Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice
Keywords: CCR5; CXCR4; genotypic; HIV-1; maraviroc; R5-tropic; tropism; X4-tropic;
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The impact of cytokine gene polymorphisms on Epstein-Barr virus infection outcome in pediatric liver transplant recipients
Keywords: EBV; Epstein-Barr virus; PTLD; post-transplant lymphoproliferative disorder; CHVL; chronically high viral load; LTx; liver transplantation; VNTR; variable number of tandem repeats; SNP; single nucleotide polymorphism; IL-1β; interleukin-1beta; IL-1RN;
The genetic variation of CCR5, CXCR4 and SDF-1 in three Chinese ethnic populations
Keywords: HIV; CCR5; CXCR4; SDF-1; Polymorphism;
Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents
Keywords: CCR5; CC chemokine receptor type 5; CXCR4; CXC chemokine receptor type 4; MAGI; Multinuclear activation of a galactosidase indicator; NNRTI; Non-nucleoside reverse transcriptase inhibitors; NRTI; Nucleoside reverse transcriptase inhibitors; Anti-HIV agent
Prolonged increase in rat hippocampal chemokine signalling after status epilepticus
Keywords: Temporal lobe epilepsy; Epileptogenesis; Chemokines; CCL4; CCR5;
V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc
Keywords: CCR5; Small molecule CCR5 inhibitors; V3 sequence; Drug resistance; CCR5 NT; Maraviroc; Vicriviroc
IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction
Keywords: IL-12; interleukin-12; TGF-β; transforming growth factor β; Th; helper T cell; NO; nitric oxide; IFN-γ; interferon γ; PE; phycoerythrin; CFSE; carboxyfluorescein succinimidyl ester; ConA; concanavalin A; LPS; lipopolysacharide; PBS; phosphate buffered
Monocyte-derived dendritic cell recruitment and allergic TH2 responses after exposure to diesel particles are CCR2 dependent
Keywords: CCR2; CCR5; CCR6; dendritic cell; diesel exhaust particles; monocyteBALF, Bronchoalveolar lavage fluid; CCL, CC chemokine ligand; CCR, CC chemokine receptor; CFSE, Carboxyfluorescein diacetate succinimidyl ester; DCs, Dendritic cells; DEPs, Diesel exhaust
Dysregulated CC receptor/ligand in monocytes/macrophages from tongue squamous cell carcinoma patients is partially rectified by interferon α-2b
Keywords: Chemokines; CCR5; IFNα2b; Monocytes; Macrophages; Tongue squamous cell carcinoma
The evolution of human immunodeficiency virus type-1 (HIV-1) envelope molecular properties and coreceptor use at all stages of infection in an HIV-1 donor-recipient pair
Keywords: HIV-1; Transmission; R5; X4; CCR5; CXCR4; Envelope; PNGS; Coreceptor use; V3;
Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C
Keywords: HIV-1; Subtype C; CCR5; CXCR4; Phylogenetic; Envelope;
Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate
Keywords: CCR5; Chemokine; Anti-HIV
The natural product CCR5 antagonist anibamine and its analogs as anti-prostate cancer agents
Keywords: CCR5; Antagonist; Anibamine; Prostate cancer;
Transcriptional regulation of the chemokine co-receptor CCR5 by the cAMP/PKA/CREB pathway
Keywords: cAMP; CCR5; HIV-1cAMP, cyclic adenosine monophosphate; CCR5, CC chemokine receptor 5; CRE, cAMP response element; CREB, cAMP response element binding; CREM, cAMP response element modulator; GPCR, G-protein coupled receptors; HIV-1, human immunodeficiency
Discovery of a novel series of cyclic urea as potent CCR5 antagonists
Keywords: Cyclic urea; CCR5; Antagonist; Pharmacokinetics; HIV-1; Chemokine
Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist
Keywords: CCR2; CCR5; Chemokine; Antagonist
Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1
Keywords: CCR5; HIV-1; Diaminobutane; Tropane; Benzimidazole
Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Keywords: CCR5; Chemokine receptor; HIV-1; Schering C
Analysis of CCR5 and CX3CR1 gene polymorphisms in association with unexplained recurrent miscarriages among north Indian women
Keywords: Pregnancy; Recurrent miscarriage; CCR5; CX3CR1; Polymophism;
Research ArticleThe predictive value of IL28B gene polymorphism for spontaneous clearance in a single source outbreak cohort is limited in patients carrying the CCR5Î32 mutation
Keywords: HCV; hepatitis C virus; IL28B; interleukin 28B; IFN; interferon; SNP; single nucleotide polymorphism; CCR5; CC chemokin receptor 5; pDC; plasmacytoid dendritic cells; WT; wildtype; HIV; human immunodeficiency virus; Hepatitis C virus; IL28B; CCR5; Polymor
Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Keywords: CCR5; Chemokine receptor; HIV-1; Schering C
Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats
Keywords: Pyridyl carboxamide; CCR5; Antagonist; Pharmacokinetics; HIV-1; Chemokine
Effects of a calcineurin inhibitor, FK506, and a CCR5/CXCR3 antagonist, TAK-779, in a rat small intestinal transplantation model
Keywords: POD, post operative day; MLN, mesenteric lymph nodes; PP, Peyer's patches; MLR, mixed lymphocyte reactionFK506; TAK-779; Rat intestinal transplantation; CCR5; CXCR3
Analysis of co‐receptor usage of circulating viral and proviral HIV genome quasispecies by ultra‐deep pyrosequencing in patients who are candidates for CCR5 antagonist treatment
Keywords: CCR5; co‐receptor; CXCR4; HIV; Maraviroc; NGS; pyrosequencing; tropism; UDPS
Thérapie génique conduisant à l'inactivation de CCR5 - Vers l'éradication du VIH?
