptor; FDA; Food and Drug Administration; HER2; human epidermal growth factor receptor 2; IRR; independent radiology review; MBC;
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat
Keywords: MDR1; BCRP; CP-100,356; drug absorption; bioavailability; P450; efflux; drug-drug interaction;
Breast Cancer Resistance Protein: Mediating the Trans-placental Transfer of Glyburide across the Human Placenta
Keywords: BCRP; Human placenta; ABC transporters; Glyburide; Active transport; Placental membrane vesicles; Novobiocin; Gestational diabetes
Bicalutamide failure in prostate cancer treatment: Involvement of Multi Drug Resistance proteins
Keywords: Bicalutamide; Calcein-AM; P-glycoprotein; BCRP; MRP1
P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state
Keywords: MDR; multidrug resistance; Pgp; P-glycoprotein; MRP1; multidrug resistance-associated protein 1; BCRP; breast cancer resistance protein; ABC; ATP-binding cassette; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; DN-c-Jun; dominant
Association of some rare haplotypes and genotype combinations in the MDR1 gene with childhood acute lymphoblastic leukaemia
Keywords: MDR1; ABCB1; BCRP; ABCG2; SNP; Haplotype; Genotype; Disease susceptibility; Acute lymphoblastic leukaemia; Hyperdiploidity;
Pharmacokinetics and Bioavailability of the Flavonoid 7,8-Benzoflavone in Rats
Keywords: 7,8-benzoflavone; BCRP; bioavailability; oral absorption; pharmacokinetics; ADME; drug interaction; AUC, area under the plasma concentrationtime curve; BCRP, breast cancer resistance protein; HPLC, high-performance liquid chromatography;
Homology modeling of breast cancer resistance protein (ABCG2)
Keywords: BCRP; ABC transporter; Homology modeling; Transmembrane prediction; Secondary structure prediction; Molecular docking
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators
Keywords: P-glycoprotein; BCRP; 4-Biphenyl-6,7-dimethoxytetrahydroisoquinoline; 2-Naphthyl-6,7-dimethoxytetrahydroisoquinoline
Mutational analysis of ABC proteins
Keywords: ABC proteins; P-glycoprotein; CFTR; MRP1; BCRP; Mutational analysis; ATPase activity; Cysteine mutagenesis; Disulfide cross-linking; Arginine mutagenesis;
Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a “never-smoked” female patient with advanced non-small cell lung cancer
Keywords: BCRP; Acquired resistance; EGFR; Gefitinib;
Effect of excipients on breast cancer resistance protein substrate uptake activity
Keywords: Efflux transporter; Inhibitors; BCRP; Excipients; P-gp
Acridone derivatives: Design, synthesis, and inhibition of breast cancer resistance protein ABCG2
Keywords: ABCG2; Acridones; MDR; BCRP
Change of drug excretory pathway by CCl4-induced liver dysfunction in rat
Keywords: ABC; ATP-binding cassette; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AUC; area under the serum concentration-time curve; Bcrp; breast cancer resistance protein; Bsep; bile-salt export pump; CCl4; carbon tetrachloride; CLtot; total
Preclinical efficacy of ST1976, a novel camptothecin analog of the 7-oxyiminomethyl series
Keywords: Camptothecins; DNA topoisomerase I; Antitumor activity; Cyotoxicity; BCRP; DNA cleavage
Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)
Keywords: BCRP; ABCG2; inhibitor; azole antifungal; ABC transporters; active transport; cell culture; efflux pumps; drug resistance; drug interactions;
Energy transfer to analyse membrane-integrated mitoxantrone in BCRP-overexpressed cells
Keywords: Mitoxantrone; FRET; Resonance; Fluorescence; Membrane; BCRP;
Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males
Keywords: Rosuvastatin; BCRP; 421C>A; Polymorphism; Pharmacokinetics
BacMam recombinant baculovirus in transporter expression: A study of BCRP and OATP1B1
Keywords: BCRP; ABCG2; MXR; Efflux transporter; OATP1B1; OATP-C; OATP2; SLC21A6; Influx transporter; BacMam; ADME; Pharmacokinetics
Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids
Keywords: Corticosteroids; p-Glycoprotein; Breast cancer resistance protein; BCRP; Calcein accumulation; ATPase activity
Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: Evidence for multifactorial multidrug resistance
Keywords: Camptothecins; CPT-K5; Resistant ratio; BCRP; TransporterBCRP, breast cancer resistant protein (ABCG2); MX, mitoxantrone; NOV, novobiocin; MDR, multidrug resistance; Top2, topoisomerase II; CPTs, camptothecins; TPT, topotecan; CPT-11, irinotecan; AML, acu
Flavonoid–drug interactions: Effects of flavonoids on ABC transporters
Keywords: ABC proteins; P-glycoprotein; MRP; BCRP; Breast cancer resistance protein; Flavonoids; Herbal dietary supplements
Impaired breast cancer resistance protein mediated drug transport in plasma cells in multiple myeloma
Keywords: Multiple myeloma; Drug resistance; ABC-transporters; BCRP; Disease pathogenesis;
Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract
Keywords: BCRP; human breast cancer resistance protein; ABCG2; human breast cancer resistance protein; PCR; polymerase chain reaction; BCRP; ABCG2; MDR1; ABCB1; Intestinal mapping; Human; Caco-2 cells; LS180 cells;
A combined cell based approach to identify P-glycoprotein substrates and inhibitors in a single assay
Keywords: A to B; apical to basolateral; ADME; absorption, distribution, metabolism, elimination; B to A; basolateral to apical; BCRP; breast cancer resistance protein; HBSS; Hank's balanced salt solution; HEPES; N-2-hydroxyethylpiperazine-Nâ²-2-ethanesulfonic aci