Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways
Keywords: MicroRNA; miR-301; ska2; CREB
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Influence of dopamine D3 receptor knockout on age-related decline of spatial memory
Keywords: D3 receptor; Aging; Spatial memory; CREB; Morris water maze
cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction
Keywords: CREB; Breast cancer; Bone metastasis; TGF-β; PTHrP;
The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice
Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; CREB; cAMP response element-binding protein; EEPV; the ethanolic extract of the flower of Prunella vulgaris var. lilacina; ERK; extracellular signal-regulated kinase; NMDA; N-methyl-d-aspartate; LTP;
Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation
Keywords: Learning and memory; Fetal alcohol spectrum disorders; Vinpocetine; CREB; Behavior;
HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death
Keywords: AP-1; activator protein 1; APC; anaphase promoting complex; ATL; adult T-cell leukemia; ATM kinase; ataxia telangiectasia mutated kinase; BES; base excision repair; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; CREB; cyclic AMP response element-bi
Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory
Keywords: Cardiac memory; cAMP response element binding protein; Angiotensin II; Reactive oxygen species; Ubiquitination; Proteasomal degradation; CREB; cyclic adenosine monophosphate response element binding protein; LA; left atrium/atrial; LAD; left anterior desc
Oxidative stress-mediated up-regulation of myocardial ischemic preconditioning up-regulated protein 1 gene expression in H9c2 cardiomyocytes is regulated by cyclic AMP-response element binding protein
Keywords: Mipu1; CREB; H2O2; Gene expression; Transcriptional regulation; Free radicals
Hypoglycemia induced behavioural deficit and decreased GABA receptor, CREB expression in the cerebellum of streptozoticin induced diabetic rats
Keywords: GABA, gamma-aminobutyric acid; GAD, glutamate decarboxylase; STZ, streptozotocin; CREB, cyclic AMP response element binding proteinHypoglycemia; GABA receptor; CREB; Cerebellum; Diabetes
Bcr–Abl-independent mechanism of resistance to imatinib in K562 cells: Induction of cyclooxygenase-2 (COX-2) by histone deacetylases (HDACs)
Keywords: Imatinib-resistant K562 cells; MDR1; COX-2; HDACs; CREB; Bax; Bcl2
n-3 Polyunsaturated fatty acids and autoimmune-mediated glomerulonephritis
Keywords: PUFAs; polyunsaturated fatty acids; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; IgAN; immunoglobulin A nephropathy; PGs; prostaglandins; LTs; leukotrienes; COX; cyclooxygenase; ESRD; end-stage renal disease; CKD; chronic kidney disease; SLE; sy
Non-canonical functions of RGS proteins
Keywords: AC; adenylyl cyclase; CHO; Chinese hamster ovary; CNK1; connector enhancer of KSR1; CREB; cAMP-response element binding protein; DH; dbl-homology; DMAP1; Dnmt1-associated protein 1; EGF; epidermal growth factor; eIF; eukaryotic initiation factor; ERK; ext
Differentiation of mouse Neuro 2A cells into dopamine neurons
Keywords: BMP; cAMP; CREB; Dopamine; GDNF; TH
α-Melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-γ-induced tumor necrosis factor-α expression but not tumor necrosis factor-α receptor expression in cultured hypothalamic neurons
Keywords: α-MSH; TNF-α; IL-1β; Hypothalamic neurons; CREB; NF-κB;
Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways
Keywords: Asperosaponin VI; Cardiomyocyte apoptosis; Phosphatidylinositol-3-kinase (PI3K)/Akt; CREB; Bcl-2/Bax; Caspase-3
Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats
Keywords: Escitalopram; BDNF; CREB; Neuroplasticity; Prefrontal cortex; Hippocampus
Gi-protein inhibitor, guanosine 5′-O-(2-thiodiphosphate), induces senescence-associated β-galactosidase positive cell formation through CREB phosphorylation
Keywords: SA-β-Gal; Cellular senescence; GOT; IMR-90; CREB
Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43
Keywords: AKT; protein kinase B; API; activator protein 1; BIM I; bisindolylmaleimide I; CMS; cyclic mechanical stretch; Cx43; connexin43; CREB; CRE-binding protein; Ct; threshold cycle; EMSA; electrophoretic mobility shift assay; ERK1/2; extracellular signal-regul
Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival
Keywords: Aging; Green tea; Catechins; Glutathione; Antioxidant enzymes; CREB; BDNF; Bcl-2; Hippocampal formation; Rat; Free radicals
Common properties between synaptic plasticity in the main olfactory bulb and olfactory learning in young rats
Keywords: aversion; beta-adrenoceptors; NMDA; noradrenaline; preference; l-type calcium channel; ACSF; artificial cerebrospinal fluid; AP5; D-(â)-2-Amino-5-phosphonopentanoic acid; CREB; cyclic-AMP response element-binding protein; CNQX; 6-cyano-2,3-dihydroxy-7-n
Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF
Keywords: 3-Nitropropionic acid; BDNF; Calpain; CREB; Excitotoxicity; Huntington's disease; Phosphodiesterase 5; Sildenafil; Vardenafil
Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons
Keywords: Hippocampus; Norepinephrine; BDNF; Akt; CREB; Nitric oxide
The HTLV-1 Tax protein: Revealing mechanisms of transcriptional activation through histone acetylation and nucleosome disassembly
Keywords: HTLV; Tax; Nucleosome eviction; Histone acetylation; Chromatin; CBP; p300; CREB
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Transgenic mice; Triflusal; Amyloid; Neuroinflammation; Cytokines; Cognition; CREB; c-fos; BDNF
cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells
Keywords: ATRA; all trans retinoic acid; CREB; cyclic-AMP response element binding protein; DMEM; high glucose Dulbecco's modified Eagle's medium; NDHFn; normal human dermal fibroblasts-neonatal; KB; human mouth epidermoid cells carcinoma; NHEK; normal human epider
Human circulating fibrocytes have the capacity to differentiate osteoblasts and chondrocytes
Keywords: aP2; adipocyte lipid-binding protein; Cbfa1; core binding factor alpha1 subunit protein; CREB; cAMP-responsive element binding; ECM; extracellular matrix; JNK; c-Jun N-terminal kinase; MCGS; mesenchymal cell growth supplement; MSC; mesenchymal stem cells;
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-d-asparate-type glutamate receptors
Keywords: glutamate; calcium; head injury; amino acid; spermidine; AMPAr; α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor; ANOVA; analysis of variance; APV; dl-2-Amino-5-phosphonopentanoic acid; BDNF; brain derived neurotrophic factor; CA; cornu ammo
Prostacyclin receptor suppresses cardiac fibrosis: Role of CREB phosphorylation
Keywords: CREB; Cardiac fibroblast; Transforming growth factor-β; Prostacyclin receptor; Collagen
Environmental living conditions introduced during forced abstinence alter cocaine-seeking behavior and Fos protein expression
Keywords: environmental enrichment; immediate early gene; cocaine cues; incentive motivation; neurocircuitry; craving; BlA; basolateral amygdala; BNST; bed nucleus of the stria terminalis; CeA; central amygdala; CPP; conditioned place preference; CREB; cAMP respons
Lysophosphatidic acid induces upregulation of Mcl-1 and protects apoptosis in a PTX-dependent manner in H19-7 cells
Keywords: LPA; lysophosphatidic acid; NPC; neuronal progenitor cell; Mcl; myeloid cell leukemia; GSK-3; glycogen synthase kinase 3; PTX; pertussis toxin; FGF; fibroblast growth factor; S1P; sphingosine 1-phosphate; GPCR; G-protein coupled receptor; E; embryonic day
Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the α2-adrenergic receptor: Implications for antidepressant drug mechanism of action
Keywords: 5-HT; serotonin; AP-1; activator protein 1; AR; adrenergic receptor; BDNF; brain derived neurotrophic factor; DEX; dexamethasone; FCS; fetal calf serum; GC; glucocorticoid; GPCR; G-protein-coupled receptor; GR; glucocorticoid receptor; GRK; G-protein rece
Cellular NeuroscienceResearch PaperHydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus
Keywords: prolyl hydroxylase; dimethyloxallyl glycine; hypoxia inducible factor-1 alpha; hippocampus; excitatory postsynaptic potential; paired pulse facilitation; aCSF; artificial cerebrospinal fluid; A1R; adenosine 1 receptor; CREB; cAMP response element binding
α7 nAChR-mediated activation of MAP kinase pathways in PC12 cells
Keywords: α7 nAChR; PAM; MAP kinase; ERK1/2; CREB; MEK1/2;
Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK
Keywords: PGE2; PKA; ERK; CREB; Brain tumors
Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter
Keywords: CART; CREB; Cocainel reward; ChIP;
A symphony of signals conducts early and late stages of adult neurogenesis
Keywords: GABA; Glutamate; GABAA receptors; Glutamate receptor; Proliferation; Migration; Differentiation; Integration; Stem cell; Progenitor; Neuroblast; Subventricular zone; Subgranular zone; Sonic hedgehog; microRNA; Neurogenesis; Transcription factors; CREB; BD
Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models
Keywords: glutamate; immortalization; cell biology; signal transduction; hippocampus; membrane estrogen receptor; Akt; homologous enzyme sequence of viral oncogene v-akt isolated from AKR mouse spontaneous thymoma cell line and also called protein kinase B; AR; and
MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis
Keywords: BDL; bile duct ligation; CCl4; carbon tetrachloride; ChIP; chromatin immunoprecipitation; CREB; adenosine 3â²,5â²-cyclic monophosphate response element-binding protein; HSC; hepatic stellate cell; MeCP2; methyl-CpG binding protein 2; PPARγ; peroxisome
The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter
Keywords: AP; Alkaline Phosphatase; BAL1; B-aggressive lymphoma 1; BBAP; B-aggressive lymphoma and BAL1 binding partner; bp; base pair(s); BCIP; 5-Bromo-4-chloro-3-indolyl phosphate toluidine salt; BT; Basal Telencephalon; C; Cytidine; cDNA; complementary DNA; CEI;
Molecular and genetic substrates linking stress and addiction
Keywords: Addiction; Stress; CREB; BDNF; Dynorphin; CRF
Cellular functions of Transient Receptor Potential channels
Keywords: TRP; transient receptor potential; ADPR; ADP ribose; ROS; reactive oxygen/nitrogen species; PARP; poly ADP-ribose polymerase; SOC; store operated channel; SOCE; store operated calcium entry; CCE; capacitative calcium entry; TNF-α; tumor necrosis factor-Î
Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury
Keywords: Akt/PKB; a serine/threonine protein kinase B; BBB; Blood Brain Barrier; BrdU; Bromodeoxyuridine; BDNF; Brain-derived neurotrophic factor; CCI; Controlled cortical impact; CREB; CyclicAMP responsive element binding protein; CNS; Central nervous system; eNO
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Keywords: Apoptosis; Brain-derived neurotrophic factor (BDNF); Glycogen synthase kinase 3 (GSK-3); Lithium; Neurodegenerative diseases; Neuroprotection; 3-NP; 3-nitropropionic acid; Aβ; β-amyloid; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AP-1;
Age-related NMDA signaling alterations in SOD2 deficient mice
Keywords: NMDA; N-methyl-d-aspartate; ROS; reactive oxidative species; RNS; reactive nitrogen species; SOD; superoxide dismutase; STEP; striatal-enriched protein tyrosine phosphatase; CREB; cAMP response element-binding; AD; Alzheimer's disease; PD; Parkinson's dis
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism
Keywords: ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;
Up-regulation of cocaine- and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated electroconvulsive shock
Keywords: CART; CREB; Depression; Electroconvulsive shock; Nucleus accumbens;
TRAIL inhibited the cyclic AMP responsible element mediated gene expression
Keywords: CRE; CREB; TRAIL; Signal transduction; Transcription;
IL-4 stimulates mouse macrophages to express APRIL through p38MAPK and two different downstream molecules, CREB and Stat6
Keywords: APRIL; IL-4; p38MAPK; Stat6; CREB
Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase
Keywords: PP1; HDAC8; CREB; CRE-Luciferase reporter
Phosphorylation of CREB, a cyclic AMP responsive element binding protein, contributes partially to lysophosphatidic acid-induced fibroblast cell proliferation
Keywords: Lysophosphatidic acid; Proliferation; c-fos; CREB; Cyclin D1