کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8258649 1534611 2018 45 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of aldosterone production by ion channels: From basal secretion to primary aldosteronism
ترجمه فارسی عنوان
مقررات تولید آلدوسترون توسط کانال های یونی: از ترشح پایه تا آلدسترونیزم اولیه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Aldosterone is produced by zona glomerulosa (ZG) cells of the adrenal cortex and plays a key role in balancing water and electrolytes levels. Autonomous overproduction of aldosterone leads to primary aldosteronism (PA), which is the most common form of secondary endocrine hypertension. Recently, significant progress has been made towards understanding the genetic basis of PA, where increasing clinical evidence suggests that mutations in ion channels appear to be the major cause of aldosterone-producing adenomas. In this review, we focused on potassium and calcium channels that regulate aldosterone secretion, and their roles in the pathology of PA. Because potassium and calcium channels are differentially expressed in ZG cells in different species of mammals, the limitations of published studies are also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1864, Issue 3, March 2018, Pages 871-881
نویسندگان
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