دانلود مقالات ISI درباره Cmax + ترجمه فارسی

Pharmacokinetics of piperacillin-tazobactam in plasma, peritoneal fluid and peritoneum of surgery patients, and dosing considerations based on site-specific pharmacodynamic target attainment

Keywords: Piperacillin; Tazobactam; Peritonitis; Inflammatory bowel disease; Pharmacokinetics; Pharmacodynamics; PIP-TAZ; piperacillin-tazobactam; AUC; area under the drug concentration-time curve; MIC; minimum inhibitory concentration; Cmax; observed maximum conce

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

A phase 1 study to evaluate the safety and pharmacokinetics of MEDI8852, an anti-influenza A monoclonal antibody, in healthy adult volunteers

Keywords: MEDI8852; Monoclonal antibody; Influenza; Hemagglutinin; ADA; anti-drug antibodies; AUC0-t; area under the concentration‒time curve from time 0 to last sampling time point; AUC∞; area under the plasma concentration‒time curve from time 0 to infinity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study

Keywords: FACS; Fluorescence activated cell sorting; γ-GC; gamma-glutamylcysteine; GCL; glutamate cysteine ligase holoenzyme; GCLC; catalytic subunit of glutamate cysteine ligase; GCLM; modifier subunit of glutamate cysteine ligase; GR; glutathione reductase; γ-G

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Recombinant Human C1-Esterase Inhibitor to Treat Acute Hereditary Angioedema Attacks in Adolescents

Keywords: C1-esterase; Hereditary angioedema; Adolescent; Safety; Efficacy; Ruconest; Pharmacokinetics; AE; Adverse event; C1-INH; C1-esterase inhibitor; Cmax; Maximum concentration; HAE; Hereditary angioedema; IV; Intravenous; OLE; Open-label extension; RCT; Rando

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Estradiol prodrugs (EP) for efficient oral estrogen treatment and abolished effects on estrogen modulated liver functions

Keywords: AUC; area under the curve; BW; body weight; C0; extrapolated concentration time zero (i. v.); Cmax; maximum concentration; CA-II; carbonic anhydrase II; CBG; cortisol binding globulin; COC; combined oral contraceptive; EDTA; ethylene diamine tetra acetic

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization

Keywords: ASD; amorphous solid dispersion; ASD/CsA; amorphous solid dispersion of cyclosporine A; AUC; area under the curve of blood concentration versus time curve; BA; bioavailability; Cmax; maximum concentration; CsA; cyclosporine A; CV; coefficient of variation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics and pharmacodynamics of a buprenorphine subcutaneous depot formulation (CAM2038) for once-weekly dosing in patients with opioid use disorder

Keywords: AUC0-7d; area under the concentration-time curve from time of dosing to 7 days; AUC0-last; area under the concentration-time curve from time zero to last observed concentration; AUC0-∞;  area under the concentration-time curve from time ze

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Quantification of IDP-73152, a novel antibiotic, in plasma from mice, rats and humans using an ultra-high performance liquid chromatography/tandem mass spectrometry method for use in pharmacokinetic studies

Keywords: AUC0→24; area under the curve from time zero to 24 h; AUC0→∞; area under the curve from time zero to infinity; AUMC0→∞; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; IS; internal s

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Quantification of EC-18, a synthetic monoacetyldiglyceride (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol), in rat and mouse plasma by liquid-chromatography/tandem mass spectrometry

Keywords: ACN; acetonitrile; AUC0→∞; area under the curve from time zero to infinity; AUMC0→∞; the area under the first moment curve from time zero to infinity; CL; clearance; Cmax; maximum concentration; FA; formic acid; IPA; isopropyl alcohol; IS; interna

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Self-micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments

Keywords: AUC; area under the curve of blood concentration versus time curve; BALF; bronchoalveolar lavage fluid; BUN; blood urea nitrogen; Cmax; maximum concentration; CsA; cyclosporine A; CsA-RP; amorphous cyclosporine A-based respirable powder; FPD; fine particl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

Keywords: ACN; acetonitrile; API; active pharmaceutical ingredient; ASD; amorphous solid dispersions; AUC; area under the curve; BCS; biopharmaceutics classification system; CD; cyclodextrin; Cmax; maximum concentration; DSC; differential scanning calorimetry; FA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Protective effects of tranilast on experimental colitis in rats

