Keywords: کییناز وابسته به کیناز; Polychlorinated biphenyls; Signalling disruption; Secondary necrosis; Casein kinase 2; AKT; Serine/Threonine kinase 1; CAR; Constitutive androstane receptor; CASP3; Caspase-3; CD; Control diet; CD+; Control diet + Aroclor 1260 exposure; CDK; Cyclin depend
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Keywords: کییناز وابسته به کیناز; CCA; Cholangiocarcinoma; iCCA; Intrahepatic CCA; pCCA; Perihilar CCA; dCCA; Distal CCA; CDK; Cyclin dependent kinase; CDKN2A/B; Cyclin-dependent kinase inhibitor 2A/B; PLK2; Polo-like kinase 2; FGF; Fibroblast growth factor; HGF; Hepatocyte growth factor;
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; CDK4/6; cyclin dependent kinase 4 and 6; cdc; cell division cycle; CDC25C; cell division cycle 25 homolog; Ser/Thr; serine/ threonine; kDa; kilodaltonsâ(molecular weight); Cip/Kip; CDK interacting protein/kinase inhibitory
Keywords: کییناز وابسته به کیناز; 4EBP1; Eukaryotic Translation Initiation Factor 4E Binding Protein 1; ATF3; activating transcription factor 3; ATM; Ataxia Telangiectasia Mutated; ATR; Ataxia Telangiectasia and Rad3-Related; ARF; alternative reading frame; BAPTA; 1,2-bis(o-aminophenoxy)e
Keywords: کییناز وابسته به کیناز; Atherosclerosis; Cardiovascular diseases; Cell cycle; Proliferation; Pulmonary hypertension; Restenosis; Signaling pathway; Vascular smooth muscle cells; ACE; angiotensin converting enzyme; aFGF; acidic FGF; Ang II; angiotensin II; AP-1; activating protei
Keywords: کییناز وابسته به کیناز; CDKs; Cell cycle; Cyclins; Germination; Glucose; Maize; Sucrose; CDK; cyclin dependent kinase; Cyc; cyclin; Glc; glucose; HAI; hours after imbibition; RAM; root apical meristem; RE; responsive element; Suc; sucrose;
Label-free quantitative phosphoproteomic profiling of cellular response induced by an insect cytokine paralytic peptide
Keywords: کییناز وابسته به کیناز; PP; Paralytic peptide; LC-MS/MS; liquid chromatography-tandem mass spectrometry; TFs; transcription factors; PKs; protein kinases; KEGG; Kyoto Encyclopedia of Genes and Genomes; MAPK; mitogen-activated protein kinase; PAK; p21-activated kinase; GBP; growt
Keywords: کییناز وابسته به کیناز; Ab; Antibody; ABC; ATP-binding cassette; AIOM; Associazione Italiana di Oncologia Medica; ALCAM; Activated leukocyte cell adhesion molecule; APOD; Apolipoprotein D; AR; androgen receptor; AURKA; Aurora kinase A; AURKB; Aurora kinase B; BCS; Biopharmaceuti
Keywords: کییناز وابسته به کیناز; Alvocidib; Flavopiridol; FLAM; Acute myeloid leukemia; Cyclin dependent kinase; CDK inhibitors;
Keywords: کییناز وابسته به کیناز; ABL; Abelson; ALL; acute lymphocytic leukemia; AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; BC; blast crisis; BCR; breakpoint cluster region; BMP; bone morphogenetic protein; CBP; CREB-binding protein; CDK; cyclin dependent kinase; CEBP
Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation
Keywords: کییناز وابسته به کیناز; Al; aluminium; ALT; alanine transaminase; AP-1; activated protein-1; AR; androgen receptor; AST; aspartate transaminase; B; boron; Ba; barium; BMI; body mass index; Ca; calcium; CDK4; cyclin dependent kinase; CEA; carcynoembrionic antigene; Chol; choles
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
Keywords: کییناز وابسته به کیناز; FOXO; Forkhead box O; DBD; DNA-binding domain; NLS; Nuclear localization sequence; NES; Nuclear export sequence; IRE; Insulin-responsive element; ARDs; Age-related diseases; RTK; Receptor tyrosine kinase; PI3K; Phosphoinositide 3kinase; SGK; Serum and glu
6,7,4â²-Trihydroxyisoflavone suppressed the estrogen receptor negative breast cancer growth via regulating glycogen synthase kinase-3β/β-catenin signaling
Keywords: کییناز وابسته به کیناز; Breast cancer; β-catenin; Cell cycle; Glycogen synthase kinase-3β; Trihydroxyisoflaovone; CDK; cyclin dependent kinase; CDKI; cyclin dependent kinase inhibitor; ER; estrogen receptor; ERK; extracellular signal-regulated kinase; GSK; glycogen synthase ki
Progesterone arrested cell cycle progression through progesterone receptor isoform A in pancreatic neuroendocrine neoplasm
Keywords: کییناز وابسته به کیناز; Pan-NEN; pancreatic neuroendocrine neoplasm; PR; progesterone receptor; PRA; PR isoform A; PRB; PR isoform B; CCNA2; cyclin A2; CCNB1; cyclin B1; CDK1; cyclin-dependent kinase 1; CDK2; cyclin-dependent kinase 2; WHO; World Health Organization; Neuroendocr
Re-evaluating the role of FOXOs in cancer
Keywords: کییناز وابسته به کیناز; RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: کییناز وابسته به کیناز; ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors
Keywords: کییناز وابسته به کیناز; Cyclin dependent kinase; Anticancer; Cell cycle; Kinase selectivity;
Pharmacokinetics and cytotoxic study of euphol from Euphorbia umbellata (Bruyns) Pax latex
Keywords: کییناز وابسته به کیناز; Euphol; Cell culture; Cytotoxic activity; UHPLC-MS; Euphorbia; Pharmacokinetics; 1D and 2D NMR; one and two dimension nuclear magnetic resonance spectroscopy; ACN; acetonitrile; ATCC; american type culture collection; CDCl3; deuterated chloroform; CDK; cy
RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo
Keywords: کییناز وابسته به کیناز; MetS; metabolic syndrome; CHD; coronary heart disease; VSMC; vascular smooth muscle cell; UPS; ubiquitin-proteasome system; RNF10; RING finger protein 10; HF; high-fat; FBG; fasting blood glucose; FSI; fasting serum insulin; HOMA-IR; homeostatic model a
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo
Keywords: کییناز وابسته به کیناز; PPI; polyphyllin I; CRPC; castration-resistant prostate cancer; EZH2; Zeste homolog 2; DNMT1; DNA methyltransferase 1; HOTAIR; HOX transcript antisense RNA; ADT; androgen deprivation therapy; NF-κB; nuclear factor-kappaB; lncRNA; Long non-coding RNA; DNM
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: کییناز وابسته به کیناز; Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
The activation of STIM1 mediates S-phase arrest and cell death in paraquat induced acute lung intoxication
Keywords: کییناز وابسته به کیناز; ALI; acute lung injury; 2-APB; 2-Aminoethoxydiphenyl borate; BSA; bovine serum albumin; CCNA/CCND/Cyclin A/D; mammalian A/D-type Cyclin; CDK; Cyclin dependent kinase; CKI; Cyclin dependent kinase inhibitor; CRISPR-CAS9; clustered regularly interspaced sho
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain
Keywords: کییناز وابسته به کیناز; ANOVA; analysis of variance; CA1; cornu ammonis 1; Cdk; cyclin dependent kinase; CNS; central nervous system; CRMP; collapsin response mediator protein; CRMP2ki/ki; CRMP2 knock-in; EDTA; ethylenediaminetetraacetic acid; GFP; green fluorescent protein; GSK
PCTAIRE1/CDK16/PCTK1 is overexpressed in cutaneous squamous cell carcinoma and regulates p27 stability and cell cycle
Keywords: کییناز وابسته به کیناز; Cdk; cyclin-dependent kinase; Dox; doxycycline; PI; propidium iodide; SCC; squamous cell carcinoma; Cutaneous squamous cell carcinoma; Cyclin dependent kinase; p27; Cell cycle;
Mechanisms of therapeutic CDK4/6 inhibition in breast cancer
Keywords: کییناز وابسته به کیناز; cyclin dependent kinase; CDK4/6 inhibitor; cell cycle; breast cancer; palbociclib;
Lucidone Promotes the Cutaneous Wound Healing Process via Activation of the PI3K/AKT, Wnt/β-catenin and NF-κB Signaling Pathways
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; COX; cyclooxygenase; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; GSK3β; glycogen synthase kinase 3 beta; ICAM; intercellular adhesion molecule; iNOS; inducible nitric oxide synthase; LY294002; (4-morph
Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy
Keywords: کییناز وابسته به کیناز; Cyclin dependent kinase; Protein–protein interaction; Cyclin groove; REPLACE; Inhibitor
Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis
Keywords: کییناز وابسته به کیناز; Aβ; Amyloid β; AD; Alzheimer's disease; Akt; protein kinase B; AraC; cytosine arabinoside; ATP; adenosine triphosphate; CaM; calmodulin; CaMKIα; Ca2 +/calmodulin-dependent kinase type 1 alpha; CaMKII; Ca2 +/calmodulin-dependent kinase type II; CDK; c
Role of XPD in cellular functions: To TFIIH and beyond
Keywords: کییناز وابسته به کیناز; ANT2; an adenine nucleotide translocase that exchanges mitochondrial ATP with cytosolic ADP; CDK; cyclin dependent kinase; CAK; CDK-activating kinase complex; CIA; cytoplasmic FeS assembly; CIA01/2; cytosolic iron-sulfur assembly component ½; CS; Cockayn
SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
Keywords: کییناز وابسته به کیناز; ACUC; Animal Care and Use Committee; AGP; andrographolide; CDK; cyclin dependent kinase; DMSO; dimethyl sulfoxide; DOX; doxorubicin; ERK1/2; extracellular signal-regulated kinases 1/2; FBS; fetal bovine serum; HPLC; high performance liquid chromatography;
KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; ChIP; chromatin immunoprecipitation; EMSA; electophoretic mobility shift assay; HOMA; homeostasis model assessments; KLF; Krüppel-like factor; OGTT; oral glucose tolerance tests; SEI-1; selected with Ink4a-1 as bait; SERTAD1
Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response
Keywords: کییناز وابسته به کیناز; 53BP1; p53 binding protein 1; ATM; ataxia-telangiectasia mutated; ATR; ataxia telangiectasia and Rad3 related; BLM; blooms syndrome RecQ helicase-like, human homolog of SGS1; BRCA1; breast cancer 1, early onset; CDC; cell division cycle; CDK; cyclin depen
The Bmi-1 helix-turn and ring finger domains are required for Bmi-1 antagonism of (â) epigallocatechin-3-gallate suppression of skin cancer cell survival
Keywords: کییناز وابسته به کیناز; Bmi-1; B-cell-specific Moloney murine leukemia virus integration site 1; HT; helix-turn; RF; ring finger; Ezh2; enhancer of zeste homolog 2; PcG; polycomb group; H2AK119ub; histone H2A ubiquitinated on lysine 119; H3K27me3; histone H3 trimethylation on
Antiproliferative activity of the isoindigo 5â²-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase
Keywords: کییناز وابسته به کیناز; Isoindigo; Anticancer; Apoptosis; Mitochondria dysfunction; Cell cycle; CDK; 5â²-Br; [(E)-1-(5â²-bromo-2â²-oxoindolin-3â²-ylidene)-6-ethyl-2,3,6,9-tetrahydro-2,9-dioxo-1H-pyrrolo[3,2-f]quinoline-8-carboxylic acid]; ÎΨm; difference in mitochondrial t
Associate editor: B. TeicherCo-targeting BRAF and cyclin dependent kinases 4/6 for BRAF mutant cancers
Keywords: کییناز وابسته به کیناز; BRAF V600E; Melanoma; CDK4/6 inhibitor; Abemaciclib; Cyclin D1; Resistance; CDK; Cyclin dependent kinase; MAPK; Mitogen activated protein kinase; RTK; Receptor tyrosine kinase; CKI; CDK inhibitory protein; EGFR; Epidermal growth factor receptor; PI3K; Pho
JUNB promotes the survival of Flavopiridol treated human breast cancer cells
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; Pol II ser2p; RNA polymerase II C-terminal domain phosphorylation on serine 2; FP; Flavopiridol; IEG; immediate early gene; DSIF; DRB Sensitivity Inhibitory Factor; NELF; Negative Elongation Factor; Chemotherapy resistance; J
Promising roles of mammalian E2Fs in hepatocellular carcinoma
Keywords: کییناز وابسته به کیناز; E2Fs; E2F family of transcription factors; HCC; hepatocellular carcinoma; pRb; retinoblastoma protein; CDK; cyclin dependent kinase; DBD; DNA binding domain; DP; dimerization partner; LZ; leuzine zipper; MB; marked box; NLS; nuclear localization signal; C
Fragment based discovery of arginine isosteres through REPLACE: Towards non-ATP competitive CDK inhibitors
Keywords: کییناز وابسته به کیناز; Cyclin dependent kinase; Drug discovery; Inhibitor; Anti-tumor therapeutic; REPLACE;
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide
Keywords: کییناز وابسته به کیناز; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; CDK; cyclin dependent kinase; CHX; cycloheximide; CO; carbon monoxide; CoPP; cobalt protoporphyrin IX; FePP; ferric protoporphyrin IX; GA; geldanamycin; HO-1; heme oxygenase-1; HSP90; heat shock protein 90;
Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; ChIP; chromatin immunoprecitiation; CKI; cyclin-dependent kinase; Egr1; early growth response 1; siRNA; small interfering RNA; Anti-proliferation; Cell cycle arrest; Egr1; p21; Shikonin;
Anti-tumor efficacy of a therapeutic peptide based on thermo-responsive elastin-like polypeptide in combination with gemcitabine
Keywords: کییناز وابسته به کیناز; ELP; elastin-like polypeptide; p21; p21Waf1/Cip1-derived cell cycle inhibitory peptide; Tt; transition temperature; CPP; cell penetrating peptide; CI; combination index; CDK; cyclin dependent kinase; Elastin-like polypeptide; Hyperthermia; p21; Anticancer
Protein degradation during the diatom cell cycle: Annotation and transcriptional analysis of SCF and APC/C ubiquitin ligase genes in Phaeodactylum tricornutum
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; SCF; Skp Cullin F-box; APC/C; anaphase promoting complex/cyclosome; CUL; cullin; CSM; CDH1-specific motif; D-box; destruction box; CKI; CDK inhibitor; RBX; RING box protein; SKP1; S-phase kinase-associated protein 1; CCS52; c
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27kip1 and FoxO3a in female rat cerebral cortex and PC12 cells
Keywords: کییناز وابسته به کیناز; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; AhR; aryl hydrocarbon receptor; CNS; central nervous system; FBS; fetal bovine serum; FoxO3a; forkhead box class O 3a; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFAP; glial fibrillary acidic protein; NeuN;
RAGE overexpression confers a metastatic phenotype to the WM115 human primary melanoma cell line
Keywords: کییناز وابسته به کیناز; RAGEs; receptor for advanced glycation end products; AGEs; advanced glycation end products; HMGB1; high mobility group box 1 protein; EMT; epithelial mesenchymal transition; cdk; cyclin dependent kinase; RAGE; S100B; Melanoma; p53 cancer; Metastatic switc
Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cells
Keywords: کییناز وابسته به کیناز; ANOVA; analysis of variance; Cdk; cyclin dependent kinase; DST; dystonin; ECL; enhanced chemiluminescence; FACS; fluorescence activated cell sorting; FBS; fetal bovine serum; FKBP5; FK506 binding protein 5; GRE; glucocorticoid responsive element; HEF1; en
Modelling cell division and endoreduplication in tomato fruit pericarp
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; CKI; cyclin dependent kinase inhibitor; APC/C; anaphase promoting complex; KRP/ICK; Kip-related protein/Interactor of CDKs, family of CKIs; E2F; family of transcription factors; DP; dimerization partner; DEL; dimerization par
Completion of cell division is associated with maximum telomerase activity in naturally synchronized cultures of the green alga Desmodesmus quadricauda
Keywords: کییناز وابسته به کیناز; CDK; cyclin dependent kinase; CP; commitment point; Ct; cycle threshold; FACS; fluorescence-activated cell sorting; ND; nuclear division; PEG; polyethylene glycol; PD; protoplast division; pS; pre-S phase; qTRAP; quantitative telomere repeat amplification
Di 2-ethyl hexyl phthalate affects differentiation and matrix mineralization of rat calvarial osteoblasts - in vitro
Keywords: کییناز وابسته به کیناز; ALP; alkaline phosphatase; BPA; bisphenol A; BSP; bone sialoprotein; CDK; cyclin dependent kinase; DEHP; di 2-ethyl hexyl phthalate; DIDP; diisodecyl phthalate; ED; endocrine disruptor; OPN; osteopontin; PCB; polychlorinated biphenyls; ROB; rat calvarial
Robustness and adaptation reveal plausible cell cycle controlling subnetwork in Saccharomyces cerevisiae
Keywords: کییناز وابسته به کیناز; PPI; protein-protein interaction; DIP; Database of Interacting Proteins; CYGD; Comprehensive Yeast Genome Database; CDK; cyclin dependent kinase; Modularity; Protein-protein interaction; Cell cycle; Saccharomyces cerevisiae; Robustness;
Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells
Keywords: کییناز وابسته به کیناز; 2DE; two-dimensional gel electrophoresis; ABC; ammonium bicarbonate; ACN; acetonitrile; BAD; BCL2 antagonist of cell death; BCL2; B-cell lymphoma 2; BP; n-butylidenephthalide; CCND1; cyclin D1; CDC25A; cell division cycle 25 homolog A; CDK; cyclin depende