دانلود مقالات ISI درباره Cccdna + ترجمه فارسی

Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication

Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Evolution in Our Understanding of Hepatitis B Virus Virology and Immunology

Keywords: Hepatitis B virus; Pathogenesis; Translational hepatology; cccDNA; Immunobiology; Immunotherapy; B and T cell responses to HBV; Therapeutic vaccination;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Advances in therapeutic CRISPR/Cas9 genome editing

Keywords: Cas9; CRISPR-associated protein 9; cccDNA; covalently closed circular DNA; CCR5; chemokine receptor 5; CFTR; cystic fibrosis transmembrane conductance regulator; CRISPRs; clustered regularly interspaced short palindromic repeats; crRNA; CRISPR RNA; Crygc;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

The intracellular dynamics of hepatitis B virus (HBV) replication with reproduced virion “re-cycling”

Keywords: Hepatitis B virus; Chronic hepatitis; CccDNA; Recycling;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status

Keywords: BCP; basal core promoter; CHB; chronic HBV; cccDNA; covalently closed circular DNA; DNMT; DNA methyltransferases; DS DNA; double stranded DNA; HATs; histone acetyltransferases; HDAC1; class 1 histone deacetylase; OC DNA; open circular DNA; ORFs; open read

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA

Keywords: HBV; Antiviral; cccDNA; Hydrolyzable tannins;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of hepatitis B virus replication by targeting ribonucleotide reductase M2 protein

Keywords: 3TC; lamivudine; cccDNA; covalently-closed-circular DNA; CI; combination index; CMC; Comprehensive Medicinal Chemistry; Gem; gemcitabine; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HU; hydroxyurea; NDPs; ribonucleoside diphosphates; dNDPs; deo

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant

Keywords: HBsAg; Antiviral Immunity; HBV Replication; Hepatocyte Proliferation; AASLD; American Association for the Study of Liver Diseases; ALT; alanine aminotransferase; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; EASL; European Association

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting hepatitis B virus cccDNA using CRISPR/Cas9

Keywords: HBV; cccDNA; Viral persistence; CRISPR/Cas; Gene therapy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Serum microRNA-210 levels in different groups of chronic hepatitis B patients

Keywords: MicroRNA-210; HBV carrier; HBV DNA; HBs antigen; Chronic hepatitis B; HBV; hepatitis B virus,; CHB; chronic hepatitis B; HCC; hepatocellular carcinoma; miRNA; microRNA; HAI; histological activity index; ALT; alanine aminotransferase; INR; international no

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Clinical Events After Cessation of Lamivudine Therapy in Patients Recovered From Hepatitis B Flare With Hepatic Decompensation

Keywords: Antiviral Therapy; Cirrhosis; Liver Cancer; Nucleos(t)ide Analog; ADV; adefovir; AFP; alpha fetoprotein; ALT; alanine aminotransferase; anti-HBe; hepatitis B e antibody; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; δPT; prolongation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleQuantification of HBsAg in nucleos(t)ide-naïve patients treated for chronic hepatitis B with entecavir with or without tenofovir in the BE-LOW study

Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; cccDNA; covalently closed circular DNA; HBsAg; hepatitis B surface antigen; peg-IFN; pegylated interferon; HBeAg; hepatitis B e antigen; ETV; entecavir; TDF; tenofovir disopr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Interleukin 6 inhibits HBV entry through NTCP down regulation

Keywords: HBV; Hepatitis B virus; NTCP; Sodium taurocholate co-transporting polypeptide; IL-6; Interleukin 6; IFN γ; Interferon gamma; ALT; Alanine aminotransferase; TNFα; Tumor Necrosis Factor alpha; IL-1β; Interleukin 1 beta; OSM; Oncostatin M; PHH; Primary Hu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

Keywords: HBV; cccDNA; CRISPR/Cas; Antiviral; DNA editing; Lentiviral vector;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleHBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase

Keywords: HBV; Hepatitis B Virus; pgRNA; pre-genomic RNA; RC-DNA; relaxed-circular HBV DNA; cccDNA; covalently closed circular HBV DNA; CBP; CREB-binding protein; PCAF; p300/CREB-binding Protein-associated Factor; H3, H4; histone 3, histone 4; HDAC1; histone deacet

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics

Keywords: Hepatitis B virus; cccDNA; DNA repair; Innate immunity; Antiviral;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2015 سفارش ترجمه

HBx affects CUL4-DDB1 function in both positive and negative manners

Keywords: Hepatitis B virus; HBx; DDB1; cccDNA; PRMT1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticlePersistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection

Keywords: HDV; hepatitis delta virus; HBV; hepatitis B virus; cccDNA; covalently closed circular DNA; HBsAg; HBV surface antigen; HBcAg; HBV core antigen; HDAg; hepatitis delta antigen; USB; uPA/SCID beige mice; HDV mono-infection; HDAg; HBV super-infection; Human

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatitis B virus DNA quantification with the three-in-one (3io) method allows accurate single-step differentiation of total HBV DNA and cccDNA in biopsy-size liver samples

Keywords: ALT; alanine transaminase; cccDNA; covalently closed circular DNA; FFPE tissue; formalin-fixed, paraffin-embedded tissue; gDNA; genomic DNA; hACTB; human β-actin gene; HBeAg; hepatitis B e antigen; HBsAg; hepatits B surface antigen; HBV; hepatitis B viru

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line

Keywords: HBV; cccDNA; Antiviral;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleHBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels

Keywords: ALT; alanine aminotransferase; cccDNA; covalently closed circular DNA; CD8+; cluster of differentiation 8 positive; CHB; chronic hepatitis B; CR; combined response; FACS; fluorescent activated cell sorter; GWAS; genome-wide association study; HBeAg; hepat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleImmune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration

Keywords: cccDNA; HBsAg; HBeAg; Interferon stimulated genes; Hepatocyte responsiveness; Humanized mice;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Modeling the effects of covalently closed circular DNA and dendritic cells in chronic HBV infection

Keywords: HBV; Hepatitis B virus; CccDNA; Covalently closed circular DNA; DCs; Dendritic cells; IFN; Interferon alpha; NAs; Nucleoside/nucleotide analogs; APCs; Antigen-presenting cells; CTL; Cytotoxic T lymphocyte; Th1; Helper T cell 1; HBsAg; HBV surface antigen;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Therapeutic strategies for a functional cure of chronic hepatitis B virus infection

Keywords: Hepatitis B virus; cccDNA; Antiviral agents

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

ReviewHepatitis B flares in chronic hepatitis B: Pathogenesis, natural course, and management

Keywords: ADV; adefovir; AFP; alphafetoprotein; ALT; alanine aminotransferase; anti-CD20; CD20 antibodies; anti-TNF; anti-tumour necrosis factors; ART; antiretroviral therapy; BHN; bridging hepatic necrosis; cccDNA; covalently closed circular DNA; CHB; chronic hepa

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

Keywords: Species Specificity; Virology; Virus Entry; Myrcludex B; cccDNA; covalently closed circular DNA; DMSO; dimethyl sulfoxide; h; human; HBcAg; hepatitis B core antigen; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface antigen; HBV; hepatitis B virus;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2014 سفارش ترجمه

Short hairpin RNA induces methylation of hepatitis B virus covalently closed circular DNA in human hepatoma cells

Keywords: cccDNA; covalently closed circular DNA; HBV; hepatitis B virus; siRNA; small interfering RNA; shRNA; short hairpin RNA; PTGS; post-transcriptional gene silencing; RdDM; RNA dependent DNA methylation; RNAi; RNA interference; TGS; transcriptional gene silen

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus

Keywords: AID; activation-induced cytidine deaminase; APOBEC; apolipoprotein B mRNA-editing enzyme catalytic subunit; UNG; uracil-DNA glycosylase; DHBV; duck hepatitis B virus; cccDNA; covalently closed circular DNA; 3D-PCR; differential denaturation DNA PCR; AID;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Virology and clinical sequelae of long-term antiviral therapy in a North American cohort of hepatitis B virus (HBV)/human immunodeficiency virus type 1 (HIV-1) co-infected patients

