کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8260224 | 1534658 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RAGE overexpression confers a metastatic phenotype to the WM115 human primary melanoma cell line
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کلمات کلیدی
CDKAGEsS100BHMGB1RAGERAGEsepithelial mesenchymal transition - انتقال مزانشیمی epithelialEMT - تکنسین فوریتهای پزشکیMelanoma - خال سرطانی یا ملانوماAdvanced glycation end products - محصولات نهایی پیشرفته گلیساسیونHigh mobility group box 1 protein - پروتئین جعبه 1 پروتئین گروه تحرکcyclin dependent kinase - کییناز وابسته به کینازReceptor for advanced glycation end products - گیرنده برای محصولات پیشرفته glycation پایان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The formation of melanoma metastases from primary tumor cells is a complex phenomenon that involves the regulation of multiple genes. We have previously shown that the receptor for advanced glycation end products (RAGE) was up-regulated in late metastatic stages of melanoma patient samples and we hypothesized that up-regulation of RAGE in cells forming a primary melanoma tumor could contribute to the metastatic switch of these cells. To test our hypothesis, we overexpressed RAGE in the WM115 human melanoma cell line that was established from a primary melanoma tumor of a patient. We show here that overexpression of RAGE in these cells is associated with mesenchymal-like morphologies of the cells. These cells demonstrate higher migration abilities and reduced proliferation properties, suggesting that the cells have switched to a metastatic phenotype. At the molecular level, we show that RAGE overexpression is associated with the up-regulation of the RAGE ligand S100B and the down-regulation of p53, ERK1/2, cyclin E and NF-kB. Our study supports a role of RAGE in the metastatic switch of melanoma cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 7, July 2014, Pages 1017-1027
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 7, July 2014, Pages 1017-1027
نویسندگان
Varsha Meghnani, Stefan W. Vetter, Estelle Leclerc,