Inhibitory effects of cytochrome P450 enzymes CYP2C8, CYP2C9, CYP2C19 and CYP3A4 by Labisia pumila extracts

Dichloromethane (DCM) extract of Labisia pumila (LP) exhibited potent inhibition of tolbutamide 4-methylhydroxylation mediated by cytochrome P450 2C9 with a Ki value of less than 1 μg/ml.376