Keywords: منطقه تعریف مکمل; Asp-N; endoproteinase AspN; BLA; biologics license application; CDR; complementarity determining region; CFR; Code of Federal Regulations; CGF; carboxyl group footprinting; cGMP; current good manufacturing practice; CHO; Chinese hamster ovary; CID; collis
مقالات ISI منطقه تعریف مکمل (ترجمه نشده)
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Keywords: منطقه تعریف مکمل; IgV; immunoglobulin variable; rHA; recombinant haemagglutinin; H; heavy; L; light; D; diversity; J; joining; K; kappa; IMGT; ImMunoGeneTics; CDR; complementarity determining region; BCR; B-cell receptor; PBMC; peripheral blood mononuclear cell; Influenza
Keywords: منطقه تعریف مکمل; BM; bone marrow; CDR; complementarity determining region; H; heavy; PB; peripheral blood; V; variable; Antibody; Antibody repertoire; Bioinformatics; Germline gene; Germline gene inference; Haplotype; Heavy chain variable domain;
Identification and characterization of monoclonal antibody fragments cleaved at the complementarity determining region using orthogonal analytical methods
Keywords: منطقه تعریف مکمل; CE-SDS; sodium dodecyl sulfate capillary electrophoresis; mAb; monoclonal antibody; RP-LC-MS; reversed phase liquid chromatography mass spectrometry; CDR; complementarity determining region; SEC-HPLC; size exclusion liquid chromatography; dSEC-HPLC; d
Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: A review
Keywords: منطقه تعریف مکمل; Immunoassay; Multianalyte analysis; Antibody; Food; Environmental; BSA; bovine serum albumin; CAMM; computer-assisted molecular modeling; CCD; charge-coupled device; CDR; complementarity determining region; CR; cross-reactivity; CoMFA; comparative molecu
Keywords: منطقه تعریف مکمل; NP; (4-hydroxy-3-nitrophenyl)acetyl; NIP; (4-hydroxy-3-iodo-5-nitrophenyl)acetyl; NNP; (4-hydroxy-3,5-dinitrophenyl)acetyl; CDR; complementarity determining region; SHM; somatic hypermutation; HEL; hen egg lysozyme; Ka; equilibrium associa tion constant;
Keywords: منطقه تعریف مکمل; IgG; Immunoglobulin G; VH; Heavy chain variable; CH; Heavy chain constant; VL; Light chain variable; CL; Light chain constant; Fab; Antigen-binding fragment; Fc; Crystallizable fragment; CDR; Complementarity determining region; Fv; Variable fragment; scFv
Keywords: منطقه تعریف مکمل; Antigen-antibody complex; Complementarity determining region; Binding free energy; Molecular dynamics simulation; Energetic contribution; Amino acid residues;
Keywords: منطقه تعریف مکمل; Humanization; Phosphospecific antibody; Phosphothreonine-binding motif; Chicken antibody; Antibody engineering; CDR; complementarity determining region; VH; heavy chain variable domain; VL; light chain variable domain;
Keywords: منطقه تعریف مکمل; ADCC; antibody-dependent cellular cytotoxicity; CDC; complement-dependent cytolysis; CDR; complementarity determining region; Fab; fragment antigen binding; H; antibody heavy chain; L; antibody light chain; Le; Lewis glycan epitope; PDB; protein data bank
Keywords: منطقه تعریف مکمل; 2D; two-dimensional; 3D; three-dimensional; CDR; complementarity determining region; CMC; chemistry, manufacturing and control; CPCA; composite protein for clinical applications; CS; canonical structure; EMBL-EBI; EMBL European Bioinformatics Institute; F
Keywords: منطقه تعریف مکمل; Variable domain of heavy-chain antibody; Inhibition of protein misfolding and aggregation; Protein misfolding diseases; Amyloidoses; VHH; Nanobody; Ab; antibody; Aβ; amyloid β-peptide; AD; Alzheimer's disease; ANS; anilino naphthalene-sulfonic acid; AP;
Structural insights into chemokine CCL17 recognition by antibody M116
Keywords: منطقه تعریف مکمل; mAb; monoclonal antibody; DTT; dithiothreitol; PEG; polyethylene glycol; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid; CDR; complementarity determining region; VH; variable domain of the heavy chain; VL;
Critical steps for computational inference of the 3â²-end of novel alleles of immunoglobulin heavy chain variable genes - illustrated by an allele of IGHV3-7
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; D; diversity; H; heavy; IG; immunoglobulin; J; joining; N; non-templated; NGS; next generation sequencing; P; palindromic; V; variable; Antibody; Bioinformatics; Germline gene allelic diversity; Germline gene infer
Identification of the cognate peptide-MHC target of T cell receptors using molecular modeling and force field scoring
Keywords: منطقه تعریف مکمل; TCR; T cel receptors; MHC; Major Histocompatibility Complex; IEDB; immune epitope database; HLA; human leukocyte antigen; CDR; complementarity determining region; RMSD; root mean square deviation; PDB; Protein Data Bank; MCM; Monte Carlo Method; AUC; area
The functional 3â²-end of immunoglobulin heavy chain variable (IGHV) genes
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; D; diversity; H; heavy; IG; immunoglobulin; J; joining; L; light; N; non-templated; NGS; next generation sequencing; P; palindromic; RSS; recombination signal sequence; V; variable; Antibody; Complementarity determ
Possible involvement of invariant natural killer T cells and mucosal-associated invariant T cells in a murine model of titanium allergy
Keywords: منطقه تعریف مکمل; CDR; Complementarity determining region; TRAT; cell receptor alpha; TRAJT; cell receptor alpha joining; TRAVT; cell receptor alpha variable; TRBT; cell receptor beta; TRBJT; cell receptor beta joining; TRBVT; cell receptor beta variable; iNKT; cells invar
Highly Selective Rational Design of Peptide-Based Surface Plasmon Resonance Sensor for Direct Determination of 2,4,6-trinitrotoluene (TNT) Explosive
Keywords: منطقه تعریف مکمل; TNT binding peptide; Amino acid sequence; Complementarity determining region; Surface plasmon resonance sensor;
Crystal structure of tissue factor in complex with antibody 10H10 reveals the signaling epitope
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; CHES; N-cyclohexyl-2-aminoethanesulfonic acid; ECD; extracellular domain; EDTA; ethylenediaminetetraacetic acid; FVII; coagulation factor VII; FX; coagulation factor X; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanes
Microbial F-type lectin domains with affinity for blood group antigens
Keywords: منطقه تعریف مکمل; F-type lectin domain; Fucose; Blood group antigens; Myxococcus hansupus FLD; Cyanobium sp. FLD; Leucothrix mucor FLD; FLD; F-type Lectin Domain; CyFkbMFLD; Cyanobium sp. PCC 7001 FkbMFLD; CyFLD; Cyanobium sp. PCC 7001 FLD; MhFLD1; Myxococcus hansupus FLD1
Construction and sequencing analysis of scFv antibody fragment derived from monoclonal antibody against norfloxacin (Nor155)
Keywords: منطقه تعریف مکمل; Complementarity determining region; Fluoroquinolone; Norfloxacin; Single chain variable fragment;
Usefulness of the ElliPro epitope predictor program in defining the repertoire of HLA-ABC eplets
Keywords: منطقه تعریف مکمل; CDR; Complementarity Determining Region; ElliPro; derived from Ellipsoid and Protrusion; HLA; Human Leukocyte Antigen; PDB; Protein Database; HLA epitope; Antibody-verified epitope; Eplet; Epitope registry;
Research paperAccurate quantitation for in vitro refolding of single domain antibody fragments expressed as inclusion bodies by referring the concomitant expression of a soluble form in the periplasms of Escherichia coli
Keywords: منطقه تعریف مکمل; CD; Circular Dichroism; ELISA; enzyme-linked immunosorbent assay; TCDR; three-step cold dialysis refolding; OHDR; one-step hot dialysis refolding; OCDR; one-step cold dialysis refolding; CDR; complementarity determining region; HV; hypervariable region; C
Site-specific photocoupling of pBpa mutated scFv antibodies for use in affinity proteomics
Keywords: منطقه تعریف مکمل; β-CD; β-cyclodextrin; CDR; complementarity determining region; FW; framework; pBpa; p-benzoyl-l-phenylalanine; scFv; single-chain Fragment variable antibody; UUA; unnatural amino acid; Antibody microarray; scFv antibodies; Antibody engineering; Dock'n'F
Anti-dsDNA antibodies and resident renal cells - Their putative roles in pathogenesis of renal lesions in lupus nephritis
Keywords: منطقه تعریف مکمل; C1q; complement 1q; CDR; complementarity determining region; CLIFT; Crithidia luciliae indirect immunofluorescence test; CTX; cyclophosphamide; dsDNA; double-stranded deoxyribonucleic acid; ELISA; enzyme-link immunosorbent assay; ER; endoplasmic reticulum
Eculizumab epitope on complement C5: Progress towards a better understanding of the mechanism of action
Keywords: منطقه تعریف مکمل; aHUS; atypical hemolytic and uremic syndrome; C5; complement protein C5; CDR; complementarity determining region; CVF; cobra venom factor; DMSO; dimethylsulfoxyde; ECZ; eculizumab; Fab; fragment antigen binding; Fv; fragment variable; mAb; monoclonal anti