Keywords: AUC; area under the concentration versus time curve; BCS; biopharmaceutics classification system; CD; Crohn's disease; Cmax; maximum concentration; DAB; 3,3′-diaminobenzidine; HDTMAB; hexadecyltrimethylammonium bromide; HE; hematoxylin-eosin; IBD; inf

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetic based study on “lagged stimulation” of Curcumae Longae Rhizoma - Piper nigrum couplet in their main active components' metabolism using UPLC-MS-MS

Keywords: Curcumae Longae Rhizoma; Piper nigrum; UHPLC-MS-MS; Lagged stimulation; Pharmacokinetics; TCM; Traditional Chinese Medicine; Cur; curcumin; Pip; piperine; UPLC-MS-MS; ultra-performance liquid chromatography-mass spectrometry; ESI; electrospray ionizatio

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis

Keywords: Acute pancreatitis; Epigenetics; BET inhibition; Drug discovery; AP; acute pancreatitis; AUC; area under the curve; BET proteins; bromodomain and extra-terminal proteins; CCL2; chemokine (C-C motif) ligand 2; CER-AP; caerulein-induced AP; Cmax; peak serum

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

ASP0028 in combination with suboptimal-dose of tacrolimus in Cynomolgus monkey renal transplantation model

Keywords: AUC(0-24); the area under the plasma concentration-time curves from 0 to 24 h; Cmax; the maximum plasma concentration; CNI; calcineurin inhibitor; MS; multiple sclerosis; MST; median survival time; NHPs; nonhuman primates; PD; pharmacodynamic; PK; phar

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri

Keywords: 3-MA; 3-methyl adenine; LC3; microtubule-associated protein light chain 3; Cmax; maximum plasma concentration; GFP; green fluorescent protein; SERCA; sarcoplasmic/endoplasmic reticulum calcium ATPase; SSa; Saikosaponin a; SSb1; saikosaponin b1; SSb2; saik

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects

Keywords: Neuromedin U (NMU); NMU-8; Polyethylene glycol (PEG); Diabetes; Obesity; NMU; neuromedin U; PEG; polyethyleneglycol; PipAc; 2-(piperazin-1-yl)acetic acid; CNS; central nervous system; DIO; diet-induced obesity; EMCS; N-(6-maleimidocaproyloxy)succinimide;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro and In Situ Characterization of Triterpene Glycosides From Cimicifuga racemosa Extract

Keywords: Biopharmaceutics Classification System (BCS); cell culture; dissolution; solubility; gastrointestinal; LC-MS; absorption; Caco-2 cells; natural products; Ze 450; Cimicifuga racemosa extract; BCS; Biopharmaceutics Classification System; ab; apical-to-baso

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Dosing considerations for rufinamide in patients with Lennox-Gastaut syndrome: Phase III trial results and real-world clinical data

Keywords: Rufinamide; Dosing; Antiepileptic drug; Lennox-Gastaut syndrome; Epilepsy; AE; adverse event; AED; antiepileptic drug; AUC; area under the curve; BID; twice daily; Cmax; peak plasma concentration; ECG; electrocardiogram; EEG; electroencephalogram; EMA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein

Keywords: Cucurbitacin E; CYP3A; P-glycoprotein; Hepatotoxicity; Drug-drug interactions; CuE; cucurbitacin E; P-gp; p-glycoprotein; Cmax; the maximum serum concentration; AUC; area under the concentration-time curve; CL; clearance; Vd; volume of distribution; t1/2;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Tumor necrosis factor-alpha inhibitors suppress CCL2 chemokine in monocytes via epigenetic modification

Keywords: RA; rheumatoid arthritis; TNF-α; tumor necrosis factor-alpha; MCP-1; chemoattractant protein-1, also called CCL2; HAT; histone acetyltransferase; HDAC; histone deacetylase; IL; interleukin; LPS; lipopolysaccharide; ELISA; Enzyme-linked immunosorbent assa

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception

Keywords: Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Dual 7-ethyl-10-hydroxycamptothecin conjugated phospholipid prodrug assembled liposomes with in vitro anticancer effects

Keywords: SN38; 7-ethyl-10-hydroxycamptothecin; CPT-11; irinotecan; TEM; transmission electron microscopy; cyro-TEM; cryogenic transmission electron microscopy; FDA; Food and Drug Administration; DDS; drug delivery system; EPR; enhanced permeability and retention;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Review articleZolpidem's use for insomnia

