Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid; OPC; oligodendrocyte precursor cell; MBP; myelin basic protein; PDGFRα; platelet-derived growth factor receptor alpha; CNPase; cyclic nucleotide phosphodiesterase; olig2; oligodendrocyte transcr
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Keywords: BDNF; brain-derived neurotrophic factor; BrdU; 5-bromo-2â²-deoxyuridine; CFA; complete Freund's adjuvant; CNPase; 2â²,3â²-Cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; DCX; doublecortin; DG; dentate gyrus; EAE; experimental aut
Keywords: BrdU; 5-bromo-2â²-deoxyuridine; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; DAPI; 4â²,6-diamidino-2-phenylindole; EYFP; enhanced fluorescent yellow protein; GFP; green fluorescent protein; GST-pi; glutathione S-transferase pi; NeuN; neur
Keywords: Cuprizone (CPZ); Expression microarray; Myelination; Synaptic transmission; KLOTHO; Glial cell development; ACHE; acetylcholinesterase; CCL2; chemokine (C-C motif) ligand 2; CD68; cluster of differentiation 68; CPZ; cuprizone; CT; threshold cycle; CNPas
Keywords: CNPase; 2â²,3â²-cyclic-nucleotide 3â²-phosphodiesterase; H&E; hematoxylin and eosin; HI; hypoxic ischemic; HIE; hypoxic-ischemic encephalopathy; IQR; interquartile range; IV; intravenous; MAP; mean arterial blood pressure; PBS; phosphate-buffered salin
Keywords: WJ; Wharton's jelly; UC; umbilical cord; MSC; mesenchymal stromal (stem) cells; WJMSC; Wharton's jelly mesenchymal stromal cells; HLA; human leukocyte antigen; HSC; hematopoietic stem cells; GvHD; graft versus host disease; NK; natural killer; TNF; tumor
Keywords: CNPase; 2-3-cyclic nucleotide 3-phosphodiesterase; GFAP; glial fibrillary acidic protein; MAP2; microtubule-associated protein 2; OD; ocular dominance; PB; phosphate buffer; PBS; phosphate-buffered saline; PBS-T; PBS containing 0.3% Triton X-100; RT; room
Keywords: A.U.; arbitrary units; CIE; chronic intermittent ethanol; CNPase; 2â², 3â²-cyclic nucleotide 3â²-phosphodiesterase; deNFP; dephosphorylated neurofilament protein; EM; electron microscopy; EtOH; ethanol; IR; immunoreactivity; LFB; Luxol Fast Blue; MBP;
Keywords: AKT1; serine-threonine-specific protein kinase AKT-PKB; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH; basic helix-loop-helix transcription factor; BMP; bone morphogenic protein; BMP2; bone morphogenic protein 2
Keywords: AII; angiotensin II; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; Ara-C; cytosine-β-d-arabino-furanoside; DIV; days in vitro; DMT1; divalent metal transporter 1; Fp1; ferroportin 1; IL-1 β; Interleucin 1 β; NAC; N-acetyl-cysteine; PD; Pa
Keywords: APP; amyloid precursor protein; CGalT; ceramide galactosyltransferase; CNPase; 2â²3â²cyclic nucleotide 3â²phosphodiesterase; COX; cytochrome c oxidase; CSF; cerebrospinal fluid; DAB; diaminobenzidine; DG; dentate gyrus; ELISA; enzyme linked immunosorbe
Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis
Keywords: BSYSC; Bu Shen Yi Sui capsule; CNPase; 2â²,3â²-cyclic nucleotide-3â²-phosphodiesterase; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; LIF; leukemia inhibitory factor; LIFR; leukemia inhibitory factor receptor; MOG; myelin
Minocycline plus N-acetylcysteine protect oligodendrocytes when first dosed 12 hours after closed head injury in mice
Keywords: CCI; controlled cortical impact; CC3; Cleaved caspase 3; CHI; closed head injury; CNPase; 2',3'-Cyclic-nucleotide 3'-phosphodiesterase; MINO; minocycline; NAC; n-acetylcysteine; PLP; proteolipid protein; TBI; traumatic brain injury; Traumatic brain injury
Research PaperThe toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury
Keywords: 2PE; Two-photon excitation; CNPase; 2â²-3â²-cyclic nucleotide 3â²-phosphodiesterase; Pam3CSK4; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-[R]-cysteinyl-[S]-seryl-[S]-lysyl-[S]-lysyl-[S]-lysyl-[S]- lysine; SCI; Spinal cord injury; TLR; Toll-like
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
