Keywords: فلوریمتری اسکن دیفرانسیل; CA; caprylic acid; mAb; monoclonal antibody; Ig; immunoglobulin; HCP; host cell protein; CHO; Chinese hamster ovary; LC; light chain; HC; heavy chain; MCBS; multi-component buffer system; TCID50; 50% tissue culture infectious dose; MuLV; murine leukemia v
مقالات ISI فلوریمتری اسکن دیفرانسیل (ترجمه نشده)
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Keywords: فلوریمتری اسکن دیفرانسیل; CE-SDS; capillary electrophoresis-sodium dodecyl sulfate; DLS; dynamic light scattering; DSC; differential scanning calorimetry; DSF; differential scanning fluorimetry; FBDS; formulated bulk drug substance; HMWS; high molecular weight species; kDa; kiloda
Keywords: فلوریمتری اسکن دیفرانسیل; Differential scanning fluorimetry; DSF-GTP assay; Biotin protein ligase (BirA); Green fluorescent protein (GFP); Isoniazid; Mycobacterium tuberculosis;
Keywords: فلوریمتری اسکن دیفرانسیل; mAb; Monoclonal antibody; MOE; Molecular Operating Environment; MDS; Multi-dimensional scaling; QSAR; Quantitative structure-activity relationship; DSC; Differential scanning calorimetry; DSF; Differential scanning fluorimetry; DMSO; Dimethyl sulfoxide;
Keywords: فلوریمتری اسکن دیفرانسیل; Differential scanning fluorimetry; Aminoacyl-tRNA synthetase; Histidyl-tRNA synthetase; SYPRO Orange; tRNA; Amino acid;
Picomolar inhibitors of carbonic anhydrase: Importance of inhibition and binding assays
Keywords: فلوریمتری اسکن دیفرانسیل; Carbonic anhydrase; Tight-binding inhibitors; Stopped-flow CO2 hydration assay; Fluorescent thermal shift assay; Differential scanning fluorimetry; Isothermal titration calorimetry; ANS; 8-anilino-1-naphthalenesulfonate; AZM; acetazolamide; CA; carbonic a
Keywords: فلوریمتری اسکن دیفرانسیل; enzymes; mutation; biopharmaceutical characterization; protein structure; biotechnology; NUV-CD; near-UV circular dichroism; FUV-CD; far-UV circular dichroism; DSC; differential scanning calorimetry; Trp IF, tryptophan intrinsic fluorescence, DSF; differe
Keywords: فلوریمتری اسکن دیفرانسیل; Differential scanning fluorimetry; Enzyme kinetics; Enzyme stability; Urea; Native denaturation; Lactate dehydrogenase;
Keywords: فلوریمتری اسکن دیفرانسیل; BH4; tetrahydrobiopterin; DSF; differential scanning fluorimetry; L-Dopa; (S)-3,4-dihydroxyphenylalanine; PAH; phenylalanine hydroxylase; PKU; phenylketonuria; TH; tyrosine hydroxylase; THD; TH deficiency; TPH2; tryptophan hydroxylase isoform 2; PD; Parki
Keywords: فلوریمتری اسکن دیفرانسیل; Differential scanning fluorimetry; Recombinant protein; SYPRO orange dye;
Keywords: فلوریمتری اسکن دیفرانسیل; βME; β-mercaptoethanol; BS3; bis[sulfosuccinimidyl]suberate; BSA; bovine serum albumin; CLP; coactosin-like protein; cv; column volume; DF; Dicer fragment containing amino acids 1650-1912; DPBS; Dulbecco's PBS; DSF; differential scanning fluorimetry;
Keywords: فلوریمتری اسکن دیفرانسیل; DSF; differential scanning fluorimetry; G-CSF; granulocyte colony stimulating factor; Th; temperature of hydrophobic exposure; CCVJ; 9-(2-carboxy-2-cyanovinyl)julolidine; Tagg; temperature of aggregation; CMC; critical micelle concentration; Differential
Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1)
Keywords: فلوریمتری اسکن دیفرانسیل; X-ray crystallography; Fluorescence polarization; Isothermal titration calorimetry; Differential scanning fluorimetry; Son of sevenless homolog 1;
Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations
Keywords: فلوریمتری اسکن دیفرانسیل; µDSC; differential scanning microcalorimetry; Cm; concentration (in M) of chemical denaturant needed to unfold 50% of the protein (“melting” concentration of denaturant); dG; Gibbs free energy of unfolding; dHionisation; enthalpy of ionisation; dpH/d
The effect of phosphate group binding cup coordination on the stability of the amine transaminase from Chromobacterium violaceum
Keywords: فلوریمتری اسکن دیفرانسیل; Cv-ATA; amine transaminase from Chromobacterium violaceum; CD; circular dichroism; DSF; Differential Scanning Fluorimetry; HEPES; 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid); KD; dissociation constant PGBC Phosphate Group Binding Cup; PLP; pyrido
New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV
Keywords: فلوریمتری اسکن دیفرانسیل; Bacterial gyrase; Topoisomerase IV; Drug resistance; Binding sites; Potency; DNA; deoxyribonucleic acid; ATP; adenosine triphosphate; GyrA; gyrase A subunit; GyrB; gyrase B subunit; ParC; topoisomerase IV C subunit; ParE; topoisomerase IV E subunit; PDB;
Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity
Keywords: فلوریمتری اسکن دیفرانسیل; Cysteine desulfurase; Friedreich's ataxia; Iron-sulfur cluster; ISCU; Zinc; ACP; acyl carrier transfer protein; BLI; BioLayer interferometry; BSA; bovine serum albumin; CD; circular dichroism; DMPD; N,N-dimethyl-p-phenylenediamine; DSF; differential scann
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Keywords: فلوریمتری اسکن دیفرانسیل; STAT3; Differential scanning fluorimetry; Differential scanning light scattering; Thermal stability assays; Protein truncations;
A potent chitinase from Bacillus subtilis for the efficient bioconversion of chitin-containing wastes
Keywords: فلوریمتری اسکن دیفرانسیل; BcChiA1; chitinase A1 from Bacillus circulans; BsChi; chitinase from Bacillus subtilis; CAD; catalytic domain; CBD; chitin-binding domain; CCSP; crude crab shell powder; DSF; differential scanning fluorimetry; EGC; ethylene glycol chitin; FCSP; fine crab
Minimum structural requirements for BMP-2-binding of heparin oligosaccharides
Keywords: فلوریمتری اسکن دیفرانسیل; Heparin; Glycosaminoglycan; BMP-2; Bone repair; BMP; bone morphogenetic protein; GAGs; glycosaminoglycans; HS; heparan sulfate; CS; chondroitin sulfate; DS; dermatan sulfate; KS; keratan sulfate; ALP; alkaline phosphatase; dp; degree of polymerization; DS
Synergistic stabilisation of NOsGC by cinaciguat and non-hydrolysable nucleotides: Evidence for sGC activator-induced communication between the heme-binding and catalytic domains
Keywords: فلوریمتری اسکن دیفرانسیل; ANOVA; analysis of variance; BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; DSF; differential scanning fluorimetry; EM; electron microscopy; FRET; Förster resonance energy transfer; HDX-MS; hydrogen/deuterium exchange mass spectrometry; HNOX; heme-
New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type
Keywords: فلوریمتری اسکن دیفرانسیل; AdoCbl; adenosylcobalamin; ATR; ATP:cob(I)alamin adenosyltransferase; DSF; differential scanning fluorimetry; HGMD; Human Gene Mutation Database; HTS; high-throughput screening; iPSCs; induced pluripotent stem cells; MMA; methylmalonic aciduria; MUT; meth
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis
Keywords: فلوریمتری اسکن دیفرانسیل; ROS; reactive oxygen species; NQO-1; NADPH:quinone oxidoreductase 1; HO-1; heme oxygenase-1; ARE; antioxidant response element; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; DMF; dimethyl fumarate; CDDO-Me;
Obtaining a high activity subtilisin preparation by controlled thermal stress in n-octane
Keywords: فلوریمتری اسکن دیفرانسیل; Caseinolytic activity; Conformational flexibility; Differential scanning fluorimetry; Non-aqueous enzymology; Structural rigidity; Transesterification;
Large-scale production of recombinant Saw1 in Escherichia coli
Keywords: فلوریمتری اسکن دیفرانسیل; Single-strand annealing; Recombination intermediates; Protein stability; Differential scanning fluorimetry; SYPRO Orange;
Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain
Keywords: فلوریمتری اسکن دیفرانسیل; Alpha; amplified luminescent proximity homogeneous assay; ATAD2; ATAD2 ATPase family, AAA domain containing 2; BAZ2A; bromodomain adjacent to zinc finger domain protein 2A; BAZ2B; bromodomain adjacent to zinc finger domain protein 2B; BRPF1; bromodomain a
