کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10904707 | 1086685 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphorylation of connexin43 induced by Src: Regulation of gap junctional communication between transformed cells
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کلمات کلیدی
CX43CASSRCpKacdc2PKCConnexin43CK1connexinsMAPK - MAPKgap junctions - اتصالات شکاف دارCell communication - ارتباط سلولیCancer - سرطانcell division cycle 2 - سلول تقسیم سلولی 2Signal transduction - هدایت سیگنالprotein kinase A - پروتئین کیناز AProtein kinase C - پروتئین کیناز سیmitogen activated protein kinase - پروتئین کیناز فعال Mitogen فعال استcasein kinase 1 - کازئین کیناز 1Kinase - کیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cx43 is a widely expressed gap junction protein that mediates communication between many cell types. In general, tumor cells display less intercellular communication than their nontransformed precursors. The Src tyrosine kinase has been implicated in progression of a wide variety of cancers. Src can phosphorylate Cx43, and this event is associated with the suppression of gap junction communication. However, Src activates multiple signaling pathways that can also affect intercellular communication. For example, serine kinases including PKC and MAPK are downstream effectors of Src that can also phosphorylate Cx43 and disrupt gap junctional communication. In addition, Src can affect the expression of other proteins that may affect intercellular communication. Indeed, disruption of gap junctions by Src appears to be complex. It has become clear that Src can affect Cx43 activity by multiple mechanisms. Here, we review how Src may orchestrate events that regulate intercellular communication mediated by Cx43.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 313, Issue 20, 10 December 2007, Pages 4083-4090
Journal: Experimental Cell Research - Volume 313, Issue 20, 10 December 2007, Pages 4083-4090
نویسندگان
Madhuri Pahujaa, Michael Anikin, Gary S. Goldberg,