Keywords: Parkinson's disease; Rodent models; Rodent behaviour; Animal models; Alpha-synuclein; LRRK2; GBA; 6-OHDA; Rotenone; MPTP; FBXO7; ATP13A2; VPS35; Parkin; PINK1; DJ-1;
مقالات ISI (ترجمه نشده)
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Keywords: Parkinson's disease; Ghrelin; Dementia; AHN; adult hippocampal neurogenesis; AD; Alzheimer's Disease; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; AMP-activated protein kinase; AB; amyloid-β; ATG; autophagy-related; BBB; blood brain
Keywords: Hypoxia; ROS; IDH; DJ-1; PINK1; Metabolism;
Keywords: Parkinson's disease; Parkinsonism; Genetics; SNCA; LRRK2; VPS35; Parkin; PINK1; DJ-1; ATP13A2; PLA2G6; FBXO7; DNAJC6; SYNJ1
Keywords: Parkinson's disease; Parkin; DJ-1; Knockout mice; Glutathione peroxidase;
Keywords: uveal melanoma; proteomics; proteomic technologies; HSP27; FABP3; TPI1; DJ-1; syntenin; PFKM
15N CEST data and traditional model-free analysis capture fast internal dynamics of DJ-1
Keywords: CEST; Protein dynamics; NMR; DJ-1;
A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1
Keywords: Parkinson's disease; DJ-1; PARK7; S-carboxymethylcysteine; Oxidative stress; LC-MS/MS; liquid chromatography tandem mass-spectrometry; NTA; nitrilotriactetic acid; PD; Parkinson's disease;
Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction
Keywords: DJ-1; Oxidative stress; Signal transduction; Cell signaling; ERK; MAPK; ASK1; Daxx; Trx1; JNK; p38;
DJ-1 preserving mitochondrial complex I activity plays a critical role in resveratrol-mediated cardioprotection against hypoxia/reoxygenation-induced oxidative stress
Keywords: Resveratrol; Hypoxia/reoxygenation injury; Oxidative stress; DJ-1; Mitochondrial complex I; Cardioprotection;
DJ-1 is a useful biomarker for invasive extrahepatic cholangiocarcinoma
Keywords: DJ-1; Extrahepatic cholangiocarcinoma; Prognosis; Biomarker; Immunohistochemical staining; ELISA;
Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation
Keywords: Tartrate; DJ-1; Parkinson's disease; Inorganic phosphate; ROS;
Cistanche deserticola polysaccharides protects PC12 cells against OGD/RP-induced injury
Keywords: Cistanche deserticola Polysaccharides; Neuroprotective; Oxygen glucose deprivation/reperfusion; Oxidative stress; DJ-1;
Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo
Keywords: DJ-1; Astrocyte; Parkinson's disease; Oxidative stress; Cell survival;
The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress
Keywords: microRNA (miRNA); Parkinson's disease; Autosomal recessive; PARK7; miR-221; DJ-1; Oxidative stress;
α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease
Keywords: Parkinson's disease; Neurodegeneration; α-synuclein; C. elegans; Genetics; Animal model; Parkin; PINK1; DJ-1; ATP13A2;
Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice
Keywords: Polybrominated diphenyl ethers; Learning and memory deficits; DJ-1; PKCδ; ROS;
Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease
Keywords: DJ-1; Astrocyte; Rotenone; Parkinson's disease; Chaperone-mediated autophagy; Neuroinflammation; Oxidative stress; Gene therapy;
A Parkinson's disease gene, DJ-1, regulates astrogliosis through STAT3
Keywords: GFAP; glial fibrillary acidic protein; STAT3; signal transducer and activator of transcription 3; pSTAT3; phosphorylation of STAT3; DPP; 5,15-diphenylporphyrin; BDNF; brain derived neurotrhophic factor; GDNF; glial cell line-derived neurotrophic factor; P
Expression of the DJ-1 protein in the serum of Chinese patients with Parkinson's disease
Keywords: Parkinson's disease; Chinese; Serum; DJ-1;
Intraperitoneal nanotherapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin
Keywords: ovarian cancer; DJ-1; cisplatin; combinatorial therapy; siRNA; IV chemotherapy; intravenous chemotherapy; IP chemotherapy; intraperitoneal chemotherapy; PTEN; phosphatase and tensin homolog; p53; tumor suppressor protein 53; NRF2; nuclear factor (erythroi
Loss of DJ-1 promotes browning of white adipose tissue in diet-induced obese mice
Keywords: ACC; acyl-CoA carboxylase; Actb; beta-actin encoding gene; AMPK; AMP-activated protein kinase; ATG; autophagy-related protein; ATGL; adipose triglyceride lipase; ATP5B; ATP synthase subunit beta; β3-AR; beta 3 adrenergic receptor; C/EBPα; CCAAT/enhancer
Ablation of DJ-1 impairs brown fat function in diet-induced obese mice
Keywords: Autophagy; Brown adipose tissue; DJ-1; Mitochondria; Obesity; Whitening;
Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells
Keywords: Human mast cells; IgE receptor; Lyn activation; DJ-1; signaling; reactive oxygen species; spleen tyrosine kinase; Csk; C-terminal Src kinase; ERK; Extracellular signal-regulated kinase; HuMC; CD34+-derived human mast cell; JNK; c-Jun N-terminal kinase; LA
Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart
Keywords: MHC; major histocompatibility complex; AMC; 7-amino-4-methylcoumarin; Z; benzyloxycarbonyl; MCA; methylcumarinamide; Legumain; DJ-1; Cystatin E/M;
DJ-1 activates autophagy in the repression of cardiac hypertrophy
Keywords: DJ-1; Cardiac hypertrophy; Autophagy; Pressure overload; Phenylephrine;
Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease
Keywords: DJ-1; Parkinson's disease; Protein structure; Oxidative stress; Molecular dynamics; Structure based drug design;
Up-regulation of caveolin-1 by DJ-1 attenuates rat pulmonary arterial hypertension by inhibiting TGFβ/Smad signaling pathway
Keywords: Pulmonary arterial hypertension; Pulmonary artery smooth muscle cells; DJ-1; Caveolin-1, TGF-β/Smad;
Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models
Keywords: AD; Alzheimer's disease; BBB; blood-brain barrier; CNS; central nervous system; DMSO; dimethyl sulfoxide; LPS; lipopolysaccharide; MCO; metal-catalyzed oxidation; OS; oxidative stress; PD; Parkinson's disease; ROS; reactive oxygen species; Parkinson´s di
DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction
Keywords: Parkinson's disease; DJ-1; α-Synuclein; Fibrillization; Aggregation; Denaturing conditions;
DJ-1 activates SIRT1 through its direct binding to SIRT1
Keywords: DJ-1; SIRT1; Deacetylase; p53;
DJ-1 mutation decreases astroglial release of inflammatory mediators
Keywords: DJ-1; Astrocyte; Neuroinflammation; Lipopolysaccharide;
DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission
Keywords: DJ-1; Myocardial ischemia; Mitochondrial fission; SUMOylation;
Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels
Keywords: Bach1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; DJ-1; Parkinson disease-associated protein; EC; Endothelial cells; GCL; Glutamate cysteine ligase; GCLM; Glutamate cysteine ligase modulatory subunit; HCAEC; Human coronary artery
Protective effects of DJ-1 medicated Akt phosphorylation on mitochondrial function are promoted by Da-Bu-Yin-Wan in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells
Keywords: Parkinson's disease; Mitochondrial dysfunction; DJ-1; Akt; Phosphorylation; Da-Bu-Yin-Wan
Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
Keywords: BD; bipolar disorder; DHEA; Dehydropiandrosterone; DJ-1; protein deglycase; DOPAC 3,4; dihydroxyphenylacetic acid; FMN; flavine mononucleotide; Grx2; glutaredoxin 2; GSH; glutathione; 6-OHDA; 6-hydroxydopamine; IMP-2; insulin-like growth factor 2 [IGF2] m
Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases
Keywords: ÎΨm; membrane potential; AD; Alzheimer's disease; AMPK; adenosine-monophosphate-activated kinase; ATG proteins; autophagy-related proteins; ATP; adenosine triphosphate; CaMKs; calcium-calmodulin-activated kinases; CDKs; cyclin-dependent kinases; CNS;
Elevated salivary protein in Parkinson's disease and salivary DJ-1 as a potential marker of disease severity
Keywords: Parkinson's disease; Biomarkers; Diagnostics; Autonomic function; DJ-1;
Research paperOverexpression of DJ-1 protects against C2-ceramide-induced neuronal death through activation of the PI3K/AKT pathway and inhibition of autophagy
Keywords: C2-ceramide; Parkinson's disease; DJ-1; mTOR; PI3K/AKT; Autophagy;
Expression and protease activity of mouse legumain are regulated by the oncogene/transcription co-activator, DJ-1 through p53 and cleavage of annexin A2 is increased in DJ-1-knockout cells
Keywords: Legumain; DJ-1; p53; Annexin A2; Z; benzyloxycarbonyl; MCA; methylcumarinamide;
DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease
Keywords: Parkinson's disease; DJ-1; Compound; MPTP; Neuroprotection
Associate Editor: P. MolenaarActivation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1
Keywords: DJ-1; Endogenous antioxidant; Mechanism-oriented therapy; Disease-oriented therapy; ASK1; apoptosis signal regulating kinase; JNK; Jun N-terminal kinase; NQO1; NAD(P)H:quinone oxidoreductase 1; Nrf2; nuclear factor erythroid 2-related factor; p53; tumor p
The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice
Keywords: DIO, diet-induced obesity; eWAT, epididymal white adipose tissue; HFD, high-fat diet; PD, Parkinson’s diseaseDiet-induced obesity; Park7; DJ-1; Mice; Neurodegeneration; High-fat diet
SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt
Keywords: Striatin; SG2NA; Auto-antigen; Akt; DJ-1; Cancer;
DJ-1 regulates the expression of renal (pro)renin receptor via reactive oxygen species-mediated epigenetic modification
Keywords: DJ-1; (Pro)Renin receptor; Epigenetic modification; Oxidative stress;
DJ-1 as a human oncogene and potential therapeutic target
Keywords: DJ-1; Cancer; Therapeutics; Post-translational modification;
Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice - A quantitative multireceptor study
Keywords: PD; Parkinson's disease; ROI; regions of interest; Parkinson's disease; neurotransmitter receptor; Parkin; DJ-1; knockout mouse;
GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3â²,5â²-cyclic adenosine monophosphate;
CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls
Keywords: Parkinson's disease; Multiple system atrophy; DJ-1; Cerebrospinal fluid; Biomarkers;
Serum DJ-1 level is positively associated with improvements in some aspects of metabolic syndrome in Japanese women through lifestyle intervention
Keywords: DJ-1; Metabolic syndrome; Risk factor; Lifestyle intervention; Improvement; BMI; body mass index; CCK; cholecystokinin; LDL; low-density lipoprotein; LDLR; low-density lipoprotein receptor; PD; Parkinson disease;