Keywords: CAP; cyclic alternating pattern; Cmax; maximum plasma concentration; CNS; central nervous system; ER; extended-release; GABA; γ-aminobutyric acid; GAD; generalized anxiety disorder; IR; immediate-release; LPS; latency to persistent sleep; MDD; major depr

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of different in vitro dissolution tests based on level A in vitro-in vivo correlations for fenofibrate self-emulsifying lipid-based formulations

Keywords: Af; absorbed API fraction without EHC; API; Active Pharmaceutical Ingredient; AUC; Area Under the Curve; BCS; Biopharmaceutics Classification System; Cmax; Maximal Concentration; CS; Saturation Concentration; DSC; Differential Scanning Calorimetry; EHC; E

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Toxicological evaluation of the flavour ingredient N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218)

Keywords: amu; atomic mass units; AUC; area under the curve; CBPI; cytokinesis-blocked proliferation index; CL; plasma clearance; Cmax; peak plasma concentration; CYP; cytochrome P450; EIC; extracted ion chromatogram; FDA; Food and Drug Administration; FEMA; Flavou

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential

Keywords: ADME; absorption, distribution, metabolism, and excretion; AML; acute myelogenous leukemia; AUC; area under the blood concentration time curve; b.i.d.; twice a day; CDK; Cyclin-dependent kinase; CLtotal; clearance; Cmax; maximum drug concentration; CRC; c

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, excretion balance, and tissue distribution of [14C]-labeled glycolipids and long chain fatty acids from Dacryopinax spathularia in rats

Keywords: Jelly mushroom glycolipids; Natural preservative; Bioavailability; Long chain fatty acids; AUC; area under the concentration versus time curve; BLQ; below the quantitation limit; CMC; carboxymethylcellulose; Cmax; peak concentration; DN; dose normalized;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Sitagliptin inhibit human lymphocytes proliferation and Th1/Th17 differentiation in vitro

Keywords: ADA; adenosine deaminase; CBA; cytometric bead array; Cmax; maximum concentration; DC; dendritic cells; DM1; type 1 diabetes mellitus; DPP-4; dipeptidyl peptidase-4; EGR2; early growth response 2; FBS; fetal bovine serum; GIP; glucose-dependent insulinotr

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats

Keywords: Gymnema sylvestre; Diabetes; Triterpenoids; Steroids; Pharmacokinetic; CYP450-Herb drug interaction; CYP; CytochromeP450; PK; Pharmacokinetics; GS; Gymnema sylvestre; HDI; Herb drug interaction; EL; Ethanolic extract; GA; Gymnemic acid; HRLC-MS; High reso

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine

Keywords: renal transporter; drug interactions; in vitro-in vivo correlation; renal clearance; inhibition; AUC; area under the concentration curve; CLcr; creatinine renal clearance; Cmax; maximal total plasma concentration; Cmax,u; maximal unbound plasma concen

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Tetrahydrocannabinol Does Not Reduce Pain in Patients With Chronic Abdominal Pain in a Phase 2 Placebo-controlled Study

Keywords: Marijuana; Chronic Pain; AE; Randomized Controlled Trial; AE; adverse event; AppLe; appetite level; AUC; area under the curve; CI; confidence interval; Cmax; maximum plasma concentration; CP; chronic pancreatitis; NRS; numeric rating scale; PGIC; patient

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)

Keywords: ABC; ATP-binding cassette; CYP; cytochrome P450; KTC; ketoconazole; MDR/MXR; multidrug/multixenobiotic resistance; P-gp; P-glycoprotein; PCN; pregnenolone 16α-carbonitrile; PXR; pregnane X-receptor; ARmax; maximum accumulation rate; Cmax; maximum concent

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model

Keywords: physiologically based pharmacokinetic modeling; transporters; statin; absorption; organic anion-transporting polypeptide; drug-drug interaction; AUC; area under the plasma concentration-time curve; Cmax; maximum plasma concentration; CLint,T; transporter-

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation

Keywords: AE; adverse event; AI; augmentation index; AUC; area under the curve; BID; twice daily; Cavg; average concentration; Cmax; maximal concentration; mg; milligrams; mL; milliliters; MPI; myocardial performance index; ng; nanograms; PAT; peripheral arterial t

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data - A case study with caffeine

Keywords: AUC; area under the curve; BMDL; benchmark dose lower confidence interval; Cmax; maximum concentration; HLV; human limit value; MOE; margin of exposure (synonymous to MOS); MOIE; margin of internal exposure; MOS; margin of safety; NOAEL; no observed adver

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Keywords: API; active pharmaceutical ingredient; AUC; area under the curve; BCS; biopharmaceutics classification system; BP; blood-to-plasma ratio; Cmax; maximum concentration; CL; clearance; Do; dose number according to BCS; DDI; drug-drug interaction; EFPIA; Euro

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Keywords: AFE; Average Fold Error; AAFE; Absolute Average Fold Error; API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CCC; Concordance Correlation Coeffici

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2017 سفارش ترجمه

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Keywords: API; Active pharmaceutical ingredient; AUC; Area under the curve; BCS; Biopharmaceutics classification system; BE; Bioequivalence; BP; Blood-to-plasma ratio; CL; Clearance; CL/F; Apparent clearance; Cmax; Maximum concentration; Do; Dose number; fa; Fracti

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Coloaded Nanoparticles of Paclitaxel and Piperlongumine for Enhancing Synergistic Antitumor Activities and Reducing Toxicity

Keywords: paclitaxel; piperlongumine; nanoparticles; synergistic effect; 5-FU; 5-fluorouracil; C6; Coumarin-6; Cmax; maximum concentration; CD31; cluster of differentiation 31; CI; combination index; CLSM; confocal laser scanning microscopy; DL; drug loading; DMEM;

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2017 سفارش ترجمه

Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice

Keywords: Metformin; OCT3; Transporter; Intestinal absorption; Bioavailability; Mouse; AUC; area under the plasma concentration-time curve; CL; clearance; Cmax; maximum concentration; OCT/Oct; organic cation transporter; SLC; solute carrier; tmax; time to maximum

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs

Keywords: ANOVA; analysis of variance; AUC; area under the curve; Cmax; maximum plasma concentration; DLA; dilauroyl apomorphine; DPA; dipalmitoyl apomorphine; Frel; relative oral bioavailability; GI; gastrointestinal; HPLC; high performance liquid chromatography;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling

Keywords: clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant

Keywords: (2R,4R)-Monatin; QT prolongation; QTc; TQT study; Food ingredient; ADME; absorption, distribution, metabolism, and elimination; AE; adverse event; Ae; amounts excreted; AUC0-inf; area under the plasma concentration-time curve to infinite time; AUC0-t; a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

Keywords: AP; cardiac action potential; CiPA; comprehensive in vitro proarrhythmia assay; CSRC; Cardiac Safety Research Consortium; Cmax; maximal plasma concentration; CTWG; clinical translational working group; DRest; rate-normalized Tpeak − Tend = Tpe inter

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients

Keywords: clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors

Keywords: AcOH; acetic acid; Ang I; angiotensin I; Ang II; angiotensin II; AUC; area under the blood concentration-time curve; C5min; concentration in plasma 5 min after administration; CLtotal; total clearance; Cmax; maximum concentration in plasma; DIEA; N,N-d

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

CYP2C8-mediated interaction between repaglinide and steviol acyl glucuronide: In vitro investigations using rat and human matrices and in vivo pharmacokinetic evaluation in rats

Keywords: CYP2C8; Steviol acyl glucuronide; Repaglinide; Reversible inhibition; Food-drug interaction; AUC; area under the plasma time-concentration curve; Cmax; plasma maximum concentration; CYP; cytochrome P450; HLM; human liver microsomes; RLM; rat liver microso

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection

Keywords: Antibiotic risk factors; Beta-lactamase; Clostridium difficile; Healthcare-associated infections; Microbiome; AAD; antibiotic-associated diarrhea; CDI; Clostridium difficile infection; Conc; concentration; Cmax; maximum concentration; CRO; ceftriaxone; FM

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Deglycosylation and absorption of marein, flavanomarein and taxifolin-7-O-β-D-glucopyranoside from capitula of Coreopsis tinctoria in rats and humans

Keywords: Coreopsis tinctoria; Flavonoid glycoside; Flavonoid aglycone; Pharmacokinetic profile; Deglycosylation; TDG; taxifolin-7-O-β-D-glucopyranoside; CCT; the capitula of Coreopsis tinctoria; CCTE; the extract of CCT; GIT; gastrointestinal tracts; AUC; the are

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه