Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia
Keywords: Sohlh2; Spermatogenesis; Oogenesis; Sohlh1; Kit; bHLH;
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Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis
Keywords: Development; Neurogenesis; Embryo; Transcription; bHLH; Spinal cord; MTGR1; NEUROG2; MTG/ETO proteins; Nervy; Transcriptional repressor
Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization
Keywords: NeuroD1; E47; bHLH; Heterodimer; Nuclear import; Nuclear localization signal
A conserved domain in the transcription factor ITF-2B attenuates its activity
Keywords: ITF-2; bHLH; Transcription; Repression; Conserved; Domain; Lysine
Methyltransferase-inhibition interferes with neuronal differentiation of P19 embryonal carcinoma cells
Keywords: AdOx; adenosine dialdehyde; bHLH; basic helix-loop-helix; BMP-4; bone morphogenetic protein 4; GFAP; glial fibrillary acidic protein; SAHH; S-adenosylmethionine hydrolase; AdoMet; S-adenosylmethionine; RA; retinoic acid; Tuj1; neuronal class III tubulin;
Transcriptional regulation of neuronal differentiation: The epigenetic layer of complexity
Keywords: miR-124; miR-9; Neurogenesis; REST; Chromatin remodeling; Histone modification; Acetylation; Methylation; miRNA; ncRNA; bHLH
Repression of Ah receptor and induction of transforming growth factor-β genes in DEN-induced mouse liver tumors
Keywords: ALDH3A1; aldehyde dehydrogenase-3A1; AHR; aryl hydrocarbon receptor; AHRE; aryl hydrocarbon receptor response element; AIP; AHR-interacting protein; ALL; acute lymphoblastic leukemia; ARA9; Ah receptor-associated protein 9; ARNT; aryl hydrocarbon receptor
Interaction between E-protein and Oct transcription factors in the function of the catfish IGH enhancer
Keywords: E-protein; Oct1 Oct2; Transcription factor; IGH; Eμ3Ⲡenhancer; Channel catfish; IGH; immunoglobulin heavy chain; bHLH; basic helix-loop-helix; CFEB; catfish E-box binding protein; O/E; the octamer#11 and μE5#2 motifs; R#2; Region#2 (core region of
IT3F: A web-based tool for functional analysis of transcription factors in plants
Keywords: Arabidopsis thaliana; Oryza sativa; Phylogenetics; Gene expression; Website; PHYLIP; Transcription factor; myb; bHLH;
Expression analysis of anthocyanin regulatory genes in response to different light qualities in Arabidopsis thaliana
Keywords: Anthocyanins; Arabidopsis; bHLH; Light regulation; MYBRT-PCR, reverse transcriptase polymerase chain reaction
Regulation of retinal cell fate specification by multiple transcription factors
Keywords: Neural retina; bHLH; Homeobox
Binding of upstream stimulatory factor 1 to the E-Box regulates the 4G/5G polymorphism-dependent plasminogen activator inhibitor 1 expression in mast cells
Keywords: Plasminogen activator inhibitor 1; 4G/5G polymorphism; transcription; human mast cells; upstream stimulatory factor 1; E-box; bHLH; Basic helix-loop-helix; DN; Dominant-negative; E-4G/5G; E-box adjacent to the 4G/5G allele; EMSA; Electrophoretic mobility
Strategies to regenerate hair cells: Identification of progenitors and critical genes
Keywords: HC; hair cell; SC; supporting cell; E; embryonic day; P; postnatal day; GER; greater epithelial ridge; LER; lesser epithelial ridge; DIV; day in vitro; EGF; epidermal growth factor; FGF2; fibroblast growth factor 2; GFP; green fluorescent protein; CDK; cy
The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans
Keywords: C. elegans; Gene regulation; Pharynx; Glands; Notch; bHLH;
Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure
Keywords: Twist1; FGFR2; FGF; BMP; bHLH; Craniosynostosis; Calvaria; Sutures; Craniofacial; Osteoblast differentiation
Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
Keywords: bHLH; Transcriptional regulation; Mesoderm; Muscle; Twist; Daughterless;
Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons
Keywords: Hand2 (dHand); Neural crest; bHLH; Neurogenesis; Cell type-specific gene regulation; Sympathetic ganglia; TH; Gata3; Phox2
Math5 expression and function in the central auditory system
Keywords: Math5; Cochlear nucleus; AVCN; PVCN; Mouse; atonal; Math1; bHLH; Globular bushy cells; Spherical bushy cells; Cochlear root neurons; Auditory processing; ABR latency; Binaural integration; Interaural intensity difference; Interaural time difference; Phase
The bHLH transcription factor Tcf12 (ME1) mRNA is abundantly expressed in Paneth cells of mouse intestine
Keywords: Paneth cell; Small intestine; Crypt; bHLH; ME1; In situ hybridization; Transcription
Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina
Keywords: BETA2/NeuroD1; Mash1; Math3; Neurogenin2; bHLH; Retina; Retinogenesis
Expression of LHX3 and SOX2 during mouse inner ear development
Keywords: LHX; LIM-homeodomain; MATH-1; Inner ear; Cochlea; ATOH1; SOX; Hmg box; Hair cell; Deafness; HLH; bHLH; Genetics; Hearing
Basic helix-loop-helix factors recruit nuclear factor I to enhance expression of the NaV 1.4 Na+ channel gene
Keywords: AChR; acetylcholine receptor; bHLH; basic helix-loop-helix; CAT; chloramphenicol acetyltransferase; DMEM; Dulbecco's modified Eagle's medium; DTT; dithiotheitol; EMSA; electrophoretic mobility shift assay; GABP; GA-binding protein; NaV 1.4; adult skel
lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny
Keywords: AGM; Aorta; Aortic clusters; bHLH; Cardiovascular; Endocardium; Endothelial cells; Fetal liver; Heart; Hematopoiesis; Hematopoietic stem cell; Lyl-1; Macrophages; Mouse embryo; Sub-aortic patches; Tal-1/SCL; Transcription factor; Yolk sacAGM, aorta–gonads
Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS
Keywords: ATP; adenosine triphosphate; bHLH; basic helix-loop-helix; BMP; bone morphogenic protein; BrdU; bromodeoxy uridine; CD44; cell determinant-44; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNTF; ciliary neurotrophic factor; CXCR4; receptor f
Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
Keywords: Hand2; bHLH; Sympathetic nervous system; Conditional knockout; Neuronal differentiation; Catecholaminergic; Noradrenergic
The C. elegans Twist target gene, arg-1, is regulated by distinct E box promoter elements
Keywords: C. elegans; Twist; bHLH; E box; hlh-2; hlh-8; arg-1; E/DA; Mesoderm; DSL homolog
Functional analysis of cis-regulatory regions within the dioxin-inducible CYP1A promoter/enhancer region from zebrafish (Danio rerio)
Keywords: AHR; aryl hydrocarbon receptor; hAHR; human AHR; bHLH; basic helix-loop-helix; ARNT; aryl hydrocarbon receptor nuclear translocator; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; PAS; PER-ARNT-SIM; HIF; hypoxia-inducible factor; SDS-PAGE; sodium dodecyl sulf
Licensing regulators Geminin and Cdt1 identify progenitor cells of the mouse CNS in a specific phase of the cell cycle
Keywords: neural progenitors; proliferation; differentiation; neurogenesis; cell cycle phase; bHLH; basic helix-loop-helix; BrdU; bromo-deoxy-uridine; Brg1; brahma-related gene 1; cdk; cyclin dependent kinases; CREB; cAMP response element binding protein; DAB;
Molecular characterization of a bHLH transcription factor involved in Arabidopsis abscisic acid-mediated response
Keywords: Abscisic acid; Transcription factor; bHLH; Suppression subtractive hybridization; Arabidopsis
Sohlh2 is a germ cell-specific bHLH transcription factor
Keywords: Oocyte; Spermatogonia; Transcription; Sohlh2; Primordial follicle; bHLH; Germ cell-specific; Spermatogenesis; Oogenesis; Sohlh1
Musculin isoforms and repression of MyoD in muscle regeneration
Keywords: Muscle regeneration; Musculin; MyoR; MyoD; bHLH; Isoform
Cloning and developmental expression of the DEC1 ortholog gene in zebrafish
Keywords: Zebrafish; DEC1/Stra13/Sharp2; bHLH; Eye; Retinal pigment epithelium (RPE); Iris; Neural crest; Somite; Pineal gland (epiphysis); Heart; Common cardinal vein (CCV); Blood cells; Pronephric duct; Spinal cord; Notochord; Midbrain; Hindbrain; Liver; Gut; Pan
Myogenin in model pufferfish species: Comparative genomic analysis and thermal plasticity of expression during early development
Keywords: bHLH; basic helix-loop-helix; BLAST; basic local alignment search tool; DIG; digoxigenin-uracyltriphosphate; hpf; hours post-fertilisation; Myog; myogenin; PCR; polymerase chain reaction; Takifugu rubripes; Tetraodon nigroviridis; Myogenin; Myogenic facto
Glutathione-peroxidase-1 null muscle progenitor cells are globally defective
Keywords: bHLH; basic helix-loop-helix; BrdU; bromodeoxyuridine; CM-H2DCFDA; carboxydichlorodihydrofluorescein diacetate; CpR; crossing point for 18S ribosomal RNA control; CpT; crossing point for target gene reaction; CuZnSOD; copper zinc superoxide dismutase; DAP
Regulation of the immunoglobulin heavy chain locus expression at the phylogenetic level of a bony fish: Transcription factor interaction with two variant octamer motifs
Keywords: IgH; immunoglobulin heavy chain; POU; Pit/Oct/Unc; CFEB; catfish E-box binding protein; PORE; palindromic Oct factor recognition element; MORE; more palindromic Oct factor recognition element; bp; base pair; EMSA; electrophoretic mobility shift assay; pM;
Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins
Keywords: AhR; aryl hydrocarbon receptor; Arnt; AhR nuclear translocator; bHLH; basic helix-loop-helix; CYP; cytochrome P450; DMSO; dimethylsulfoxide; DRE; dioxin response element; DTT; dithiothreitol; ELISA; enzyme-linked immunosorbent assay; EROD; ethoxyresol
Id3 is important for proliferation and differentiation of the hepatoblasts during the chick liver development
Keywords: Liver; Embryonic; Chicken; Endoderm; Organogenesis; Hepatoblasts; Proliferation; Differentiation; Id3; bHLH
Protein and genomic organisation of vertebrate MyoR and Capsulin genes and their expression during avian development
Keywords: MyoR; Capsulin; Eya; bHLH; Genomic organisation; Head mesoderm; Lateral mesoderm; Branchial arches; Somite; Skeletal muscle; Heart; Epicardium; Mesenteries; Lung; Intestine; Allantois
Proneural gene requirement for hair cell differentiation in the zebrafish lateral line
Keywords: Lateral line; Neuromasts; Hair cells; Proneural genes; bHLH; Atonal homolog; NeuroD
Identification of novel target genes of CeTwist and CeE/DA
Keywords: Twist; E/Daughterless; bHLH; C. elegans; Target genes; hlh-2; hlh-8
Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1
Keywords: bHLH; ref-1; Hes; C. elegans; Asymmetry
Preferential posterior cerebellum defect in BETA2/NeuroD1 knockout mice is the result of differential expression of BETA2/NeuroD1 along anterior–posterior axis
Keywords: BETA2; NeuroD1; bHLH; TrkC; A/P axis; Cerebellum
Math5 is required for both early retinal neuron differentiation and cell cycle progression
Keywords: Retina; RGC; Mouse; bHLH; Math5; Ngn2; NeuroD1; Neurogenesis; Cell cycle progression
Gene families encoding transcription factors expressed in early development of Strongylocentrotus purpuratus
Keywords: Transcription factor; Sea urchin; Development; bHLH; Sox; Nuclear receptor; Basic zipper; smad
Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene
Keywords: bHLH; basic helix-loop-helix; FAS; fatty acid synthase; HMG-CoA; 3-hydroxy-3-methylglutaryl Coenzyme A; LDLr; low-density lipoprotein receptor; SRE; sterol regulatory element; SREBP; sterol regulatory element binding protein; Human caspase-2; SREBP; L
Phylogenetic profiling of protein interaction networks in eukaryotic transcription factors reveals focal proteins being ancestral to hubs
Keywords: NR; nuclear receptor; bHLH; basic helix-loop-helix protein; bZIP; basic leucine zipper protein; Protein-protein interaction networks; Eukaryotic transcription factors; Gene duplication; Homo/hetero-dimerisation; Phylogenetic profiling; Small world n
Molecular cloning and characterization of the clock gene period2 in the testis of lizard Podarcis sicula and its expression during seasonal reproductive cycle
Keywords: per2; period2; SCN; suprachiasmatic nucleus; ck1É; casein kinase 1É; cry; cryptochrome1; cry2; cryptochrome2; per1; period1; per3; period3; per; period; PAS; Per (period circadian protein)-Arnt (Ah receptor nuclear translocator protein)-Sim (single-
A proximal E-box modulates NGF effects on rat PPT-A promoter activity in cultured dorsal root ganglia neurones
Keywords: AAV; adeno-associated virus; rAAV; recombinant adeno-associated virus; AP1; activator protein 1; bHLH; basic helix-loop-helix; DRG; dorsal root ganglion; Luc; luciferase; NGF; nerve growth factor; rtPPT-A; rat preprotachykinin-A; NK1; neurokinin recep
When hypoxia signalling meets the ubiquitin-proteasomal pathway, new targets for cancer therapy
Keywords: ARD1; arrest defective-1 protein; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH; basic helix loop helix; CBP; CREB binding protein; CPT; camptothecin; C-TAD; C-terminal transactivation domain; FIH-1; factor inhibiting HIF-1; HAT; histone acet
Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
Keywords: Human trophoblast; Signal transduction; Differentiation; Cell invasion; ALKs; activin-receptor-like kinases; bHLH; basic helix-loop-helix; CaMKII; Ca/calmodulin-dependent kinase II; CTB; cytotrophoblast; eCTB; endovascular cytotrophoblast; ECM; extracellu