Keywords: Preeclampsia; CYP11B2; ACEgene; Gene polymorphism;
مقالات ISI (ترجمه نشده)
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Keywords: ZG; zona glomerulosa; Ang II; angiotensin II; PA; primary aldosteronism; APA; aldosterone-producing adenoma; IHA; idiopathic hyperaldosteronism; FH; familial hyperaldosteronism; CYP11B2; aldosterone synthase; StAR; steroidogenic acute regulatory protein;
Keywords: Aldosterone; Chimera; CYP11B1; CYP11B2; KCNJ5; ATP1A1; ATP2B3; CACNA1D; CACNA1H; CTNNB1;
Keywords: Aldosterone; CYP11B2; Hypertension; Imidazopyridine; Heart failure;
Keywords: ACTH; adrenocorticotropin; ACTH-R; adrenocorticotropin receptor; ActRI; activin type-I receptor; ActRII; activin type-II receptor; ALK; activin receptor-like kinase; AngII; angiotensin II; AT1R; Ang II type 1 receptor; BMP; bone morphogenetic protein; BMP
Keywords: ACTH; adrenocorticotropic hormone; cAMP/PKA; cAMP-dependent protein kinase A; CD; cluster of differentiation; CRH; corticotrophin releasing hormone; CYP11A1 or P450scc; cytochrome P450 side-chain cleavage enzyme; CYP11B1; 11β-hydroxylase type 1; CYP11B2;
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity
Keywords: CYP11B2; Aldosterone; Diabetic nephropathy; Isoxazole; Reductive metabolism;
Catalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid
Keywords: CYP17A1; cytochrome P450 17A1; CYP11B1; cytochrome P450 11B1; CYP11B2; cytochrome P450 11B2; POR; cytochrome P450-oxidoreductase; 12:0 PC (DLPC); 1,2-dioleoyl-sn-glycero-3-phosphocholine; 14:0 PC; 1,2-dimyristoyl-sn-glycero-3-phosphocholine; 16:0 PC; 1,2-
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension
Keywords: Aldosterone synthase; CYP11B2; Indazole; Hit-to-lead; Hypertension;
4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures
Keywords: Aldosterone; CYP11B2; CYP11B1; Aldosterone synthase inhibitor; Amino-pyrimidine;
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3
Keywords: Primary aldosteronism; Aldosterone; CYP11B2; KCNJ5; CYP17A1;
CRISPR/Cas9-induced disruption of wt1a and wt1b reveals their different roles in kidney and gonad development in Nile tilapia
Keywords: Amh; Anti-Müllerian hormone; Cyp19a1a; cytochrome P450, family 19, subfamily A, polypeptide 1a; Cyp11b2; cytochrome P450, family 11, subfamily B, polypeptide 2; dah; days after hatching; Dmrt1; double sex- and mab-3-related transcription factor-1; Gsdf;
The metabolic fate and receptor interaction of 16α-hydroxyprogesterone and its 5α-reduced metabolite, 16α-hydroxy-dihydroprogesterone
Keywords: Adrenal 16α-hydroxyprogesterone; SRD5A; CYP11B2; AKR1C2; Progesterone receptor; UHPLC-MS/MS;
Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17
Keywords: Aldosterone-producing adenoma; CYP11B1; CYP11B2; CYP17; Double-immunostaining; Triple-immunostaining;
Expression of steroidogenic enzymes and their transcription factors in cortisol-producing adrenocortical adenomas: immunohistochemical analysis and quantitative real-time polymerase chain reaction studies
Keywords: Cortisol-producing adrenocortical adenoma; HSD3B1; HSD3B2; CYP11B1; CYP11B2;
Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human
Keywords: Aldosterone; Aldosterone synthase; Cortisol; CYP11B1; CYP11B2; Cytochrome P450; Inhibitors
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase
Keywords: CYP11B1 inhibitors; CYP11B2; CYP19; CYP17; Coumarins; Imidazolyl-acetophenonesCYP, cytochrome P450; SAR, structure–activity relationship; SSR, structure–selectivity relationship; QSAR, quantitative structure–activity relationship; CYP19, aromatase; CYP17,
An investigation of the endocrine disrupting potential of enniatin B using in vitro bioassays
Keywords: HMGR; hydroxy-methyl-glutaryl CoA reductase; StAR; steroidogenic acute regulatory; CYP11A; cytochrome P450 11A; CYP11B1; cytochrome P450 11B1; CYP11B2; aldosterone synthetase; CYP17; cytochrome P450 17; CYP21; cytochrome P450 21; 3βHSD2; 3-beta-hydroxyst
The CYP11B subfamily
Keywords: A, aldosterone; B, corticosterone; DOC, 11-deoxycorticosterone; E, cortisone; F, cortisol; S, 11-deoxycortisolCYP11B1; CYP11B2; Steroid hormone; Regulation; Species diversity; Cytochrome P450; Aldosterone; Cortisol
Development of monoclonal antibodies against human CYP11B1 and CYP11B2
Keywords: CYP11B1; CYP11B2; Adrenal cortex; Monoclonal antibodies; 17α-Hydroxylase; Immunofluorescence;
Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies
Keywords: CYP11B1; Cytochrome P450, family 11, subfamily B, polypeptide 1; CYP11B2; Cytochrome P450, family 11, subfamily B, polypeptide 2; CYP17; 17α-hydroxylase; NA; normal adrenal gland; IHA; idiopathic hyperaldosteronism; APA; aldosterone-producing adenoma; ZG
Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA)
Keywords: Gonadotropin-releasing hormone receptor (GnRHR); Adrenal aldosterone-producing adenoma (APA); CYP11B2; Aldosterone
Regulation of CYP11B1 and CYP11B2 steroidogenic genes by hypoxia-inducible miR-10b in H295R cells
Keywords: Hypoxia-inducible factor; miR-10b; CYP11B1; CYP11B2; Aldosterone; Cortisol;
Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells
Keywords: AII; angiotensin II; ARB; AII receptor blocker; RAAS; renin-angiotensin-aldosterone system; PPAR; peroxisome proliferator-activated receptor; CaMK; Ca2+/calmodulin-dependent kinase; NGFIB; nerve growth factor-induced clone B; NURR1; Nur-related factor
Lessons from the gene expression pattern of the rat zona glomerulosa
Keywords: zG; zona glomerulosa; zF; zona fasciculata; zR; zona reticularis; Cyp11b1; steroid 11β-hydroxylase; Cyp11b2; aldosterone synthase; TGF-β; transforming growth factor β; Gpc3; glypican 3; Kcnn2; potassium intermediate/small conductance calcium-activated
11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
Keywords: 11KA4; 11-ketoandrostenedione; 11KT; 11-ketotestosterone; 11OH-5α-dione; 11β-hydroxy 5α-androstanedione; 11OH-AST; 11β-hydroxyandrosterone; 11OHA4; 11β-hydroxyandrostenedione; 11OHT; 11β-hydroxytestosterone; 11βHSD; 11β-hydroxysteroid dehydrogenas
Non-adrenal synthesis of aldosterone: A reality check
Keywords: Aldosterone; Extra-adrenal; Hypertension; CYP11B2
An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland
Keywords: Ang II; angiotensin II; ActRII; activin type II receptor; ALK; activin receptor-like kinase; 3βHSD2; 3β-hydroxysteroid dehydrogenase type 2; BMP; bone morphogenetic protein; BMPRII; BMP type II receptor; KLH; keyhole limpet hemocyanin; P450aldo; P450 al
Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level
Keywords: CYP11B2; Aldosterone; Hypertension; Steroidogenesis
Regulation of human CYP11B1 and CYP11B2 promoters by transposable elements and conserved cis elements
Keywords: CYP11B1; CYP11B2; Transposable elements; Ad5; ERRα; SF-1
The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells
Keywords: P450; cytochrome P450; 3βHSD; 3β-hydroxysteroid dehydrogenase II; CYP11A1; cytochrome P450 side-chain cleavage; PREG; pregnenolone; CYP17A1; P450 17α-hydroxylase/1720 lyase; 17OH-PREG; 17-hydroxypregnenolone; DHEA; dehydroepiandrosterone; DHEA-S; dehyd
Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma
Keywords: Primary aldosteronism; Microadenoma; CYP11B2; Gene expression
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2)
Keywords: CYP11B2; Aldosterone synthase; Selective inhibition; Metyrapone; Aldosterone; Congestive heart failure; Myocardial fibrosis;
Adrenocortical stem and progenitor cells: Unifying model of two proposed origins
Keywords: AGP; adrenogonadal primordium; FAdE; fetal adrenal enhancer; DAdE; definitive adrenal enhancer; Sf1; steroidogenic factor 1; E; embryonic day; Shh; sonic hedgehog; Cyp11b1; cytochrome P450, family 11, subfamily b, polypeptide 1; Cyp11b2; cytochrome P450,
Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations
Keywords: Hypoaldosteronism; Corticosterone methyloxidase deficiency; Aldosterone synthase; CYP11B2; P450 mutants; Whole-cell system; Fission yeast; Schizosaccharomyces pombe;
Differential effects of 17β-estradiol and 11-ketotestosterone on the endocrine stress response in zebrafish (Danio rerio)
Keywords: HPI-axis; Cortisol; Sex steroids; Gene expression; crf; star; cyp11b2; Superfusion
The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase
Keywords: CYP11B2; Aldosterone; CYP11B1; Aldosterone synthase inhibitor; Hypertension;
Hipoaldosteronismo primario e hipoacusia bilateral moderada en un niño con una mutación sin sentido en homocigosis (Thr318Met) en el gen CYP11B2
Keywords: Hipoaldosteronismo; Hipoacusia; CYP11B2; Hypoaldosteronism; Hypocusia; CYP11B2;
Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses
Keywords: Aldosterone synthase deficiency (ASD); CYP11B2; Steroid hydroxylation;
Aldosterone: From biosynthesis to non-genomic action onto the proteome
Keywords: Aldosterone; Non-genomic; CYP11B1; CYP11B2; Schizosaccharomyces pombe
Spironolactone exhibits direct renoprotective effects and inhibits renal renin–angiotensin–aldosterone system in diabetic rats
Keywords: Aldosterone; Diabetic nephropathy; Mineralocorticoid receptor antagonist; CYP11B2
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene
Keywords: Aldosterone synthase deficiency (CMO I); CYP11B2; Steroid hydroxylation; Cell culture; GC–MS
â344C/T Variant in the Promoter of the Aldosterone Synthase Gene (CYP11B2) Is Associated With Metabolic Syndrome in Men
Keywords: Aldosterone synthase; CYP11B2; polymorphism; metabolic syndrome; population study;
Interacting influence of potassium and polychlorinated biphenyl on cortisol and aldosterone biosynthesis
Keywords: PCB; Potassium; Adrenal; Cortisol; Aldosterone; CYP11B1; CYP11B2
Role of aldosterone availability in preeclampsia
Keywords: Aldosterone; Preeclampsia; CYP11B2; Mineralocorticoid receptor
CYP17- and CYP11B-dependent steroid hydroxylases as drug development targets
Keywords: CYP11B1; CYP11B2; CYP17; Hypertension; Heart fibrosis; Prostate cancerACE, angiotensin-converting enzyme; ADME, absorption, distribution, metabolism, and excretion; AdR, adrenodoxin reductase; Adx, adrenodoxin; AGS (CAH), Adrenogenital syndrome (congenita
Molecular identity and gene expression of aldosterone synthase cytochrome P450
Keywords: Aldosterone synthase; 11β-Hydroxylase; Salt-inducible kinase; CYP11B1; CYP11B2; P450;
Human renal mesangial cells produce aldosterone in response to low-density lipoprotein (LDL)
Keywords: Mesangial cells; Aldosterone; Pregnenolone; LDL receptor; P450scc; 3β-HSD; 21-Hydroxylase; CYP11B2; Low-density lipoprotein (LDL); Mineralocorticoid receptor;
The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11β-hydroxylase) inhibitors
Keywords: CYP11B2; CYP11B1; Inhibitor screening; Selective inhibition; Myocardial fibrosis; Congestive heart failure; Renin-angiotensin-aldosterone system; Adrenocortical tumor cell line NCI-H295R;