Keywords: دفع ادرار; Drug disposition; Efflux transporters; Biliary excretion; Basolateral efflux; Sandwich cultured human hepatocyte; Liquid chromatography mass spectrometry; Membrane vesicle; Ko143;
مقالات ISI دفع ادرار (ترجمه نشده)
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Keywords: دفع ادرار; biliary excretion; drug interactions; efflux pumps; MRP; permeability; ATV; atorvastatin; MET; metformin; 2-OH ATV; 2-hydroxyatorvastatin; CYP; cytochrome P450; MDCK; Madin-Darby canine kidney; MDR; multidrug resistance gene; BCRP; breast cancer resistanc
Keywords: دفع ادرار; cilostazol; hepatic transport; OATP 1B1/1B3; biliary excretion; efflux transporter; AP; apical; BL; basolateral; DMEM; Dulbecco's modified Eagle's medium; EGCG; (-)-epigallocatechin gallate; HEK293 cells; human embryonic kidney cells; MDCKII cells; Madi
Keywords: دفع ادرار; biliary excretion; hepatocytes; ADME; hepatobiliary disposition; cell culture; tissue engineering; toxicology; membrane transport/transporters; disposition; metabolism; 3D; 3-dimensional; 3D-HLT; 3D-bioprinted human liver tissue; APAP; acetaminophen; DMPK
Keywords: دفع ادرار; physiologically based pharmacokinetic modeling; drug interactions; Monte Carlo; in vitro-in vivo correlations (IVIVC); nonlinear regression; biliary excretion; biliary recycling; hepatic metabolism; hepatic transport; AUC; area under the curve of concen
Keywords: دفع ادرار; Drug disposition; Hepatocyte; Uptake; Basolateral efflux; Biliary excretion; Sandwich culture;
Keywords: دفع ادرار; fluorine MRI; bile acid malabsorption; enterohepatic circulation; imaging methods; intestinal absorption; site-specific delivery; transporters; targeted drug delivery; bile acid transporters; biliary excretion;
Keywords: دفع ادرار; biliary excretion; hepatocytes; clearance; drug transport; hepatobiliary disposition; in vitro/in vivo correlations (IVIVC); organic aniontransporting polypeptide transporters; P-glycoprotein;
Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay for simultaneous quantifications of CZ48, lactone-stabilized camptothecin, and camptothecin and their pharmacokinetic and biliary evaluations in rats
Keywords: دفع ادرار; CZ48; Camptothecin; UHPLC-MS/MS; Solid phase extraction (SPE); Pharmacokinetics (PK); Biliary excretion;
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: دفع ادرار; Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: دفع ادرار; Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Effects of Adjuvant-Induced Inflammation on Disposition of Diclofenac and Its Metabolites in Perfused Rat Liver
Keywords: دفع ادرار; biliary excretion; disposition; metabolism; MRP; transporters;
Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2
Keywords: دفع ادرار; ABC transporters; P-glycoprotein; multidrug resistance-associated proteins; pharmacokinetics; biliary excretion; ABC; ATP-binding cassette; Bcrp; breast cancer resistance protein; BMAL1; brain and muscle arnt-like protein-1; CLOCK; circadian locomotor out
Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes
Keywords: دفع ادرار; biliary excretion; in vitro models; toxicology; bile acid transporters; efflux pumps; BA; bile acid; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; CsA; cyclosporin A; DCA; deoxycholic acid; DILI; drug-induced liver injury; DM
Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations
Keywords: دفع ادرار; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c
Establishment of a Drug-Induced, Bile Acid-Dependent Hepatotoxicity Model Using HepaRG Cells
Keywords: دفع ادرار; hepatocytes; bile acid transporters; biliary excretion; in vitro models; toxicology; cell lines; ALP; alkaline phosphatase; BA; bile acid; BEI; biliary excretion index; BSEP/Bsep; bile salt export pump; CsA; cyclosporine A; DILI; drug-induced liver injur
Screening and verifying potential NTCP inhibitors from herbal medicinal ingredients using the LLC-PK1 cell model stably expressing human NTCP
Keywords: دفع ادرار; Herbal medicinal ingredients; Human NTCP; Inhibitor; Transport; Biliary excretion
Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203
Keywords: دفع ادرار; ADME; biliary excretion; bioavailability; cancer chemotherapy; hepatocytes; transporters
Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model
Keywords: دفع ادرار; biliary excretion; hepatobiliary disposition; drug interactions; in vitro-in vivo correlations (IVIVC); hepatic clearance; permeability; transporters; hepatocytes;
Ursodeoxycholic acid stimulates the formation of the bile canalicular network
Keywords: دفع ادرار; Ursodeoxycholic acid; Bile canalicular; Biliary excretion; Bile acid
The enterohepatic circulation of amanitin: Kinetics and therapeutical implications
Keywords: دفع ادرار; Amanitin intoxication; Enterohepatic circulation; Biliary excretion
A physiologically based model of hepatic ICG clearance: Interplay between sinusoidal uptake and biliary excretion
Keywords: دفع ادرار; ICG; Hepatic uptake; Biliary excretion; Pharmacokinetic model; Isoflurane; Dog
Reduced cytochrome P4501A activity and recovery from oxidative stress during subchronic benzo[a]pyrene and benzo[e]pyrene treatment of rainbow trout
Keywords: دفع ادرار; Cytochrome P4501A activity; Oxidative stress; Benzo[a]pyrene; Benzo[e]pyrene; Aryl hydrocarbon receptor; Biliary excretion; Fish
Efficient sequential synthesis of PET Probes of the COX-2 inhibitor [11C]celecoxib and its major metabolite [11C]SC-62807 and in vivo PET evaluation
Keywords: دفع ادرار; Drug transporter; Biliary excretion; PET (positron emission tomography); Radiochemistry; Celecoxib; SC-62807
Alteration in the Pharmacokinetics of Hemoglobin-Vesicles in a Rat Model of Chronic Liver Cirrhosis Is Associated with Kupffer Cell Phagocyte Activity
Keywords: دفع ادرار; pharmacokinetics; hepatocyte; biliary excretion; metabolism; liposomes;
In vitro metabolism and disposition of honokiol in rat and human livers
Keywords: دفع ادرار; honokiol; hepatic metabolism; hepatic clearance; biliary excretion; glucuronidation; sulfation;
Biliary excretion in dogs: Evidence for a molecular weight threshold
Keywords: دفع ادرار; Biliary excretion; Dog; Molecular weight; ROC curve analysis; MRP2
Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats
Keywords: دفع ادرار; Dexamethasone; Methotrexate; Conjugated bilirubin; Drug transporters; Biliary excretion
Rapid and enhanced repolarization in sandwich-cultured hepatocytes on an oxygen-permeable membrane
Keywords: دفع ادرار; Drug development; Hepatocyte; Oxygen-permeable membrane; Sandwich culture; Polarity; Biliary excretion
Pharmacokinetics and Biliary Excretion of Mitoxantrone in Rats
Keywords: دفع ادرار; active transport; biliary clearance; biliary excretion; breast cancer resistance protein; mitoxantrone; pharmacokinetics; Pâglycoprotein; QSAR; QSPKR; rat;
Dose-Dependent Inhibition of Transporter-Mediated Hepatic Uptake and Biliary Excretion of Methotrexate by Cyclosporine A in an Isolated Perfused Rat Liver Model
Keywords: دفع ادرار; methotrexate; cyclosporine; drug interactions; isolated rat liver perfusion; hepatobiliary disposition; hepatic transport; hepatocyte uptake; biliary excretion; efflux pumps; Mrp2;
Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of Rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers
Keywords: دفع ادرار; Rhodamine 123; rhodamine 123 glucuronide; cyclosporine; dibromosulfophthalein; isolated rat liver perfusion; microsomes; hepatobiliary disposition; hepatic metabolism; biliary excretion; efflux pumps;
Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats
Keywords: دفع ادرار; Irinotecan (CPT-11); Verapamil; Bioavailability; P-glycoprotein; Biliary excretion
The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men
Keywords: دفع ادرار; Finasteride; Hypericum perforatum; Biliary excretion; Herb–drug interactions; Human volunteers; Finasteride-ω-oic acid (Carboxy-finasteride)
Hepatic Metabolism and Biliary Excretion of Valerenic Acid in Isolated Perfused Rat Livers: Role of Mrp2 (Abcc2)
Keywords: دفع ادرار; valerenic acid; hepatic metabolism; hepatic clearance; biliary excretion; multidrug resistance-associated protein 2; HPLC;
Role of Fixed Coefficients and Exponents in the Prediction of Human Drug Clearance: How Accurate are the Predictions from One or Two Species?
Keywords: دفع ادرار; allometric scaling; clearance; bioavailability; biliary excretion;
Chlordecone altered hepatic disposition of [14C]cholesterol and plasma cholesterol distribution but not SR-BI or ABCG8 proteins in livers of C57BL/6 mice
Keywords: دفع ادرار; Organochlorines; Chlordecone; Cholesterol disposition; Liver; Biliary excretion; Lipoproteins
Pharmacokinetics and Metabolism of the Antimalarial Piperaquine After Intravenous and Oral Single Doses to the Rat
Keywords: دفع ادرار; pharmacokinetics; metabolism; renal excretion; biliary excretion; bioanalysis; clearance; distribution; mass spectrometry; preclinical pharmacokinetics;
Characterization of biliary conjugates of 4,4′-methylenedianiline in male versus female rats
Keywords: دفع ادرار; Methylene dianiline; Bile duct cells; Xenobiotic metabolism; Sex differences; Conjugation; Glutathione; Biliary excretion
Metabolism and Disposition of Resveratrol in the Isolated Perfused Rat Liver: Role of Mrp2 in the Biliary Excretion of Glucuronides
Keywords: دفع ادرار; resveratrol; hepatic metabolism; hepatic clearance; biliary excretion; multidrug resistanceâassociated proteins; HPLC;
Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography
Keywords: دفع ادرار; Berberine; Biliary excretion; Cefoperazone; Microdialysis; Pharmacokinetics;
Physiologically Based Pharmacokinetic (PBPK) Modeling of Disposition of Epiroprim in Humans
Keywords: دفع ادرار; allometric scaling; biliary excretion; clearance; distribution; hepatocyte; PBPK modeling;
Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats
Keywords: دفع ادرار; Gender-related difference; Doxorubicin; P-glycoprotein; Mrp2 (multidrug resistance-associated protein 2); Biliary excretion; Rat;
Investigation of the absorption mechanisms of baicalin and baicalein in rats
Keywords: دفع ادرار; baicalin; Baicalein; absorption mechanism; intestinal absorption; intestinal excretion; intestinal metabolism; biliary excretion; in situ perfusion; oral drug delivery; HPLC (high-performance/pressure liquid chromatography);
Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes
Keywords: دفع ادرار; (9) Pulmonary; Renal and Hepatic PharmacologySandwich-cultured; Hepatocytes; Transport proteins; Biliary excretion; In vitro models
Prediction of human drug clearance from animal data: Application of the rule of exponents and 'fu corrected intercept method' (FCIM)
Keywords: دفع ادرار; allometric scaling; preclinical pharmacokinetics; clearance; protein binding; biliary excretion; renal clearance; vertical allometry;
Enhanced bioavailability of a new thiazolidine derivative FPFS-410, an antidiabetic and lipid-lowering drug, after oral administration of its hydroxypropyl-β-cyclodextrin complex to bile duct-cannulated rats
Keywords: دفع ادرار; biliary excretion; metabolism; cytochrome P450; cyclodextrins; bioavailability;
Hepatobiliary Disposition of Liposomal Amphotericin B in the Isolated Perfused Rat Liver
Keywords: دفع ادرار; liposomes; hepatobiliary disposition; hepatic clearance; biliary excretion; nonlinear pharmacokinetics;
Mechanism of the Stationary Canalicular Excretion of Tributylmethyl Ammonium in Rats with a CCl4-Induced Acute Hepatic Injury
Keywords: دفع ادرار; disease state; hepatocytes; efflux pumps; biliary excretion; P-glycoprotein; CCl4-induced hepatic injury; in vivo excretion clearance; TBuMA; bile salts; ion-pair complex;
Interspecies Scaling of Biliary Excreted Drugs: A Comparison of Several Methods*
Keywords: دفع ادرار; preclinical pharmacokinetics; allometric scaling; correction factors; clearance; monkey liver blood flow; biliary excretion; the rule of exponents; bile flow; UDP-glucuronyl transferase (UDPGT); mean absolute error;