
Multilevel pharmacological manipulation of adenosine-prostaglandin E2/cAMP nexus in the tumor microenvironment: A 'two hit' therapeutic opportunity
Keywords: AC; adenylyl cyclase; ATP; adenosine-5â²-triphosphate; ADP; adenosine-5â²-diphosphate; AMP; adenosine-5â²-monophosphate; CADO; 2-chloroadenosine; COX; cyclo-oxygenase; COXIBs; cyclo-oxygenase 2 (COX-2) inhibitors; CINODs; COX-inhibiting nitric oxide do