Hyperosmolarity induced by high glucose promotes senescence in human glomerular mesangial cells

- Hyperglycemia induced hyperosmolar stress.
- Hyperosmolarity induces senescence in renal glomeruli and glomerular mesangial cells.
- Senesce induced by hyperosmolarity was due to oxidative stress.
- Hyperosmolarity induced constitutive activation of Ras-ERK pathway.