Keywords: سیکلوسپورین A; AOC, area over the curve; BBR, benzbromarone; CsA, cyclosporin A; CYP, cytochrome P450; DRLM, dexamethasone-treated Sprague–Dawley rat liver microsome; DILI, Drug-induced liver injury; G6P, glucose 6-phosphate; G6PDH, glucose-6-phosphate dehydrogenase; mt
مقالات ISI سیکلوسپورین A (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: سیکلوسپورین A; CsA, Cyclosporin A; SFAs, semifluorinated alkanes; EVEIT, Ex Vivo Eye Irritation Test; HPLC, high-performance liquid chromatographySemifluorinated alkanes; Ocular drug delivery; Cyclosporine; Ocular pharmacokinetics; Ex vivo model; EVEIT
Keywords: سیکلوسپورین A; Disulfide bonds; Cyclic peptide; Cyclotide; GraftingBBI, Bowman Birk inhibitor; BTD-2, baboon θ-defensin 2; CCK, cyclic cystine knot; CsA, Cyclosporin A; GC-C, guanylyl cyclase C; GPCR, G-protein coupled receptor; HIV, human immunodeficiency virus; kB1, k
Keywords: سیکلوسپورین A; MPTP, mitochondrial permeability transition pore; CYPD, cyclophilin D; HFD, high fat diet; LFD, low fat diet; WT, wild type; KO, knockout; CSA, cyclosporin A; BKA, bongkrekic acid; O2, superoxide; [3H]-2-DOG, [3H]-2-deoxyglucose; Rg′, rate of glucose tran
Keywords: سیکلوسپورین A; AD, Alzheimer's disease; Aβ, amyloid-β; APP, amyloid precursor protein; Arg1, arginase 1; BrdU, 5-bromo-2′-deoxyuridine; CBD, calbindin; CsA, cyclosporin A; DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride; DCX, doublecortin; GAD65, glutamate decarboxy
Keywords: سیکلوسپورین A; AAF, 2-acetamidofluorene; ANIT, α-naphthylisothiocyanate; AUC, area under the curve; CCL, CC-chemokine ligand; CCR2, CC chemokine receptor type 2; CSA, cyclosporin A; CSP, cisplatin; CXCL, CXC chemokine ligand; DEN, N-nitrosodiethylamine; DFNa, diclofenac
Keywords: سیکلوسپورین A; αMEM, α-minimal essential medium; BzATP, 3′-O-(4-benzoyl)benzoyl ATP; Cbfβ, core binding factor β; CNS, central nervous system; CsA, cyclosporin A; DMEM, Dulbecco’s modified Eagle medium; DMEM/F12, Dulbecco’s modified Eagle’s and Ham’s F-12 medium; DMSO,
Keywords: سیکلوسپورین A; A1/2, half maximum absorbance; Amin, minimum absorbance; CCCP, carbonyl cyanide m-chlorophenyl hydrazone; CsA, cyclosporin A; DCF, dihydrodichlorofluorescein diacetate; ΔΨm, mitochondrial membrane potential; MK-801, dizocilpine; NMDA, N-methyl-d-aspartate
Keywords: سیکلوسپورین A; AM, acetoxymethyl ester; CsA, cyclosporin A; DMEM, Dulbecco's modified Eagle's medium; ΔΨm, mitochondrial membrane potential; FBS, fetal bovine serum; HBS, HEPES-buffered saline; MPT, mitochondrial permeability transition; t-BuOOH, t-butyl hydroperoxide;
(E)-1,3-diphenyl-1H-pyrazole derivatives containing O-benzyl oxime moiety as potential immunosuppressive agents: Design, synthesis, molecular docking and biological evaluation
Keywords: سیکلوسپورین A; Immunosuppressant; Molecular docking; Oxime ethers; PI3Kγ; PyrazolePI3K, Phosphoinositide 3-kinase; IL-6, interleukin-6; AKT, protein kinase B; NaOAc, CH3COONa; CsA, cyclosporin A; ConA, Concanavalin A; SAR, structure–activity relationships; CADD, compute
Effects of mTOR and calcineurin inhibitors combined therapy in Epstein–Barr virus positive and negative Burkitt lymphoma cells
Keywords: سیکلوسپورین A; BL, Burkitt lymphoma; BrdU, bromodeoxyuridine; CI, combination index; CNI, calcineurin inhibitor; CsA, cyclosporin A; EBV, Epstein–Barr virus; Eve, everolimus; LDH, lactate dehydrogenase; mTOR, mammalian target of rapamycin; mTORC1, mammalian target of ra
Cyclosporin A enhances neurogenesis in the dentate gyrus of the hippocampus
Keywords: سیکلوسپورین A; CsA, cyclosporin A; BrdU, 5-bromo-2-deoxyuridine; DCX, doublecortin; DG, dentate gyrus; EGF, epidermal growth factor; bFGF, basic fibroblast growth factor; GFAP, glial fibrillary acidic protein; LV, lateral ventricles; NPC, neural precursor cell; SVZ, sub
The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells
Keywords: سیکلوسپورین A; Arsenite; Mitochondria; NADPH Oxidase; Superoxide; ER Stress; Autophagy; ApoptosisAnt, antimycin A; Apo, apocynin; CHOP, GADD153/C/EBP homologous protein; Cf, caffeine; CsA, cyclosporin A; DHR, Dihydrorhodamine 123; DPI, diphenyleneiodonium; ER, endoplasm
The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease
Keywords: سیکلوسپورین A; ALT, alanine aminotransferase; CN-PAGE, clear native polyacrylamide gel electrophoresis; CsA, cyclosporin A; GSH, glutathione; HIF1α, hypoxia-inducible factor 1 alpha; iNOS, inducible nitric oxide synthase; MPT, mitochondrial permeability transition; NO,
Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics
Keywords: سیکلوسپورین A; BMC, benchmark concentration; CSA, cyclosporin A; DES, diethylstilbestrol estrogenic, transplacental carcinogen; EC, effect concentration; EHA, ethylhexanoic acid; ESF, endosulfan; EST, embryonic stem cell assay; GSA, gluphosinate ammonium; HPM, human pla
Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture
Keywords: سیکلوسپورین A; AUC, area under the curve; BA(s), bile acid(s); Bsep/BSEP, bile salt export pump (rat/human); CDCA, chenodeoxycholic acid; CDF, 5-(6)-carboxy-2′,7′-dichlorofluorescein; CDFDA, 5-(6)-carboxy-2′,7′-dichlorofluorescein diacetate; CsA, cyclosporin A; DCA, deo
Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines
Keywords: سیکلوسپورین A; ABC, ATP-binding cassette; ATCC, American Type Culture Collection; CMFDA, 5-chloromethylfluorescein diacetate; CSA, cyclosporin A; GSMF, glutathione methylfluorescein; H33342, 2′-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5′-bi-1H-benzimidazole3HCl; MD
Characterisation of the membrane transport of pilocarpine in cell suspension cultures of Pilocarpus microphyllus
Keywords: سیکلوسپورین A; 2,4-D, 2,4-dichlorophenoxyacetic acid; BA, bafilomicin; BSO, buthionine sulfoximine; CSA, cyclosporin A; DMSO, dimethyl sulfoxide; FW, cell fresh weight; HPLC, high-performance liquid chromatography; NaN3, sodium azide; Na3VO4, sodium orthovanadate; NFD,
Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro
Keywords: سیکلوسپورین A; 1H NMR, proton nuclear magnetic resonance imaging; BSEP, Bile Salt Export Pump; CAR, constitutive androstane receptor; CsA, Cyclosporin A; DEG, differentially expressed gene; ER, endoplasmic reticulum; FC, fold change; FDR, False Discovery Rate; FXR, farn
18FDG a PET tumor diagnostic tracer is not a substrate of the ABC transporter P-glycoprotein
Keywords: سیکلوسپورین A; CSA, cyclosporin A; 18FDG, 2-[18F]fluoro-2-deoxy-d-glucose; FDG, 2-[19F]fluoro-2-deoxy-d-glucose; 18FDG-6-P, 2-[18F]fluoro-2-deoxy-d-glucose-6-phosphate; FDG-6-P, 2-[19F]fluoro-2-deoxy-d-glucose-6-phosphate; GLUT, glucose transporter; HK-II, hexokinase en
Gemcitabine-induced pancreatic cancer cell death is associated with MST1/Cyclophilin D mitochondrial complexation
Keywords: سیکلوسپورین A; Gemcitabine; Pancreatic cancer; MST1; Cyclophilin D; Cell deathCyp-D, Cyclophilin D; CsA, cyclosporin A; H2O2, hydrogen Peroxide; MST1, mammalian sterile 20-like kinase 1; ROS, reactive oxygen species; NAC, n-acetyl-cysteine
Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity
Keywords: سیکلوسپورین A; 1H-NMR, proton nuclear magnetic resonance imaging; AOP, adverse outcome pathway; BSEP, bile salt export pump; CsA, cyclosporin A; DEG, differentially expressed gene; ER, endoplasmic reticulum; FC, fold change; FDR, false discovery rate; MDR1, multidrug re
NFAT1 transcription factor in dendritic cells is required to modulate T helper cell differentiation
Keywords: سیکلوسپورین A; Cytokines; Dendritic cells; Lymphocyte differentiation; NFAT; Th1/Th2 cellsAb, antibody; APC, antigen-presenting cell; CFA, Complete Freund's Adjuvant; CsA, cyclosporin A; DC, dendritic cell; Iono, ionomycin; OVA, ovalbumin; RPA, RNase protection assay; T
Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening
Keywords: سیکلوسپورین A; ANT, adenine nucleotide transporter; BLM, black-lipid membrane; CsA, cyclosporin A; CyP-D, cyclophilin D; DCCD, dicyclocarbodiimide; DOC-Na, sodium deoxycholate; mPTP, mitochondrial permeability transition pore; PKA, protein kinase A; RLM, rat liver mitoc
Cyclosporin A affects the bioavailability of ginkgolic acids via inhibition of P-gp and BCRP
Keywords: سیکلوسپورین A; ADME, absorption, distribution, metabolism and excretion; BBB, blood–brain barrier; BCRP, breast cancer resistant protein; CsA, Cyclosporin A; DMEM, Dulbecco’s modified Eagle’s medium; GA, ginkgolic acid; HBSS, Hanks’ balanced salt solution; IS, internal
Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: A systematic review
Keywords: سیکلوسپورین A; Atopic dermatitis; evidence-based medicine/systematic review; immunosuppressive therapy; immunomodulator; systemic treatment; recommendations; GRADEAD, Atopic dermatitis; AE, Adverse event; AZA, Azathioprine; CsA, Cyclosporin A; EASI, Eczema Area and Seve
C1 metabolism plays an important role during formaldehyde metabolism and detoxification in petunia under liquid HCHO stress
Keywords: سیکلوسپورین A; C1 metabolism; Formaldehyde detoxification; Formaldehyde metabolism; Liquid formaldehyde stress; PetuniaANOVA, Analysis of variance; CSA, Cyclosporin A; FDH, formate dehydrogenase; FGH, S-Formyl GSH hydrolase; FTD, 10-formyl-THF deformylase; FTS, 10-formy
Mitf regulates osteoclastogenesis by modulating NFATc1 activity
Keywords: سیکلوسپورین A; Atp6v0d2, vacuolar ATPase Vo domain d2 isoform; BMM, bone marrow macrophages; CsA, cyclosporin A; Ctsk, cathepsin K; DC-STAMP, dendritic cell-specific transmembrane protein; GFP, green fluorescent protein; HA, hemagglutinin; KO, knockout; Mitf, microphtha
Lymphocytes and autoimmunity after spinal cord injury
Keywords: سیکلوسپورین A; DC, dendritic cell; NK, natural killer; RAG, recombination-activating gene; BCKO, B-cell knockout; BMS, Basso Mouse Scale; BBB, Basso–Beattie–Bresnahan; Ig, immunoglobulin; CR3, complement receptor 3; FcγR, Fc gamma receptor; CsA, cyclosporin A; Treg, reg
Neuroprotective effects of gallic acid against hypoxia/reoxygenation-induced mitochondrial dysfunctions in vitro and cerebral ischemia/reperfusion injury in vivo
Keywords: سیکلوسپورین A; ANT, adenine nucleotide translocator; BCA, bicinchoninic acid; CsA, cyclosporin A; CypD, Cyclophilin D; Cyt C, Cytochrome C; DAPI, 4׳, 6-diamidino-2-phenylindole; DCF-DA, dichlorofluorescin diacetate; DMEM, dulbecco’s modified Eagle׳s medium; DMSO, dimeth
Can P-glycoprotein mediate resistance to nilotinib in human leukaemia cells?
Keywords: سیکلوسپورین A; DNR, Daunorubicin; Ph+, Philadelphia chromosome-positive; CsA, cyclosporin A; MFI, mean fluorescence intensityABCB1 gene; K562 cells; K562/Dox cells; Drug resistance; Intracellular drug level
In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs
Keywords: سیکلوسپورین A; MDR1, reverse multidrug resistance 1; P-gp, P-glycoprotein; MRP2, MDR-associated protein 2; GF120918, N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide; CsA, cyclosporin A; Calcein
The role of cyclophilin D in interspecies differences in susceptibility to hepatotoxic drug-induced mitochondrial injury
Keywords: سیکلوسپورین A; MPT, mitochondrial permeability transition; CsA, cyclosporin A; CyPD, cyclophilin D; ANT, adenine nucleotide translocator; VDAC, voltage-dependent anion channel; kd, knock down; NADH, nicotinamide adenine dinucleotide; FADH, flavin adenine dinucleotide; N
Doxorubicin induced myocardial injury is exacerbated following ischaemic stress via opening of the mitochondrial permeability transition pore
Keywords: سیکلوسپورین A; ANT, Adenine nucleotide translocase; ATP, Adenosine triphosphate; CsA, Cyclosporin A; Cyp-D, Cyclophilin D; Dox, Doxorubicin; Erk, Extracellular signal-regulated kinase; FCCP, Carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone; HR, Hypoxia reoxygenation
Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations”
Keywords: سیکلوسپورین A; BCS, Biopharmaceutical Classification Scheme; GI, Gastrointestinal; p-GP, p-Glycoprotein; MRP, multidrug resistance-related protein; BCRP, breast cancer resistant protein; CMC, critical micelle concentration; CsA, cyclosporin A; TEER, transepithelial elec
Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats
Keywords: سیکلوسپورین A; AIF, apoptosis-inducing factor; ANOVA, analysis of variance; AP, Antero-Posterior; BSA, bovine serum albumin; CAPE, caffeic acid phenethyl ester; CPu, caudate putamen; CsA, cyclosporin A; DCFH-DA, dihydrodichlorofluorescein diacetate; DMSO, dimethyl sulfo
Mitochondrial handling of excess Ca2+ is substrate-dependent with implications for reactive oxygen speciesgeneration
Keywords: سیکلوسپورین A; ΔΨ, Membrane potential; CCCP, Carbonyl cyanide-m-chlorophenylhydrazenone; CsA, Cyclosporin A; ETC, Electron transport chain; e[Ca2+], Extramitochondrial Ca2+; FET, Forward electron transfer; IMM, Inner mitochondrial membrane; IR, Ischemia and reperfusion;
The function of the ATP-binding cassette (ABC) transporter ABCB1 is not susceptible to actin disruption
Keywords: سیکلوسپورین A; ABC, ATP-binding cassette; ABCB1, P-glycoprotein; ABCC1, multidrug resistance-protein 1; AM, acetoxymethyl ester; Cav-1, caveolin-1; CSA, cyclosporin A; DRM, detergent-resistant membrane; ERM, ezrin, radixin and moesin; FCS, fetal calf serum; HBSS, Hank's
A family of cyclophilin-like molecular chaperones in Plasmodium falciparum
Keywords: سیکلوسپورین A; CLD, cyclophilin-like domain; CYP, cyclophilin; CsA, cyclosporin A; FKBP, FK506-binding protein; PPIase, peptidyl–prolyl cis–trans isomerasePlasmodium falciparum; Malaria; Cyclophilin; Molecular chaperone; Protein folding; Cyclosporin A
The over-exaggerated chronic nephrotoxicity of calcineurin inhibitors
Keywords: سیکلوسپورین A; CSA, cyclosporin A; CNI, calcineurin inhibitor; AZA, azathioprine; MMF, mycophenolate mofetil; CKD, chronic kidney disease; AR, acute rejectionGraft loss; Calcineurin inhibitors; Chronic nephrotoxicity; Chronic kidney disease; Kidney transplantation
The immunosuppressant cyclosporin A inhibits recurrent seizures in an experimental model of temporal lobe epilepsy
Keywords: سیکلوسپورین A; TLE, temporal lobe epilepsy; kainate, KA; CsA, cyclosporin A; SRS, spontaneous recurrent seizure; EEG, electroencephalography; SE, status epilepticus; 4-AP, 4-aminopyridine; MPT, mitochondrial permeability transitionCyclosporin A; Temporal lobe epilepsy;
Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients
Keywords: سیکلوسپورین A; PCR-RFLP, polymerase chain reaction-restriction fragments length polymorphism; SNP, single nucleotide polymorphism; HLA, human leucocyte antigen; CsA, cyclosporin A; ICOS, inducible costimulator; CTLA4, cytotoxic T lymphocyte associated antigen 4; PD.1, p
Protective effect of sulforaphane against oxidative stress: Recent advances
Keywords: سیکلوسپورین A; ARE, antioxidant response element; CsA, cyclosporin A; GPx, glutathione peroxidase; GR, glutathione reductase; GSH, glutathione; GST, glutathione-S-transferase; γGCL, γ glutamyl cysteine ligase; H2O2, hydrogen peroxide; HO-1, heme oxygenase-1; ICH, intrac
Rapid clearance of supplemented tetrahydrobiopterin is driven by high-capacity transporters in the kidney
Keywords: سیکلوسپورین A; BH4, tetrahydrobiopterin; 6RBH4, (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin dihydrochloride; BH2, 7,8-dihydrobiopterin; BP, tissue biopterin (BH2 + BH4) including a trace of fully oxidized biopterin; CsA, cyclosporin A; RBC, red blood cellTetrahydrobiopte
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for monitoring drug exposure in hematopoietic stem cell transplant recipients
Keywords: سیکلوسپورین A; Chromatography; Mass spectrometry; Calcineurin inhibitor; Corticosteroid; Methotrexate; Mycophenolic acidMMF, mycophenolate mofetil; CsA, cyclosporin A; Mtx, methotrexate; -G, glucuronide; HSCT, hematopoietic stem cell transplantation; LC–MS/MS, high-perf
A moderate decline in U937 cell GSH levels triggers PI3 kinase/Akt-dependent Bad phosphorylation, thereby preventing an otherwise prompt apoptotic response
Keywords: سیکلوسپورین A; BSO, dl-buthionine-[S,R]-sulfoximine; CsA, cyclosporin A; DHR, dihydrorhodamine 123; GDH, glutamate dehydrogenase; GSHMEE, reduced glutathione monoethyl ester; LDH, lactate dehydrogenase; MPT, mitochondrial permeability transition; PI3K, phosphatidylinosi
Immunosuppressive drugs on inducing Ag-specific CD4+CD25+Foxp3+ Treg cells during immune response in vivo
Keywords: سیکلوسپورین A; CFA, complete Freund's adjuvant; CsA, cyclosporin A; Cy, cyclophosphamide; FCM, flow cytometry; Foxp3, transcription factor forkhead box p3; FTY720, Fingolimod; GITR, glucocorticoid-induced tumor necrosis factor receptor; LEF, leflunomide; LNs, lymph node
Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling
Keywords: سیکلوسپورین A; ADAM-17, a disintegrin and metalloproteinase 17; PPIase, peptidyl-prolyl cis/trans isomerase; CsA, cyclosporin A; ERK, extracellular signal-regulated kinase; MAPK, mitogen activated protein kinase; MC, mesangial cells; NAC, N-acetyl cysteine; ROS, reactiv
Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms
Keywords: سیکلوسپورین A; 3-MA, 3-MethylAdenine; BAPTA-AM, 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); BTPI, ButylTriphenylPhosphonium Iodide; CQ, Chloroquine; CsA, Cyclosporin A; CsH, Cyclosporin H; Δμ̃H, proton electrochemical gradient
The mitochondrial permeability transition pore (PTP) — An example of multiple molecular exaptation?
Keywords: سیکلوسپورین A; ANT, adenine nucleotide translocator; TSPO, outer membrane translocator protein of 18 kDa (formerly known as the peripheral benzodiazepine receptor); CsA, cyclosporin A; CyP-D, cyclophilin-D; DhMUC, Debaryomyces hansenii mitochondrial unspecific channel;