Keywords: HIV; CCR5; Ãradication; Thérapie génique; Allogreffe de moelle; SiRNA; Zinc finger; HIV; CCR5; Eradication; Stem cell therapy; Stem cell transplantation; siRNA; Zinc finger;
A combination of polymorphic mutations in V3 loop of HIV-1 gp120 can confer noncompetitive resistance to maraviroc
Keywords: HIV-1; CCR5; gp120; V3 loop; Viral entry; Maraviroc; Noncompetitive resistance
TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4+ T-cells with no measurable effect on susceptibility to SIV infection
Keywords: AIDS; CCR5; CD4; SIV; Rhesus macaques;
Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions
Keywords: Ccr5; Natural killer cells; Proliferation; Trafficking
Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants
Keywords: CCR5; CXCR4; HIV-1; R5; X4; Coreceptor use; Coreceptor switch; V3; Envelope
HIV-1 clade C envelopes obtained from late stage symptomatic Indian patients varied in their ability towards relative CD4 usages and sensitivity to CCR5 antagonist TAK-779
Keywords: HIV-1; Coreceptor; Clade C; CD4; CCR5; CD4+ T cells; TAK-779; T20
Cell derived liposomes expressing CCR5 as a new targeted drug-delivery system for HIV infected cells
Keywords: Liposome; Cell-derived; HIV; AIDS; CCR5; EDTA
Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1
Keywords: HIV-1; V3; Coreceptor; Tropism; X4; R5; Dual; CXCR4; CCR5; CCR5 antagonist
Dependence on different Rab GTPases for the trafficking of CXCR4 and CCR5 homo or heterodimers between the endoplasmic reticulum and plasma membrane in Jurkat cells
Keywords: G protein coupled receptor; CXCR4; CCR5; Rab GTPase; Trafficking; Dimerization
HIV-1 entry inhibition by small-molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high-throughput assay
Keywords: HIV-1; CCR5; Small molecule antagonists; Aplaviroc; Maraviroc; Vicriviroc; Mutagenesis; Antifusogenic assay; Homology modeling; Binding site characterization
Homology modeling of human CCR5 and analysis of its binding properties through molecular docking and molecular dynamics simulation
Keywords: CCR5; Homology modeling; Molecular docking; Molecular dynamics simulation;
Engineering and screening the N-terminus of chemokines for drug discovery
Keywords: Chemokine analogues; Chemokine receptors; Antagonists; Therapeutic peptides; CXCR4; CCR5
Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles
Keywords: CCR5; Chemokine; Anti HIV-1
Monoclonal antibody–assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4+ T-cells
Keywords: Adenosine A2A receptor; CXCR4; CCR5; HIV-1; Monoclonal antibody
Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles
Keywords: CCR5; Azacycles; Intrinsic permeability
CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain
Keywords: Chemokine; CCL3; CCR1; CCR5; Allodynia; Hyperalgesia;
Development and performance of a new recombinant virus phenotypic entry assay to determine HIV-1 coreceptor usage
Keywords: HIV-1; Phenotypic entry assay; Coreceptor; CCR5
An in situ oxidation strategy towards overcoming hERG affinity
Keywords: CCR5; hERG; In situ oxidation; Prodrug; HIV
Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection
Keywords: HIV-1; Nef; CTL; CCR5; CXCR4; Superinfection
Plasmacytoid dendritic cells in multiple sclerosis: Chemokine and chemokine receptor modulation by interferon-beta
Keywords: Multiple sclerosis; Interferon-beta; Plasmacytoid dendritic cells; Chemokines; TLR9; Chemokine receptors; CCR7; CCL3; CCL4; CCL5; CCR5;
Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations
Keywords: CCR5; HIV-1; South African population; Genetic variation;
Role of CCL3/MIP-1α and CCL5/RANTES during acute Trypanosoma cruzi infection in rats
Keywords: Chemokines; CCR5; Trypanosoma cruzi; Myocarditis
The design and validation of a novel phenotypic assay to determine HIV-1 coreceptor usage of clinical isolates
Keywords: Chemokine receptor; Luciferase; Pseudovirus; Viral fitness; HIV; Viral tropism; Coreceptor usage; CCR5; CXCR4;
Association of CCR5, TLR2, TLR4 and MBL genetic variations with genital tract infections and tubal factor infertility
Keywords: CCR5; CC chemokine receptor 5; CT+; Chlamydia trachomatis-positive; MBL; mannose-binding lectin; PID; pelvic inflammatory disease; RFLP; restriction fragment length polymorphism; SNP; single nucleotide polymorphism; TFI; tubal factor infertility; TLR; Tol
Chemokine Receptor CCR5 Mediates AlloImmune Responses in Graft-versus-Host Disease
Keywords: CCR5; GVHD; Chemokine; CD4; CD8