Full length articleNext generation sequencing of all variable loops of synthetic single framework scFv-Application in anti-HDL antibody selections
Keywords: منطقه تعریف مکمل; CAD; coronary artery disease; CDR; complementarity determining region; HDL; high density lipoprotein; LDL; low density lipoprotein; NGS; next generation sequencing; scFv; single-chain variable fragment; scFv; Antibody library; Phage display; Next generati
Selection and characterization of single domain antibodies against human CD20
Keywords: منطقه تعریف مکمل; RTX; rituximab; SdAb; single domain antibody; CDR; complementarity determining region; FR; framework region; Bt; biotinylated; NA-PE; NeutrAvidin-phycoerythrin conjugate; Ab; antibody; CDC; complement-dependent cytotoxicity; CD20; Single domain antibody
Single B-cell deconvolution of peanut-specific antibody responses in allergic patients
Keywords: منطقه تعریف مکمل; Peanut; allergy; B cell; antibody; IgE; IgG4; immunotherapy; high-throughput DNA sequencing; antigen specific; allergen specific; repertoire; somatic mutation; CDR; Complementarity determining region; IGHD; Immunoglobulin heavy chain D; IGHJ; Immunoglobul
Phage display aided improvement of a unique prostate-specific antigen (PSA) antibody unreactive with Lys145-Lys146 internally cleaved forms
Keywords: منطقه تعریف مکمل; PSA; prostate-specific antigen; fPSA; free prostate-specific antigen; fPSA-I; intact free prostate-specific antigen; fPSA-N; internally cleaved “nicked” free prostate-specific antigen; proPSA; pro-form of prostate-specific antigen; BPH; benign prostat
IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome
Keywords: منطقه تعریف مکمل; ALPS; Bim; Bcl-2 pathway; IL-10; BH3 mimetic; ABT-737; T cell homeostasis; double negative T cells; apoptosis; ALPS; Autoimmune lymphoproliferative syndrome; CDR; Complementarity determining region; DNTC; Double negative T cells; IL-10R; IL-10 receptor; J
The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody
Keywords: منطقه تعریف مکمل; Alzheimer's disease; ScFv MO6 antibody; Aβ42 aggregate; Neurotoxicity; Mechanism; AD; Alzheimer's disease; CDR; complementarity determining region; scFv; single-chain variable fragment; VH; variable heavy; VL; variable light;
ReviewTargeting FcRn for the modulation of antibody dynamics
Keywords: منطقه تعریف مکمل; Abdeg; antibodies that enhance IgG degradation; CDR; complementarity determining region; Epo; erythropoietin; HMEC; human microvasculature-derived endothelial cells; ITP; idiopathic thrombocytopenic purpura; IC; immune complex; IL-6; interleukin-6; IL-6R;
Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; Dmax; maximum particle distance; FBS; fetal bovine serum; GAM; goat anti-mouse; HABD; hyaluronate-binding domain; HSQC; heteronuclear single quantum coherence; I(0); forward scattering; IPTG; isopropyl β-d-1-thiog
PURE ribosome display and its application in antibody technology
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; ELISA; enzyme-linked immunosorbent assay; ER; enrichment ratio; Fab; fragment antigen binding; KinExA; kinetic exclusion assay; Kd; dissociation constant; ORF; open reading frame; PURE system; Protein synthesis Usi
T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: Towards tumor-directed oligoclonal T cell therapy
Keywords: منطقه تعریف مکمل; CAR; chimeric antigen receptor; CDR; complementarity determining region; HCAb; heavy-chain antibodies; IPTG; isopropyl-β-D-thio-galactoside; MHC; major histocompatibility complex; TAG 72; tumor associated glycoprotein 72; TCR; T cell receptor; TMB; 3,3â
Retrocyte Display® technology: Generation and screening of a high diversity cellular antibody library
Keywords: منطقه تعریف مکمل; A-MuLV; Abelson murine leukemia virus; BCR; B cell receptor; BiP; binding immunoglobulin protein; CDR; complementarity determining region; DR6; death receptor 6; FACS; fluorescence activated cell sorting; FCS; fetal calf serum; IRES; internal ribosome ent
Comparative functional characterization of canine IgG subclasses
Keywords: منطقه تعریف مکمل; ADCC; antibody-dependent cell-mediated cytotoxicity; CDC; cell-mediated cytotoxicity; CDR; complementarity determining region; Canine; Immunoglobulin; IgG subclass; Fc receptor; Effector functions;
Analysis of heavy and light chain sequences of conventional camelid antibodies from Camelus dromedarius and Camelus bactrianus species
