Syndromic and non-syndromic disease-linked Cx43 mutations
Keywords: Cx43; Gap junction; Germ-line; Oculodentodigital dysplasia;
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Ca2+ Responses in Enteric Glia Are Mediated by Connexin-43 Hemichannels and Modulate Colonic Transit in Mice
Keywords: Intestinal Nervous System; Aging; Purines; Mouse Model; ADP; adenosine diphosphate; ATP; adenosine triphosphate; Ca2+; calcium; CBX; carbenoxolone; Cx43; connexin-43; EG; enteric glia; ENS; enteric nervous system; ERT2; mutated estrogen receptor; GFAP; gl
The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke
Keywords: aCSF; artificial cerebrospinal fluid; BHT; butylated hydroxytoluene; Cx43; connexin 43; DCPIB; 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid; DHK; dihydrokainate; DHR123; dihydrorhodamine 123; DMSO; dimethyl sulf
Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects
Keywords: DCM-CD; Dilated Cardiomyopathy with Conduction System Disease; EDMD; Emery-Dreifuss Muscular dystrophy; LGMD; Limb-Girdle Muscular Dystrophy; Cx43; Connexin43; MAPK; Mitogen-Activated Protein Kinase; ERK; Extracellular Signal-Regulated Kinase; MEF; Mous
Cell motility in models of wounded human skin is improved by Gap27 despite raised glucose, insulin and IGFBP-5
Keywords: CMC; Connexin-mediated communication; CMP; Connexin mimetic peptide; Cx43; Connexin43; ECM; Extracellular matrix; GJIC; Gap junctional intercellular communication; HGI; High glucose and insulin; IGFBP-5; Insulin-like growth factor binding protein 5; NGI;
Altered Kir and gap junction channels in temporal lobe epilepsy
Keywords: Epilepsy; Astrocyte; Kir4.1; Cx43; Cx30; Dye coupling
Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway
Keywords: Cx43; TMZ; Glioma; Cytochrome C
Gap junctions and arrhythmogenic cardiomyopathy
Keywords: Gap junctions; Arrhythmogenic cardiomyopathy; ARVC; arrhythmogenic right ventricular cardiomyopathy; Cx43; connexin 43; TNFα; tumor necrosis factor α;
Channeling diversity: Gap junction expression in the heart
Keywords: Gap junctions; Connexins; Heart development; Arrhythmia; Cx30.2; connexin 30.2; Cx31.9; connexin 31.9; Cx37; connexin 37; Cx40; connexin 40; Cx43; connexin 43; Cx45; connexin 45;
Gap junctions, stem cells, and cell therapy: Rhythmic/arrhythmic implications
Keywords: Stem cells; Gap junctions; Cell therapy; Arrhythmias; Cx43; connexin 43; ESC; embryonic stem cell; hESC; human ESC; NRVM; neonatal rat ventricular myocytes;
The perinexus: A new feature of Cx43 gap junction organization
Keywords: Connexin43; ZO-1; Gap junction; Hemichannel; Perinexus; CT; carboxyl terminus; Cx43; connexin43; EM; electron microscope; GJ; gap junction; MAGUK; membrane-ssociated GUanylate kinase; ZO-1; zonula occludens-1;
Adrenergic deficiency leads to impaired electrical conduction and increased arrhythmic potential in the embryonic mouse heart
Keywords: APX; Apex of ventricle; A-V; Atrioventricular; AVJ; Atrioventricular junction; Cx43; Connexin 43; Dbh; Dopamine β-hydroxylase; EPI; Epinephrine (adrenaline); Hcn4; Hyperpolarization-activated cyclic nucleotide-modulated channel isoform 4; ICA; Intrinsic
Posttranscriptional regulation of connexin-43 expression
Keywords: Gap junctions; Connexin; RNA; miRNA; RNA binding proteins; HuR; Cx43;
Disturbed myocardial connexin 43 and N-cadherin expressions in hypoplastic left heart syndrome and borderline left ventricle
Keywords: 20; BLV; borderline left ventricle; Cx43; connexin 43; EPDC; epicardium-derived cell; HLH; hypoplastic left heart; HLHS; hypoplastic left heart syndrome; ICD; intercalated disk; PBS; phosphate-buffered saline solution;
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice
Keywords: Cx43; Nav1.5; Heterogeneity; Sodium current; ArrhythmiaCVL, longitudinal conduction velocity; CVT, transversal conduction velocity; Cx43, connexin43; ERP, effective refractory period; INa, sodium current; LV, left ventricle; RV, right ventricle; VT, ventr
Original Full Length ArticleSost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Keywords: DMP1; dentin matrix protein 1; PTHrP; PTH related protein; BMP; bone morphogenetic protein; Cx43; connexin 43; WT; wild type; TG; transgenic mice; ChoB; ribosomal protein S2; LRP; low density lipoprotein receptor-related protein; Tph1; Tryptophan hydroxyl
