Novel lead for potent inhibitors of breast cancer resistance protein (BCRP)

From our modulator library an interesting inhibitor of breast cancer resistance protein (BCRP) was identified. Due to its high inhibitory potency, this compound may serve as a promising novel lead for the design of new and potent modulators. This adds a new structural class to the few known highly active BCRP inhibitors.

Compound 5 is a novel lead for the design of new and potent BCRP modulators.Figure optionsDownload as PowerPoint slide