Keywords: ALT; alanine aminotransferase; anti-HBs; antibodies to hepatitis B surface antigen; anti-HBe; antibodies to hepatitis B e antigen; APRI; AST-platelet-ratio-index; ART; antiretroviral therapy; cccDNA; HBV covalently closed circular DNA; CHB; chronic hepati

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleThe entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

Keywords: IFN; interferon; HBV; hepatitis B virus; pgRNA; pregenomic RNA; cccDNA; covalently closed circular DNA; rcDNA; relaxed circular DNA; HBV; uPA; Humanized mice; Entry inhibitor; cccDNA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleLong-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: Finite treatment duration unlikely

Keywords: HBV; hepatitis B virus; HBsAg; hepatitis B surface antigen; cccDNA; covalently closed circular DNA; HBeAg; hepatitis B e antigen; IFN; interferon; IU; international unit; HDV; hepatitis D virus; PCR; polymerase chain reaction; IQR; interquartile range; He

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Original ResearchFull Report: Basic and Translational-LiverT Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

Keywords: Immunotherapy; Chronic Hepatitis B; Hepatocellular Carcinoma; Adoptive T-Cell Therapy; ALT; alanine aminotransferase; CAR; chimeric antigen receptor; cccDNA; covalently closed circular DNA; CEA; carcinoembryonic antigen; DC; dendritic cells; HBsAg; hepati

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Reduction of Hepatitis B Surface Antigen and Covalently Closed Circular DNA by Nucleos(t)ide Analogues of Different Potency

Keywords: Antiviral Therapy; Viral Hepatitis; Response to Therapy; Prognosis; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; HBeAg; hepatitis B e antigen; HBV; hepatitis B virus; NA; nucleos(t)ide analogue; qHBsAg; quantitative hepatitis B surfac

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleDecreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants

Keywords: HBV; hepatitis B virus; RT; reverse transcriptase; S; surface; HDV; hepatitis delta virus; PCR; polymerase chain reaction; WT; wild type; ORF; open reading frame; Ag; antigen; SVP; subviral particle; cccDNA; covalently closed circular DNA; HBV; Nucleos(t)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleKinetics of hepatitis B surface antigen differ between treatment with peginterferon and entecavir

Keywords: Peginterferon; Entecavir; Hepatitis B; Quantitative HBsAg; CHB; chronic hepatitis B; HBV; hepatitis B virus; cccDNA; covalently closed circular DNA; IFN; interferon; NA; nucleos(t)ide analogue; HBsAg; hepatitis B surface antigen; LAM; lamivudine; ADV; ade

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of hepatitis B virus (HBV) by LNA-mediated nuclear interference with HBV DNA transcription

Keywords: HBV; hepatitis B virus; LNA; locked nucleic acid; RNAi; RNA interference; cccDNA; covalently closed circular DNA; pgRNA; pregenomic RNA; TFOs; triple-helix-forming oligonucleotides; RNA interference; Hepatocyte; Oligonucleotide; Lipofectamine; Triple-heli

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR

Keywords: HBV; hepatitis B virus; cccDNA; covalently closed circular DNA; rcDNA; relaxed circular DNA; FFPE; formalin fixed paraffin-embedded; PSAD; plasmid-safe ATP-dependent DNase; RCA; rolling circle amplification; CHB; chronic hepatitis B; ALT; alanine aminotra

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Research ArticleHepatitis B surface antigen: Relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B

Keywords: Serum HBsAg levels; HBeAg-negative chronic hepatitis B; cccDNA; Total liver HBV DNA; Serum HBV DNA; HBsAg-immunostaining; HBcAg-immunostaining; ALT; alanine aminotransferase; cccDNA; covalently closed circular DNA; CHBe−; HBeAg-negative chronic hepatiti

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Research ArticleHepatitis B virus X protein is essential to initiate and maintain virus replication after infection

Keywords: HBV; hepatitis B virus; HBx; hepatitis B virus X protein; PHH; primary human hepatocytes; cccDNA; covalently closed circular DNA; ChIP; chromatin immunoprecipitation; Hepatitis B virus; HBx protein; Natural infection; Primary human hepatocytes; HepaRG;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

ReviewTherapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: Perspectives and challenges

Keywords: Hepatitis B; Chronic infection; Immunotherapy; Vaccine; DNA vaccine; T-cell therapy; Clinical trial; HBV; hepatitis B virus; cccDNA; covalently closed circular DNA; HBeAg; hepatitis B “e” antigen; HBsAg; hepatitis B surface antigen; NK; natural killer

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

ReviewHepatitis B surface antigen quantification: Why and how to use it in 2011 - A core group report

Keywords: Anti-HBe; antibodies to hepatitis B e antigen; ALT; alanine aminotransferase; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; HBV; hepatitis B virus; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface antigen; NA; nuclet(s)ide anal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Research ArticleHepatitis B surface antigen levels during the natural history of chronic hepatitis B: A perspective on Asia

Keywords: CHB; chronic hepatitis B; IT; immune-tolerant; IC; immune-clearance; LR; low-replicative; ENH; e antigen negative hepatitis; HBeAg; hepatitis B e antigen; HBV DNA; hepatitis B virus DNA; cccDNA; covalently closed circular DNA; HBsAg; hepatitis B surface a

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α

Keywords: Hepatitis B virus; Metabolovirus; Anti-viral therapy; Nutrition; HBV; hepatitis B virus; PGC-1α; peroxisome proliferator-activated receptor-coactivator-1α; HBsAg; hepatitis B virus surface antigen; cccDNA; covalently closed circular DNA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Enhanced specificity of real-time PCR for measurement of hepatitis B virus cccDNA using restriction endonuclease and plasmid-safe ATP-dependent DNase and selective primers

Keywords: Hepatitis B virus; cccDNA; Quantitation; Real-time PCR; Restriction endonuclease; Plasmid-safe ATP-dependent DNase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

ReviewLiver grafts from anti-hepatitis B core positive donors: A systematic review

Keywords: HBV; hepatitis B virus; LT; liver transplantation; anti-HBc; HBV core antigen; HBsAg; hepatitis B surface antigen; cccDNA; covalently closed circular DNA; HBIG; hepatitis B immunoglobulin; LAM; lamivudine; De novo HBV infection; Liver transplantation; Mar

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Hepatitis B Surface Antigen Serum Levels Help to Distinguish Active From Inactive Hepatitis B Virus Genotype D Carriers

Keywords: HBsAg Quantification; Inactive HBV Infection; HBeAg Negative Chronic Hepatitis B; AC; active carriers; AC1; active carriers with HBV-DNA persistently <20,000 IU/mL; AC2; active carriers with HBV-DNA ≥20,000 IU/mL; ALT; alanine aminotransferase; anti-HBc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Development of cell cultures that express hepatitis B virus to high levels and accumulate cccDNA

Keywords: Hepatitis B virus; cccDNA; Secretion; Envelope proteins; Intracellular amplification; EBNA-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Liver cancer: From molecular pathogenesis to new therapies

Keywords: DEB; drug-eluting bead; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; hTERT; human telomerase reverse transcriptase; PDGF; platelet derived growth factor; FAK; focal adhesion kinase; Pyk2; proline-rich tyrosine kinase 2; M

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Research ArticleHepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: A European perspective

Keywords: Hepatitis B virus; HBsAg; Chronic hepatitis B; HBV-genotype; HBV-DNA; HBsAg; hepatitis B surface antigen; HBV; hepatitis B virus; HBeAg; hepatitis B early antigen; PEG-IFN; pegylated interferon alpha; cccDNA; covalently closed circular DNA; IT; immune tol

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Hepatitis B Virology for Clinicians

Keywords: Hepatitis B virus; Polymerase; Antiviral Therapy; cccDNA;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه