دانلود مقالات ISI درباره Cdk5 + ترجمه فارسی

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways

Keywords: AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Acute stress regulates phosphorylation of N-methyl-d-aspartate receptor GluN2B at S1284 in hippocampus

Keywords: AMPAR; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Cdk5; Cyclin-dependent kinase 5; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; NMDAR; N-methyl-D-aspartate receptor; PSD; postsynapti

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Transforming growth factor-β1 induces cell cycle arrest by activating atypical cyclin-dependent kinase 5 through up-regulation of Smad3-dependent p35 expression in human MCF10A mammary epithelial cells

Keywords: TGF-β1; Cell cycle arrest; Cdk5; p35; Smad3;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

TREMs in Alzheimer's disease: Genetic and clinical investigations

Keywords: AD; Alzheimer's disease; TREM; Triggering receptor expressed on myeloid cells; TREML; TREM like transcript; NHD; Nasu-Hakola disease; NFTs; neurofibrillary tangles; p-tau; hyperphosphorylated tau; GWAS; genome-wide association studies; sTREM2; soluble f

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A hydrogen peroxide safety valve: The reversible phosphorylation of catalase from the freeze-tolerant North American wood frog, Rana sylvatica

Keywords: Akt; Protein kinase B; AMPK; Adenosine monophosphate-activated protein kinase; cAMP; Cyclic adenosine monophosphate; CAMK; Calmodulin dependent kinase; Cdc2; Cyclin dependent kinase 1; Cdk5; Cyclin dependent kinase 5; cGMP; Cyclic guanidine monophosphate;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

Keywords: Pyrido[3,4-g]quinazoline; Protein kinase inhibition; CLK1; DYRK1A; CDK5; GSK3; CK1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Binding mechanism of CDK5 with roscovitine derivatives based on molecular dynamics simulations and MM/PBSA methods

Keywords: Roscovitine derivatives; CDK5; Molecular dynamics simulation; Molecular docking; Binding mechanism

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders

Keywords: Lead neurotoxicity; Hyperphosphorylation; Tau protein; GSK-3β; CDK5; Rat brain

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors

Keywords: Pyridoisoindolones; Curtius rearrangement; Isocyanates; Valmerins; GSK3; CDK5; Molecular modeling; Kinase profiling; Cell effects

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice

Keywords: Alzheimer's disease; Protein phosphorylation; CRMP; Mouse; Cerebellum; APP; amyloid precursor protein; BSA; bovine serum albumin; Cdk5; cyclin dependent kinase 5; CRMP2; collapsin response mediator protein 2; GSK3β; glycogen synthase kinase 3β; PS1; pre

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

The neuroprotective mechanism of puerarin in the treatment of acute spinal ischemia-reperfusion injury is linked to cyclin-dependent kinase 5

Keywords: Puerarin; Spinal ischemia-reperfusion; Cdk5; Inhibitor; Roscovitine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation

Keywords: Calpain; Cdk5; GSK-3β; p25; S-nitrosoglutathione; Tau;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model

Keywords: Cdk5; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); p25; p35; Panax ginseng

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A novel phosphorylation site of N-methyl-d-aspartate receptor GluN2B at S1284 is regulated by Cdk5 in neuronal ischemia

Keywords: NMDA receptor; GluN2B; S1284; Cdk5; Ischemia; LTP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis

Keywords: AC1MMYR2; Taxol; CDK5; CDK5RAP1; Metastasis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Reduced phosphorylation of synapsin I in the hippocampus of Engrailed-2 knockout mice, a model for autism spectrum disorders

Keywords: ASD; autism spectrum disorders; CA1/CA2/CA3; hippocampal pyramidal cell layers; Cdk5; cyclin-dependent kinase 5; En2; Engrailed-2; ERK; extracellular-regulated kinase; GABA; γ-aminobutyric acid; GCL; granule cell layer; mf; mossy fibers; MWM; Morris wate

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats

Keywords: CCA; common carotid artery; GR; glucocorticoid receptor; HI; hypoxia/ischemia; TTC; 2,3,5-triphenyltetrazolium chloride; Cdk5; hypoxia/ischemia injury; apoptosis; p35; p35 mimetic peptide;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity

Keywords: CNS; central nervous system; HIV-1; human immunodeficiency virus-1; HAND; HIV-1-associated neurocognitive disorders; cART; combination antiretroviral therapy; Tat; trans-activator of transcription; gp120; glycoprotein 120; GSK3β; glycogen synthase kinase

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia

Keywords: Cdk5; TRPV1; Phosphorylation; Membrane trafficking; Hyperalgesia;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Research ReportCdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia

Keywords: Inflammatory pain; Hyperalgesia; Cdk5; P38; OX-42; TNF-a; Roscovitine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation

Keywords: BAT; Brown adipose tissue; CBP; cAMP responsive element binding protein (CREBP) binding protein; CDK5; Cyclin-dependent kinase 5; EC50; half-maximal effective concentration; FFA; Free fatty acids; HOMA-IR; HOMA of insulin resistance; ITT; Insulin toleranc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Translational implications of the β-cell epigenome in diabetes mellitus

Keywords: Arx; arista-less-related homeobox protein; CDK5; cyclin-dependent kinase 5; CpG; Cytosine-phosphodiester-bond-guanine; DM; diabetes mellitus; EZH2; enhancer of zeste homolog 2; GLP-1; glucagonlike peptide 1; GWAS; genomewide association study; H3-K4; Lys-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens

Keywords: Cdk5; p39; Muskelin; Myosin; Stress fibers; Cytoskeleton; Cell migration; Lens;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors

Keywords: Pyridoisoindolone; Valmerin; GSK3; CDK5; Kinase research; In vitro assays;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease

Keywords: Cdk5; Dopaminergic activation; Drp1; Huntingtin; Mitochondrial dynamics

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1

Keywords: CDK5; cyclin-dependent kinase; GLU; glutamate; AD; Alzheimer's disease; DIV; day in vitro; ROS; reactive oxygen species; BDNF; brain-derived neurotrophic factor; ROCK; Rho kinase; LDH; lactate dehydrogenase; G-LISA; GTP enzyme-linked immunosorbent assay;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1

Keywords: Imidazo[1,2-b]pyridazine; Anti-apicomplexan; Toxoplasma gondii; Toxoplasma gondii calcium-dependent protein kinase 1; IC50; 50% inhibitory concentration; EC50; 50% effective concentration; CC50; 50% cytotoxic concentration; SAR; structure-activity relatio

دانلود رایگان متن کامل مقاله ISI 129 صفحه سال انتشار : 2015 سفارش ترجمه

Valproic acid downregulates Cdk5 activity via the transcription of the p35 mRNA

Keywords: Cdk5; cyclin-dependent kinase 5; GABA; γ-aminobutyric acid; HDAC; histone deacetylase; MG132; benzyloxycarnonyl-leucyl-leucyl-leucinal; TSA; trichostatin A; VPA; valproic acid; VPM; valpromide; Cdk5; Valproic acid; Transcription; p35; Autism; HDAC;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Short CommunicationInhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning

Keywords: Cdk5; Conditioning; Learning; Locomotion; Psychostimulants; Roscovitine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Acetylation of cyclin-dependent kinase 5 is mediated by GCN5

Keywords: CDK5; GCN5; Acetylation; K33; ATP;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: Relevance to AD

Keywords: Aging; Hyperphosphorylation; CDK5; Lead; Tau

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32

Keywords: Striatum; Dopamine; Orphan nuclear receptors; Antipsychotics; A2AR; adenosine 2A receptor; CDK5; cyclin-dependent kinase 5; DAPI; 4′,6′-Diamidino-2-phenylindole; DARPP-32; dopamine- and cAMP-regulated phosphoprotein of 32 kDa; D1R, D2R, and D3R; dopa

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice

Keywords: CDK5; GSK3β; Prenatal alcohol; Hippocampus; Frontal cortex

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors

Keywords: Pyridopyrimidine; CDK5; DYRK1A; Synthesis; SAR; Molecular modelling

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Preferential targeting of p39-activated Cdk5 to Rac1-induced lamellipodia

Keywords: ca; constitutive active; Cdk; cyclin-dependent kinase; F-actin; filamentous actin; kn; kinase negative; Cdk5; Rac1; Lamellipodia; Cyclin-dependent kinase; Rho small GTPase; Cell adhesion;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice

Keywords: Cdk5; cyclin-dependent kinase 5; FTDP-17; frontal temporal dementias with Parkinsonism linked to chromosome 17; GSK-3β; glycogen synthase kinase 3β; MAPK (Erk1/2); mitogen-activated protein kinase; SAPK; stress-activated protein kinase; Environmental ne

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review

Keywords: PPAR gamma; Nuclear receptor; Natural product; Nutrition; Diabetes; 9-(S)-HODE; (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid; AF-2; activation function-2; CAP; c-Cbl-associated protein; Cdk5; cyclin-dependent kinase 5; DCM; dichloromethane; DIO; diet

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

ReviewMechanisms regulating the development of oligodendrocytes and central nervous system myelin

Keywords: AN2/NG2; neural/glial antigen 2; BDNF; brain-derived neurotrophic factor; BMP; bone morphogenic protein; bHLH; basic helix-loop-helix; (PI3K)/PKC; phosphoinositide 3-kinase; PKA; protein kinase A; cdkn1c; cyclin-dependent kinase inhibitor; CDK5; cyclin-de

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?

Keywords: 3-MA; 3-methyladenine; 15d-PHJ2; 15-deoxy-Δ12,14-prostaglandin J2; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid; AMPAR; AMPA receptors; APC/C; anaphase-promoting complex/cyclosome; APV; D-aminophosphonovalerate; ATF4; activating transcri

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2014 سفارش ترجمه

Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser116 signaling cascade in endothelial cells and mice

Keywords: eNOS; endothelial nitric oxide synthase; CDK5; cyclin-dependent kinase 5; JNK; c-Jun N-terminal kinase; Abl; Abelson kinase; SH-PTP; SH2 domain-containing protein tyrosine phosphatase; VPA; valproic acid; HDAC; histone deacetylase; HUVEC; human umbilical

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of a rod domain-truncated isoform of nestin, Nes-SΔ107-254, in rat dorsal root ganglia

Keywords: IF; intermediate filament; DRG; dorsal root ganglia; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; RT-PCR; reverse transcription polymerase chain reaction; GFP; green fluorescent protein; NFH; neurofilament heavy polypeptide; Cdk5; cy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling

Keywords: CDK5; Kinase; Roscovitine; Buchwald-Hartwig amination;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment

Keywords: Cdk5; Open field; Hyperactivity; Transmitter release; Cognitive function; Lithium;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium

Keywords: CaM; calmodulin; Ca2 +; calcium; CaMBP; CaM-binding protein; CaMBD; CaM-binding domain; Cdk5; cyclin-dependent kinase 5; PsaA; puromycin-sensitive aminopeptidase A; GFP; green fluorescent protein; NLS; nuclear localization sequence; Cyclin-dependent kina

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62

Keywords: AD; Alzheimer's disease; Beclin-1; Bcl-2-interacting protein-1; BSA; bovine serum albumin; CaMKII; calcium/calmodulin-dependent protein kinase II; CDK5; cyclin dependent kinase 5; CYPA; cyclophilin A; LC3B; microtubule-associated protein 1 light chain 3;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

Keywords: AD; Alzheimer's disease; NFT; neurofibrillary tangles; PHF; paired helical filaments; SP; senile plaques; APP; apolipoprotein; PP1; protein phosphatase-1; PP2A; protein phosphatase-2A; PP2B; protein phosphatase-2B; PP5; protein phosphatase-5; PTEN; phosph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5

Keywords: Neuronal activity; Homeostatic plasticity; Synaptic scaling; EphA4; Cdk5;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways

Keywords: 5-HTR7; Cytoskeletal proteins; MAP1B; Neurite outgrowth; Neuronal primary cultures; 5-HT; 5-hydroxytryptamine; 5-HTR7; serotonin receptor 7; ADHD; attention deficit hyperactivity disorder; Cdk5; cyclin-dependent kinase 5; CHX; cycloheximide; CTX; cortex;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Tau protein kinases: Involvement in Alzheimer's disease

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Arg; Abl-related gene; SFK; Src family kinase; Aβ; β-amyloid; BBB; blood brain barrier; LD50; lethal dose 50; c-Abl; c-Abelson; Cables; c-Abl-binding adaptator protein; CaMKII; Ca2+/calmodulin-dep

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)

Keywords: Aging; Alzheimer's disease; cdk5; Hyperphosphorylation; Lead; Tau protein

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه