Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation
Keywords: Myoblast differentiation; C2C12; NFATc3; STIM1; Orai1; SOCE;
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Ability of plasmid DNA complexed with histidinylated lPEI and lPEI to cross in vitro lung and muscle vascular endothelial barriers
Keywords: BCA; bicinchoninic acid; C2C12; mouse myoblasts; ΣCFTE29o-; immortalized human tracheal epithelial cells; DTT; dithiothreitol; EBM-2; endothelial basal medium-2; EC; endothelial cells; EDTA; ethylenediaminetetraacetic acid; FBS; foetal bovine serum; FITC
The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells
Keywords: Girdin; C2C12; Insulin sensitivity; Akt; Abl;
Continuous bone morphogenetic protein-2 gradients for concentration effect studies on C2C12 osteogenic fate
Keywords: BMP-2 gradient; Concentration effects; poly(methyl methacrylate); C2C12; Biotin-streptavidin
Antidiabetic Activity of Standardized Extracts of Balanites aegyptiaca Fruits using Cell-based Bioassays
Keywords: balanites; C2C12; diabetes; fruit; sugars; 3T3-L1;
Synergism between baltergin metalloproteinase and Ba SPII RP4 PLA2 from Bothrops alternatus venom on skeletal muscle (C2C12) cells
Keywords: Bothrops alternatus; Cytotoxicity; Phospholipase A2; Metalloproteinase; Baltergin; C2C12; Synergism;
In vitro haematic proteins adsorption and cytocompatibility study on acrylic copolymer to realise coatings for drug-eluting stents
Keywords: Protein adsorption; Cytocompatibility; Cell culture tests; C2C12; Drug-eluting coatings; Paclitaxel;
Splicing transitions of the anchoring protein ENH during striated muscle development
Keywords: Scaffolding protein; Alternative splicing; C2C12; Heart;
Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation
Keywords: mAKAP; muscle specific A-kinase anchoring protein; MEF2; myocyte enhancer factor 2; PKA; protein kinase A; PDE4D3; phosphodiesterases type 4D3; ERK5; big mitogen-activated protein kinase; GFP; green fluorescent protein; NFAT; nuclear factor of activated T
PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation
Keywords: Eicosapentaenoic acid; Peroxisome proliferator-activated receptor-γ; C2C12; Interleukin-6; Tumor necrosis factor-α;
Terminal differentiation program of skeletal myogenesis is negatively regulated by O-GlcNAc glycosylation
Keywords: FBS; fetal bovine serum; HRP; horseradish peroxidase; MHC; myosin heavy chain; MRF; myogenic regulatory factor; O-GlcNAcylation; O-linked β-N-acetylglucosaminylation; OGT; O-GlcNAc transferase; PVDF; polyvinylidene difluoride; C2C12; Differentiation; Gly
Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model
Keywords: ADAM12; disintegrin and metalloproteinase domain-containing protein 12; α9β1; integrin receptor composed of α9 and β1 sub-units; C2C12; a clonal cell derived from mouse skeletal muscle; EC50; effective concentration 50%; ELISA; enzyme-linked immunosor
Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2
Keywords: C2C12; Myoblast; IL-17; Myogenic differentiation; Osteogenic differentiation; ERK1,2
Gap junctional channels are parts of multiprotein complexes
Keywords: 42GPA9; mouse Sertoli cell line; βTC-3; mouse pancreatic β cell line derived from insulinomas; A431; human squamous carcinoma cells; A7r5; rat aortic smooth muscle cell line; BICR/M1Rk; a permanently growing cell line derived from a spontaneous rat mamm
Determination of bioactive markers in Cleome droserifolia using cell-based bioassays for antidiabetic activity and isolation of two novel active compounds
Keywords: Diabetes; Cleome droserifolia; Flavonoids; Terpenoids; C2C12; 3T3-L1
Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom
Keywords: Snake venom; Naja; Cytotoxicity; Cardiotoxin; Antivenom; Neutralization; C2C12;
Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes
Keywords: Ex-4; Ex-9; C2C12; MyHC; PGC-1α; Calcineurin A
Sodium arsenite delays the differentiation of C2C12 mouse myoblast cells and alters methylation patterns on the transcription factor myogenin
Keywords: Arsenic; C2C12; Myogenin; Methylation; Mef2c; Ptgis; Muscle; Myocyte
Development of poly(l-lactic acid) hollow fiber membranes for artificial vasculature in tissue engineering scaffolds
Keywords: 3D; 3 dimensional; BCA; bi-cinchoninic acid; BSA; bovine serum albumin; C2C12; mouse pre-myoblast cells; D-MEM; Dulbecco's modified eagle's medium; EDTA; ethylene-di-amine-tetra-acetic acid; FBS; fetal bovine serum; LIPS; liquid induced phase separation;
Micropatterning of single myotubes on a thermoresponsive culture surface using elastic stencil membranes for single-cell analysis
Keywords: Polydimethylsiloxane (PDMS); Orientation; Tissue engineering; Skeletal muscle; C2C12; Myoblast; Myotube; Cell patterning; Cell differentiation; Single-cell analysis
Yap is a novel regulator of C2C12 myogenesis
Keywords: Skeletal muscle; Myogenesis; C2C12; Hippo pathway; YapbHLH, helix-loop-helix transcription factors; cdk, cyclin dependent kinase; DMEM, Dulbecco’s modified Eagle’s medium; Frmd6, FIRM domain containing 6; IdU, iododeoxyuridine; LAP, liver associated prote
Hypoxia induces adipogenic differentitation of myoblastic cell lines
Keywords: Adipogenesis; Myoblasts; C2C12; G8; Hypoxia; Wnt10b
Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells
Keywords: Ecdysteroid; Skeletal muscle; Akt; GPCR; Calcium; C2C12
Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors
Keywords: Lysine specific demethylase 1 (LSD1); Skeletal muscle differentiation; C2C12; MyoD; Mef2
A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation
Keywords: Cytoskeleton; Phosphatidic acid; AGPAT2; C2C12; Skeletal muscle; Actin
Effects of a combined mechanical stimulation protocol: Value for skeletal muscle tissue engineering
Keywords: Stretch protocols; Tissue engineering; Muscle progenitor cells; C2C12; Muscle maturation
TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2
Keywords: TRIM72; MyoD; Myogenin; MEF2; C2C12
Dexamethasone induces dysferlin in myoblasts and enhances their myogenic differentiation
Keywords: Dysferlinopathy; Limb-girdle muscular dystrophy type 2B; Miyoshi myopathy; Glucocorticoid; Myotube; C2C12; Myoblast differentiation; Dysferlin; Dexamethasone
The use of established skeletal muscle cell lines to assess potential toxicity from embedded metal fragments
Keywords: Skeletal muscle; Embedded fragments; Cytotoxicity; Tungsten alloy; L6; C2C12
Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14
Keywords: Bone morphogenetic protein-4; Bone morphogenetic protein-9; Bone morphogenetic protein-10; Growth differentiation factor-11; Growth differentiation factor-5; C2C12;
Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1
Keywords: eIF, eukaryotic initiation factor; m7GTP, 7-methyl guanosine triphosphate; SDS, sodium dodecyl sulphate; PVDF, polyvinylidine difluoride; PAGE, polyacrylamide gel electrophoresis; TCA, trichloroacetic acidInitiation factor; C2C12; Translation; Myoblasts;
Increased spermine oxidase (SMO) activity as a novel differentiation marker of myogenic C2C12 cells
Keywords: AcSpm; N1Ac-spermine; ASMA; alpha skeletal muscle actin; C2C12; mouse skeletal myoblast cell line; FCM; flow cytometric; DM; differentiation medium; GM; growth medium; IGF-1; insulin-like growth factor; APAO; acetylpolyamine oxidase; MCK; muscle creatine
Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program
Keywords: ZBP-89; Myogenesis; C2C12; p21; MyoD; Mrf4; Myogenin;
The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis
Keywords: ZBP-89; Vimentin; Myogenesis; Sp1/Sp3; c-Jun; Stat3; C2C12
Characteristics of l-carnitine import into heart cells
Keywords: Extracellular ATP; Muscle; C2C12; Carnitine;
Antidiabetic screening and scoring of 11 plants traditionally used in South Africa
Keywords: 3T3-L1; C2C12; Chang liver; Glucose utilisation; Antidiabetic; Medicinal plants; South Africa
Synaptogenetic mechanisms controlling postsynaptic differentiation of the neuromuscular junction are nerve-dependent in human and nerve-independent in mouse C2C12 muscle cultures
Keywords: Acetylcholinesterase; Neuromuscular junction; Human muscle; C2C12; Acetylcholine receptor; MuSK
Surface and inner cell behaviour along skeletal muscle cell in vitro differentiation
Keywords: C2C12; Myoblasts; Myotubes; Contractility; Membrane; TEM; SEM; Patch clamp
The effects of Ankrd2 alteration indicate its involvement in cell cycle regulation during muscle differentiation
Keywords: Myogenic differentiation; C2C12; Cell cycle regulation; Transcriptional profiling;
TRB3 modulates C2C12 differentiation by interfering with Akt activation
Keywords: Akt; Tribbles; TRB3; Differentiation; Muscles; C2C12; MyoD; Myogenin
ACE activity affects myogenic differentiation via mTOR signaling
Keywords: ACE; mTOR; IGF-II; Differentiation; Maturation; Myogenesis; C2C12
Variation in ACE activity affects myogenic differentiation in C2C12 cells
Keywords: ACE; Captopril; Angiotensin II; AT2 receptor; Differentiation; Myogenesis; C2C12
C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia
Keywords: Myoblast; Differentiation; Filopodia; c6orf32 (gene); C6ORF32 (protein); C2C12
Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes
Keywords: C2C12; Ca2+ oscillation; Calpain; Myofibrillogenesis; Contractility; Electrical pulse stimulation; Extracellular matrix; Sarcomere assembly
Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway
Keywords: Sema4C; C2C12; Muscle regeneration; Myogenesis; Differentiation; siRNA; p38 MAPK
Differential roles of HIC-5 isoforms in the regulation of cell death and myotube formation during myogenesis
Keywords: C2C12; Differentiation; Satellite cell; Anoikis; Integrin signaling
Lignan compounds and 4,4′-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress
Keywords: Gomisin J; GR-12; Furoguaiacin; 4,4′-Dihydroxybiphenyl; Oxidative stress; C2C12
Calcium release from ryanodine receptors in the nucleoplasmic reticulum
Keywords: Ryanodine receptor; Nuclear signaling; Nucleoplasmic reticulum; C2C12; Channel
Downregulation of cAMP-dependent protein kinase inhibitor γ is required for BMP-2-induced osteoblastic differentiation
Keywords: PKA; PKIγ; BMP-2; Osteoblastic differentiation; C2C12;
Identification and characterization of the Mustang promoter: Regulation by AP-1 during myogenic differentiation
Keywords: Mustang; Promoter; AP-1; C2C12; Differentiation; Musculoskeletal