دانلود مقالات ISI درباره Cytochromes P450 + ترجمه فارسی

تعامل هم افزایی اسیدهای چرب و اکسسترتیرول باعث کاهش عملکرد میتوکندری می شود و انطباق کبد را در طول پیشرفت ناباروری محدود می کند.

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

Keywords: NAFLD; non-alcoholic fatty liver disease; NAFL; non-alcoholic fatty liver; NASH; non-alcoholic steatohepatitis; mtDNA; mitochondrial DNA; FFAs; free fatty acids; TNF; tumor necrosis factor; CTRL; control; HF; high-fat; HF+HCh; high-fat+high-cholesterol; 7

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

نقش سلولهای غیر اندوتلیال در نفوذ نانوذرات از طریق مانع مغزی خون

The role of non-endothelial cells on the penetration of nanoparticles through the blood brain barrier

Keywords: ALA; 5-aminolevulinic acid; AMT; Adsorptive-mediated transcytosis; BBB; Blood-brain barrier; B-CSF; Blood-cerebrospinal fluid barrier; CNS; Central nervous system; CSF; Cerebrospinal fluid; CYPs; Cytochromes P450; FUS; Focused ultrasound; GLUT-1; Glucose

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

ویژگی های واضح واکنش پذیری پلاکتی نوزادان

Distinct characteristics of neonatal platelet reactivity

Keywords: ADP; adenosine 5′-diphisphate; COX; cyclooxygenase; CYP; cytochromes P450; GP; glycoprotein; IP3; inositol triphosphate; PFA-100; platelet function analyzer; PSGL-1; P-selectin glycoprotein ligand-1; sCD40L; subule CD40 ligand; TXA2; thromboxane A2; vWF

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

تعاملات میکروبیولوژیک روده با متابولیسم دارو، اثربخشی و سمیت

Gut microbiome interactions with drug metabolism, efficacy, and toxicity

Keywords: ADMET; absorption, distribution, metabolism, excretion, toxicity; AHR; aryl hydrocarbon receptor; AUC; area under the curve; BVU; (E)-5-(2-bromovinyl) uracil; CAR; constitutive androstane receptor; cMOAT; Canalicular multispecific organic anion transporte

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

استرس اکسیداتیو و متابولیسم ناشی از پرممتورین. بازنگری

Permethrin-induced oxidative stress and toxicity and metabolism. A review

Keywords: 3-PBA; 3-phenoxybenzoic acid; 3-PBAlc; 3-phenoxy-benzylalcohol; 8-OhdG; 8-hydroxy-2′-deoxyguanosine; AchE; acetylcholinesterase; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; ANT; anthracene; ARE; antioxidant response element; AUC; area unde

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

مطالعات مکانیکی بر روی فرآیند فعال سازی پراکسید هیدروژن متالورژی متمرکز برای انگیزه های زیست پزشکی و محیط زیست

Mechanistic studies on versatile metal-assisted hydrogen peroxide activation processes for biomedical and environmental incentives

Keywords: Hydrogen peroxide activation; Metal complexes; Photosensitizers; Semiconductors; Redox reactions; Photocatalysis; ROS; reactive oxygen species; SOD; superoxide dismutase; Por; porphyrin; TAML; tetraamido macrocyclic ligand; DFT; density functional theory;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

در معرض قرار گرفتن در معرض دوزهای پایین داروها، بیان کبدی ژنهای روزانه در موشهای نابالغ و چاق اختلال ایجاد میکند

Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice

Keywords: Alas1; aminolevulinic acid synthase 1; ALT; alanine aminotransferase; APAP; acetaminophen; Arntl; aryl hydrocarbon receptor nuclear translocator-like; Arrdc3; arrestin domain containing 3; AST; aspartate aminotransferase; Atp2b2; ATPase calcium transporti

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

A CYP2B6-humanized mouse model and its potential applications

Keywords: CYP2B6; Liver; Drug metabolism; Xenobiotic toxicity; Knockout mice; Humanized mice; WT; wild-type; CYPs; cytochromes P450; CAR; constitutive androstane receptor; PXR; pregnane X receptor; GR; glucocorticoid receptor; PB; phenobarbital; and DEX; dexamethas

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of hydrogen peroxide on Microcystic aeruginosa: Role of cytochromes P450

Keywords: Microcystis aeruginosa; Hydrogen peroxide; Cytochromes P450; Photosynthesis; Microcystins;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Transcriptional activity of detoxification genes is altered by ultraviolet filters in Chironomus riparius

Keywords: Ultraviolet filters; Detoxification; Cytochromes P450; Multidrug resistance protein 1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

AhR signaling pathways and regulatory functions

Keywords: AhR; ARNT; AhRR; Dioxins; Src; Cytochromes P450;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Keywords: Neobavaisoflavone; Cytochromes P450; UDP-glucuronosyltransferase; Species difference; Metabolic pathway;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases

Keywords: Steroid hormone biosynthesis; Sulfonated steroids; Cytochromes P450;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Diverse responses of tanshinone biosynthesis to biotic and abiotic elicitors in hairy root cultures of Salvia miltiorrhiza and Salvia castanea Diels f. tomentosa

Keywords: AACT; acetyl-CoA C-acetyltransferase; CPS; copalyl diphosphate synthase; CT; cryptotanshinone; CYPs; cytochromes P450; DMAPP; dimethylallyl diphosphate; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulo

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib

Keywords: CA; caffeic acid; CT; cryptotanshinone; CYP76AH1; cytochrome P450 dependent monooxygenase; CYPs; cytochromes P450; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DW; dry weigh

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells

Keywords: PAIB-SOs; phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates; CYPs; cytochromes P450; PAIB-SAs; 4-(3-alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides; PIB-SOs; phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates; PIB-SAs; phenyl 4-(2-oxoim

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Metabolic profiling of corylin in vivo and in vitro

Keywords: Corylin; Metabolites profile; Cytochromes P450; UDP-glucuronosyltransferase; Species differences;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells

Keywords: 2-DG; 2-deoxyglucose; 3-MST; 3-mercaptopyruvate sulfurtransferase; 5-FU; 5-fluorouracil; AA; antimycin A; ABC; ATP-binding cassette; AMPK; AMP kinase; AOAA; aminooxyacetic acid; ATM; ataxia-telangiectasia mutated serine/threonine protein kinase; ATP; aden

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo

Keywords: BER; berberine; CYP; cytochromes P450; TCMs; traditional Chinese medicines; OTC; over the counter; BNF; β-Naphthoflavone; dem-BER; demethyleneberberine; BERB; berberubine; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; PCR; polymerase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases

Keywords: Oxycodone; Cytochromes P450; UDP-glucuronosyltransferases; In vitro metabolism;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Highly regioselective hydroxylation of polydatin, a resveratrol glucoside, for one-step synthesis of astringin, a piceatannol glucoside, by P450 BM3

Keywords: NADPH; β-nicotinamide adenine dinucleotide phosphate (reduced form); p-NP; p-nitrophenol; P450 or CYP; cytochromes P450; TTN; total turnover number; WT; wild-type; Biocatalyst; Bacterial CYP102A1; Regioselective CH hydroxylation; Resveratrol; (E)-Astring

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Efficacy and safety of “Yahom” as a traditional Thai herbal therapy: A systematic review

Keywords: 2-AA; 2-aminoanthracene; Ach; Acetylcholine; AF2; 2-aminofluorene; Aq; Aqueous; BMI; Body mass index; BP; Blood pressure; BUN; Blood urea nitrogen; CYPs; Cytochromes P450; DBP; Diastolic blood pressure; DPPH; 2,2-diphenyl-1-picrylhydrazyl; ECG; Electrocar

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Cannabidiol: State of the art and new challenges for therapeutic applications

Keywords: (5-HT)1A; 5-hydroxytryptamine receptor;  ∆9-THC; delta-9-tetrahydrocannabinol; 2-AG; 2-arachidonoylglycerol; A2A; adenosine receptor; AEA; anandamide; ALI; acute lung injury; Aml-1; acute myeloid leukemia; APP; amyloid precursor protein; AR; androgen r

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

The inhibitory effects of β-caryophyllene, β-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro

Keywords: Sesquiterpenes; Enzyme inhibition; cytochromes P450; Drug-sesquiterpene interactions;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Effect of sildenafil on human aromatase activity: From in vitro structural analysis to catalysis and inhibition in cells

Keywords: Aromatase inhibitors; Sildenafil; Cytochromes P450; Estrogens; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

R- and S-Warfarin Were Transported by Breast Cancer Resistance Protein: From In Vitro to Pharmacokinetic-Pharmacodynamic Studies

Keywords: ABC transporters; drug transport; mass spectrometry; preclinical pharmacokinetics; pharmacokinetics/pharmacodynamics; INR; international normalized ratio; BCRP; breast cancer resistance protein; ABCG2; ATP-binding cassette transporter G2; CYP450; cytochro

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of duration of phenytoin administration on mRNA expression of cytochrome P450 and P-glycoprotein in the liver and small intestine of rats

Keywords: Phenytoin; Cytochromes P450; Microsomes; mRNA; Liver

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

The natural anthraquinones from Rheum palmatum induced the metabolic disorder of melatonin by inhibiting human CYP and SULT enzymes

Keywords: Mel; Melatonin; 6-O-Mel; ,6-hydroxymelatonin; NAS; N-acetylserotonin; AFMK; N1-Acetyl-N2-formyl-5-methoxy-kinuramine; AMK; N-acetyl-5-methoxy-kinuramine; HDIs; herb-drug interactions; CYP450s; cytochromes P450; R. palmatum; Rheum palmatum; DDIs; drug-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity

Keywords: Cytochromes P450; Monosodium glutamate; MSG-obese mice

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Selective inhibitory effects of machilin A isolated from Machilus thunbergii on human cytochrome P450 1A and 2B6

Keywords: Machilus thunbergii; Competitive inhibition; Cytochromes P450; Human liver microsomes; Machilin A

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450

Keywords: Aspirin (acetylsalicylic acid); Salicylic acid; Cytochromes P450; Aromatic hydroxylation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Characterization of the Gly45Asp variant of human cytochrome P450 1A1 using recombinant expression

Keywords: CHO; Chinese Hamster Ovary; CYPs; cytochromes P450; CYP1A1; cytochrome P450 1A1; dALA; δ-aminolevulinic acid; EDTA; ethylenediaminetetraacetic acid; ER; 7-ethoxyresorufin; EROD; 7-ethoxyresorufin O-dealkylation; EV; empty control vector; ME; β-mercaptoe

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation

Keywords: Cytochromes P450; Whole-cell system; Steroids; CYP11A1; Cholesterol; Steroid 2β,-6β- and 16β-hydroxylation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

Keywords: Coumarins; Anticancer; Synthesis; Targets; SAR; IC50; ARI; aromatase inhibitor; CAM; choriallanotoic membrane; CDC; cell cycle division protein; CDK2; cyclin dependent kinase 2; CDKN1A; cyclin-dependent kinase inhibitor 1A; CYP; cytochromes P450; DDIT4; D

دانلود رایگان متن کامل مقاله ISI 72 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of CYP27B1 and CYP24A1 gene expression by recombinant pro-inflammatory cytokines in cultured human trophoblasts

Keywords: Calcitriol; 1α,25-dihydroxyvitamin D3; CYP27B1; 25-hydroxyvitamin D3 [25-OHD3] 1α-hydroxylase; CYP24A1; 25-OHD3-24-hydroxylase; ETC; enriched trophoblastic cell preparations; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; hCG; human chorionic gonadotr

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Development and evaluation of a whole-cell system for the directed evolution of human cytochromes P450 in recombinant fission yeast Schizosaccharomyces pombe

Keywords: Cytochromes P450; Fission yeast Schizosaccharomyces pombe; Whole-cell screening system; Directed evolution;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Metabolic profiling of praziquantel enantiomers

Keywords: Cytochromes P450; Enantioselective metabolism; In silico metabolomics; Praziquantel;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2014 سفارش ترجمه

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway

Keywords: CD; Crohn's disease; COX2; cyclooxygenase 2; CYPs; cytochromes P450; DSS; dextran sodium sulfate; ELISA; enzyme linked immunosorbent assay; GSTs; glutathione S-transferases; IBD; inflammatory bowel disease; ICAM-1; Intercellular adhesion molecule-1; IL-2/

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2014 سفارش ترجمه

Effects of 4-nonylphenol on hepatic gene expression of peroxisome proliferator-activated receptors and cytochrome P450 isoforms (CYP1A1 and CYP3A4) in juvenile sole (Solea solea)

Keywords: Solea solea; 4-Nonylphenol; Peroxisome proliferator-activated receptors; Cytochromes P450;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer

Keywords: Aromatase; Sulfatase/Sulfotransferase; 17β-Hydroxysteroid dehydrogenase; Cytochromes P450; Catechol-O-methyl transferase; Estrogen receptors;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna

Keywords: Xenobiotic metabolism; Cytochromes P450; Daphnia magna; Zebrafish; Solvents;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts

Keywords: Lamisia pumila; Herbal extracts; Cytochromes P450; CYP2C subfamily; Drug-herb interactions;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats

Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood urea nitrogen; CDNB; 1-chloro-2,4-dinitrobenzene; CYPs; cytochromes P450; DPIP; 2,6-dichlorophenolindophenol; EROD; ethoxyresorufin-O-deethylase; GGT; ga

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper

Keywords: Venerupis (Ruditapes) philippinarum; Cytochromes P450; mRNA expression; Benzo[a]pyrene; Heavy metals; Biomarker

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test

Keywords: Genotoxicity; Cytochromes P450; Scavenger; Oxidative stress; in vivo; Cell division;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacogenetics of tacrolimus: ready for clinical translation?

Keywords: cytochromes P450; pharmacogenetics; pharmacokinetics; renal transplantation; tacrolimus

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Multi-panel drugs detection in human serum for personalized therapy

Keywords: Carbon nanotubes; Cytochromes P450; Drugs detection; Multi-drug detection; Personalized therapy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7

Keywords: Cytochromes P450; Terpenoid metabolism; Genome organization; Phytoalexin biosynthesis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cytochrome P450 enzymes in the fungal kingdom

Keywords: Cytochromes P450; Primary metabolism; Secondary metabolism; Detoxification; P450ome

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Brief historical overview and recent progress on cytochromes P450: Adaptation of aerobic organisms to their chemical environment and new mechanisms of prodrug bioactivation

Keywords: Cytochromes P450; Drug metabolism; Xenobiotics; Oxidation; Prodrug bioactivation; Sulfenic acids; Cytochromes P450; Métabolisme des médicaments; Xénobiotiques; Bioactivation des médicaments; Acides sulféniques;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه