Relaxin alleviates TGFβ1-induced cardiac fibrosis via inhibition of Stat3-dependent autophagy
Keywords: فیبروز قلب; Relaxin; Autophagy; Cardiac fibrosis; Stat3;
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Epicardium-derived fibroblasts in heart development and disease
Keywords: فیبروز قلب; MI; myocardial infarction; HHD; hypertensive heart disease; HI; hypertensive injury; ECM; extracellular matrix; CF; cardiac fibroblast; EMT; epithelial-to-mesenchymal transition; EndMT; endothelial-to-mesenchymal transition; EPDCs; epicardium-derived cell
Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1/p38 signaling in mice
Keywords: فیبروز قلب; Cardiac remodeling; Transforming growth factor β activated kinase-1; Olmesartan; Cardiac fibrosis; Transverse aorta constriction;
Lysyl oxidase expression in cardiac fibroblasts is regulated by α2β1 integrin interactions with the cellular microenvironment
Keywords: فیبروز قلب; Lysyl oxidase; Cardiac fibroblast; Cardiac fibrosis; TGF-beta; Integrins; Cell-matrix interactions;
ReviewAmplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse
Keywords: فیبروز قلب; Vitamin D receptor (VDR); Diacylglycerol acyltransferase 1 (DGAT1); Cardiac steatosis; Cardiac fibrosis;
The Janus face of myofibroblasts in the remodeling heart
Keywords: فیبروز قلب; cardiac fibrosis; myofibroblast; epithelial-to-mesenchymal transition; fibrocyte; mesenchymal stem cell; signaling;
Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis
Keywords: فیبروز قلب; Diabetes mellitus; Anthocyanin; Cardiomyopathy; Cardiac inflammation; Cardiac fibrosis;
MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5
Keywords: فیبروز قلب; Methyl-CpG-binding protein 2; Cardiac fibrosis; Dual-specificity phosphatase 5;
Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways
Keywords: فیبروز قلب; Activin A; MAPKs; ALK4; Proliferation and differentiation; Cardiac fibrosis; Cardiac fibroblasts
(Pro)renin Receptor Blockade Ameliorates Cardiac Injury and Remodeling and Improves Function After Myocardial Infarction
Keywords: فیبروز قلب; (Pro)renin receptor; myocardial infarction; cardiac fibrosis; cardiac remodelling; left ventricular function
TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis
Keywords: فیبروز قلب; RAAS; Aldosterone; TRAF3IP2; CIKS; Act1; Cardiac fibrosis; Cardiac hypertrophyAct1, activator of NF-κB; Ang II, angiotensin II; ANP, atrial natriuretic peptide; AOPPs, advanced oxidation protein products; AP-1, activator protein-1; C/EBP, CCAAT/enhancer-b
Store-Operated Ca2+ Entry (SOCE) contributes to angiotensin II-induced cardiac fibrosis in cardiac fibroblasts
Keywords: فیبروز قلب; Cardiac fibrosis; Store-operated Ca2+ entry; Angiotensin II; Stromal interaction molecule1; Orai1;
PPAR-γ is involved in the protective effect of 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside against cardiac fibrosis in pressure-overloaded rats
Keywords: فیبروز قلب; 2,3,4',5-Tetrahydroxystilbene-2-O-beta-D-glycoside; Cardiac fibrosis; Peroxisome proliferator-activated receptor gamma;
Autophagy activation attenuates angiotensin II-induced cardiac fibrosis
Keywords: فیبروز قلب; Autophagy; Angiotensin II; Cardiac fibrosis; Rapamycin; ChloroquineAng II, angiotensin II; ECM, extracellular matrix; CFs, cardiac fibroblasts; Rapa, rapamycin; CQ, chloroquine; Col-I, type I collagen; FN, fibronectin; LAMP1, lysosomal associated membrane
p21CIP1/WAF1-dependent inhibition of cardiac hypertrophy in response to Angiotensin II involves Akt/Myc and pRb signaling
Keywords: فیبروز قلب; p21; Cdkn1a; p27; Cdkn1b; Myc; Retinoblastoma; Cyclin D2; Cdk; Cell cycle; Cardiac hypertrophy; Heart failure; Cardiac fibrosis; Angiotensin
Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis
Keywords: فیبروز قلب; apoptosis; gene therapy; heart failure; NFκB; AAV; adeno-associated virus; CF; cardiac fibrosis; EndMT; endothelial-mesenchymal transition; FACS; fluorescence-activated cell sorting; HCAEC; human coronary artery endothelial cell; HF; heart failure; LV; l
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation
Keywords: فیبروز قلب; AMPK; Cardiac fibrosis; Cardiac metabolism; Hypertrophy; Ischemia; Cardiac remodeling;
MicroRNA: A new therapeutic strategy for cardiovascular diseases
Keywords: فیبروز قلب; MicroRNAs; Endothelial cells; Cardiac fibrosis; Atherosclerosis; Myocardial infarction; Stroke; Hypertension; ATH; atherosclerosis; ALDH2; aldehyde dehydrogenase 2; BMP; bone morphogenetic protein; Bcl-2; B-cell lymphoma; CAD; coronary artery diseases; CD
Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition
Keywords: فیبروز قلب; Transverse aortic constriction; Cardiac fibrosis; Velvet antler peptide; TGF-Î1; Connective tissue growth factor;
Non-coding RNAs as modulators of the cardiac fibroblast phenotype
Keywords: فیبروز قلب; CFs; cardiac fibroblasts; ECM; extracellular matrix; Alpha-SMA; alpha smooth muscle actin; SMemb; non-muscle myosin heavy chain; TGF-beta; transforming growth factor-beta; IL1-beta; interleukin 1-beta; TNF-alpha; tumor necrosis factor-alpha; MI; myocardia
Chronic expression of Ski induces apoptosis and represses autophagy in cardiac myofibroblasts
Keywords: فیبروز قلب; Myofibroblast; Ski; Apoptosis; Autophagy; Cardiac fibrosis; TGFβ1;
Metformin inhibits aldosterone-induced cardiac fibroblast activation, migration and proliferation in vitro, and reverses aldosterone + salt-induced cardiac fibrosis in vivo
Keywords: فیبروز قلب; Aldosterone; Metformin; AMPK activators; TRAF3IP2; Cardiac fibrosis;
Insulin sensitizing and cardioprotective effects of Esculetin and Telmisartan combination by attenuating Ang II mediated vascular reactivity and cardiac fibrosis
Keywords: فیبروز قلب; Insulin resistance; Esculetin; Telmisartan; Cardiac fibrosis; Ang II; TGF-β;
Extracellular Matrix Biomarker, Fibulin-1 and Its Association with Soluble uPAR in a Bi-ethnic South African Population: The SAfrEIC Study
Keywords: فیبروز قلب; African; Cardiac fibrosis; Caucasian; Fibulin-1; Inflammation; Soluble Urokinase-Type Plasminogen Activator Receptor.
Resveratrol inhibits high glucose induced collagen upregulation in cardiac fibroblasts through regulating TGF-β1–Smad3 signaling pathway
Keywords: فیبروز قلب; Ang II, angiotensin II; CFs, cardiac fibroblasts; ECM, extracellular matrix; HG, high glucose; RAAS, rennin-angiotensin system; Res, resveratrol; TGF-β1, transforming growth factor-β1Resveratrol (Res); Cardiac fibrosis; Angiotensin II (Ang II); Cardiac fi
Protein kinase C promotes cardiac fibrosis and heart failure by modulating galectin-3 expression
Keywords: فیبروز قلب; Protein kinase; Cardiac fibrosis; Heart failure; Collagen; Angiotensin II;
CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages
Keywords: فیبروز قلب; CYP2J2; cytochrome P450 2J2 epoxygenase; EET; epoxyeicosatrienoic acids; Iso; isoprenaline; Ang II; angiotensin II; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; TGF-β1; transforming growth factor-beta 1; α-SMA; alpha smooth mu
Pellino1-mediated TGF-β1 synthesis contributes to mechanical stress induced cardiac fibroblast activation
Keywords: فیبروز قلب; Pellino1; Cardiac fibrosis; Cardiac fibroblasts; Mechanical stretch; TGF-β1;
Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110α) signaling
Keywords: فیبروز قلب; Type 1 diabetes; Antioxidant; Cardiomyocyte hypertrophy; Cardiac fibrosis; Superoxide; Left ventricular function; Myocardium; NADPH oxidase; Reactive oxygen species;
Idiopathic Hypereosinophilic Syndrome with Löeffler's Endocarditis
Keywords: فیبروز قلب; cardiac fibrosis; echocardiography; hypereosinophilic syndrome; Löeffler's endocarditis
DNA methylation in cardiac fibrosis: New advances and perspectives
Keywords: فیبروز قلب; ECM; extracellular matrix; α-SMA; α-smooth muscle actin; EMT; epithelial to mesenchymal transition; ET-1; endothelin-1; DNMT; DNA methyltransferase; MeCP2; methyl-CpG-binding protein 2; MBD; methylcytosine-binding domains; miRNA; microRNAs; SAM; S-adeny
Histone deacetylases in cardiac fibrosis: Current perspectives for therapy
Keywords: فیبروز قلب; HDACs; Histone deacetylases; ECM; Extracellular matrix; α-SMA; α-smooth muscle actin; HATs; Histone acetyltransferases; TGF-β1; Transforming growth factor β1; PDGF; Platelet-derived growth factor; FGF; Fibroblast growth factor; TIMPs; Tissue inhibitor
NF-κB-Mediated Integrin-Linked Kinase Regulation in Angiotensin II-Induced Pro-fibrotic Process in Cardiac Fibroblasts
Keywords: فیبروز قلب; ILK; NF-κB; cardiac fibrosis
SLC41A1 knockdown inhibits angiotensin II-induced cardiac fibrosis by preventing Mg2+ efflux and Ca2+ signaling in cardiac fibroblasts
Keywords: فیبروز قلب; SLC41A1; Cardiac fibrosis; Calcium; Magnesium; Na+/Mg2+ exchanger;
DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2
Keywords: فیبروز قلب; Ras association domain family 1 isoform A; Cardiac fibroblasts; Cardiac fibrosis; Smooth; muscle α-actin; DNA methyltransferase 3A;
TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx
Keywords: فیبروز قلب; Cardiac fibrosis; TRPM7; Calcium; Magnesium
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
Keywords: فیبروز قلب; Pressure overload; Cardiac fibrosis; Cardiac fibroblasts; Glycoproteins; Heart failure;
Aminoguanidine inhibits ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs
Keywords: فیبروز قلب; Aminoguanidine; Isoproterenol; Cardiac hypertrophy; Cardiac fibrosis; Extracellular matrix; Cardiac remodeling; Matrix metalloproteinases
Circulating biomarkers of collagen type I metabolism mark the right ventricular fibrosis and adverse markers of clinical outcome in adults with repaired tetralogy of Fallot
Keywords: فیبروز قلب; Cardiac fibrosis; Collagen; Magnetic resonance imaging; Tetralogy of Fallot;
Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK
Keywords: فیبروز قلب; ADAM; a disintegrin and metalloproteinase domain; AP-1; activator protein-1; ARB; angiotensin receptor blockers; AT1; angiotensin II type 1 receptor; AT2; angiotensin II type II receptor; CF; cardiac fibroblasts; CMV; cytomegalovirus; CVD; cardiovascular
Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts
Keywords: فیبروز قلب; Cardiac fibrosis; S100A4; p53; Myofibroblast;
TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation
Keywords: فیبروز قلب; RNA interference; Cardiac fibroblasts; Migration; TRAF3IP2; Cardiac fibrosis; Remodeling;
Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats
Keywords: فیبروز قلب; Cardiac fibrosis; Diabetes; Irbesartan; Endothelial-to-mesenchymal transition; Rats; Human aortic endothelial cells
3,3′-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway
Keywords: فیبروز قلب; 3,3′-Diindolymethane; BRCA1; Adriamycin; Cardiac fibrosis
EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast
Keywords: فیبروز قلب; Epigallocatechin-3-gallate; Cardiac fibrosis; Connective tissue growth factor; Reactive oxygen species; NF-κB
Fibrocytes are associated with the fibrosis of coronary heart disease
Keywords: فیبروز قلب; CHD, coronary heart disease; αSMA, alpha smooth muscle actin; SDF-1, stromal-derived factor-1; ECM, extracellular matrixCoronary heart disease; Fibrocytes; Cardiac fibrosis; Human
Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype
Keywords: فیبروز قلب; Cardiac fibrosis; Collagen; Atomic force microscopy; Myocardial stiffness; Atrial fibrillation;
Increased Procollagen Type I C-Terminal Peptide Levels Indicate Diastolic Dysfunction in End-Stage Renal Disease Patients Undergoing Maintenance Dialysis Therapy
Keywords: فیبروز قلب; PICP; Cardiac fibrosis; Diastolic dysfunction; Hemodialysis; ASE; American Society of Echocardiography; ESRD; End-stage renal disease; IVC; Inferior vena cava; IVCe; Average value of measured end-expiratory inferior vena cava diameter; LV; Left ventricula
Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3 infection and its potential role in cardiac fibrosis
Keywords: فیبروز قلب; Coxsackievirus B3; Endothelial-to-mesenchymal transition; Cardiac fibrosis; TGF-β1; Cardiac microvascular endothelial cells;
ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy
Keywords: فیبروز قلب; Angiotensin-II; Endothelin-1; Cardiac hypertrophy; Cardiac fibrosis; Genetic mouse model; Protein kinase C;