کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2999800 | 1180304 | 2008 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape
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کلمات کلیدی
TNFEDNUVRHGFCGHCDKERKFGFIGFMAPK - MAPKMAPK/ERK kinase - MAPK / ERK kinaseendothelin - اندوتلینcomparative genomic hybridization - ترکیب هیبریداسیون ژنومی مقایسه شدهHepatocyte growth factor - عامل رشد هپاتوسیتVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)insulinlike growth factor - فاکتور رشد انسولینfibroblast growth factor - فاکتور رشد فیبروبلاستtumor necrosis factor - فاکتور نکروز تومورUV radiation - فرابنفش MEK - مجاهدین خلقmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیcyclin-dependent kinase - کییناز وابسته به سیکلین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Malignant melanoma presents a substantial clinical challenge. Current diagnostic methods are limited in their ability to diagnose early disease and accurately predict individual risk of disease progression and outcome. The lack of adequate approaches to properly define disease subgroups precludes rational treatment design and selection. Better tools are urgently needed to provide more accurate and personalized melanoma patient management. Recent progress in the understanding of the molecular aberrations that underlie melanoma oncogenesis will likely advance the diagnosis, prognosis, and treatment of melanoma. The emerging pattern of molecular complexity in melanoma tumors mirrors the clinical diversity of the disease and highlights the notion that melanoma, like other cancers, is not a single disease but a heterogeneous group of disorders that arise from complex molecular changes. Understanding of molecular aberrations involving important cellular processes, such as cellular signaling networks, cell cycle regulation, and cell death, will be essential for better diagnosis, accurate assessment of prognosis, and rational design of effective therapeutics. Defining an individual patient's unique tumor characteristics may lead to personalized prediction of outcomes and selection of therapy. We review the emerging molecular landscape of melanoma and its implications for better management of patients with melanoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 83, Issue 7, July 2008, Pages 825-846
Journal: Mayo Clinic Proceedings - Volume 83, Issue 7, July 2008, Pages 825-846
نویسندگان
Aleksandar MD, PhD, Paul MD, PhD, Arlo J. MD, PhD, Josep Genebriera MD, Samuel MD, Jose S. MD, MS, MPH, MBA, Diva R. MD, Erik C. PhD, Richard G. PhD, David L. MD, Barbara A. MD, Susan D. MD, MPH, Mark R. MD, Svetomir N. MD, PhD,