دانلود مقالات ISI درباره Cdk5 + ترجمه فارسی

p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease

Keywords: p73; p53 family; Tau phosphorylation; Pin1; Alzheimer's disease; Aging; Neurodegeneration; GSK-3β; c-Abl; Cdk5; Tauopathy; Paired helical filaments; TgCRND8

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Differential striatal spine pathology in Parkinson's disease and cocaine addiction: A key role of dopamine?

Keywords: 6-OHDA; 6-hydroxydopamine; CaM; Calmodulin; cAMP; cyclic AMP; CaN; Calcineurin; Cdk5; cyclin-dependent kinase 5; DA; dopamine; GP; globus pallidus; MEF2; myocyte enhancer factor 2; MSNs; medium spiny neurons; NAc; nucleus accumbens; PD; Parkinson's dise

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors

Keywords: Kinase; cdk5; cdk2; Alzheimer disease; 4-(1,3-Benzothiazol-2-yl)thiophene-2-sulfonamide;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives

Keywords: 3-Aminopyrazole; Synthesis; Anticancer activity; CDK5; GSK3β;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2

Keywords: CaV2.2; N-type voltage-gated Ca2+ channel; CBD; Ca2+ channel binding domain; CRMP-2; collapsin response mediator protein 2; Cdk5; cyclin dependent kinase 5; DIV; days in vitro; DsRed; Discosoma sp. red fluorescent protein E19, embryonic day 19; GSK3β; gl

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Intrathecal administration of roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA

Keywords: Cancer pain; Cdk5; NR2B; Roscovitine; mRNA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Regular ArticleDual actions of brain-derived neurotrophic factor on GABAergic transmission in cerebellar Purkinje neurons

Keywords: BDNF; GABAA; KCC2; Cdk5; Purkinje neurons;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons

Keywords: Tanshinone IIA; β-Amyloid protein; p35/p25; Tau protein; Cdk5

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Going out of the brain: Non-nervous system physiological and pathological functions of Cdk5

Keywords: Cdk5; Cell cycle; Transcription; Cancer; Diabetes; Inflammation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

GDNF induces mechanical hyperalgesia in muscle by reducing IBK in isolectin B4-positive nociceptors

Keywords: AHP; after-hyperpolarization; ANOVA; analysis of variance; BK channel; large-conductance voltage- and calcium-activated potassium channel; CDK5; cyclin-dependent kinase 5; DiI; 1,1′-dioctadecyl-3,3,3′,3′-tertamethyllindocarbocyanine perchlorate; DRG

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Multiple patterns of spatiotemporal changes in layer-specific gene expression in the developing visual cortex of higher mammals

Keywords: OD column; ocular dominance column; MD; monocular deprivation; BDNF; brain-derived neurotrophic factor; DIG; digoxigenin; GPX1; glutathione peroxidase 1; TCFL5; transcription factor-like 5; TPI1; triosephosphate isomerase 1; MYL6; myosin light chain 6; LA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners

Keywords: AMPK; AMP-activated protein kinase; ARF; ADP-ribosylation factor; CDK5; cyclin-dependent kinase 5; CEM; caveolin-enriched membrane; CRMP-2; collapsin response mediator protein-2; EGF; epidermal growth factor; EGFR; EGF receptor; GAP; GTPase-activating pro

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Striatal inhibition of calpains prevents levodopa-induced neurochemical changes and abnormal involuntary movements in the hemiparkinsonian rat model

Keywords: Parkinson's disease; 6-Hydroxydopamine; Levodopa; Dyskinesia; Caudate-putamen; cdk5; Calpains;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish

Keywords: Dpysl2; CRMP2; Dpysl3; CRMP4; Cdk5; DYRK2; Rohon-Beard; Neural crest; Zebrafish

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain

Keywords: BCA; bicinchoninic acid; cAMP; cyclic AMP; cdk5; cyclin-dependent kinase 5; ctx; cerebral cortex; DARPP-32; dopamine- and cAMP-regulated phosphoprotein of 32 kDa; DMSO; dimethyl sulphoxide; ECL; enhanced chemiluminescence; ERK; extracellular signal-regul

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Diabetes: New conductors for the peroxisome proliferator-activated receptor γ (PPARγ) orchestra

Keywords: Diabetes; Thiazolidinedione; Selective PPARγ modulators; Cdk5

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Structure–activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors

Keywords: Cdk5; Kinase; Inhibitor; Alzheimer’s disease; 2,4-Diaminothiazoles

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Research reportModulation of ultra-low-molecular-weight heparin on [Ca2+]i in nervous cells

Keywords: Aβ; β-amyloid peptide; AD; Alzheimer's disease; BBB; blood-brain barrier; CaMKII; calcium/calmodulin-dependent protein kinase II; Cdk5; cyclin-dependent kinase 5; CNS; central nervous system; CSF; cerebrospinal fluid; DMEM/F12; Dulbecco's modified Eag

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: Synthesis, neuronal cell culture investigations, and CDK5 docking studies

Keywords: CDK5; Docking methods; ATP; Roscovitine; Flavopiridol; Purine triazoles; Cell cycle inhibitors; Neuroprotectors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Evidence for amylase release by cyclin-dependent kinase 5 in the rat parotid

Keywords: Rat parotid gland; Cdk5; Cyclin I; Amylase release; Munc18c; Phosphorylation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668

Keywords: Alzheimer disease; Cultured rat cortical neurons; Calcium oscillations; T668; Phosphorylation; JNK; GSK3; CDK5; Trafficking

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Alterations of Cyclin dependent kinase 5 expression and phosphorylation in Amyloid precursor protein (APP)-transfected PC12 cells

Keywords: Cdk5; Gsk-3β; Amyloid beta; Phosphorylation; Alzheimer’s disease

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cdk5: Mediator of neuronal development, death and the response to DNA damage

Keywords: Cdk5; Central nervous system; Cell death; DNA damage; Neurodegenerative disease

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways

Keywords: Alzheimer's disease; Tau; CDK5; GSK3; APP/PS1 transgenic mouse; Valproate; Okadaic acid

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular machinery of macroautophagy and its deregulation in diseases

Keywords: Autophagy; Autophagosome; Cdk5; Endophilin B1; Post-translational modification; Neurodegenerative disorder

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Twice switched at birth: Cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells

Keywords: Cdk5; Cyclin-dependent kinase 5; p35; p39; p25; p29

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease

Keywords: Alzheimer's disease; Cdk5; memory; p25; p35;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

Keywords: c-Abl; Cdk5; Neurotoxicity; Tau phosphorylation; Apoptosis; Amyloid-β-peptide; Alzheimer's disease; Transgenic mice model

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25

Keywords: CDK5; Cyclin dependent kinase; Benzimidazole; 1-Isopropyl benzimidazole;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

Keywords: NFTs; neurofibrillary tangles; AD; Alzheimer's disease; MAP; microtubule-associated protein; GSK3β; glycogen synthase kinase-3β; PP2A; protein phosphatase-2A; CDK5; cyclin-dependent kinase-5; DYRK1A; dual-specificity tyrosine-phosphorylation regulated

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells

Keywords: Calcium; Capacitative calcium entry (CCE); Cdk5; PC12 cells; Roscovitine;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner

Keywords: OA, okadaic acid; E2, 17β-estradiol; ER, estrogen receptorAlzheimer's disease; Estrogen; Tau; cdk5; Phosphatase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35

Keywords: Attention-deficit/hyperactivity disorder (ADHD); Cdk5; dopamine; methylphenidate; p35; prefrontal cortex

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex

Keywords: electron microscopy; dendritic spines; D1; D5; protein phosphatase-1; dopamine; AC; adenylyl cyclase; ANOVA; analysis of variance; CaM; calmodulin; cAMP; cyclic AMP; Cdk5; cyclin-dependent kinase 5; DAB; 3,3′-diaminobenzidine; DARPP-32; dopamine- and cA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Glycogen synthase kinase-3β and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

Keywords: axoplasmic transport; glycogen synthase kinase-3β; cyclin dependent kinase 5; p25; mitochondrion transport; Cdk5; cyclin dependent kinase 5; DAPI; 4′6′ diamidino 2 phenylindole; ECL; enhanced chemiluminescent; EGFP; enhanced green fluorescent protein

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Many roads lead to primary autosomal recessive microcephaly

Keywords: 53BP1; tumor-suppressor protein p53 binding protein 1; APC; anaphase-promoting complex; ASPM; abnormal spindle-like, microcephaly associated protein; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and RAD3-related protein; BACH1; BRCA1-ass

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

Keywords: Apoptosis; Brain-derived neurotrophic factor (BDNF); Glycogen synthase kinase 3 (GSK-3); Lithium; Neurodegenerative diseases; Neuroprotection; 3-NP; 3-nitropropionic acid; Aβ; β-amyloid; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AP-1;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors

Keywords: GSK-3; CDK5; Kinase inhibitors; Alzheimer’s disease; Pyrazolo[3,4-b]pyridines; 3,6-Diamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles; Molecular modelling

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain

Keywords: Aluminium chloride; Bax. Convolvulus pluricaulis; Cdk5; M1 receptor; NGF receptor (TrkA)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology

Keywords: PP1; type 1 protein phosphatase; Ca; Calcium; PP1c; type 1 protein phosphatase catalytic subunit; I-1; inhibitor-1; I-2; inhibitor-2; SR; sarcoplasmic reticulum; LTCC; L-type Ca channel; RyR; ryanodine receptor; SERCA2a; SR/ER-Ca ATPase 2a; PLN; phosphola

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells

Keywords: p39; cdk5; GC box; E box; Transcription factor; Promoter; Sp1; Sp3; Neuron

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways

Keywords: Dopamine receptor; Tau; Calcium; cdk5; GSK3; PKA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

Keywords: Retinal ganglion cells; Cdk5; rho kinase; Regeneration; Retinal explants; Optic nerve crush

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats

Keywords: IBS; irritable bowel syndrome; LUT; lower urinary tract; NMDA; N-methyl-d-aspartate; NMDAR; N-methyl-d-aspartate receptor; Cdk5; cyclin-dependent kinase-5; DRG; dorsal root ganglion; PSD95; postsynaptic density 95; MO; mustard oil; SRP; spinal reflex pote

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease

Keywords: PD, Parkinson's disease; CDKs, cyclin-dependent kinases; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MEF2, myocyte enhancer factor 2Parkinson's disease; cdk5; E2F-1; Cell cycle

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C

Keywords: Cdk5; PKC; Inhibitor-1; DARPP-32; Phorbol ester

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain

Keywords: Roscovitine; Cdk5; Erk1/2; Pharmacokinetics; Brain

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5

Keywords: CDK5, cyclin-dependent kinase 5; dn, dominant negative; PCR, polymerase chain reactionp35; E-cadherin; CDK5; Lysosomal degradation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis

Keywords: Amyotrophic lateral sclerosis; ALS; Cyclin-dependent kinase 5; cdk5; G93A hSOD1; Transgenic mice; Muscle; MyoD; Cyclin D1; Presymptomatic

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of β-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons

Keywords: AD; Alzheimer's disease; Aβ; β-amyloid; MT; microtubule; CDK5; cyclin-dependent kinase 5; NFTs; neurofibrillary tangles; Ginsenoside Rb1; β-amyloid (Aβ); Tau; Cyclin-dependent kinase 5 (CDK5); p35; p25;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه