Keywords: سیتوکروم P450s; AHR; aryl hydrocarbon receptor; ALD; alcoholic liver disease; BAs; bile acids; CAR; constitutive androstane receptor; CARM1; coactivator associated arginine methyltransferases 1; CBP/P300; CREB-binding protein/p300; CYP27A1/Cyp27a1; sterol 27α-hydroxylas
مقالات ISI سیتوکروم P450s (ترجمه نشده)
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Keywords: سیتوکروم P450s; Carcinogenesis; Chemoprevention; Chemotherapy; Oxidative stress; Nrf2; Phytochemicals; AKT; protein kinase B; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ATF-2; activating transcriptional factor; BBN; N-butyl-N-(4-hydroxybutyl)n
Keywords: سیتوکروم P450s; Bayesian analysis; Glutathione conjugation; Oxidative metabolism; Tetrachloroethylene; Physiologically based pharmacokinetic (PBPK) model; Risk assessment; CC; Collaborative Cross; CDC; Centers for Disease Control and Prevention; CU; coefficient of uncert
Metabolic profiling of five flavonoids from Dragon's Blood in human liver microsomes using high-performance liquid chromatography coupled with high resolution mass spectrometry
Keywords: سیتوکروم P450s; CYPs; cytochrome P450s; DB; Dragon's Blood; HLMs; human liver microsomes; HPLC-HR-MS; high performance liquid chromatography coupled with high resolution mass spectrometry; tR; retention time; Dragon's Blood; Human liver microsomes; HPLC-HR-MS; Metabolite
Keywords: سیتوکروم P450s; drug interaction; cytochrome P450s; membrane transport/transporters; substrate; inhibitor; inducer; AE; adverse event; CYP; cytochrome P-450; DDI; drug-drug interaction; E-R; exposure-response; FDA; Food and Drug Administration; PK; pharmacokinetic;
Keywords: سیتوکروم P450s; ASTRO; astroglial brain tumors; CBT; childhood brain tumor; CNS; central nervous system; CYPs; cytochrome P450s; 95% CI; 95% confidence interval; 2,4-D; 2,4-dichlorophenoxy acetic acid; ICCC; international classification of children cancer; ICD; internati
Keywords: سیتوکروم P450s; Cancer; Target therapy; Prodrug; MDR; Multidrug resistance; ROS; Reactive oxygen species; GSH; Glutathione; ADCs; Antibody-drug conjugates; ADEPT; Antibody-directed enzyme prodrug therapy; GDEPT; Gene-directed enzyme prodrug therapy; HIF; Hypoxia-inducibl
Keywords: سیتوکروم P450s; DP; Dechlorane Plus; e-waste; electronic waste; GT; the great tit (Parus major); OMR; the oriental magpie-robin (Copsychus saularis); LVB; the light-vented bulbul (Pycnonotus sinensis); RWB; the red-whiskered bulbul (Pycnonotus jocosus); SBSB; the streak-
Keywords: سیتوکروم P450s; Cytochrome P450s; Experimental colitis; Dextran sulfate sodium; Testosterone; Metabolism
Keywords: سیتوکروم P450s; Traditional medicine Asia and Oceania; Herb-drug interactions; Cytochrome P450s; Antiretroviral therapy; Papua New Guinea;
Keywords: سیتوکروم P450s; Biocatalyst; Metagenomics; Database mining; Protein engineering; Transaminases; Cytochrome P450s; Baeyer–Villiger monooxygenases
Keywords: سیتوکروم P450s; Cytochrome P450s; N-Deethylation; Enrofloxacin; Ciprofloxacin
Degradation of bisphenol A and acute toxicity reduction by different thermo-tolerant ascomycete strains isolated from arid soils
Keywords: سیتوکروم P450s; Bisphenol A; Ascomycete fungi; Cytochrome P450s; Laccases; LC-MS analysis; Degradation pathway;
Safety assessment of Oryeong-san, a traditional herbal formula: Study of subacute toxicity and influence of cytochrome P450s and UDP-glucuronosyltransferases
Keywords: سیتوکروم P450s; Herbal formula; Oryeong-san; Subacute toxicity; Cytochrome P450s; UDP-glucuronosyltransferase;
Genome-wide identification of 31 cytochrome P450 (CYP) genes in the freshwater rotifer Brachionus calyciflorus and analysis of their benzo[α]pyrene-induced expression patterns
Keywords: سیتوکروم P450s; Freshwater rotifer; Brachionus calyciflorus; Cytochrome P450s; Benzo[α]pyrene;
Molecular characterization of pyrethroid resistance in the olive fruit fly Bactrocera oleae
Keywords: سیتوکروم P450s; Olive fruit fly; Pyrethroid resistance; Gene expression; Detoxification; Cytochrome P450s;
Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects
Keywords: سیتوکروم P450s; CYPs; cytochrome P450s; HDIs; herb-drug interactions; HLMs; human liver microsomes; NADPï¼; β-nicotinamide adenine dinucleotide phosphate; QSAR; quantitative structure activity relationship; CoMFA; comparative molecular field analysis; LC-MS; liquid c
Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii
Keywords: سیتوکروم P450s; cdm; cell dry mass; IPP; isopentenyl pyrophosphate; DMAPP; dimethylallyl pyrophosphate; FPPs; farnesyl pyrophosphate (synthase); GGPP; geranylgeranyl pyrophosphate; TAP; Tris acetate phosphate medium; YFP; mVenus yellow fluorescent protein; CFP; mCerulean
An integrated strategy for the quantitative analysis of endogenous proteins: A case of gender-dependent expression of P450 enzymes in rat liver microsome
Keywords: سیتوکروم P450s; Cytochrome P450s; Gender difference; Rat liver microsome; Standard curve slope;
Nonmonotonic responses to low doses of xenoestrogens: A review
Keywords: سیتوکروم P450s; AhR; aryl hydrocarbon receptor; AR; androgen receptor; BPA; bisphenol A; CYPs; cytochrome P450s; DES; diethylstilbestrol; DnBP; di-n-butyl phthalate; Dpf; days post-fertilization; Dph; days post-hatch; E2; 17β-estradiol; EE2; 17α-ethynylestradiol; EDCs;
In vitro inhibitory mechanisms and molecular docking of 1â²-S-1â²-acetoxychavicol acetate on human cytochrome P450 enzymes
Keywords: سیتوکروم P450s; 1â²-S-1â²-acetoxychavicol acetate; Drug interaction; Cytochrome P450; Inhibition; Enzyme kinetics; Molecular docking; ACA; 1â²-s-1â²-acetoxychavicol acetate; BOMCC; 7-benzyloxymethyloxy-3-cyanocoumarin; CYPS; cytochrome p450s; DBOMF; dibenzyloxymethyl
Ectopic expression of an apple cytochrome P450 gene MdCYPM1 negatively regulates plant photomorphogenesis and stress response in Arabidopsis
Keywords: سیتوکروم P450s; Cytochrome P450s; Skotomorphogenesis; Stress response; Apple;
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity
Keywords: سیتوکروم P450s; MPS; microphysiological system; LDH; lactate dehydrogenase; ALT; alanine aminotransferase; BNF; beta-naphthoflavone; Rif; rifampin; EROD; ethoxyresorufin-O-deethylase; CYPs; cytochrome P450s; HNF4α; hepatocyte nuclear factor 4 alpha; MDZ; midazolam; AFB;
In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods
Keywords: سیتوکروم P450s; drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;
Lycopene, resveratrol, vitamin C and FeSO4 increase damage produced by pro-oxidant carcinogen 4-nitroquinoline-1-oxide in Drosophila melanogaster: Xenobiotic metabolism implications
Keywords: سیتوکروم P450s; Wing spot test; Antioxidants; Cytochrome P450s;
Lycopene protects against atrazine-induced hepatotoxicity through modifications of cytochrome P450 enzyme system in microsomes
Keywords: سیتوکروم P450s; Atrazine; Lycopene; Cytochrome P450s; Hepatic microsome; Transcriptional regulation
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
Keywords: سیتوکروم P450s; Drug-induced liver toxicity; HepG2; Drug metabolizing enzyme; Cytochrome P450s
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1â²-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism
Keywords: سیتوکروم P450s; CYP; cytochrome P450s; DEX; dexamethasone; E-3â²-N2-dGuo; N2-(trans-isoestragol-3â²-yl)-2â²-deoxyguanosine; GSTs; glutathione S transferases; OTM; olive tail moment; PAPSS; 3â²-phosphoadenosine 5â²-phosphosulphate synthase; PCP; pentachlorophenol; PN
In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes
Keywords: سیتوکروم P450s; l-Corydalmine; Metabolism; Hepatic microsomes; Cytochrome P450s; Interspecies difference; CyLM; cynomolgus monkey liver microsomes; CYP450; cytochrome P450; DLM; dog liver microsomes; HLM; human liver microsomes; HPLC; high-performance liquid chromatograp
An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease
Keywords: سیتوکروم P450s; Bile Acids; Farnesoid X Receptor; Metabolic Disease; Ceramides; BSH; bile salt hydrolase; CA; cholic acid; cAMP; cyclic adenosine monophosphate; CDCA; chenodeoxycholic acid; CYP; cytochrome P450s; CYP7A1; CYP with cholesterol 7α-hydroxylase; DCA; deoxych
An ex vivo approach to botanical–drug interactions: A proof of concept study
Keywords: سیتوکروم P450s; Botanical–drug interactions; Cytochrome P450s; Ex-vivo model; Milk thistle; Goldenseal
Effect of prenatal exposure of lindane on alterations in the expression of cerebral cytochrome P450s and neurotransmitter receptors in brain regions
Keywords: سیتوکروم P450s; Lindane; Rats; Cytochrome P450s; Neurotransmitter receptors; Expression
Role of cytochrome P450 and UDP-glucuronosyltransferases in metabolic pathway of homoegonol in human liver microsomes
Keywords: سیتوکروم P450s; Homoegonol; 4-O-demethylation; Glucuronidation; Human liver microsomes; Cytochrome P450s; UDP-Glucuronosyltransferases
Cytochrome P450s from the Chinese white pine beetle, Dendroctonus armandi (Curculionidae: Scolytinae): Expression profiles of different stages and responses to host allelochemicals
Keywords: سیتوکروم P450s; Chinese white pine beetle; Cytochrome P450s; Allelochemicals; Detoxification; Toxicity;
Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases
Keywords: سیتوکروم P450s; HLMs; human liver microsomes; UGTs; UDP-glucuronosyltransferases; SGR; Structure-glucuronidation relationship; HPLC; high performance liquid chromatography; NADPH; nicotinamide adenine dinucleotide phosphate reduced; CYP450s; cytochrome P450s; PAPS; 3â
Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models
Keywords: سیتوکروم P450s; Benfuracarb; Human variability; Cytochrome P450s; CYP assignment; Metabolism; Risk assessment;
Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism
Keywords: سیتوکروم P450s; Flavonoids; Cytochrome P450s; Cancer; Cell cycle; Benzo[a]pyrene; CYP1 induction;
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart
Keywords: سیتوکروم P450s; Mercury; Cardiac hypertrophy; Cytochrome P450s; Arachidonic acid metabolism; Soluble epoxide hydrolase20-HETE, 20-hydroxyeicosatetraenoic acid; AhR, aryl hydrocarbon receptor; ANP, atrial natriuretic peptide; BaP, benzo(a)pyrene; BNP, brain natriuretic pe
Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems
Keywords: سیتوکروم P450s; ABC; ATP binding cassette; CYPs; cytochrome P450s; DHEAS; dehydroepiandrosteronesulfate; ER; endoplasmic reticulum; E17βG; estradiol-17β-glucuronide; E3S; estrone-3-sulfate; G6P; glucose-6-phosphate; HPTLC; high performance thin layer chromatography; MR
Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism
Keywords: سیتوکروم P450s; CYP; Cytochrome P450; PAH; polycyclic aromatic hydrocarbon; EROD; ethoxyresorufin 7-dealkylase; PROD; pentoxyresorufin 7-dealkylase; B[α]P; benzo[α]pyrene; PNP; p-nitrophenol hydroxylation; FMO; flavin-containing monoxygenases; EH; epoxide hydrolases; G
Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: A role of heme oxygenase-1
Keywords: سیتوکروم P450s; AhR; aryl hydrocarbon receptor; MeHg; methyl mercury chloride; CYPs; cytochrome P450s; HO-1; heme oxygenase-1; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); XRE; xenobiotic responsive element; ARE; antioxidant responsive element; SnMP; Tin mesoporphyr
Optimizations to achieve high-level expression of cytochrome P450 proteins using Escherichia coli expression systems
Keywords: سیتوکروم P450s; N-terminus modifications; Cytochrome P450s; Cytochrome P450 protein; Recombinant expression; Expression systems; Silent mutations;
Murine atrial HL-1 cell line is a reliable model to study drug metabolizing enzymes in the heart
Keywords: سیتوکروم P450s; HL-1; Cytochrome P450s; Arachidonic acid metabolism; Epoxyeicosatrienoic acids; Dihydroxyeicosatrienoic acids; Epoxygenases; Hydroxylases; Cardiac hypertrophy
Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development
Keywords: سیتوکروم P450s; Genomics; Animal models; Drug discovery; Beagle; Minipig; Cytochrome P450s
Dammar resin, a non-mutagen, inducts oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline
Keywords: سیتوکروم P450s; Dammar resin; IQ; Genotoxicity; Oxidative stress; Cytochrome P450s
Cardiovascular actions and therapeutic potential of tanshinone IIA
Keywords: سیتوکروم P450s; Ang-II; angiotensin II; AP-1; activator protein-1; ApoEâ/â; ApoE deficient; AT1R; type 1 Ang-II receptor; [Ca2+]i; intracellular calcium; CVD; cardiovascular diseases; CYP; cytochrome P450s; DOX; doxorubicin; eNOS; endothelial nitric oxide synthase; E
Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors
Keywords: سیتوکروم P450s; ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A
Bioelectrocatalytic properties of Agrocybe aegerita peroxygenase
Keywords: سیتوکروم P450s; Peroxygenase; Cytochrome P450s; Horseradish peroxidase; 4-Nitrophenol; Agrocybe
Adaptation of a corticosterone ELISA to demonstrate sequence-specific effects of angiotensin II peptides and C-type natriuretic peptide on 1α-hydroxycorticosterone synthesis and steroidogenic mRNAs in the elasmobranch interrenal gland
Keywords: سیتوکروم P450s; Corticosteroids; Steroidogenesis; StAR; Cytochrome P450s; Elasmobranch; 1α-Hydroxycorticosterone; Angiotensin II;
2,3,7,8-Tetrachlorodibenzo-p-dioxin and β-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism
Keywords: سیتوکروم P450s; H9c2 cells; TCDD; AhR; Cytochrome P450s; Heart; Hypertrophy