کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5629174 1406403 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review ArticleAxon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Review ArticleAxon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration
چکیده انگلیسی

How axons repair themselves after injury is a fundamental question in neurobiology. With its conserved genome, relatively simple nervous system, and transparent body, C. elegans has recently emerged as a productive model to uncover the cellular mechanisms that regulate and execute axon regeneration. In this review, we discuss the strengths and weaknesses of the C. elegans model of regeneration. We explore the technical advances that enable the use of C. elegans for in vivo regeneration studies, review findings in C. elegans that have contributed to our understanding of the regeneration response across species, discuss the potential of C. elegans research to provide insight into mechanisms that function in the injured mammalian nervous system, and present potential future directions of axon regeneration research using C. elegans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 287, Part 3, January 2017, Pages 300-309
نویسندگان
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