کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8316556 | 1538703 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Free immunoglobulin light chain: Its biology and implications in diseases
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کلمات کلیدی
BCRCDRPre-B cellsFLCTNPinflammation - التهاب( توروم) immunoglobulin - ایمونوگلوبولینAutoimmune diseases - بیماری خودایمنیTrinitrophenol - ترنیتروفنلlight chain variable domain - دامنه متغیر زنجیره سبکheavy chain variable domain - دامنه متغیر زنجیره سنگینB cells - سلول های Bendoplasmic reticulum - شبکه آندوپلاسمی Lambda - لامبداCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیcomplementarity determining region - منطقه تعریف مکملAntibody - پادتَن یا آنتیبادیAntigen - پادگِن یا آنتیژنKappa - کاپاB-cell receptor - گیرنده سلول B
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Immunoglobulin light chain (IgLC) is a component of antibodies, but its free form is observed in the circulation, which originates from 10 to 40% excess synthesis over heavy chain in B cells. Complete antibodies function as a defined tetramer structure unit, H2L2; thus, separation of heavy and light chains results in considerable or complete loss of antigen-binding ability. Free IgLC has been considered as an inconsequential spillover during antibody assembly because, unlike heavy chain, neither effector functions such as complement activation nor specific-receptor binding has been identified in IgLCs. Free IgLC in sera and cerebrospinal fluids increases in inflammatory diseases such as autoimmune diseases and infections, presumably as a result of B-cell activation. This may be just a concomitant event during elevated disease activity, but recent findings suggest that free IgLC is involved in a wide range of immunological phenomena as a signaling effector or an anti-inflammatory molecule. These effects are likely to be intrinsic to IgLC. In this review, we attempt to give a comprehensive view about the biological roles of free IgLC together with the gene expression, secretion, antigen-binding ability, and its metabolic characteristics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 412, Issues 11â12, 12 May 2011, Pages 843-849
Journal: Clinica Chimica Acta - Volume 412, Issues 11â12, 12 May 2011, Pages 843-849
نویسندگان
Takanari Nakano, Masanori Matsui, Ikuo Inoue, Takuya Awata, Shigehiro Katayama, Takayuki Murakoshi,