Keywords: منطقه تعریف مکمل; C1q; multivalent complex and immunoglobulin binding component of the complement activation cascade; CDR; complementarity determining region; CH1 CH2 & CH3; first, second and third heavy chain constant region domains; FcRn; neonatal Fc receptor; Cκ; kappa
Ligation-based assembly for constructing mouse synthetic scFv libraries by chain shuffling with in vivo-amplified VH and VL fragments
Keywords: منطقه تعریف مکمل; LYS; hen egg lysozyme; BSA; bovine serum albumin; S.A.; streptavidin; EMCS; N-(6-maleimidocaproyloxy) succinimide; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CDR; complementarity determining region; HCDR; VH-CDR; Fw; framework region
The Global Sequence Signature algorithm unveils a structural network surrounding heavy chain CDR3 loop in Camelidae variable domains
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; FR; framework; GSS; Global Sequence Signature analysis; Ig; immunoglobulin G; MSA; multiple sequence alignment; MDS; multidimensional scaling; PCA; principal component analysis; SCA; statistical coupling analysis;
Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; CEA; carcinoembryonic antigen; EGFR; epidermal growth factor receptor; HER2; human epidermal growth factor receptor 2; MAbs; monoclonal antibodies; MGL; macrophage galactose-type C-type lectins; MMR; macrophage man
Monoclonal Antibodies for Therapeutic Use: Specific Characteristics of Clinical Development, Evaluation by the Agencies, and Long-term Monitoring of Safety
Keywords: منطقه تعریف مکمل; monoclonal antibodies; clinical trials, phase I; clinical trials, phase II; clinical trials, phase IV; ADCC; antibody dependent cellular cytotoxicity; (ex-)Afssaps; ex-Agence française de sécurité sanitaire des produits de santé (at present french Nat
MH2c: Characterization of major histocompatibility α-helices - an information criterion approach
Keywords: منطقه تعریف مکمل; MH2c; MH helix curves (name of software); TR; T cell receptor; p; peptide; MH; major histocompatibility; MH1; major histocompatibility class I; MH2; major histocompatibility class II; G; binding groove; CDR; complementarity determining region; MD; Molecul
Free immunoglobulin light chain: Its biology and implications in diseases
Keywords: منطقه تعریف مکمل; Ag; Antigen; BCR; B-cell receptor; pre-B cells; Precursor B-cells; CDR; Complementarity determining region; CH; Heavy chain constant domain; CL; Light chain constant domain; ER; Endoplasmic reticulum; FLC; Free immunoglobulin light chain; Ig; Immunoglobul
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; gRNA; guide RNA; KREL; kinetoplastid RNA-editing ligase; KREPA6; kinetoplastid RNA-editing interaction protein A6; KRET2; kinetoplastid RNA-editing TUTase 2; KREX2; kinetoplastid RNA-editing 3â²Â â 5â²-exonucl
Purification and functional characterization of a Camelid-like single-domain antimycotic antibody by engineering in affinity tag
Keywords: منطقه تعریف مکمل; CDR; complementarity determining region; ELISA; enzyme-linked immunosorbent assay; HM-1; HM-1 killer toxin; His6; 6Ã-histidine; IMAC; immobilized metal affinity chromatography; IPTG; isopropyl β-d-1-thiogalactopyranoside; nmAb-KT; HM-1 killer toxin neut
In vitro antiviral activity of single domain antibody fragments against poliovirus
Keywords: منطقه تعریف مکمل; VHH; variable part of the heavy chain of a heavy chain antibody; mAb; monoclonal antibody; CDR; complementarity determining region; Anti-poliovirus compound; Poliovirus; Antiviral; VHH; Nanobody;
ReviewCharacterisation of a panel of anti-tetanus toxin single-chain Fvs reveals cooperative binding
Keywords: منطقه تعریف مکمل; B-TeNT-Hc; biotinylated TeNT-Hc; bp; base pairs; BSA; bovine serum albumin; CDR; complementarity determining region; CNS; central nervous system; CRAb; chelating recombinant antibody; ELISA; enzyme linked immunosorbant assay; E. coli; Escherichia coli; GT
Stromal cell independent B cell development in vitro: Generation and recovery of autoreactive clones
Keywords: منطقه تعریف مکمل; Ab; antibody; APC; antigen presenting cell; AFC; antibody-forming cell; BAFF; B cell activating factor belonging to the TNF family; BCR; B cell receptor for antigen; CD; culture-derived; CD-RAG; RAG-deficient mice reconstituted with CD cells; CSR; class-s