Split luciferase-based biosensors for characterizing EED binders
Keywords: فلوریمتری اسکن دیفرانسیل; PRC2; EED; H3K27me3-pocket; Split luciferase; Biosensor; EED[G255D]; EED; embryonic ectoderm development; PRC2; polycomb repressive complex 2; DSF; differential scanning fluorimetry; ITC; isothermal titration calorimetry; EZH2; enhancer of zeste homolog 2
Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E
Keywords: فلوریمتری اسکن دیفرانسیل; Fcε3-4; sub-fragment of IgE-Fc consisting of the dimer of Cε3 and Cε4 domains; DSF; differential scanning fluorimetry; GlcNAc; N-acetylglucosamine; Man; mannose; Antibody; Immunoglobulin E; Glycosylation; Domain flexibility; Thermal unfolding; Differ
Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase
Keywords: فلوریمتری اسکن دیفرانسیل; BG-VG; SNAP-Vista Green⢠substrate; Cter; C-terminal domain; DDMP; Difference Distance Matrix Plot; dsDNAm; O6-methyl-guanine-containing double-strand DNA; DSF; Differential Scanning Fluorimetry; hAGT; human AGT; MD; molecular dynamics; Nter; N-terminal
Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes
Keywords: فلوریمتری اسکن دیفرانسیل; DSF; differential scanning fluorimetry; Tm; melting temperature; CD; circular dichroism; MHC protein; Binding affinity; Thermal stability; Kinetic stability; Differential scanning fluorimetry;
The unusual substrate specificity of a virulence associated serine hydrolase from the highly toxic bacterium, Francisella tularensis
Keywords: فلوریمتری اسکن دیفرانسیل; DSF; differential scanning fluorimetry; FTT0941c; virulence associated serine hydrolase from Francisella tularensis; HSL; hormone sensitive lipase; KEGG; Kyoto Encyclopedia of Genes and Genomes; LB; Luria-Bertani broth; MWCO; molecular weight cut-off; Ni-
Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway
Keywords: فلوریمتری اسکن دیفرانسیل; NGLY1; N-glycanase; ER; endoplasmic reticulum; ERAD; endoplasmic reticulum associated degradation; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; TSA; thermal shift assay; DSF; differential scanning fluorimetry; Drug discovery; N-g
First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes
Keywords: فلوریمتری اسکن دیفرانسیل; p38 kinase; Structure-based drug design; Chronic inflammatory lung disease; Kinase inhibitor; Inhibitor half-lives; Differential scanning fluorimetry;
Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors
Keywords: فلوریمتری اسکن دیفرانسیل; Medium throughput virtual screening; Mycobacterium tuberculosis; DNA gyrase; Differential scanning fluorimetry
Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51
Keywords: فلوریمتری اسکن دیفرانسیل; PPI; protein-protein interaction; HR; homologous recombination; NF; nucleoprotein filament; BRC4; fourth BRC repeat; HumRadA1; first humanised RadA protein; DSF; differential scanning fluorimetry; ITC; isothermal titration calorimetry; FP; fluorescence
Influence of GTP on system specific chaperone - Twin arginine signal peptide interaction
Keywords: فلوریمتری اسکن دیفرانسیل; DmsD; DmsA signal peptide; Twin-arginine translocase; Guanosine nucleotides; Binding; Dissociation; Differential scanning fluorimetry; Bis-MGD; molybdenum-bis(pyranopterin guanine dinucleotide); CISM; complex iron-sulfur molybdoenzyme; DmsAL; DmsA leader
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach
Keywords: فلوریمتری اسکن دیفرانسیل; Mycobacterium tuberculosis; Enoyl-ACP reductase; Apo InhA; Isoniazid; INH-NADH adduct; X-ray structure; Differential scanning fluorimetry
Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure–activity relationships
Keywords: فلوریمتری اسکن دیفرانسیل; Short-chain dehydrogenase/reductase; Chemical biology; Structural genomics; Differential scanning fluorimetry; Metabolism
4-Aminoquinoline derivatives as novel Mycobacterium tuberculosis GyrB inhibitors: Structural optimization, synthesis and biological evaluation
Keywords: فلوریمتری اسکن دیفرانسیل; Mycobacterium tuberculosis; DNA gyrase B; DNA supercoil assay; Cytotoxicity; Differential scanning fluorimetry;
Expression and characterization of the Arabidopsis thaliana 11S globulin family
Keywords: فلوریمتری اسکن دیفرانسیل; His-proAtCRU; N-terminally 6-His-tagged A. thaliana procruciferin; SB; super broth media; DSF; differential scanning fluorimetry; TB; terrific broth media; Trp; tryptophan; Arabidopsis thaliana; Seed storage protein; Procruciferin; Protein engineering; Di
Complex coacervates of hyaluronic acid and lysozyme: Effect on protein structure and physical stability
Keywords: فلوریمتری اسکن دیفرانسیل; Isothermal titration calorimetry; Differential scanning calorimetry; Stability; Binding characteristics; Differential scanning fluorimetry; Hydrogel; Bovine serum albumin; Complex coacervation; Hyaluronan; Sodium hyaluronate
The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90 kDa heat shock protein Hsp90α, a chaperone implicated in the stabilization of the tumor phenotype
Keywords: فلوریمتری اسکن دیفرانسیل; CD; circular dichroism; DLS; dynamic light scattering; DSC; differential scanning calorimetry; DSF; differential scanning fluorimetry; PAGE; polyacrylamide gel electrophoresis; SDS; sodium dodecyl sulfate; SEC-MALS; size-exclusion chromatography coupled
Hemorrhagin VaH4, a covalent heterodimeric P-III metalloproteinase from Vipera ammodytes ammodytes with a potential antitumour activity
Keywords: فلوریمتری اسکن دیفرانسیل; Vipera ammodytes ammodytes; Snake venom; Hemorrhagin; Metalloproteinase; Structure; Antitumour; ACN; acetonitrile; ADAM; a disintegrin and metalloproteinase; ADAMTS; ADAM with thrombospondin type-1 motif; BM; basement membrane; BSA; bovine serum albumin;
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1
Keywords: فلوریمتری اسکن دیفرانسیل; Fragment screening; Virtual screening; Differential scanning fluorimetry; MEK1;
Detection of soluble co-factor dependent protein expression in vivo: Application to the 4â²-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis
Keywords: فلوریمتری اسکن دیفرانسیل; ACP; acyl carrier protein; AcpS; acyl carrier protein synthase; AnTet; anhydrotetracycline; BSA; bovine serum albumin; CoA; Coenzyme A; DHFR; dihydrofolate reductase; DSF; differential scanning fluorimetry; DTT; dithiothreitol; GFP; green fluorescent prot
VaH3, one of the principal hemorrhagins in Vipera ammodytes ammodytes venom, is a homodimeric P-IIIc metalloproteinase
Keywords: فلوریمتری اسکن دیفرانسیل; Vipera ammodytes ammodytes; Snake venom; Hemorrhagin; Metalloproteinase; Structure; ADAM; a disintegrin and metalloproteinase; ADAMTS; ADAM with thrombospondin type-1 motif; BM; basal membrane; CR; cysteine-rich; Dis; disintegrin-like; DSF; differential s
DSF Method Optimization and Its Application in Predicting Protein Thermal Aggregation Kinetics
Keywords: فلوریمتری اسکن دیفرانسیل; differential scanning fluorimetry; differential scanning calorimetry; aggregation kinetics; surfactant; biopharmaceuticals characterization; biotechnology; protein aggregation; protein formulation; analytical biochemistry;
Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia
Keywords: فلوریمتری اسکن دیفرانسیل; ANS-1; 1-anilinonaphthalene-8-sulphonic acid; BS3; suberic acid bis(3-sulfo-N-hydroxysuccinimide ester); DSF; differential scanning fluorimetry; GALT; galactose-1-phosphate uridylyltransferase; Gal-1P; galactose 1-phosphate; Glc-1P; glucose 1-phosphate; h
Differential scanning fluorimetry: Rapid screening of formulations that promote the stability of reference preparations
Keywords: فلوریمتری اسکن دیفرانسیل; Differential scanning fluorimetry; SYPRO Orange dye; Protein stability; DSC; Formulation
MTSA—A Matlab program to fit thermal shift data
Keywords: فلوریمتری اسکن دیفرانسیل; Thermal shift analysis; Differential scanning fluorimetry; Temperature-dependent fluorescence; Thermofluor; Matlab