Keywords: PD; Parkinson's disease; DLB; dementia with Lewy bodies; MSA; multiple system atrophy; HNE; 4-hydroxy-2-nonenal; GFAP; glial fibrillary acidic protein; CNPase; 2â²,3â²-cyclic-nucleotide 3â²-phosphodiesterase; mAb; monoclonal antibody; IgG; immunoglobul
Developmental cuprizone exposure impairs oligodendrocyte lineages differentially in cortical and white matter tissues and suppresses glutamatergic neurogenesis signals and synaptic plasticity in the hippocampal dentate gyrus of rats
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; CaMK; calcium/calmodulin-dependent kinase; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; COX2; cyclooxygenase-
Selective and compartmentalized myelin expression of HspB5
Keywords: CNPase; 2â²,3â²-Cyclic-Nucleotide 3â²-Phosphodiesterase; CNS; central nervous system; EDTA; ethylenediaminetetraacetic acid; MAP; microtubule-associated protein; MBP; myelin basic protein; MS; multiple sclerosis; MT; microtubule; NG2; neuron-glial anti
ReviewStructural and functional evolution of 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase
Keywords: CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; N4BP2; NEDD4 binding protein 2; PFKFB; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; PNK; polynucleotide kinase; RICH; regeneration-induced CNPase homolog; Trl1; tRNA ligase; Myelin prote
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system
Keywords: Tβ4; thymosin beta 4; MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; OPC; oligodendrocyte progenitor cell; EGFR; epidermal growth factor receptor; pEGFR; phosphorylated EGFR; APP; amyloid beta/A4 precursor protein; BrdU; bromodeo
Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder
Keywords: Postmortem; Myelin; CNPase; MOG; PLP1; OLIG1;
Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis
Keywords: MS; multiple sclerosis; CNS; central nervous system; S1P; sphingosine 1-phosphate; BBB; blood-brain barrier; OPC; oligodendrocyte progenitor cell; Shh; sonic hedgehog; Smo; smoothened; EAE; experimental autoimmune encephalomyelitis; PLP; myelin proteoli
Treatment with UDP-glucose, GDNF, and memantine promotes SVZ and white matter self-repair by endogenous glial progenitor cells in neonatal rats with ischemic PVL
Keywords: BrdU; 5-bromodeoxyuridine; CNPase; 2â²,3â²-cyclic-nucleotide 3â²-phosphodiesterase; GDNF; glial cell line-derived neurotrophic factor; GPR17; G protein-coupled receptor 17; MBP; myelin basic protein; Mem; memantine; NG2; neuron glial antigen 2; NMDA; N
Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta
Keywords: Parkinson's disease; Autopsied human midbrains; Stereology; Morphometry; Densitometry; GFAP; CNPase; Iba1; S100β;
Meningeal inflammation and demyelination in a patient clinically diagnosed with acute disseminated encephalomyelitis
Keywords: Meningeal inflammation; Demyelination; Acute disseminated encephalomyelitis; Tumefactive multiple sclerosis; B lymphocyte; CNPase;
Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the FcγR I and TLR4 pathways
Keywords: 6-OHDA; 6-hydroxydopamine; AEC; 3-amino-9-ethyl-carbazole; CNPase; cyclic nucleotide 3â²-phosphohydrolase; CNS; central nervous system; DA; dopaminergic; FcγRI; Fc gamma receptor I; FcγRs; Fc gamma receptors; GFAP; glial fibrillary acidic protein; hVLJ
Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation
Keywords: HOG; human oligodendroglioma; ODGs; oligodendrogliomas; OPCs; oligodendrocyte progenitor cells; Shh; sonic hedgehog; SFRP1; secreted frizzled related protein; Sox17; SRY-Box containing gene 17; CNPase; 2â²,3â²-cyclic-nucleotide 3â²-phosphodiesterase; M
Research ReportWhite matter and SVZ serve as endogenous sources of glial progenitor cells for self-repair in neonatal rats with ischemic PVL
Keywords: SVZ; subventricular zone; WM; white matter; PVL; periventricular leukomalacia; OGD; oxygen glucose deprivation; OLs; oligodendrocytes; GPR17; G protein-coupled receptor 17; BrdU; 5-bromodeoxyuridine; NG2; neuron glial antigen 2; CNPase; 2â²,3â²-cyclic-n
Increase in phosphorylation of PDK1 and cell survival after acute spinal cord injury
Keywords: PDK1; 3-Phosphoinositidedependent protein kinase-1; PKB; protein kinase B; PIP3; phosphoinositol 3,4,5-triphosphate; CNS; Central nervous system; SCI; Spinal cord injury; SDS; Sodium dodecyl sulfate; PAGE; Polyacrylamide gel electrophoresis; BSA; Bovine s
Investigation of autoantibody profiles for cerebrospinal fluid biomarker discovery in patients with relapsing-remitting multiple sclerosis
Keywords: AUC; area under curve; BIND; biomolecular interaction network database; CNPase; 2â², 3â²-cyclic nucleotide 3â²-phosphodiesterase; CSF; cerebrospinal fluid; EBNA-1; Epstein-Barr nuclear antigen 1; FDR; false discovery rate; HSP; heat shock protein; IM
Valproic acid increases white matter repair and neurogenesis after stroke
Keywords: BSA; bovine serum albumin; BrdU; bromodeoxyuridine; CNPase; 2â³,3â³-cyclic nucleotide 3â²-phosphodiesterase; DAPI; 4â²,6â²-diamidino-2-phenylindole; DCX; doublecortin; GFAP; glial fibrillary acidic protein; GLT1; glutamate transporter 1; HDAC; histon
Basic NeuroscienceLentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons
Keywords: ALS; Amyotrophic Lateral Sclerosis; ChAT; choline acetyl transferase; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; EF1a; elongation factor 1 alpha; GFAP; Glial Fibrillary Acidic Protein; MAP2; microtubule-associated protein 2; MBP; Myelin B
Immunohistochemical demonstration of increased prostaglandin F2α levels in the rat hippocampus following kainic acid-induced seizures
Keywords: ANOVA; analysis of variance; AOI; areas of interest; BSA; bovine serum albumin; CA; cornu Ammonis; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; DG; dentate
Research ReportzRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin
Keywords: BCIP; 5-bromo-4-chloro-3-indolyl phosphate; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; GAP; growth associated protein; NBT; nitroblue tetrazolium; NGF; nerve growth factor; PAGE; polyacrylamide gel electrophoresis; RGC; retinal ganglion c
Conditionally immortalised neural stem cells promote functional recovery and brain plasticity after transient focal cerebral ischaemia in mice
Keywords: MHP36, Maudsley hippocampal murine neural stem cell line clone 36; MCAO, transient middle cerebral artery occlusion; CBF, cerebral blood flow; NAC, N-acetyl-l-cysteine; MAP-2, microtubule-associated protein 2; GFAP, glial fibrillary acidic protein; CNPase
Regular ArticleAdult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination
Keywords: EGFP; enhanced green fluorescent protein; CNPase; 2-3-cyclic nucleotide 3-phosphodiesterase; OLG; oligodendrocyte; WT; wild type; CPZ; cuprizone; OPC; oligodendroglial progenitor cell; MS; multiple sclerosis; CNS; central nervous system; CC; corpus call
Caveolin-1 inhibits oligodendroglial differentiation of neural stem/progenitor cells through modulating β-catenin expression
Keywords: Cav-1; caveolin-1; Cav-1 KO mice; caveolin-1 knockout mice; NPCs; neural progenitor cells; GalC; galactocerebroside; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; siRNA; small interfering RNA; Con P; Cav-1 scrambled control peptide; Cav P; C
Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation
Keywords: BCA; bicinchoninic acid; BSA; bovine serum albumin; CA; carnosic acid; CNPase; cyclic nucleotide phosphohydrolase; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immumosorbent assay; E
Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis
Keywords: CNPase; 2â²,3â²-Cyclic Nucleotide 3â²-Phosphodiesterase; dpi; days post MOG immunization; EAE; Experimental Autoimmune Encephalomyelitis; GFAP; Glial Fibrillary Acidic Protein; GRP; glial restricted progenitor; GST-Ï; glutathione S-transferase isoform
The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo
Keywords: solasodine; neurogenesis; TSPO; neurosteroids; GAP43; subventricular zone; AD; Alzheimer's disease; ChAT; choline acetyltransferase; CNPase; 2â²,3â²-cyclic nucleotide 3â² phosphodiesterase; DCX; doublecortin; DMSO; dimethyl sulfoxide; GABA-A; gamma-ami
Isolation rearing in rats: Effect on expression of synaptic, myelin and GABA-related immunoreactivity and its utility for drug screening via the subchronic parenteral route
Keywords: AcbC; Nucleus accumbens core; AcbSh; Nucleus accumbens shell; Amy; Amygdala; CA1; Hippocampal CA1 subfield; CA2; Hippocampal CA2 subfield; CA3; Hippocampal CA3 subfield; CNPase; 2â²,3â²-Cyclic nucleotide 3â²-phosphodiesterase; CPu; Caudate putamen; DG;
Voxel-based analysis of postnatal white matter microstructure in mice exposed to immune challenge in early or late pregnancy
Keywords: DTI; VBM; FA; CNPase; PolyIC; Prefrontal-striatal-limbic circuits;
Intercellular calcium signaling between astrocytes and oligodendrocytes via gap junctions in culture
Keywords: glial cells; Ca2+ wave; connexin 43; connexin 47; BSA; bovine serum albumin; Ca2+; calcium ion; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesteras; Cx; connexin; DAB; 3,3â² diaminobenzidine; eGFP; enhanced green fluorescent protein; GFAP; glial fi
High resolution in situ zymography reveals matrix metalloproteinase activity at glutamatergic synapses
Keywords: CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; DQ; dye-quenched; GFAP; glial fibrillary acidic protein; GluR2/3; glutamate receptor subunits 2 and 3; ICAM-5; intracellular adhesion molecule 5; LTP; long-term potentiation; MMP; matrix metallop
The septin cytoskeleton in myelinating glia
Keywords: CNP; CNPase; CNS; central nervous system; GST; glutathione-S-transferase; MAL; myelin and lymphocyte protein; MBP; myelin basic protein; OPC; oligodendrocyte precursor; P#; postnatal day #; P0; protein zero; PNS; peripheral nervous system; Sept; septin; S
Myelin glycoproteins targeted by lead in the rodent model of prolonged exposure
Keywords: CNS; central nervous system; CNPase; 2â²3â² cyclic nucleotide 3â²-phosphodiesterase; EPR; electron paramagnetic resonance; M16NS; methyl 16â²doxylostearate stearate; MAG; myelin-associated glycoprotein; MOG; myelin oligodendrocyte glycoprotein; TMA-DP
Cellular responses in the spinal cord during development of hypomyelination in the mv rat
Keywords: EGF; epidermal growth factor; CNS; central nervous system; PLP; proteolipid protein; GFAP; glial fibrillary acidic protein; PCR; polymerase chain reaction; PFA; paraformaldehyde; PB; phosphate buffer; PBS; phosphate-buffered saline; CNPase; 2â², 3â²-cyc
Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in adult rat cerebral cortex in vivo
Keywords: oligodendrocyte progenitor cells; NG2; CNPase; RIP; BrdUBrdU, 5-bromodeoxyuridine; CNPase, 2′,3′-cyclic nucleotide 3′-phosphodiesterase; GST, glutathione S-transferase; PBS, phosphate-buffered saline; PBST, 0.3% Triton X-100 in phosphate-buffered saline
Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS
Keywords: ATP; adenosine triphosphate; bHLH; basic helix-loop-helix; BMP; bone morphogenic protein; BrdU; bromodeoxy uridine; CD44; cell determinant-44; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNTF; ciliary neurotrophic factor; CXCR4; receptor f
A novel neuronal cell line derived from the ventrolateral region of the suprachiasmatic nucleus
Keywords: circadian rhythm; N14.5; NMDA; NR2B subunit; MAPK; suprachiasmatic nucleus; AVP; arginine vasopressin; bFGF; basic fibroblast growth factor; CNPase; 2â²-3â²-cyclic-nucleotide 3â²-phosphodiesterase; dbcAMP; dibutyryl cAMP; Dex; dexamethasone; EGF; epide
Expression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in the amoeboid microglial cells in the developing rat brain
Keywords: CNPase; amoeboid microglial cells; development; rat; lipopolysaccharideAMC, amoeboid microglial cells; CNPase, 2′,3′-cyclic nucleotide 3′-phosphodiesterase; CNP-IR, CNPase-immunoreactive; DAB, 3–3′ diaminobenzidine tetrahydrochloride; DMEM, Dulbecco’s mod