Review ArticleAxon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration
Keywords: Axon regeneration; C. elegans;
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Featured ArticleSystems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments
Keywords: Alzheimer's disease; SNP; Protein-protein interaction; C. elegans; Brain expression; Network analysis; Systems biology;
Functional analysis of microRNA pathway genes in the somatic gonad and germ cells during ovulation in C. elegans
Keywords: MicroRNA; Ovulation; Somatic gonad; Germ cells; C. elegans;
Peptides from sesame cake reduce oxidative stress and amyloid-β-induced toxicity by upregulation of SKN-1 in a transgenic Caenorhabditis elegans model of Alzheimer's disease
Keywords: C. elegans; Caenorhabditis elegans; PSC; peptides from sesame cake; AD; Alzheimer's disease; Aβ; amyloid-β; FUdR; 5-fluoro-2â²-deoxyuridine; E. coli; Escherichia coli; DCF-DA; dichlorofluorescin diacetate; ROS; reactive oxygen species; qRT-PCR; quant
Partially compromised specification causes stochastic effects on gut development in C. elegans
Keywords: C. elegans; Endoderm; Cell specification; Robustness; Gene regulatory networks; Morphogenesis; Hyperplasia;
Research articleA new platform for long-term tracking and recording of neural activity and simultaneous optogenetic control in freely behaving Caenorhabditis elegans
Keywords: C. elegans; Behavior; Automatic tracking; Ca2+ imaging; G-CaMP; Optogenetics;
Characterization of gene expression associated with the adaptation of the nematode C. elegans to hypoxia and reoxygenation stress reveals an unexpected function of the neuroglobin GLB-5 in innate immunity
Keywords: Neuroglobin; GLB-5; Hypoxia; C. elegans; Innate immunity; Hypoxia-reoxygenation stress; HIF-1; EGL-9; npr-1;
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan
Keywords: AGE; advanced glycation end-product; AU; arbitrary units; C. elegans; Caenorhabditis elegans; ctrl; control; DAF; abnormal dauer formation; DN; diabetic neuropathy; E. coli; Escherichia coli; FCCP; carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; FOX
5-Desmethylnobiletin augments synaptic ACh levels and nicotinic ACh receptor activity: A potential candidate for alleviation of cholinergic dysfunction
Keywords: 5-Desmethylnobiletin; Acetylcholine; C. elegans; Reactive oxygen species; Gardenia lucida;
Zinc deficiency reduces fertility in C. elegans hermaphrodites and disrupts oogenesis and meiotic progression
Keywords: Zinc; C. elegans; Oogenesis; Fertility; NGM; Nematode Growth Media; TPEN; N,N,Nâ²,Nâ²-tetrakis(2-pyridylmethyl)ethane-1,2-diamine;
Mexican Arnica (Heterotheca inuloides Cass. Asteraceae: Astereae): Ethnomedical uses, chemical constituents and biological properties
Keywords: ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); Akt/PKB; protein kinase B; BRL15572; 3-(4-(4-chlorophenyl)piperazin-1-yl)â1,1-diphenyl-2-propanol; CCl4; carbon tetrachloride; C. elegans; Caernorhabditis elegans; COE-EDQM; Council of Eur
Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors
Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr
The effects of groove height and substrate stiffness on C. elegans locomotion
Keywords: C. elegans; Locomotion; Kinematics;
Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans
Keywords: ER; endoplasmic reticulum; NGM; nematode growth medium; Se; selenium; Sec; selenocysteine; SELENOT; selenoprotein T; SELT-1.1; selenoprotein T1; SELT-1.2; selenoprotein T2; Trx; thioredoxin. Note: the use of the root symbol SELENO followed by a letter has
Non-linear impact of glutathione depletion on C. elegans life span and stress resistance
Keywords: BCA; bicinchoninic acid; C. elegans; Caenorhabditis elegans; CTL; catalase; DAF-16; abnormal dauer formation 16; DEM; diethyl maleate; DMSO; dimethyl sulfoxide; DTNB; 5,5'-dithiobis-(2-nitrobenzoic acid); E. coli; Escherichia coli; EGL; egg laying defecti
A water-soluble and biocompatible polymeric nanolabel based on naphthalimide grafted poly(acrylic acid) for the two-photon fluorescence imaging of living cells and C. elegans
Keywords: Polymeric nanoparticle; Two-photon fluorescence imaging; Living cell; C. elegans; Poly(acrylic acid); Naphthalimide;
GPCRs in invertebrate innate immunity
Keywords: Signalling; Drosophila; C. elegans; Host defence; Damage-associated molecular pattern;
Locus-specific integration of extrachromosomal transgenes in C. elegans with the CRISPR/Cas9 system
Keywords: C. elegans; CRISPR/Cas9; Transgenic integration
Delivery of dietary triglycerides to Caenorhabditis elegans using lipid nanoparticles: Nanoemulsion-based delivery systems
Keywords: C. elegans; Caernohabditis elegans; CLA; conjugated linoleic acid; SOR; surfactant-to-oil ratio; Caenorhabditis elegans; C. elegans; Conjugated linoleic acid; CLA; Nanoemulsion; Delivery systems;
Quantitative gene expression analysis in Caenorhabditis elegans using single molecule RNA FISH
Keywords: Gene expression; Single molecule analysis; RNA FISH; C. elegans; Image analysis; Nascent transcription;
Mini-ReviewNetrin-1: A regulator of cancer cell motility?
Keywords: C. Elegans; Caernohabtidis Elegans; DCC; deleted in colorectal cancer; D. Melanogaster; Drosophila Melanogaster; DSCAM; Down syndrome cell adhesion molecule PMEC primary midgut epithelial cell; UNC-6; uncoordinated-6; UNC5; uncoordinated5; YAP; yes associ
A simple and rapid method for combining fluorescent in situ RNA hybridization (FISH) and immunofluorescence in the C. elegans germline
Keywords: Fluorescent in situ hybridization (FISH); Immunofluorescence; C. elegans; Germline;
The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein
Keywords: Asymmetric division; PAR-5; LET-99; C. elegans; Embryo
C. elegans screening strategies to identify pro-longevity interventions
Keywords: Aging; C. elegans; Development; In vivo drug screening; Mitochondria
The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans
Keywords: Cytochrome b5 reductase HPO-19 and T05H4.4; Fatty acid desaturation; Polyunsaturated fatty acids (PUFAs); C. elegans;
The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity
Keywords: (AD); Alzheimer's disease; (Aβ); amyloid-β; (APP); amyloid precursor protein; (A673V); alanine-to-valine substitution at codon 673; (AβA2V); A-V mutated Aβ; (WT); wild-type; (Aβ1-6A2V); peptide homologous to residues 1-6 of AβA2V; [Aβ1-6A2V(D
Full length articleBio-identity and fate of albumin-coated SPIONs evaluated in cells and by the C. elegans model
Keywords: Iron oxide nanoparticles; Protein corona; Cytotoxicity; C. elegans; Biodistribution;
Biological modeling the undulatory locomotion of C. elegans using dynamic neural network approach
Keywords: Undulatory locomotion; Dynamic neural networks; C. elegans
Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes
Keywords: Huntington's disease; polyglutamine toxicity disorder; aggregation; oxidative stress; superoxide dismutase; reactive oxygen species (ROS); C. elegans; animal model; genetics;
Mutagenesis of GATA motifs controlling the endoderm regulator elt-2 reveals distinct dominant and secondary cis-regulatory elements
Keywords: Endoderm; Cis-regulation; Promoter; smFISH; Transcription; GATA; C. elegans;
Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo
Keywords: Astaxanthin; Stereoisomeric; Antioxidation; Anti-ageing; Cellular antioxidant activity; Caenorhabditis elegans; Astaxanthin (PubChem CID: 2246); DPPH (PubChem CID: 2735032); ABTS (PubChem CID: 16240279); Trolox (PubChem CID: 40634); AAPH (PubChem CID: 196
Ultrastructural immunogold localization of major sperm protein (MSP) in spermatogenic cells of the nematode Acrobeles complexus (Nematoda, Rhabditida)
Keywords: C. elegans; Spermatogenesis; High-pressure freezing; Cytoskeleton; Membranous organelles; Fibrous bodies;
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins
Keywords: C. elegans; FUdR; Hypertonic stress; FOXO; Sirtuin; Hormesis;
A novel function for the DEAD-box RNA helicase DDX-23 in primary microRNA processing in Caenorhabditis elegans
Keywords: DEAD-box RNA helicase; DDX-23; DDX-17; microRNA biogenesis; let-7; C. elegans;
C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division
Keywords: ham-1; Asymmetric cell division; Neuroblast; Nuclear localization; C. elegans;
CACN-1 is required in the Caenorhabditis elegans somatic gonad for proper oocyte development
Keywords: CACN-1; Somatic gonad; Sperm-oocyte switch; Spliceosome; Post-transcriptional regulation; C. elegans;
Conservation in the involvement of heterochronic genes and hormones during developmental transitions
Keywords: Developmental transitions; Metamorphosis; Stem and progenitor cells; Heterochronic genes; Lin-28; Thyroid hormone; Drosophila; C. elegans; Xenopus;
The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans
Keywords: C. elegans; Fate specification; Differentiation; Gene expression; PAX; Epidermis
The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans
Keywords: EGFR; SWI/SNF; C. elegans; Vulva; LET-23; SMARCA4;
Continuous-flow C. elegans fluorescence expression analysis with real-time image processing through microfluidics
Keywords: Real time image analysis; Continuous flow microfluidics; C. elegans; Fluorescence expression assay; In vivo screening;
Gene-diet interactions and aging in C. elegans
Keywords: Diet-gene pairs; C. elegans; Metabolism; E. coli;
Benchmarking of protein carbonylation analysis in Caenorhabditis elegans: specific considerations and general advice
Keywords: PC; Protein carbonylation; UTC, the numbers that follow relate to individual component molarity or detergent percentage; urea-thiourea CHAPS-containing buffer; C. elegans; Caeonorhabditis elegans; DNPH; dinitrophenylhydrazine; ROS; reactive oxygen species
The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans
Keywords: Single cell gel electrophoresis assay; Comet assay; C. elegans; Benzo[a]pyrene; DNA repair;
C. elegans as a model organism for human mitochondrial associated disorders
Keywords: Mitochondria; Mitochondrial diseases; Neurodegeneration; C. elegans; In vivo drug screening; Therapy;
The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks
Keywords: CPT; camptothecin; DSB; double-strand breaks; HU; hydroxyurea; IR; ionizing irradiation; C. elegans; DNA damage response; DNA damage checkpoint; Werner syndrome protein;
Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor
Keywords: C. elegans; Caenorhabditis elegans; MEK; mitogen-activated protein kinase kinase; ERK; extracellular signal-regulated kinase; CPD; CDC4 phosphodegron; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulphoxide; MEFs; mouse embryonic fibroblasts; A
Role of DAF-21protein in Caenorhabditis elegans immunity against Proteus mirabilis infection
Keywords: C. elegans; P. mirabilis; Host-pathogen interaction; 2D-DIGE; MALDI-TOF; DAF-21;
Proteome analysis reveals translational inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis
Keywords: C. elegans; 2D-DIGE; EEF-2; Exotoxin A; Host-pathogen interactions; P. aeruginosa;
Acute exposure to a Mn/Zn ethylene-bis-dithiocarbamate fungicide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans
Keywords: PD; Parkinson's disease; MZ; Manzate; Mn/Zn-EBDC; Mn/Zn ethylene-bis-dithiocarbamate; C. elegans; Caenorhabditis elegans; ROS; reactive oxygen species; E. coli; Escherichia coli; CGC; Caenorhabditis Genetics Center; GFP; Green fluorescent protein; NGM;
The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans
Keywords: Mitochondrial dysfunctions; Protein homeostasis; Lifespan; Mitochondrial unfolded protein response; GCN-2; C. elegans;