Hierarchical zeolite ZSM-58 as shape selective catalyst for methanol-to-olefins reaction
Keywords: DDR; Hierarchical; Desilication; Pore growth moderator; Methanol-to-olefins;
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Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer
Keywords: HAT; histone acetyltransferase; PTM; post translational modification; ROS; reactive oxygen species; PARP; poly ADP-ribose polymerase; Dox; doxycycline; TRRAP; transformation/transcription domain associated protein; p400; E1A binding protein p400; RUVBL1;
Mechanism of Action of G-Quadruplex-Forming Oligonucleotide Homologous to the Telomere Overhang in Melanoma
Keywords: DDR; DNA-damage response; G4; G-quadruplex; GRO; guanine-rich oligonucleotide; hTERT; human telomerase reverse transcriptase; NMR; nuclear magnetic resonance; qRT-PCR; quantitative real-time reverse transcriptase-PCR; SS; single-stranded;
High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s
Nebulized coenzyme Q10 nanosuspensions: A versatile approach for pulmonary antioxidant therapy
Keywords: CoQ10; coenzyme Q10; DD; drug delivered; DDR; drug delivery rate; DLS; dynamic light scattering; DMEM; Dulbecco's Modified Eagle's Medium; FBS; foetal bovine serum; HPH; high pressure homogenizer; LOD; limit of detection; LOQ; limit of quantitation; MMD;
The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
Keywords: ABCB1; ATP-binding cassette sub-family B member 1; AML; acute myeloid leukaemia; AMPK; adenosine monophosphate-activated protein kinase; ATM; Ataxia-telangiectasia mutated; AURKA; aurora kinase A; BER; base excision repair; Bim; B-cell lymphoma 2 interact
Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS)
Keywords: CMV; cytomegalovirus; DDR; DNA damage response; GFP; green fluorescent protein; Gy; gray; H2B; histone H2B; n.s.; not significant; qPCR; quantitative polymerase chain reaction; s.d.; standard deviation; zmpste24; zinc metallopeptidase, STE24 homolog; Lami
Redox control of cancer cell destruction
Keywords: ABC transporters; ATP-binding cassette transporters; ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cancer cell phagocytosis; AML; acute myeloid leukemia; APE1; apurinic/apyrimidinic endonuclease 1; ASK-1; apoptosis signal-r
R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome
Keywords: Primary immunodeficiency; Wiskott-Aldrich syndrome; X-linked thrombocytopenia; TH1/TH2 differentiation; R-loops; DNA damage; genomic instability; ChIP; Chromatin immunoprecipitation; DDR; DNA damage response; DRB; 5,6-Dichlorobenzimidazole-1-β-D-ribofura
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
Gas Separation Process for CO2 Removal from Natural Gas with DDR-type Zeolite Membrane
Keywords: DDR; Zeolite; Inorganic; Membrane; CO2; Natural gas; Gas separation;
Synthesis of all-silica DDR zeolite in an environment-friendly way
Keywords: Zeolite; DDR; Solvent-free; Green synthesis; Template;
PerspectiveDNA-Damage Response RNA-Binding Proteins (DDRBPs): Perspectives from a New Class of Proteins and Their RNA Targets
Keywords: 53BP1; tumor protein p53 binding protein 1; AGO2; Argonaute 2; ATM; ataxia telangiectasia mutated; BRCA1; breast cancer 1; DDR; DNA-damage response; DDRBP; DNA-damage response RNA-binding protein; DDSR1; DNA-damage-sensitive RNA 1; diRNA; double-strand-br
Taming Tricky DSBs: ATM on duty
Keywords: ATM; ataxia telangiectasia mutated; DSB; double strand breaks; DDR; DNA damage response; HR; homologous recombination; NHEJ; non-homologous end joining; PI3K; phosphoinositide 3-kinase; RNA pol II; RNA polymerase II; TAD; topologically associated domain;
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development
Keywords: HU; hydroxyurea; APH; aphidicolin; MN; micronuclei; 53BP1-NBs; 53BP1-nuclear bodies; MEFs; mouse embryonic fibroblasts; B6; C57BL/6; C3H; C3HeB/; CNAs; copy number alterations; ICLs; inter-strand crosslinks; DDR; DNA damage repair/response; FA; Fanconi an
Original ArticleSEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer
Keywords: SEI1; SERTAD1; Genomic instability; DDR; Ovarian cancer;
Research paperA novel spliced variant of the TIN2 shelterin is present in chronic lymphocytic leukemia
Keywords: ACD or TPP1; adrenocortical dysplasia homolog; B2M; β2-microglobulin; CIRS; cumulative illness rating scale; CLL; chronic lymphocytic leukemia; DDR; DNA damage response; EV; empty vector; FL; full-length; HD; healthy donors; IGHV; immunoglobulin variable
Original ArticleSilencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2
Keywords: Apoptosis; Caspase-2; Colorectal carcinoma cells; HuR; Radiotherapy resistance; CRC; colorectal cancer; DDR; DNA-damage response; HuR; human antigen R; PARP; poly ADP-ribose polymerase; 5â²UTR; 5â²-untranslated region;
Original ArticleThe depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades
Keywords: ATM; Colon cancer; B56γ2; CD44; Tumorigenic potential; ATM; Ataxia-telangiectasia mutated; PIKK; phosphatidylinositol-3 kinase related kinase; FAT; FRAP-ATM-TRRAP domain; FATC; FAT-C-terminal domain; DDR; DNA damage response; DSBs; double strand breaks;
Unveiling the non-repair face of the Base Excision Repair pathway in RNA processing: A missing link between DNA repair and gene expression?
Keywords: AP-site; apurinic/apyrimidinic site; APE1; apurinic/apyrimidinic endonuclease 1; BER; Base Excision Repair; DDR; DNA damage response; miRNA; microRNA; ncRNA; non coding RNA; NIR; Nucleotide Incision Repair; PARP; poly(ADP-ribose) polymerase; RBP; RNA bind
DNA damage repair in breast cancer and its therapeutic implications
Keywords: DNA damage response; breast cancer; DDR; defects; therapeutic implications;
CommunicationsThe G-Quadruplex-Specific RNA Helicase DHX36 Regulates p53 Pre-mRNA 3â²-End Processing Following UV-Induced DNA Damage
Keywords: CstF; cleavage stimulatory factor complex; nt; nucleotides; DDR; DNA damage response; G4/G4s; G quadruplex(es); RBP; RNA binding protein; UTR; untranslated region; TBP; TATA-binding protein; polyadenylation; genome stability; G-quadruplex ligand; RNA bind
Interaction of Quindoline derivative with telomeric repeat-containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
Keywords: ALT; alternative lengthening of telomeres; ATM; ataxia telangiectasia mutated; CD; circular dichroism; ChIP; chromatin immunoprecipitation; DAPI; 4â²,6-diamidino-2-phenylindole; DDR; DNA damage response; DMSO; dimethyl sulfoxide; DSBs; DNA double-strand
The Cell Cycle Inhibitors p21Cip1 and p27Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells
Keywords: CSC; cancer stem cell; DDR; DNA damage response; GSC-ECLs; glioma stem cell-enriched cell line; NR; nutrient restriction;
PARP, transcription and chromatin modeling
Keywords: ABCA1; ATP-binding cassette transporter A1; ADP-ribosylation; adenosine diphosphate ribosylation; ALC1; amplified in-liver-cancer 1; AR; androgen receptor; ARH3; ADP-ribosylhydrolase 3; ART; ADP-ribosyl transferase; ASF/SF2; alternative splicing factor/sp
Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes
Keywords: AhR; aryl hydrocarbon receptor; AMC; 7-amino-4-methylcoumarin; α-NF; alpha-naphthoflavone; ATM; ataxia telangiectasia mutated; B[a]P; benzo[a]pyrene; BPDE; B[a]P diol epoxide; CYPs; cytochromes P-450; DMSO; dimethyl sulfoxide; DDR; DNA damage response; D
Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence
Keywords: ACC; adenoid cystic carcinoma; ALDH1; aldehyde dehydrogenase 1; BSA; bovine serum albumin; CD44-APC; cell surface glycoprotein CD44 - allophycocyanin; CK7; cytokeratin 7; CK14; cytokeratin 14; CSC; cancer stem cells; DAB; 3,3â²-diaminobenzidine; DDR; DNA
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
Review articleChemotherapy induces alternative transcription and splicing: Facts and hopes for cancer treatment
Keywords: ALTS; alternative transcription and splicing; AS; alternative splicing; CLL; chronic lymphocytic leukemia; CPC; cleavage and polyadenylation complex; DDR; DNA damage response; PAS; polyadenylation site; PolII; polymerase II; SR; serine and arginine-rich;
ReviewTranscription and DNA Damage: Holding Hands or Crossing Swords?
Keywords: DSBs; DNA double-strand breaks; DDR; DNA damage response; MRN; MRE11-RAD50-NBS1; ATM; ataxia telangiectasia mutated; MDC1; mediator of DNA-damage checkpoint; 53BP1; p53-binding protein; NHEJ; non-homologous end joining; ncRNA; non-coding RNA; HR; homo
Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway
Keywords: DDR; DNA damage response; DMSO; dimethyl sulfoxide; GFP; green fluorescent protein; IP; immunoprecipitation; LC50; Lethal Concentration 50; MRT; malignant rhabdoid tumor; MSP58; 58-kDa Microspherule Protein; NC; non-specific; PI; Propidium Iodide; PVDF; p
Functional relevance of miRNAs in premature ageing
Keywords: CRP; C-reactive protein; DDR; DNA damage response; DSB; double-strand breaks; HATs; histone acetyltransferases; HDACs; histone deacetylases; hMSCs; human mesenchymal stem cells; HRR; homologous recombination repair; MEFs; mouse embryonic fibroblast; ROS;
Proximity of Radiation Desiccation Response Motif to the core promoter is essential for basal repression as well as gamma radiation-induced gyrB gene expression in Deinococcus radiodurans
Keywords: DDR; DNA damage regulon; GFP; green fluorescent protein; ORF; open reading frame; PIR; post-irradiation recovery; RDRM; Radiation Desiccation Response Motif; RNAP; RNA polymerase; TSS; transcription start site; Deinococcus radiodurans; Radiation responsiv
NADPH Oxidase-1 Plays a Key Role in Keratinocyte Responses to UV Radiation and UVB-Induced Skin Carcinogenesis
Keywords: CPD; cyclobutane pyrimidine dimer; DDR; DNA damage response; InhNOX1; peptide inhibitor of NOX1; NADPH; nicotinamide adenine dinucleotide phosphate; NER; nucleotide excision repair; NOX; nicotinamide adenine dinucleotide phosphate oxidase; ROS; reactive o
The RNAs of RNA-directed DNA methylation
Keywords: AGO1; ARGONAUTE 1; AGO2; ARGONAUTE 2; AGO4; ARGONAUTE 4; AGO6; ARGONAUTE 6; CLSY1; CLASSY 1; CMT2; CHROMOMETHYLASE 2; CMT3; CHROMOMETHYLASE 3; CTD; carboxy-terminal domain; DCL1; DICER-LIKE 1; DCL2; DICER-LIKE 2; DCL3; DICER-LIKE 3; DCL4; DICER-LIKE 4; DD
Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation
Keywords: IR; irradiation; ROS; reactive oxygen species; DDR; DNA damage response; SASP; senescence-associated secretory phenotype; O/N; overnight; Senescence; Endothelial cell; Mitochondrial oxidative stress; Ionizing radiation;
p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo
Keywords: CPC; cardiac progenitor cell; DDR; DNA damage response; WT; wild type; LV; left ventricle; p53-tg; super-p53 transgenic mouse; Aogen; angiotensinogen; Ang II; angiotensin II; AT1R; Ang II type-1 receptor; PDT; population doubling time; ROS; reactive oxyge
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
Ultrafast microwave synthesis of all-silica DDR zeolite
Keywords: Zeolite synthesis; DDR; Ultrafast; Microwave-aided synthesis; Template;
Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia
Keywords: A-T; Ataxia-telangiectasia; ATM; Ataxia-telangiectasia mutated; DDR; DNA damage repair; FEV1%; Percent Forced expiratory volume in 1Â second; FVC%; Percent forced vital capacity; IL; Interleukin; IVIG; Intravenous immunoglobulin;
DNA damage tolerance by recombination: Molecular pathways and DNA structures
Keywords: DDT; DNA damage tolerance; DDR; DNA damage response; ss; single stranded; DSBs; Double strand breaks; TLS; Translesion Synthesis; PRR; Postreplication repair; HR; Homologous recombination; PCNA; proliferating cell nuclear antigen; SLDs; SUMO-like domains;
Lemon balm extract (Melissa officinalis, L.) promotes melanogenesis and prevents UVB-induced oxidative stress and DNA damage in a skin cell model
Keywords: 6-4PPs; pyrimidine (6-4) pyrimidone; CPDs; cyclobutane pyrimidine dimers; DDR; DNA damage response; DMSO; dimethyl sulfoxide; DSBs; double-strand brakes; H2DCF-DA; 2â²,7â²-dichlorofluorescein diacetate; HNE; 4-hydroxy-2-nonenal; IBMX; 3-isobutyl-1-methy
Synthesis and characterization of all-silica DDR zeolite by microwave heating
Keywords: Zeolite; DDR; All-silica; Hydrothermal synthesis; Microwave synthesis
DNA damage processing at telomeres: The ends justify the means
Keywords: 6-4PP; pyrimidine (6-4) pyrimidine photoproducts; ALT; alternative lengthening of telomeres; BER; base excision repair; CPD; cyclobutane pyrimidine dimer; DDR; DNAdamage response; DSB; DNA double strand break; dsDNA; double stranded DNA; G4; G-quadruple
Non-DSB clustered DNA lesions. Does theory colocalize with the experiment?
Keywords: BER; Base excision repair; B-NHEJ; backup NHEJ; DDR; DNA damage response; D-NHEJ; referred as canonical or classical NHEJ; DSBR; double-strand break repair; DSBs; DNA Double strand breaks; Flike; Foci-like analysis parameter; IR; Ionizing Radiation; HR; H
VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage
Keywords: VRK1; vaccinia-related kinase 1; NBS1; Nijmegen breakage syndrome 1; DDR; DNA damage response; IR; ionizing radiation; DNA damage foci; Phosphorylation; Signaling; DNA double strand breaks; Nibrin; NBN;
Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics
Keywords: 53BP1; tumor suppressor p53 binding protein 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related; Chk; checkpoint kinase; DSB; DNA double-strand break; DDR; DNA damage response; DNA-PKcs; DNA-dependent protein kinase, catalyt
LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs
Keywords: Quinolone; NSCLC; ROS; DDR; Apoptosis;
Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis
Keywords: FBS; fetal bovine serum; HE; hematoxylin-eosin; SA- β -Gal; senescence-associated β-galactosidase; IC50; half maximal inhibitory concentration; gv; tumor growth velocity; DDR; DNA damage response; Sesquiterpene lactones; Dehydroleucodine; Melanoma; Math
Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells
Keywords: DDR; DNA damage response; DSB; double-strand break; CRISPR; clustered regularly interspaced short palindromic repeats; CSK; cytoskeletal; DTT; dithiothreitol; EdU; 5-ethynyl-2â²-deoxyuridine; EM-CCD; electron multiplying-charge coupled device; γ-H2AX; p