Regulatory mechanism of the initiation step of DNA replication by CDK in budding yeast
Keywords: CDK; DNA-replication; Eukaryotes; Yeast; Multiple phosphorylation;
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Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones
Keywords: CDK; Inhibitor; Cancer; Cell cycle; Paullones; Synthesis
The Physiological Significance of p27KIP1 Expression in Detrusor Function
Keywords: urinary bladder; urinary bladder neck obstruction; cyclin-dependent kinase inhibitor p27; hyperplasia; mice; BOO; bladder outlet obstruction; CDK; cyclin-dependent kinase; CKI; CDK inhibitor; DLPP; detrusor leak point pressure; NFAT; nuclear factor of act
A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding
Keywords: Cyclin-dependent kinase; cdk; PSTAIRE; p21Cip1; p27Kip1; cdc28;
Research ArticleThe let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma
Keywords: Liver; Mcl-1; Bcl-2; Tumour; Epigenetic; miRNA; microRNA; 3â²UTR; 3â²-untranslated region; mRNA; messenger RNA; HCC; hepatocellular carcinoma; CDK; cyclin-dependent kinase; DMEM; Dulbecco's modified Eagle medium; RT; reverse transcription; PCR; polyme
The activated aryl hydrocarbon receptor synergizes mitogen-induced murine liver hyperplasia
Keywords: AhR; Aryl hydrocarbon receptor; BrdU; bromodeoxyuridine; CKO; conditional knockout; CDK; cyclin-dependent kinase; PH; partial hepatectomy; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCPOBOP; 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene; TCPOBOP; TCDD; AhR;
Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives
Keywords: Imidazo[1,2-a]pyridine; Quinoline; Bioisosteric replacement; CDK; Apoptosis
Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis
Keywords: 6BIO; 6-bromoindirubin-3â²-oxime; 5BIO; 5-bromoindirubin-3â²-oxime; 5A6BI; 5-amino-6-bromoindirubin; 5-HIAA; 5-hydroxyindoleacetic acid; 5-HT; serotonin/5-hydroxytryptamine; AhR; aryl hydrocarbon receptor; BSA; bovine serum albumin; CDK; cyclin-dependen
Recent developments in cyclin-dependent kinase biochemical and structural studies
Keywords: CDK; cyclin-dependent kinase; CKI; cyclin-dependent kinase inhibitor; T160pCDK2/cyclinA; CDK2 phosphorylated on Thr160 bound to cyclinA; Y15pT160pCDK2/cyclinA; CDK2 phosphorylated on Tyr15 and on Thr160 bound to cyclinA; CBF; cyclin box fold; CDK; Cyclin;
Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing
Keywords: Kinase; Cyclin dependent kinases; CDK; Kinase inhibitor; Tumor cell proliferation inhibition; Cell cycle; Anti-cancer
Research ArticleReperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway
Keywords: Selective clamping; Intermittent clamping; Reperfusion stress; Liver regeneration; Cell division; TNF; tumor necrosis factor; IL; interleukin; JNK; c-Jun N-terminal kinase; HGF; hepatocyte growth factor; EGF; epidermal growth factor; CDK; cyclin-dependent
The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus
Keywords: Malaria; CDK; Pfmrk; DNA replication; Cell cycle; Plasmodium;
Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest
Keywords: Controlled proliferation; Hypothermic growth; Sodium butyrate; CHO; Recombinant protein; CDK; CKI
Efficacy of lanreotide in preventing the occurrence of chemically induced hepatocellular carcinoma in rats
Keywords: AAF; acetylaminofluorene; ALT; alanine aminotransferase; CdK; cyclin-dependent kinase; CKi; cyclin-dependent kinase inhibitor; CTL; control; CYP; cytochrome p450; DEN; diethylnitrosamine; FAH; foci of altered hepatocytes; GSTp; glutathione S-transferase o
δEF1 promotes breast cancer cell proliferation through down-regulating p21 expression
Keywords: δEF1; p21; CDK; Cell cycle; Breast cancer proliferation
Proliferative Suppression by CDK4/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells
Keywords: Retinoblastoma Tumor Suppressor; Hepatocellular Carcinoma; HCC; CDK4/6 Inhibitor; BrdU; bromodeoxyuridine; CCRE; cell cycle regulatory element; CDK; cyclin-dependent kinase; CHX; cycloheximide; HA; hemagglutinin; HCC; hepatocellular carcinoma; miNS; micro
Replication origins are already licensed in G1 arrested unfertilized sea urchin eggs
Keywords: DNA replication; Pre-replication complex; G1 arrest; Fertilization; Cdk; Checkpoint kinase; Sea urchin;
ReviewNew advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients
Keywords: AP-1; activator protein-1; Ca2+; calcium; CBR1; carbonyl reductase 1; CDK; cyclin dependent kinase; CoQ; Coenzyme Q; DOX; doxorubicin; ERK; extracellular signal-regulated kinase; H2O2; hydrogen peroxide; HO; hydroxyl radical; iNOS; inducible nitric oxide
Isolation and characterization of cytoplasmic cyclin D1 mutants
Keywords: Cyclin D1; Random mutagenesis; Cytoplasmic localization; Nuclear import; Cdk; Complex formation
CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215
Keywords: Influenza virus; NS1; Phosphorylation; ERK; CDK;
The selenium analog of the chemopreventive compound S,Sâ²-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer
Keywords: CDK; cyclin dependent kinases; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; MTT; methylthiazoletetrazolium; NO; nitric oxide; PBIT; S,Sâ²-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea; PLA2; phospholipase A2; p-XSC; phenylenebis(met
Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A
Keywords: CDK; Cell cycle; Cyclin; RINGO/Speedy; Ubiquitination
Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia
Keywords: ACPT; acid phosphatase, testicular; APC; adenomatous polyposis coli; BCL; B-cell lymphoblastic leukemia; BDNF; brain-derived neurotrophic factor; BMP; bone morphogenic protein; CA; Cornus Ammonis; CDK; cyclin-dependent kinase; CK; casein kinase; CNV; copy
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-ζ-dependent cell cycle arrest
Keywords: cdk; cyclin dependent kinase; DG; diacylglycerol; DGK; diacylglycerol kinase; ECL; enhanced chemiluminescence; GSK; glycogen synthase kinase; mTOR; mammalian Target Of Rapamycin; NLS; nuclear localization signal; p70S6K; p70S6 kinase; PA; phosphatidic aci
Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1–5, GSK-3) inhibitors
Keywords: Tripentone; Dipyrrolopyrazinone; Furopyrrolopyrazinone; Curtius rearrangement; Cyclin-dependent kinase; CDK; GSK-3
A quantitative model of the effect of unreplicated DNA on cell cycle progression in frog egg extracts
Keywords: Checkpoint; Hysteresis; Cdk; MPF; Cdc25; Wee1Cdk, cyclin-dependent kinase; MPF, mitosis-promoting factor; NEB, nuclear envelope breakdown; ODE, ordinary differential equation; PET, parameter estimation tools
DNA double-strand breaks in meiosis: Checking their formation, processing and repair
Keywords: Double-strand breaks; Meiosis; Checkpoint; CDK; Mek1; Rad53
Loss of p53 Induces Tumorigenesis in p21-Deficient Mesenchymal Stem Cells
Keywords: CDK; cyclin-dependent kinase; CIN; chromosome instability; CPT; camptothecin; HSC; hematopoietic stem cell; MEF; mouse embryonic fibroblast; MSC; mesenchymal stem cell;
The RASSF proteins in cancer; from epigenetic silencing to functional characterization
Keywords: AP-1; Activator protein-1; APC/C-CDC20; complex anaphase-promoting complex/cyclosom-cell division cycle 20 homolog; ATM; ataxia telangiectasia mutated; C19ORF5; chromosome 19 open reading frames 5; CDC20; cell division cycle protein 20; CDH1; Cdc20 homolo
Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents
Keywords: 311; 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone; BpT; 2-benzoylpyridine thiosemicarbazone; CDK; cyclin-dependent kinase; CDKi; cyclin-dependent kinase inhibitor; DFO; desferrioxamine; DMT1; divalent metal ion transporter 1; DpT; di-2-pyridylketo
Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin
Keywords: BrdU; bromodeoxyuridine; Ccn; cyclin; cdk; cyclin-dependent kinase; FACS; fluorescence-activated cell sorting; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; PCNA; proliferating cell nuclear antigen; PH; partial hepatectomy; RB; retinoblastoma; WT; wild
Therapeutic role of sirolimus in non-transplant kidney disease
Keywords: AKI; acute kidney injury; AMPK; AMP-activated kinase; ADPKD; autosomal dominant polycystic kidney disease; CAN; chronic allograft nephropathy; CD2AP; CD2-associated protein; Cdk; cyclin-dependent kinase; CNI; calcineurin inhibitor; CTGF; connective tissue
SKP2 and CKS1 Promote Degradation of Cell Cycle Regulators and Are Associated With Hepatocellular Carcinoma Prognosis
Keywords: APC/C; anaphase-promoting complex; CDH1; cyclosome with cell division cycle 20 related 1; CDK; cyclin-dependent kinase; CKS1; CDC28 protein kinase b1; CDC14B; cell division cycle 14; FOXM1; forkhead box M1B; FOXO1; forkhead box O1; HCC; hepatocellular car
Modifications of the isonipecotic acid fragment of SNS-032: Analogs with improved permeability and lower efflux ratio
Keywords: CDK; Cyclin; SNS-032; Kinase
Pyrogallol inhibits the growth of human lung cancer Calu-6 cells via arresting the cell cycle arrest
Keywords: PG; pyrogallol; ROS; reactive oxygen species; FBS; fetal bovine serum; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PI; propidium iodide; CDK; cyclin-dependent kinase; DHE; dihydroethidium; CDKI; cyclin-dependent kinase inhibitor; NA
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Keywords: CDK; Kinase; Inhibitor; Cancer
Repression of Ah receptor and induction of transforming growth factor-β genes in DEN-induced mouse liver tumors
Keywords: ALDH3A1; aldehyde dehydrogenase-3A1; AHR; aryl hydrocarbon receptor; AHRE; aryl hydrocarbon receptor response element; AIP; AHR-interacting protein; ALL; acute lymphoblastic leukemia; ARA9; Ah receptor-associated protein 9; ARNT; aryl hydrocarbon receptor
Ku, Artemis, and ataxia-telangiectasia-mutated: Signalling networks in DNA damage
Keywords: AT; ataxia-telangiectasia; ATM; ataxia-telangiectasia-mutated; ATR; ataxia-telangiectasia and Rad3-related; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; catalytic subunit of DNA-dependent protein kinase; DSBs; double-strand breaks; ROS; reactive oxygen
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors
Keywords: CDK; Kinase; Inhibitor; Cancer
(–)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis
Keywords: (−)-syringaresinol; Cdk; Cdki; Bax; Bcl-2; Caspase-3; Apoptosis
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4)
Keywords: Peripheral nerves; Schwan cells; Development; Nerve injury; Cyclin-dependent kinases; Proliferation; cdk; Myelin
Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375
Keywords: CDK, cyclin-dependent kinase; ERK, extracellular signal-regulated kinase; ODC, ornithine decarboxylaseCytokines; Melanoma; IL-1; ERK1/2; E2F; CDK; p21; RB
Strategies to regenerate hair cells: Identification of progenitors and critical genes
Keywords: HC; hair cell; SC; supporting cell; E; embryonic day; P; postnatal day; GER; greater epithelial ridge; LER; lesser epithelial ridge; DIV; day in vitro; EGF; epidermal growth factor; FGF2; fibroblast growth factor 2; GFP; green fluorescent protein; CDK; cy
Coenzyme Q10 as a potent compound that inhibits Cdt1-geminin interaction
Keywords: CoQn; Coenzyme Qn; MCM; Mini-chromosome maintenance; pre-RC; Pre-replication complexes; ORC; Origin recognition complex; Cdk; Cyclin-dependent kinase; APC/C; Anaphase-promoting complex/cyclosome; HRP; Horseradish peroxidase; GST; Glutathione S-transferase
Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape
Keywords: CDK; cyclin-dependent kinase; CGH; comparative genomic hybridization; EDN; endothelin; ERK; extracellular signal-regulated kinase; FGF; fibroblast growth factor; HGF; hepatocyte growth factor; IGF; insulinlike growth factor; MAPK; mitogen-activated protei
Control of cell proliferation by neurotransmitters in the developing vertebrate retina
Keywords: Cell cycle; Development; Glutamate; ATP; Dopamine; Calcium; CDK; Retinoblastoma
Cigarette tar phenols impede T cell cycle progression by inhibiting cyclin-dependent kinases
Keywords: Cdk; cyclin-dependent kinases; HQ; hydroquinone; Cat; catechol; NS; non-stimulated; PBMC; peripheral blood mononuclear cells; Phen; phenol; Stim; stimulated; Human; T cells; Cell activation; Cell differentiation; Cell proliferation;
Glucose regulation of CDK7, a putative thiol related gene, in experimental diabetic nephropathy
Keywords: CDK; candidate diabetes associated kidney genes; GK; Goto Kakizaki; DN; diabetic nephropathy; RT-PCR; reverse transcription polymerase chain reaction; HMC; human mesangial cells; Diabetic nephropathy; Mesangial cells; Hyperglycemia; Glucose regulation; Ox
The motility and dynamic properties of intermediate filaments and their constituent proteins
Keywords: cdk; cell cycle-dependent kinase; DM-EBS; Dowling-Meara epidermolysis bullosa simplex; FISH; fluorescence in situ hybridization; FRAP; fluorescence recovery after photobleaching; GFP; green fluorescent protein; IF; intermediate filament; IFAP; IF associ
ReviewCell cycle regulation in Trypanosoma brucei
Keywords: BSF; bloodstream form; PCF; procyclic form; CDK; cyclin-dependent kinase; CRK; cdc2-related kinase; MAPK; mitogen-activated protein kinase; RNAi; RNA interference; BB; basal body; IFT; intraflagellar transport; N; nucleus; K; kinetoplast; kDNA; kinetoplas