High pressure-induced retinal ischaemia reperfusion causes upregulation of gap junction protein connexin43 prior to retinal ganglion cell loss
Keywords: CNS; Central Nervous System; Cx43; Connexin43; Cx43-ir; Cx43 immunoreactivity; DAPI; 4â²,6-diamidino-2-phenylindole; GCL; Ganglion Cell Layer; GFAP; Glial Fibrillary Acidic Protein; GS; Glutamine Synthetase; INL; Inner Nuclear Layer; NFL; Nerve Fibre Lay
Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration
Keywords: Cx43; Semaphorin; Bone; Fin regeneration; Zebrafish;
Mechanical preconditioning enables electrophysiologic coupling of skeletal myoblast cells to myocardium
Keywords: AP; action potential; Cx43; connexin43; DMEM; Dulbecco's Modified Eagle Medium; EGFP; enhanced green fluorescent protein; EHS; embryonic heart slice; ETC; engineered tissue construct; FBS; fetal bovine serum; K-ETC; killed engineered tissue construct; NP-
Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors
Keywords: AQP; aquaporin; BBB; blood-brain-barrier; COX-2; cyclooxegenase-2; CX43; connexin 43; DAPC; dystrophin-associated protein complex; GFAP; glial fibrilary acidic protein; Kir4.1; K+ channel 4.1; mGluR; metabotropic glutamate receptor; NF-κB; nuclear fact
The role of gap junctions in the brain in health and disease
Keywords: Brain injury; Connexins; Cx30; Cx36; Cx43; Cx45; Drug addiction; Epilepsy; Gamma frequency; High-frequency oscillation; Learning and memory; Mutant mice; Neuronal synchronization; Theta frequency;
The connexin43 carboxyl terminus and cardiac gap junction organization
Keywords: Aa; amino acid; CT; Carboxyl-Terminal; CL; Cytoplasmic loop; Cx43; Connexin 43; Dlg; Disks Large; GJ; Gap Junction; LSCM; Laser Scanning Confocal Microscope; NT; Amino Terminal; MAGUK; Membrane-Associated Guanylate Kinase; ODDD; oculodentodigital dysplasi
Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists
Keywords: BSA; bovine serum albumin; C; carboxyl; Cx; connexin; Cx43; connexin43; DG; deoxyglucose; ET; endothelin; ERK; extracellular signal-regulated kinase; G; GTP-binding protein; GJ; gap junction; GJIC; gap junctional intercellular communication; GPCR; GTP-bin
No-reflow disrupts the expression and distribution of Connexin 43 in a swine model
Keywords: LAD; left anterior descending artery; Cx43; Connexin 43; AAR; area at risk; RPP; systolic arterial pressure multiply heart rate;
A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions
Keywords: Cardiomyopathy; Conduction; Connexin43; Desmocollin-2; Desmoglein-2; Desmosome; Functional studies; Gap junction; Mutation; Plakoglobin; ARVC; arrhythmogenic right ventricular cardiomyopathy; Cx43; connexin43; DAPI; 4â²,6-diamidino-2-phenylindole; DSC2;
The large GTPase dynamin2: A new player in connexin 43 gap junction endocytosis, recycling and degradation
Keywords: Dynamin; Cx43; Endocytosis; Rab protein; Carcinogen
GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation
Keywords: CNS; central nervous system; GABA; gamma-aminobutyric acid; GAD65; glutamic acid decarboxylase, 65 kDa form; GAD67; glutamic acid decarboxylase, 67 kDa form; GAT; GABA transporter (membrane); GABAR; GABA receptor(s); GABAAR; GABA-A receptor(s); GABAAβ3
Heteromeric connexin 43/connexin 33 complex endocytosis: A connexin phosphorylation independent mechanism
Keywords: Cx33; Cx43; c-Src; Gap junction plaque; Endocytosis
Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication
Keywords: Myofibroblasts; Connexin43; Cx43; Intercellular coupling; TGF-β
Opposing and synergistic effects of cyclic mechanical stretch and α- or β-adrenergic stimulation on the cardiac gap junction protein Cx43
Keywords: AKT; protein kinase B; API; activator protein 1; BIM I; bisindolylmaleimide I; CMS; cyclic mechanical stretch; Cx43; connexin43; CREB; CRE-binding protein; Ct; threshold cycle; EMSA; electrophoretic mobility shift assay; ERK1/2; extracellular signal-regul
Novel missense mutations in exon 15 of desmoglein-2: Role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy?
Keywords: Arrhythmogenic right ventricular cardiomyopathy; Desmoglein-2; Desmosome; Genetics; Missense mutation; Plakophilin-2; ARVC; arrhythmogenic right ventricular cardiomyopathy; Cx43; connexin43; DSC2; desmocollin-2; DSG2; desmoglein-2; DSP; desmoplakin; GFP;
Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions
Keywords: Arrhythmia; Connexin 43; Gap junction; Cx43; connexin43;
5-HT4 and 5-HT2 receptors antagonistically influence gap junctional coupling between rat auricular myocytes
Keywords: Serotonin; 5-HT2A; 5-HT2B; 5-HT4a; 5-HT4b; Calcium current; cAMP; Connexin; Gap junction; Cx40; Cx45; Cx43; Cardiomyocytes; Syncytial properties
The carboxyl tail of Cx43 augments p38 mediated cell migration in a gap junction-independent manner
Keywords: Connexin; Cx43; Gap junction; Migration; Endothelial progenitor cells; EPC; p38 MAP kinase
A novel vascularized patch enhances cell survival and modifies ventricular remodeling in a rat myocardial infarction model
Keywords: 30; 39; CABG; coronary artery bypass grafting; Cx43; connexin 43; DAPI; 4â²-6-diamidino-2-phenylindole dihydrochloride; LVEDD; left ventricular end-diastolic diameter; LVEF; left ventricular ejection fraction; LVESD; left ventricular end-systolic diamete
Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility
Keywords: Cx43; Gap junction; Sertoli cell knockout Cx43; siRNA; Tight junction; Adherens junction; Fertility
Regulation of brain aquaporins
Keywords: ANP; atrial natriuretic peptide; AQP; aquaporin; ATP; adenosine triphosphate; BBB; blood-brain barrier; BSE; bovine spongiform encephalopathy; CaMKII; calcium/calmodulin dependent protein kinase II; cAMP; cyclic adenosine monophosphate; cGMP; cyclic gua
Cx40.8, a Cx43-like protein, forms gap junction channels inefficiently and may require Cx43 for its association at the plasma membrane
Keywords: ODDD, oculodentodigital dysplasia; GJIC, gap junction intercellular communication; ISH, in situ hybridization; H3P, histone-3-phosphate; dpa, days post amputationConnexin; Cx40.8; Cx43; Gap junction; Zebrafish; Short fin
The extent of the specialized atrioventricular ring tissues
Keywords: Atrioventricular ring tissues; Atrioventricular conduction system; Cx43; HCN4
Connexin43 regulates joint location in zebrafish fins
Keywords: Joint morphogenesis; Fin growth; Zebrafish; Gap junctions; Cx43; short fin; another long fin
Modulation of genomic and postgenomic alterations in noncancer diseases and critical periods of life
Keywords: AP-1; activator protein-1; BAL; bronchoalveolar lavage; 5,6-BF; 5,6-benzoflavone; B(a)P; benzo(a)pyrene; COPD; chronic obstructive pulmonary diseases; CS; cigarette smoke; Cx43; connexin 43; DMBA; 7,12-dimethylbenz(a)anthracene; ÉdA; 1,N-ethenodeoxyadeni
A pilot study of Connexin 43 (Cx43) in human bladder tissue in patients with idiopathic detrusor overactivity
Keywords: Cx43; Overactive bladder syndrome; Incontinence; Bladder capacity
Decreased intercellular coupling improves the function of cardiac pacemakers derived from mouse embryonic stem cells
Keywords: Gap junction; Multielectrode array; Pacemaker; Stem cell derived cardiomyocyte; Cardiac myocyte; Cx43
Purification and reconstitution of the connexin43 carboxyl terminus attached to the 4th transmembrane domain in detergent micelles
Keywords: Cx43; Cx43 carboxyl terminal domain; Gap junctions
Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration
Keywords: Bone growth; short fin; Regeneration; Zebrafish; Cell proliferation; Cx43; GJIC;
Modulation of osteoblast gap junction connectivity by serum, TNFα, and TRAIL
Keywords: DR4; CX43; Osteoblast; Osteocyte; Gap junction;
In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms
Keywords: Calcineurin; Cardiac hypertrophy; Cardiac sodium channel Nav1.5; Cx43; Cx40; Gene expression; Protein expression;
Zebrafish short fin mutations in connexin43 lead to aberrant gap junctional intercellular communication
Keywords: Gap junction; Cx43; Bone growth; Zebrafish; short fin
Phosphorylation of connexin43 induced by Src: Regulation of gap junctional communication between transformed cells
Keywords: Cas; Crk associated substrate; CDC2; cell division cycle 2; CK1; casein kinase 1; Cx43; connexin43; MAPK; mitogen activated protein kinase; PKA; protein kinase A; PKC; protein kinase C; Connexins; Gap junctions; Cell communication; Src; Kinase; Signal tra