Increased Procollagen Type I C-Terminal Peptide Levels Indicate Diastolic Dysfunction in End-Stage Renal Disease Patients Undergoing Maintenance Dialysis Therapy

Hemodialysis patients with high average E/e′ ratios showed increased levels of LV filling pressure and higher severity levels of cardiac fibrosis, which occurred before the development of systolic dysfunction. PICP was a potential indicator of diastolic dysfunction and increased LV filling pressure.