An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland

► Neutralization of endogenous BMP-6 by immunization reduced aldosterone production in vivo. ► Chronic Ang II treatment impaired the neutralization effect of BMP-6. ► Adrenal CYP11B2 expression and plasma aldosterone/corticosterone were reduced by blocking BMP-6. ► Endogenous BMP-6 is linked to aldosterone synthesis in the adrenal.