
Original ArticleNegative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts
Keywords: پیری سلولی; Metformin; Sirtuin 1; AMP-activated protein kinase; Cellular senescence; Hepatocellular carcinoma; SIRT1; Sirtuin 1; AMPK; AMP-activated Protein Kinase; TIS; therapy-induced senescence; SA-β-gal; senescence-associated β-galactosidase;